*  Significant quantitative and qualitative transition in pituitary stem / progenitor cells occurs during the postnatal...
We reported recently that a pituitary-specific transcription factor PROP1 is present in SOX2-positive cells and disappears at the early stage of the transition from progenitor cell to committed cell during the embryonic development of the rat pituita
*  The glucocorticoid receptor inhibits the human prolactin gene expression by interference with Pit-1 activity - Nalda Asunción M
en] Glucocorticoids have been shown to inhibit the activity of the human prolactin (hPRL) promoter. Using transient expression experiments in rat pituitary cells, we located the sequence conferring glucocorticoid inhibition to a region which contains Pit-1 binding sites, responsible for pituitary-specific expression, but does not seem to contain a glucocorticoid receptor (GR) binding site. Co-transfection experiments in non-pituitary cell lines, using expression vectors for Pit-1 and different mutants of the human GR show that inhibition of the hPRL gene is seen only in the presence of Pit-1 and GR, and that the DNA binding function of the receptor is not required. Immunoprecipitation studies show that either anti-GR or anti-Pit-1 antibodies are able to co-precipitate GR and Pit-1, suggesting an interaction between these ...
*  Regulation of Pituitary Genes by the Transcription Factor, Pit-1, in the Domestic Turkey (A Turkey is NOT a Feathered Rat)
The transcription factor, Pit-1, is involved in the transcriptional regulation of the mammalian prolactin (Prl), growth hormone (GH) and thyroid stimulating hormone b-subunit genes (TSHb) as well as its own gene. The role of Pit-1 in avian species is unknown. Three turkey (t) Pit-1 isoforms have been identified that arise from alternative transcription initiation and alternative splicing. Splicing of exon 1 to an alternative acceptor splice site in exon 2 results in a 28 amino acid insertion in tPit-1β* relative to tPit-1*. Both isoforms initiate transcription at exon 1. A tPit-1 transcript unique to the turkey has been identified and arises following transcription initiation upstream of the ...
*  Psych Central - Remote control for human growth hormone gene expression
Researchers recently discovered a novel mechanism that works over an extensive genomic distance and controls the expression of human growth hormone (hGH) in the pituitary gland. This mechanism involves a newly discovered set of 'non-coding RNAs' expressed in the vicinity of the hGH gene. This may aid researchers in the development of therapeutics for growth hormone defects and lead to a greater understanding of the causes of other genetic disorders.
*  Growth hormone gene expression in canine normal growth plates and spontaneous osteosarcoma.
The indirect growth-promoting action of pituitary-derived growth hormone (GH) on skeletal growth is thought to be mediated by systemically released insulin-like growth factor-I (IG..
*  Control of growth hormone gene expression | Biochemical Society Transactions
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
*  Giant Hemorrhagic Prolactinoma with Sparse Prolactin Expression Presenting with Thalamic Infarction-A Case Report |...
Pituitary tumors are the most common form of intracranial neoplasms. Their prevalence in autopsy series was reported as 5-20 %.1 However, clinically relevant pituitary tumors presenting with disturbances of hormonal secretion or mass effect are rare, with an estimated prevalence of 200/1,000,000 and an incidence of 2/100,000 per year.2 Therefore, they only represent about 10 % of all surgically resected intracranial neoplasms.3,4
*  Homeobox-Protein-Prophet von Pit-1
Vieira TC et. al. (2003) Familial combined pituitary hormone deficiency due to a novel mutation R99Q in the hot spot region of Prophet of Pit-1 presenting as constitutional growth delay.. [^] ...
*  JCVI: Cloning and Sequencing of the Grass Carp (Ctenopharyngodon Idellus) Growth Hormone Gene.
Citation. Ho WK, Wong MW, Chan AP. Cloning and Sequencing of the Grass Carp (Ctenopharyngodon Idellus) Growth Hormone Gene.. Biochimica Et Biophysica Acta. 1991 Oct 08; 1090: 245-8.. External Citation. Abstract. An enriched lambda gt11 library for screening the grass carp (Ctenopharyngodon idellus) growth hormone gene was constructed using HindIII digested genomic DNA extracted from the spleen of the fish. Probing this library with a homologous cDNA, a clone carrying the growth hormone gene was obtained. The gene is 2501 bp long and consists of five exons and four introns. The sequence of nucleotide in the exons is almost identical to that of the cDNA except for ten positions. Analysis of the 5' sequence up to 1220 bp from the +1 position reveals the presence of a TATA box as well as a number of consensus regulatory sequences. Comparison of the grass carp growth hormone gene with those of other fish indicates that there is a ...
*  Nancy E. Cooke | Faculty | About Us | Perelman School of Medicine | Perelman School of Medicine at the University of...
The human growth hormone (hGH) gene cluster includes 5 genes: the pituitary hGH-N gene, and hCS-A, hCS-L, hGH-V, and hCS-B expressed in placenta. These 5 genes are regulated by a locus control region (LCR) located in the far 5' region of this multigene locus. The B-cell specific CD79b/Igß gene is interposed between the hGH LCR and the hGH-N gene. The LCR is made up of 5 DNaseI hypersensitive sites (HS) located between -14.5 kb (HSI) and -32 kb (HSV) 5' to hGH-N. These HS are only present in placenta and/or pituitary. When this 32 kb domain plus the linked GH genes are present in a transgenic construct, transgenic mice reproducibly and robustly express the hGH-N gene specifically in pituitary somatotropes and the hCS genes specifically in the placenta. Expression in both tissues is ...
*  PROP-1 - Wikipedia
PROP1 è un gene umano codificante per la proteina Homeobox protein prophet of Pit-1. PROP1 ha sia un'attività legante il DNA, che attivante la trascrizione. La sua espressione porta a genesi delle cellule gonadotrope dell'ipofisi così come le somatotrope, lattotrope e tireotrope. Mutazioni inattivanti PROP-1 causano deficit di ormone luteinizzante (LH; MIM 152780, ormone follicolo-stimolante (FSH; MIM 136530), ormone della crescita (GH; MIM 139250), prolattina (PRL; MIM 176760) e ormone tireostimolante (TSH; MIM 188540). (CPHD; MIM 262600).[supplied by OMIM] ^ Wu W, Cogan JD, Pfaffle RW, Dasen JS, Frisch H, O'Connell SM, Flynn SE, Brown MR, Mullis PE, Parks JS, Phillips JA 3rd, Rosenfeld MG, Mutations in PROP1 cause familial combined pituitary hormone deficiency, in Nat Genet, vol. 18, nº 2, febbraio 1998, pp. 147-9, DOI:10.1038/ng0298-147, PMID 9462743. ^ a b Entrez Gene: PROP1 prophet of ...
*  Role of LHX3 Protein Isoforms in Pituitary Development - Simon Rhodes
The long term goal of this research program is to understand the mechanisms that underlie human pituitary development and function and to apply that knowledge t...
*  PRL Gene - GeneCards | PRL Protein | PRL Antibody
Complete information for PRL gene (Protein Coding), Prolactin, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
*  PRL Gene - GeneCards | PRL Protein | PRL Antibody
Complete information for PRL gene (Protein Coding), Prolactin, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
*  PRL Gene - GeneCards | PRL Protein | PRL Antibody
Complete information for PRL gene (Protein Coding), Prolactin, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
*  PRL Gene - GeneCards | PRL Protein | PRL Antibody
Complete information for PRL gene (Protein Coding), Prolactin, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
*  LHX3 gene - Genetics Home Reference
From NCBI Gene:. This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]. From UniProt: ...
*  Donna E. Crone | Faculty at Rensselaer
Crone, DE*, Kim, H-S*, and Spindler, SR.. 1990. Alpha and beta thyroid hormone receptors bind immediately adjacent to the rat growth hormone gene TATA box in a negatively hormone responsive promoter region. J. Biol. Chem. 265(19):10851-6. (* co 1st authors ...
*  KAKEN - Researchers | YAMADA Shozo (80260131)
Affiliation:(財)冲中記念成人病研究所,その他部局等,研究員, Research Field:Respiratory organ internal medicine,Endocrinology,Cerebral neurosurgery,Tumor biology, Keywords:成長ホルモン,Pituitary gland,神経内分泌腫瘍,下垂体腫瘍,IGF-1受容体,下垂体腺腫,遺伝子発現,Pit-1,Pit-1核蛋白,Pituitary adenomas, # of Research Projects:4, # of Research Products:0, Ongoing Project:Cushing病におけるUSP8変異体標的蛋白を介したシグナル伝達異常の解明
*  Gene Expression Literature Detail
J:53310 Szeto DP, Rodriguez-Esteban C, Ryan AK, O'Connell SM, Liu F, Kioussi C, Gleiberman AS, Izpisua-Belmonte JC, Rosenfeld MG, Role of the Bicoid-related homeodomain factor Pitx1 in specifying hindlimb morphogenesis and pituitary development. Genes Dev. 1999 Feb 15;13(4):484-94 ...
*  Gene Expression Literature Summary - MGI
J:16215 Ontell MP, Sopper MM, Lyons G, Buckingham M, Ontell M, Modulation of contractile protein gene expression in fetal murine crural muscles: emergence of muscle diversity. Dev Dyn. 1993 Nov;198(3):203-13 ...
*  KAKEN - Researchers | SHIBUYA Makoto (50201546)
Affiliation:東京医科大学,医学部,教授, Research Field:Human pathology, Keywords:Pit-1,glioma,in situ hybridization,p16 gene,増殖能,神経膠腫,FISH,転写因子,receptor,FLSH, # of Research Projects:3, # of Research Products:0
*  John Snell Featured on WX TV | Thermal Imaging Blog from Fluke Thermography
Just recently, John Snell was featured on a WX TV weekly production on weatherization. For those of you who are unfamiliar with the department of energy's we
*  CiNii 論文 - Hypothalamic Gonadotropin-Releasing Hormone Gene Expression during Rat Estrous...
*  Gifted & Homeschool Friendly Professionals GHF
Everyone listed here was referred by GHF staff or members on the basis of good service, an understanding of giftedness, and an open mind regarding alternative forms of education.