*  HLA A1-B8-DR3-DQ2 - Wikipedia
A multigene haplotype is set of inherited alleles covering several genes, or gene-alleles; common multigene haplotypes are ... one expects 1/2 of adjacent genes to have new gene-alleles, unless the genes are small and very close together. This dynamic ... Two-point haplotype analysis between TNFB(B*01 allele) and HLA show that the allele is in linkage disequilibrium with HLA-A1, ... Other haplotypes exist in the region of Europe where this haplotype formed and expanded, some of these haplotypes also are ...
  https://en.wikipedia.org/wiki/HLA_A1-B8-DR3-DQ2
*  Gene polymorphisms of novel immunotolerant molecule BTLA: distribution of alleles, genotypes and haplotypes in Polish Caucasian...
gene polymorphism B lymphocyte T lymphocyte interleukin T helper cell allele distribution genotype haplotype Polish Caucasian ... Gene polymorphisms of novel immunotolerant molecule BTLA: distribution of alleles, genotypes and haplotypes in Polish Caucasian ...
  http://agro.icm.edu.pl/agro/element/bwmeta1.element.agro-0638aecc-d17c-4b32-be09-98f8aa1e2418
*  HLA-DR3 - Wikipedia
DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this ... Ratanachaiyavong S, Lloyd L, Darke C, McGregor A (1993). "MHC-extended haplotypes in families of patients with Graves' disease ... Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1*0501 gene is almost always found within the DR3-DQ2 haplotype ... gene with Graves' disease is a result of linkage disequilibrium with the HLA haplotype DRB1*0304-DQB1*02-DQA1*0501". Clinical ...
  https://en.wikipedia.org/wiki/HLA-DR3
*  C H O R I
... haplotypes. The group A haplotype has six inhibitory genes and only one stimulatory gene (KIR2DS4). The group B haplotype has ... KIR haplotypes are classified into two distinct groups based on their gene content and allele combination 11-15 The group A ... The group B haplotypes have greater heterogeneity in gene content, including additional stimulatory KIR genes (KIR2DS1, KIR2DS2 ... Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes. Genome Res 19, 757-769 (2009 ...
  http://www.chori.org/Principal_Investigators/Trachtenberg_Elizabeth_A/tracht_research.html
*  Genetic Basis of Hypertension | Hypertension
Angiotensinogen gene haplotype and hypertension: interaction with ACE gene I allele. Hypertension. 2003; 41: 9-15. ... Six major haplotypes of AGT account for most of the variation in the AGT gene, although the frequency of each differed ... 20A allele.57 Interestingly, whereas the −20C/−6A/235Thr haplotype would normally be considered the high plasma AGT haplotype, ... 64 generated a haplotype map of each gene in the RAS and then performed association studies with individual SNPs and haplotype ...
  http://hyper.ahajournals.org/content/48/1/14.long
*  An investigation of 10 Y-STR loci and the detection of specific haplotype frequencies in Turkish population
Allele frequencies, gene diversities and haplotype frequencies were analyzed. Gene diversity per locus varied from 0.5788 ( ... When our minHt haplotypes frequencies compared with the other seven populations, we have found statistically significant ... The aHt haplotype has found a higher discriminatory potential than minHt haplotype with a better Pd combined value (0.9999936 ... aHt haplotype can be proposed as an alternative to minHt in paternity testing and forensic medicine applications involving ...
  http://www.scirp.org/journal/PaperInformation.aspx?PaperID=6248
*  β2-Adrenergic Receptor Genetic Variants and Risk of Sudden Cardiac Death | Circulation
Figure 1. Haplotype tree of the B2AR gene. Ten SNPs differ between the 3 common haplotypes. Two evolutionary distant clades are ... TABLE 1. B2AR Gene Polymorphism Allele Frequencies and Haplotype Structure and Frequency in White and Black CHS Participants ... of the haplotypes seen in this population.8 A haplotype tree of these 3 common haplotypes was constructed with the MEGA program ... Among blacks, 3 haplotypes account for ,95% of the variation seen in the coding and promoter regions of the B2AR gene. The ...
  http://circ.ahajournals.org/content/113/15/1842.long
*  HLA B7-DR15-DQ6 - Wikipedia
A multigene haplotype is set of inherited alleles covering several genes, or gene-alleles, common multigene haplotypes are ... HLA A*0201Cw*0702 : B*0702 : DRB1*1501 : DQA1*0102 : DQB1*0602 The gene-allele representation of the haplotype is: HLA A*0301Cw ... The appendation of the B7::DQ6 haplotype creates the A2-B7::DQ6 haplotype. This haplotype if found often in Northern Spain, ... Schipper R, Schreuder G, D'Amaro J, Oudshoorn M (1996). "HLA gene and haplotype frequencies in Dutch blood donors". Tissue ...
  https://en.wikipedia.org/wiki/HLA_B7-DR15-DQ6
*  A30-Cw5-B18-DR3-DQ2 (HLA Haplotype) - Wikipedia
A multigene haplotype is a set of inherited alleles covering several genes, or gene-alleles. Long haplotypes, like A30::DQ2, ... Excepting A*3002:Cw*0501:B*1801 haplotype, A*3002, the A30 allele found in the A30-Cw5-B18 haplotype, is rare in Europe. ... and combined these haplotypes represent approximately 30 percent of Sardinians haplotypes by gene frequency, indicating the ... Because the haplotype is indifferent to Cw allele the level is high in the Basque of Northern Spain. A30-B18 frequencies at ...
  https://en.wikipedia.org/wiki/A30-Cw5-B18-DR3-DQ2_(HLA_Haplotype)
*  Coeliac disease - Wikipedia
This haplotype is composed of two adjacent gene alleles, DQA1*0501 and DQB1*0201, which encode the two subunits, DQ α5 and DQ ... "Extended HLA haplotypes in a Carib Amerindian population: the Yucpa of the Perija Range". Hum Immunol. 62 (9): 992-1000. doi: ... Most people with coeliac bear a two-gene HLA-DQ2 haplotype referred to as DQ2.5 haplotype. ... The reason these genes produce an increase in risk of coeliac disease is that the receptors formed by these genes bind to ...
  https://en.wikipedia.org/wiki/Coeliac_disease
*  HLA A1-B8 haplotype - Wikipedia
A multigene haplotype is set of inherited alleles covering several genes, or gene-alleles; common multigene haplotypes are ... These gene-alleles are markers for a haplotype, a stretch of chromosome 6 that contains many gene alleles. In its natural ... Two-point haplotype analysis between TNFB(B*01 allele) and HLA show that the allele is in linkage disequilibrium with HLA-A1, ... This disequilibrium made it appear that A1 and other class I gene-alleles were disease factors, when these alleles were only ...
  https://en.wikipedia.org/wiki/HLA_A1-B8_haplotype
*  Sharp Look at Complement in Genetics of Macular Degeneration | ALZFORUM
... it is genes and their alleles that matter, not individual polymorphisms. This is one of the reasons haplotype analysis can be ... CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration ... One possibility is that the variants affect complement factor H gene expression. Alleles that change a gene's expression level ... A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular ...
  http://www.alzforum.org/news/research-news/sharp-look-complement-genetics-macular-degeneration?id=1449
*  History and naming of human leukocyte antigens - Wikipedia
Each person has two HLA haplotypes, a cassette of genes passed on from each parent. The haplotype frequencies in Europeans are ... An HLA allele coding non-expressed gene is termed "Null Allele", for example: HLA-B*15:01:01:02N. The expression level can also ... Currently there are 7,678 Class I alleles and 2,268 Class II alleles. HLA Naming can be quite confusing at first. All alleles ... The next portion (HLA-A or HLA-B) identifies which gene the allele is a modification of. The first two numbers (HLA-A*02) ...
  https://en.wikipedia.org/wiki/History_and_naming_of_human_leukocyte_antigens
*  Severe Familial HDL Deficiency in French-Canadian Kindreds | Arteriosclerosis, Thrombosis, and Vascular Biology
Haplotypes of the apo AI gene, determined by use of the restriction enzymes Pst I, Xmn I, and Sst I and of the apo AII gene by ... Quantitative Southern blot analysis of the apo AI-CIII-AIV gene cluster reveals no gene rearrangements or allele deletion. ... Haplotype analysis of the lipoprotein lipase gene did not show segregation with the low HDL trait. Plasma lecithin:cholesterol ... For determination of haplotypes of the apo AI and apo AII genes, DNA was isolated from probands and all family members who were ...
  http://atvb.ahajournals.org/content/15/8/1015
*  Patent WO2009132089A2 - A method to identify asian soybean rust resistance quantitative trait loci ... - Google Patents
The analysis may be used to select for genes, QTL, alleles, or genomic regions (haplotypes) that comprise or are linked to a ... A haplotype within that window can be defined by the unique fingerprint of alleles at each marker. As used herein, an allele is ... Specifically, an "allele of a QTL" in the present invention can denote a haplotype within a haplotype window wherein a ... A genotype may constitute an allele for at least one genetic marker locus or a haplotype for at least one haplotype window. In ...
  http://www.google.com.au/patents/WO2009132089A2?cl=en
*  Genetic diversity testing for Standard Poodles
... and breed-wide allele frequency is provided. DLA haplotypes: STR loci linked to the DLA class I and II genes were used to ... This data will be updated as more dogs are tested, so allele and DLA haplotype frequencies may change to a limited extent over ... Groups of genes and their alleles that are inherited as a block, rather than singly, are called haplotypes. The class II region ... and DQB1 genes. One (or more) STR haplotypes is associated with each of the official DRB1/DQA1/DQB1 haplotypes identified in ...
  http://www.vgl.ucdavis.edu/services/dog/GeneticDiversityInStandardPoodles.php
*  Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension | Hypertension
Δ values show deviation from linkage equilibrium (Δ=h−p1p2; h, haplotype frequency; p1, p2, frequencies of two alleles at two ... To determine whether a particular linkage was present between any of these polymorphisms, we estimated eNOS haplotypes by ... Comparison of Genotype and Allele Frequencies for Glu298Asp Variants of eNOS Gene in Each Gender Population of Kyoto Group ... Comparison of Genotype and Allele Frequencies for Glu298Asp Variants of eNOS Gene in Two Distinct Areas in Japan ...
  http://hyper.ahajournals.org/content/32/1/3
*  Functional Variant of Manganese Superoxide Dismutase (SOD2 V16A) Polymorphism Is Associated with Prostate Cancer Risk in the...
However, SOD1 is a small gene and alleles in SOD1 show strong linkage disequilibrium in Caucasians (9). In addition, SOD2 Ex2+ ... Each haplotype pair was weighted by its probability, rather than assigning a most likely haplotype to an individual, and the ... polymorphism was excluded because of low variant allele frequency (G: ,1.5%). Haplotypes were estimated separately for ... Similar to our study, men homozygous for the SOD2 Ala allele had a 70% increase in risk over men homozygous for the Val allele ...
  http://cebp.aacrjournals.org/content/16/8/1581.long
*  P Gene as an Inherited Biomarker of Human Eye Color | Cancer Epidemiology, Biomarkers & Prevention
Hypopigmentation in the Prader-Willi syndrome correlates with P gene deletion but not with haplotype of the hemizygous P allele ... simultaneously consider multiple P gene variants or haplotypes, consider other genotype combinations in addition to the simple ... Gel electrophoresis of P gene variants. Arg305Trp and Arg419Gln alleles were determined by using a PCR-based assay that ... We also evaluated whether P gene alleles were associated with hair color. There was a marginally significant difference in the ...
  http://cebp.aacrjournals.org/content/11/8/782
*  Statistics in HLA Association Studies [M.Tevfik DORAK]
Allele (AF) or haplotype frequency (HF) is analogous to gene frequency (GF) in that they are always calculated in terms of the ... An example has been presented for HLA haplotypes (Ahmad, 2003). Haplotype-specific patterns of LD may reflect haplotype- ... study are the use of haplotypes rather than alleles and even an ancestral haplotype approach in a cladistic haplotype analysis ... The haplotype frequency (HFij) equals to GFi x GFj + D ij, where GF is the gene frequency (the proportion of the chromosomes ...
  http://dorakmt.tripod.com/hla/stat_2012.html
*  11.03.2017 | Computer Science and Engineering
"At the same time, precise haplotyping will allow for the genotyping of haplotypes, combinations of different genes or alleles ... "Each gene has two alleles, one from each parent. One of the alleles may contain disease-causing mutations. The carriers may be ... Project researchers generated the 2.2 billion DNA sequences for a highly variable region of a gene called 16S rRNA (a gene that ... but their offspring may show symptoms due to the combination of bad alleles or haplotypes from both parents." ...
  http://cse.ucsd.edu/node/1382
*  HLA-A1 - Wikipedia
HLA-A1 has a predominant genetic risk relative to other gene-alleles in the vicinity of the A1 gene on the larger haplotype. A1 ... 2008). "Type 1 diabetes risk for HLA-DR3 haplotypes depends on genotypic context: Association of DPB1 and HLA class I loci ... B8 only later to show the association drift toward the class II region gene alleles, DR3 and DQ2.5. While it is not clear what ... For A1, the alpha "A" chain are encoded by the HLA-A*01 allele group and the β-chain are encoded by B2M locus. This group ...
  https://en.wikipedia.org/wiki/HLA-A1
*  St. Clair Research
Haplotype (Ht): A set of closely linked alleles (genes or DNA polymorphisms) inherited as a unit. A contraction of the phrase " ... Haplogroup (Hg): a collection of closely related haplotypes. Haploid: A single set of chromosomes (half the full set of genetic ... Genetic markers: Alleles of genes, or DNA polymorphisms, used as experimental probes to keep track of an individual, a tissue, ... Allele: Alternative form of a genetic locus; a single allele for each locus is inherited separately from each parent (e.g., at ...
  http://www.stclairresearch.com/content/glossary.html
*  Haploid-relative-risk - Wikipedia
The Haplotype-relative-risk (HRR) method is a family-based method for determining gene allele association to a disease in the ... Nuclear families with one affected child are sampled using the parental haplotypes not transmitted as a control. While similar ... Under these parameters a linkage disequilibrium of more than 50% means there is a possible link to the gene allele and ... H is the allele of interest. Falk CT, Rubinstein P (1987) "Haplotype relative risks: and easy reliable way to construct a ...
  https://en.wikipedia.org/wiki/Haploid-relative-risk
*  Plus it
The presence of these alleles in a haplotype spanning the AKT2 gene region was also associated with PCOS. ... These were selected because they are predicted to tag the haplotypes (across the entire gene, plus 10 kb upstream and 10 kb ... Carriers of both minor alleles, in a haplotype, had the same OR as carriers of either risk allele alone, as a SNP. This finding ... Gene structure and LD plot for AKT2. A: The gene structure of AKT2 is shown; the gene has 14 exons and is located on the ...
  http://care.diabetesjournals.org/content/31/12/2284