*  Muscarinic Acetylcholine Receptor M1/CHRM1 Proteins: Novus Biologicals
Muscarinic Acetylcholine Receptor M1/CHRM1 Proteins available through Novus Biologicals. Browse our Muscarinic Acetylcholine Receptor M1/CHRM1 Protein catalog backed by our Guarantee+.
  https://www.novusbio.com/product-type/peptides-and-proteins?related_diseases=Depressive%20Disorder&common_name=Muscarinic%20Acetylcholine%20Receptor%20M1/CHRM1
*  AID 141718 - Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M1, using [3H]- pirenzepine, a...
BioAssay record AID 141718 submitted by ChEMBL: Compound was evaluated for its affinity towards Muscarinic acetylcholine receptor M1, using [3H]- pirenzepine, a radioligand displacement assay in rat hippocampal membranes.
  https://pubchem.ncbi.nlm.nih.gov/bioassay/141718
*  AID 142804 - Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates - ...
BioAssay record AID 142804 submitted by ChEMBL: Displacement of [3H]QNB from Muscarinic acetylcholine receptor M2 from rat heart homogenates.
  https://pubchem.ncbi.nlm.nih.gov/bioassay/142804
*  Chrm3 - Muscarinic acetylcholine receptor M3 - Rattus norvegicus (Rat) - Chrm3 gene & protein
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
  http://www.uniprot.org/uniprot/P08483
*  Chrm4 - Muscarinic acetylcholine receptor M4 - Rattus norvegicus (Rat) - Chrm4 gene & protein
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
  http://www.uniprot.org/uniprot/P08485
*  CHRM1 - Muscarinic acetylcholine receptor M1 - Homo sapiens (Human) - CHRM1 gene & protein
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
  http://www.uniprot.org/uniprot/P11229
*  Muscarinic acetylcholine receptor M1
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008 ...
  https://pharos.nih.gov/idg/targets/P11229
*  M1-M5 muscarinic receptor knockout mice as novel tools to study the physiological roles of the muscarinic cholinergic ...
A large body of evidence indicates that muscarinic acetylcholine receptors (mAChRs) play critical roles in regulating the activity of many important functions of the central and peripheral nervous systems. However, identification of the physiological and pathophysiological roles of the individual mAChR subtypes (M(1)-M(5)) has proven a difficult task, primarily due to the lack of ligands endowed with a high degree of receptor subtype selectivity and the fact that most tissues and organs express multiple mAChRs. To circumvent these difficulties, we used gene targeting technology to generate mutant mouse lines containing inactivating mutations of the M(1)-M(5) ...
  https://www.semanticscholar.org/paper/M1-M5-muscarinic-receptor-knockout-mice-as-novel-t-Wess-Duttaroy/cf9bf604935bd278ada8f821fda7183df0599ab0
*  DIGITAL.CSIC: Muscarinic M2-selective ligands also recognize M4 receptors in the rat brain: Evidence from combined in situ...
We have used autoradiographic techniques to examine the characteristics and distribution of the binding of reported selective M2 muscarinic ligands and compared them with the distribution of cells expressing mRNAs for the different subtypes of muscarinic receptors. Our results suggest that the M2 ligands used in the present study ([3H]OXO-M, [3H]AF-DX 384, AF-DX 116, methoctramine) also recognize M4 receptors present in regions such as the striatum and olfactory tubercle. This is supported by 1) relative abundances of the different transcripts, with m2 mRNA being very scarce and m4 mRNA very abundant in these regions; 2) comparison of the ...
  https://digital.csic.es/handle/10261/112690
*  Leicester Research Archive: FRET-Based Detection of M1 Muscarinic Acetylcholine Receptor Activation by Orthosteric and...
Background and Objective: Muscarinic acetylcholine receptors (mAChRs) are 7-transmembrane, G protein-coupled receptors that regulate a variety of physiological processes and represent potentially important targets for therapeutic intervention. mAChRs can be stimulated by full and partial orthosteric and allosteric agonists, however the relative abilities of such ligands to induce conformational changes in the receptor remain unclear. To gain further insight into the actions of mAChR agonists, we have developed a fluorescently tagged M1 mAChR that reports ligand-induced conformational changes in real-time by changes in Förster resonance energy transfer (FRET). Methods: Variants of CFP and YFP ...
  https://lra.le.ac.uk/handle/2381/12662
*  Toward activated homology models of the human M1 muscarinic acetylcholine receptor - UM Repository
BUCKLE, MICHAEL JAMES CHRISTOPHER (2014) Toward activated homology models of the human M1 muscarinic acetylcholine receptor. Journal of Molecular Graphics Modelling, 49. pp. 91-98. ...
  http://repository.um.edu.my/39959/
*  AID 141019 - Tested in vitro for the binding affinity against muscarinic receptor subtype 3 (M3); not active - PubChem
BioAssay record AID 141019 submitted by ChEMBL: Tested in vitro for the binding affinity against muscarinic receptor subtype 3 (M3); not active.
  https://pubchem.ncbi.nlm.nih.gov/bioassay/141019
*  Regulator of G-protein signaling 7
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:10521509, PubMed:10862767). The RGS7/GNB5 dimer enhances GNAO1 GTPase activity (PubMed:10521509). May play a role in synaptic vesicle exocytosis (PubMed:12659861). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling (PubMed:15897264 ...
  https://pharos.nih.gov/idg/targets/P49802
*  RASGRP2 - RAS guanyl-releasing protein 2 - Homo sapiens (Human) - RASGRP2 gene & protein
Functions as a calcium- and DAG-regulated nucleotide exchange factor specifically activating Rap through the exchange of bound GDP for GTP. May also activates other GTPases such as RRAS, RRAS2, NRAS, KRAS but not HRAS. Functions in aggregation of platelets and adhesion of T-lymphocytes and neutrophils probably through inside-out integrin activation. May function in the muscarinic acetylcholine receptor M1/CHRM1 signaling pathway.
  http://www.uniprot.org/uniprot/Q7LDG7
*  Most recent papers with the keyword tachycardia ventricular | Read by QxMD
Atropine is a clinically relevant anticholinergic drug, which blocks inhibitory effects of the parasympathetic neurotransmitter acetylcholine on heart rate leading to tachycardia. However, many cardiac effects of atropine cannot be adequately explained solely by its antagonism at muscarinic receptors. In isolated mouse ventricular cardiomyocytes expressing a Förster resonance energy transfer (FRET)-based cAMP biosensor, we confirmed that atropine inhibited acetylcholine-induced decreases in cAMP. Unexpectedly, even in the absence of acetylcholine, after G-protein inactivation with pertussis toxin or in myocytes from M2- or M1/3-muscarinic receptor knockout mice, atropine ...
  https://www.readbyqxmd.com/keyword/109175
*  AID 140995 - Antimuscarinic activity was evaluated against muscarinic M3 receptor in Guinea-Pig ileum - PubChem
BioAssay record AID 140995 submitted by ChEMBL: Antimuscarinic activity was evaluated against muscarinic M3 receptor in Guinea-Pig ileum.
  https://pubchem.ncbi.nlm.nih.gov/bioassay/140995
*  AID 743109 - Discovery of Novel Antagonists of Muscarinic Receptor M5: Counterscreen against human M2 - PubChem
BioAssay record AID 743109 submitted by Vanderbilt Specialized Chemistry Center: Discovery of Novel Antagonists of Muscarinic Receptor M5: Counterscreen against human M2.
  https://pubchem.ncbi.nlm.nih.gov/bioassay/743109
*  Compounds Having Muscarinic Receptor Antagonist And Beta2 Adrenergic Receptor Agonist Activity (Chiesi Farmaceutici S.p.a.)
Compounds of formula (I) defined herein act both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists and are useful for the prevention and/or treatment of broncho-obstructive or inflammatory diseases.
  http://www.freshpatents.com/-dt20150521ptan20150139916.php
*  CHO-K1/M4/Gα15 Stable Cell Line Molecule - GenScript
Muscarinic acetylcholine receptors belong to a superfamily of seven-TM-domain receptors that interact with G-proteins to initiate intracellular responses. Five muscarinic receptor subtypes have been identified and named from M1 to M5. The M4 muscarinic receptor couples to Gi/o to inhibit cAMP p...
  https://www.genscript.com/molecule/M00238-M4.html
*  Research programme: muscarinic receptor antagonists - Dong-A ST - AdisInsight
Dong-A ST is developing a series of muscarinic M3 receptor antagonists for the treatment of overactive bladder. Development of the lead compound, designated DA
  http://adisinsight.springer.com/drugs/800043396
*  Muscarinic receptor activators as antipsychotic agents - Jeffrey Conn
Selective agonists of the M1 subtype of muscarinic acetylcholine receptor (mAChR) may provide a novel approach for treatment of both psychosis and cognitive dis...
  http://grantome.com/grant/NIH/R01-MH073676-09
*  ValiScreen Muscarinic M4 (human) cell line | PerkinElmer
Stable recombinant cell line expressing the Muscarinic, M1 receptor. Human recombinant, in CHO-K1 host cell. We provide: Two vials of the recombinant cell line as frozen cells; Detailed product information including sequence, cell line properties, culture conditions, pharmacological properties of the recombinant receptor in binding and functional assays (cAMP). In addition, for total reassurance, we will provide up to two free replacements within in a 2 year period should you accidently lose your cell line ...
  https://www-punchout.perkinelmer.com/product/muscarinic-m4-human-cell-line-es-213-c
*  The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular FunctionNovelty...
The results of this study indicate that NOSTRIN interacts directly with the M3R and is required for its correct spatial localization at the plasma membrane in aortic endothelial cells. In the absence of NOSTRIN, the function of the M3R was markedly impaired, resulting in abolition of the calcium response to acetylcholine, an impaired activation of eNOS, and the inhibition of vascular relaxation. These changes at the cellular level were reflected in vivo in the existence of elevated blood pressure and diastolic dysfunction in NOSTRINΔEC mice.. The interaction of NOSTRIN with the M3R is to our knowledge the first example of an F-BAR protein interacting with a Gαq/11-protein-coupled receptor. The interaction is direct and involves the SH3 domain of NOSTRIN. The SH3 ...
  http://circres.ahajournals.org/content/117/5/460.full
*  Heparin Induces Rat Aorta Relaxation via Integrin-Dependent Activation of Muscarinic M3 Receptors | Hypertension
Thank you for your interest in spreading the word on Hypertension.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address. ...
  http://hyper.ahajournals.org/content/early/2010/08/30/HYPERTENSIONAHA.110.156877
*  Muscarinic Receptors - BET-bromodomain inhibition research
All these equipment called our interest, considering that the super model tiffany livingston can be equipped directly using the explicit type of the equation over (Eq. 2) where ocean level at year depends on a mean level (with respect to the temperature during the first year. When this equation is usually fitted to smoothed and binned observations, parameter estimates and projections of future sea-level rise are, as expected, much like those offered in ref. 2. However, updated parameter estimates improved the ability of the Rahmstorf (1) model to fit the data and resulted in projections of sea-level rise much like those produced by the extended version of the model (2) (Table 1). Table 1. Contribution of each term included in the ...
  http://healthandwellnesssource.org/category/muscarinic-receptors/