*  Loss of stromal androgen receptor leads to suppressed prostate tumourigenesis via modulation of pro-inflammatory cytokines...
B mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1{beta}. J Biol Chem ... gene was originally identified as a tumour suppressor gene located at chromosome 10q23 (Myers et al, 1997). The PTEN gene is ... Ma WL, Hsu CL, Wu MH, Wu CT, Wu CC, Lai JJ, Jou YS, Chen CW, Yeh S, Chang C (2008) Androgen receptor is a new potential ... The biallelic mutation of the PTEN gene or the 2nd hit of loss-of-function in tumour suppressor genes could promote advanced ...
  http://onlinelibrary.wiley.com/doi/10.1002/emmm.201101140/full?globalMessage=0
*  CCR1 - Wikipedia
This gene encodes a member of the beta chemokine receptor family, which belongs to G protein-coupled receptors. The ligands of ... this receptor include CCL3 (or MIP-1 alpha), CCL5 (or RANTES), CCL7 (or MCP-3), and CCL23 (or MPIF-1). Chemokines and their ... This gene and other chemokine receptor genes, including CCR2, CCRL2, CCR3, CCR5 and CXCR1, are found to form a gene cluster on ... Daugherty BL, Springer MS (April 1997). "The beta-chemokine receptor genes CCR1 (CMKBR1), CCR2 (CMKBR2), and CCR3 (CMKBR3) ...
  https://en.wikipedia.org/wiki/CCR1
*  CCL4 - Wikipedia
1995). "Molecular characterization of two murine eosinophil beta chemokine receptors". J. Immunol. 155 (11): 5299-305. PMID ... Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in humans is encoded by the CCL4 gene. CCL4, also known ... Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta. CCL4 has been shown to interact with CCL3. Macrophage ... Combadiere C, Ahuja SK, Murphy PM (1995). "Cloning and functional expression of a human eosinophil CC chemokine receptor". J. ...
  https://en.wikipedia.org/wiki/CCL4
*  CCR5 - Wikipedia
"CCR5 - chemokine (C-C motif) receptor 5 (gene/pseudogene)". Genetics Home Reference. Samson M, Labbe O, Mollereau C, Vassart G ... The CCR5 protein belongs to the beta chemokine receptors family of integral membrane proteins. It is a G protein-coupled ... receptor which functions as a chemokine receptor in the CC chemokine group. CCR5's cognate ligands include CCL3, CCL4 (also ... and HIV co-receptor activity. HIV-1 most commonly uses the chemokine receptors CCR5 and/or CXCR4 as co-receptors to enter ...
  https://en.wikipedia.org/wiki/CCR5
*  Index of immunology articles - Wikipedia
... alpha Interleukin 8 receptor, beta Interleukin receptor Interleukin-1 receptor Interleukin-1 receptor family Interleukin-1 ... C-C chemokine receptor type 6 C-C chemokine receptor type 7 Calreticulin Cancer immunology Cancer immunoprevention Cancer ... gene) CCR4 CCR5 CCR8 (gene) CCR9 CCRL1 CCRL2 CD117 CD32B CD4 CD4+ T cells and antitumor immunity CD74 CD94/NKG2 Cell-mediated ... CCL1 CCL11 CCL12 CCL13 CCL14 CCL15 CCL16 CCL17 CCL18 CCL19 CCL2 CCL20 CCL21 CCL22 CCL23 CCL24 CCL25 CCL26 CCL27 CCL28 CCL3 CCL5 ...
  https://en.wikipedia.org/wiki/Index_of_immunology_articles
*  CCL4L1 - Wikipedia
"The assignment of chemokine-chemokine receptor pairs: TARC and MIP-1 beta are not ligands for human CC-chemokine receptor 8". ... Townson JR, Barcellos LF, Nibbs RJ (2002). "Gene copy number regulates the production of the human chemokine CCL3-L1". Eur. J. ... C-C motif chemokine 4-like is a protein that in humans is encoded by the CCL4L1 gene. This gene is one of several cytokine ... Guan E, Wang J, Roderiquez G, Norcross MA (2002). "Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor ...
  https://en.wikipedia.org/wiki/CCL4L1
*  CC chemokine receptors - Wikipedia
CC chemokine receptors (or beta chemokine receptors) are integral membrane proteins that specifically bind and respond to ... The CC chemokines CCL3, CCL5, CCL17 and CCL22 signal through this receptor. CCR5 is expressed on several cell types including ... CCR1 was the first CC chemokine receptor identified and binds multiple inflammatory/inducible (see inducible gene) CC ... The orphan chemokine receptor G protein-coupled receptor-2 (GPR-2, CCR10) binds the skin-associated chemokine CCL27 (CTACK/ALP/ ...
  https://en.wikipedia.org/wiki/CC_chemokine_receptors
*  CCL3 - Wikipedia
... is a protein that in humans is encoded by the CCL3 gene. CCL3 is a cytokine belonging to the CC chemokine family that is ... 1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4). CCL3 produces a ... the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes through binding to the receptors ... Human CCL3 genome location and CCL3 gene details page in the UCSC Genome Browser. Menten P, Wuyts A, Van Damme J (Dec 2002). " ...
  https://en.wikipedia.org/wiki/CCL3
*  Adenylate Cyclase Activating Polypeptide 1 (Pituitary) Receptor Type I (ADCYAP1R1) ELISA Kits
... increased macrophage resistance to HIV-1 replication by inducing the synthesis of beta-chemokines CCL3 (show CCL3 ELISA Kits) ... This gene encodes type I adenylate cyclase activating polypeptide receptor, which is a membrane-associated protein and shares ... PACAP receptor 1 , PACAP type I receptor , PACAP-R1 , pituitary adenylate cyclase activating polypeptide 1 receptor type I ... ADCYAP receptor type I (adcyap1r1) Elisa Kit * adenylate cyclase activating polypeptide 1 (pituitary) receptor type I S ...
  http://www.antibodies-online.com/neurotrophin-signaling-pathway-pathway-29/adcyap1r1-elisa-kit-205/
*  Nanobodies
This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions ... CCL3, also known as Macrophage inflammatory protein-1α (MIP-1α), is a cytokine belonging to the CC chemokine family that is ... 1988) demonstrated 2 protein components of MIP1, called by them alpha and beta. ... The effects of CCL11 are mediated by its binding to a G-protein-linked receptor known as a chemokine receptor. Chemokine ...
  http://invivosaglik.com/nanobodies_63_en.html
*  Interactive Effects of Morphine on HIV Infection: Role in HIV-Associated Neurocognitive Disorder
47]. Morphine regulates gene expression of alpha- and beta-chemokines and their receptors on astroglial cells via the opioid mu ... and CCL3 (MIP-1α) protein and mRNA expression levels were significantly exacerbated when exposed to Tat and morphine together ... and beta-chemokines and their receptors on astroGlial cells via the opioid mu receptor," The Journal of Immunology, vol. 169, ... "Chemokine and chemokine-receptor expression in human Glial elements: induction by the HIV protein, Tat, and chemokine ...
  https://www.hindawi.com/journals/art/2012/953678/
*  Macrophage inflammatory protein - Wikipedia
"High-resolution solution structure of the beta chemokine hMIP-1 beta by multidimensional NMR". Science. 263 (5154): 1762-1767. ... The genes for CCL3 and CCL4 are both located on human chromosome 17. They are produced by many cells, particularly macrophages ... Polymerization buries receptor-binding sites of MIP-1, thus depolymerization mutations enhance MIP-1 to arrest monocytes onto ... December 2010). "Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzyme". EMBO J ...
  https://en.wikipedia.org/wiki/Macrophage_inflammatory_protein
*  Anti-HMGB1 antibody [HAP46.5] (ab12029) | Abcam
Mediates the release of cytokines/chemokines such as TNF, IL-1, IL-6, IL-8, CCL2, CCL3, CCL4 and CXCL10 (PubMed:12765338, ... Can bind to IL1-beta and signals through the IL1R1:IL1RAP receptor complex (PubMed:18250463). Binding to class A CpG activates ... Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters ... In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively ...
  http://www.abcam.com/hmgb1-antibody-hap465-ab12029.html
*  Yang Hu, MD, Ph.D | Stanford Medicine Profiles
... in response to chemokines CCL3 and CCL5 that recruit DCs to inflammatory sites, but not the lymphoid-homing chemokine CCL21. ... by TLR ligands induces expression of IFN-beta and autocrine activation of IFN-inducible Stat1-dependent genes important for DC ... Costimulation of chemokine receptor signaling by matrix metalloproteinase-9 mediates enhanced migration of IFN-alpha dendritic ... Thus, cell motility is regulated by integrating signaling inputs from chemokine receptors and molecules such as MMP-9, CD11b, ...
  https://med.stanford.edu/profiles/yang-hu
*  Frontiers | Peroxisome proliferator-activated receptor agonists modulate neuropathic pain: a link to chemokines? | Frontiers in...
... pain ameliorating effects and suppression of inflammatory gene expression, including chemokines. In early clinical research, ... Peroxisome proliferator-activated receptors are a family of nuclear receptors known for their roles in metabolism. Recent ... Peroxisome proliferator-activated receptors are a family of nuclear receptors known for their roles in metabolism. Recent ... pain ameliorating effects and suppression of inflammatory gene expression, including chemokines. In early clinical research, ...
  https://www.frontiersin.org/articles/10.3389/fncel.2014.00238/full
*  005427 - B6.129P2-Ccr5|tm1Kuz|/J
... receptor 5 in these knock-out mice affects immune and a number of other physiological responses. They are useful for widespread ... Gene Symbol and Name. Ccr5, chemokine (C-C motif) receptor 5. Gene Synonym(s). CC-CKR-5; CCCKR5; CCR-5; CD195; CKR-5; CKR5; ... Evidences of the cooperative role of the chemokines CCL3, CCL4 and CCL5 and its receptors CCR1+ and CCR5+ in RANKL+ cell ... CC chemokine receptor 5 signaling pathway in the neuroinflammatory response and cognitive deficits induced by beta-amyloid ...
  https://www.jax.org/strain/005427
*  CC chemokine receptor 4 modulates Toll-like receptor 9-mediated innate immunity and signaling
... of the CC chemokines TARC and macrophage inflammatory protein-1 beta as novel functional ligands for the CCR8 receptor. Eur J ... A) Gene expressions of FIZZ1, Arginase-1, and Mannose receptor (proteins expressed by alternatively activated (M2-skewed) cells ... CCL3, and IL-12 p70 were measured. Inhibitors of Akt, JNK, and IKK, but not p38 MAPK suppressed the expression of TNF-α, CCL3, ... CC chemokine receptor 4 (CCR4), a specific receptor for CCL17 and CCL22, is generally recognized as a receptor expressed on T ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2925393/
*  The 'immunologic advantage' of HIV-exposed seronegative indi... : AIDS
... that confers cellular resistance to HIV infection is the homozygous 32 base-pair deletion in the CCR5 chemokine receptor gene ( ... African infants' CCL3 gene copies influence perinatal HIV transmission in the absence of maternal nevirapine. AIDS 2007; 21: ... and beta-chemokines, is increased [10-12], secretory HIV-specific IgA as well as T helper cells and CTLs can be observed in ... Vitamin D receptor gene sequence variations and polymorphisms in the transcriptional regulator gene interferon regulatory ...
  https://journals.lww.com/aidsonline/fulltext/2009/01140/the__immunologic_advantage__of_hiv_exposed.2.aspx
*  Role of microglia in disease - Wikipedia
"HIV-1 can enter the microglial cell via CD4 receptors and chemokine co-receptors such as CCR3, CCR5, and CXCR4, with CCR5 being ... The chemokines CCL5/RANTES, CCL3/MIP-1α, CCL4/MIP-1β, all of which bind to CCR5, are inhibitory to HIV-1 replication in ... When microglia are activated they take on an amoeboid shape and they alter their gene expression. Altered gene expression leads ... Then, the oxygen species encourage the aggregation of beta amyloid in order to form plaques. The growing size of these plaques ...
  https://en.wikipedia.org/wiki/Role_of_microglia_in_disease
*  Leukotactin-1/CCL15 induces cell migration and differentiation of human eosinophilic leukemia EoL-1 cells through PKCδ...
CCL15 is a CC chemokine that binds to the CCR1 and CCR3. Lkn-1 functions as an essential factor in the migration of monocytes, ... Rossi D, Zlotnik A (2000) The biology of chemokines and their receptors. Annu Rev Immunol 18:217-242CrossRefPubMedGoogle ... Pardigol A, Forssmann U, Zucht HD, Loetscher P, Schulz-Knappe P, Baggiolini M et al (1998) HCC-2, a human chemokine: gene ... cells from human cord blood and murine bone marrow is suppressed by C6 beta-chemokines. Mol Cells 15:176-180PubMedGoogle ...
  https://link.springer.com/article/10.1007%2Fs11033-009-9687-z
*  CC-CKR-5 | definition of CC-CKR-5 by Medical dictionary
A gene on chromosome 3p21.31 that encodes a member of the beta chemokine receptor family, which is similar to G protein-coupled ... 6584) reporting the discovery that the Beta-chemokine receptor CC-CKR-5 is a second receptor for HIV infection. ... Progenics and ADARC scientists show for the first time that the Beta-chemokine receptor CC-CKR-5 is a second receptor for ... CCR5 is expressed by T cells and macrophages; it is a receptor for various CC-chemokines, including MIP-1-alpha, MIP-1-beta and ...
  https://medical-dictionary.thefreedictionary.com/CC-CKR-5
*  The Inflammatory Microenvironment in Hepatocellular Carcinoma: A Pivotal Role for Tumor-Associated Macrophages
In fact, several NF-κB-regulated genes such as IL-12p40, TNF-α, Chemokine (C-C motif) Ligand 3 (CCL3), and IL-6 were ... P. Bedossa, E. Peltier, B. Terris, D. Franco, and T. Poynard, "Transforming growth factor-beta 1 (TGF-β1) and TGF-β1 receptors ... 3.1.5. Chemokines. In HCC progression, chemokines and their receptors play an intricate role. Chemokines could affect the ... H. Liu, Z. Pan, A. Li et al., "Roles of chemokine receptor 4 (CXCR4) and chemokine ligand 12 (CXCL12) in metastasis of ...
  https://www.hindawi.com/journals/bmri/2013/187204/
*  Similar articles for PubMed (Select 23228695) - PubMed - NCBI
Identification of C-C chemokine receptor 1 (CCR1) as the monocyte hemofiltrate C-C chemokine (HCC)-1 receptor. ... Skin reactivity and local cell recruitment in human atopic and nonatopic subjects by CCL2/MCP-1 and CCL3/MIP-1alpha. ... Actions of the chemotactic cytokines MCP-1, MCP-2, MCP-3, RANTES, MIP-1 alpha and MIP-1 beta on human monocytes. ... protein-1alpha in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene ...
  https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=23228695
*  Near-Normalized Gene Expression Profiles in Bladder With Detrusor Overactivity in Rats With Bladder Outlet Obstruction After...
Chemokine (C-X-C motif) ligand 14. CXCL14. 0.959. 0.490. 0.495. Colony stimulating factor 2 receptor, beta 1, low-affinity ( ... In particular, the degree of expression of genes such as chemokine ligand 2 (CXCL2), chemokine ligand 4 (CCL4), CCL3, CCL5, and ... The genes belonging to this group are almost identical to those found in the chemokine and receptor and immune response ... Chemokine and receptor pathways. A total of 30 genes related to this functional pathway were overexpressed (approximately 70% ...
  http://einj.org/journal/view.php?number=702&viewtype=pubreader