*  Plus it
8B). This model is homozygous for a mutation in pituitary transcription factor-1 (Pit-1), which plays a key role in the ... Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature347 :528 -533, ... pituitary transcription factor-1; PND, postnatal day; SSC, sodium chloride-sodium citrate. ... Elevated levels of some of these factors, including tumor necrosis factor-α (2), plasminogen-activator inhibitor-1 (3), ...
  http://diabetes.diabetesjournals.org/content/52/2/268
*  The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3, Mammalian Genome | 10.1007...
"The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3, Mammalian Genome" on DeepDyve, ... Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1 ... The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3. The costimulatory genes Cd80 ... The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3. Reeves, Roger; Patch, David; ...
  https://www.deepdyve.com/lp/springer_journal/the-costimulatory-genes-cd80-and-cd86-are-linked-on-mouse-chromosome-olJox1SFja
*  Pituitary-specific positive transcription factor 1 - Wikipedia
"Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1". Gene. 122 (2): 387-8. doi:10.1016/ ... is a transcription factor for growth hormone. PIT1 is a pituitary-specific transcription factor responsible for pituitary ... PIT1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Transcription Factor Pit-1 at the US ... Lew AM, Elsholtz HP (1991). "Cloning of the human cDNA for transcription factor Pit-1". Nucleic Acids Res. 19 (22): 6329. doi: ...
  https://en.wikipedia.org/wiki/Pituitary-specific_positive_transcription_factor_1
*  Hypothyroidism in children: diagnosis and treatment
... linked to gene mutations of transcription factors involved in hypothalamic-pituitary embriogenesis. POU1F1 (previously Pit1) ... TH receptor proteins are coded by two genes: a gene, located in chromosome 17, and b gene, located in chromosome 3. The ... Kambe E, Seo H. Thyroid specific transcription factors. Endocr J. 1997; 44:775-84. [ Links ]. 15. Ares S, Escobar-Morreale, HF ... The binding of TH with their nuclear receptors allows the transcription of specific mRNA (nuclear receptors are transcription ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572007000700013&lng=en&nrm=iso&tlng=en
*  Hypophysenspezifischer Transkriptionsfaktor 1
al. (1996) A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone ... al. (1992) Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1. ... al. (1999) The tissue-specific transcription factor Pit-1/GHF-1 binds to the c-fos serum response element and activates c-fos ... al. (1990) Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. ...
  http://www.moldiag.com/moldiag/de/id/G0410
*  PROP1 - Wikipedia
"Entrez Gene: PROP1 prophet of Pit1, paired-like homeodomain transcription factor". Osorio MG, Kopp P, Marui S, et al. (2000). " ... Homeobox protein prophet of PIT-1 is a protein that in humans is encoded by the PROP1 gene. PROP1 has both DNA-binding and ... 2001). "PROP1 gene screening in patients with multiple pituitary hormone deficiency reveals two sites of hypermutability and a ... Rodriguez R, Andersen B (2003). "Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes ...
  https://en.wikipedia.org/wiki/PROP1
*  POU1F1 | Cancer Genetics Web
... by using a dominant-negative form of this gene involved in human pituitary deficiencies: transcription factor Pit-1 (POU1F1) ... Transcription factor (gene : POUF1) essential for transcription of Pituitary hormones GH, PRL and TSHb], which in turn leads to ... The transcription factor Pit-1/Pou1f1 regulates GH and prolactin (PRL) secretion in the pituitary gland. Pit-1 expression and ... Inactivation of transcription factor pit-1 to target tumoral somatolactotroph cells.. Hum Gene Ther. 2012; 23(1):104-14 [PubMed ...
  http://www.cancerindex.org/geneweb/POU1F1.htm
*  POU1F1 Gene - GeneCards | PIT1 Protein | PIT1 Antibody
Complete information for POU1F1 gene (Protein Coding), POU Class 1 Homeobox 1, including: function, proteins, disorders, ... Entrez Gene Summary for POU1F1 Gene. * This gene encodes a member of the POU family of transcription factors that regulate ... Gene-Enhancer Score. TSS distance (kb). Number of Genes Away. Size (kb). Transcription Factor Binding Sites within enhancer. ... RNA polymerase II transcription factor binding. IPI. 26612202. GO:0001102. RNA polymerase II activating transcription factor ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=POU1F1&genscript_clones_seq=2
*  General Information | Richard Maurer, Ph.D. | OHSU People | OHSU
"The pituitary-specific transcription factor, Pit-1, can direct changes in the chromatin structure of the prolactin promoter." ... "Expression of the synaptotagmin I gene is enhanced by binding of the pituitary-specific transcription factor, POU1F1." ... "In Vivo mutational analysis of the DNA binding domain of the tissue-specific transcription factor, Pit-1." Journal of ... "Thyrotropin releasing hormone stimulates transient phosphorylation of the tissue-specific transcription factor, Pit-1." Journal ...
  http://www.ohsu.edu/people/richard-maurer/BFD4C89E55524FEFA6F336D4AF82D60C
*  Molecular Cloning and Characterization of Human Cardiac Homeobox Gene CSX1 | Circulation Research
For example, the MyoD gene family of skeletal muscle-specific transcription factors plays a critical role in skeletal muscle ... differentiation.12 13 Many non-Hox class homeobox genes have been identified to date, and some of them, eg, Pit-1,14 TTF-1 ( ... 3 4 5 Mammalian homeobox genes could be divided into two classes, Hox class genes and non-Hox class genes. Hox class genes ... tk-luc gene was significantly higher than that of tk-luc (pT81luc), it is possible that some other transcription factors that ...
  http://circres.ahajournals.org/content/79/5/920
*  September, 2016 | Cholesterol Absorption Inhibitors cholesterol-absorption.com
Pit1 is important but not ample for basal transcription of the TSHb gene, in truth, the basal activity of the TSHb promoter was ... A pituitary-precise transcription factor, Pit1, was initially postulated as a applicant protein that influences TRH-induced ... Pit1 has also been claimed to be essential for regulation of the TSHb gene by TRH [13]. TRHdependent phosphorylation of Pit1 ... NP and NS genes of classical swine virus origin, the PB2 and PA genes from North American avian viruses, the PB1 gene from ...
  http://www.cholesterol-absorption.com/2016/09/
*  IJMS | Free Full-Text | Tailoring the Models of Transcription | HTML
... study of transcriptional regulation has been greatly facilitated by the development of reporter genes and transcription factor ... as well as transcription factors in order to examine their function. The understanding of promoter complexity and transcription ... Transcription is the first step in protein expression and the major point of regulation of the components that determine the ... on some of the many applications of molecular cut-and-paste tools for the manipulation of promoters and transcription factors ...
  http://mdpi.com/1422-0067/14/4/7583/htm
*  IGF-1 | Insulin Like Growth Factor 1 | Growth Hormone
odent T. Perhaps Editor's note: The HESX1 gene was among the new generation of transcription factors associated with ... developmental pituitary defects following the early characterization of Pit-1 and POUF-1. most pediatric endocrine units work ... GH receptor gene mutations The gene encoding the GH receptor contains 10 exons. and a partial deletion of the GH receptor gene ... and bind to DNA to induce transcription of target genes. and GH-IGF axis abnormalities of the patient described by Kofoed et al ...
  https://www.scribd.com/document/85704870/IGF-1
*  The glucocorticoid receptor inhibits the human prolactin gene expression by interference with Pit-1 activity - Nalda Asunción M
Transcription Factor Pit-1 ; Transcription Factors/drug effects/*metabolism/physiology ; Tumor Cells, Cultured. ... We conclude that the activated GR functionally interferes with the pituitary specific factor Pit-1, thereby leading to the ... The glucocorticoid receptor inhibits the human prolactin gene expression by interference with Pit-1 activity. ... Immunoprecipitation studies show that either anti-GR or anti-Pit-1 antibodies are able to co-precipitate GR and Pit-1, ...
  http://orbi.ulg.ac.be/handle/2268/31656
*  POU3F2 - Wikipedia
POU domain, class 3, transcription factor 2 is a protein that in humans is encoded by the POU3F2 gene. N-Oct-3 is a protein ... PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription ... "Entrez Gene: POU3F2 POU domain, class 3, transcription factor 2". Mühleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F ... "The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene ...
  https://en.wikipedia.org/wiki/POU3F2
*  Hypopituitarism - Wikipedia
This requires particular transcription factors that induce the expression of particular genes. Some of these transcription ... For instance, POU1F1 (also known as Pit-1) mutations cause specific deficiencies in growth hormone, prolactin and TSH. In ... Each transcription factor acts in particular groups of cells. Therefore, various genetic mutations are associated with specific ... some of the transcription factors are also required for the development of other organs; some of these mutations are therefore ...
  https://en.wikipedia.org/wiki/Hypopituitarism
*  POU1F1 recombinant protein | Pituitary-specific positive transcription factor 1 (POU1F1) Recombinant Protein-NP 001036325.1
Pituitary-specific positive transcription factor 1 (POU1F1) Recombinant Protein-NP_001036325.1 (MBS1353963) product datasheet ... Product Gene Name POU1F1 recombinant protein. [Similar Products] Product Synonym Gene Name POU1F1; GHF1; PIT1 [Similar Products ... This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein ... UniProt Synonym Gene Names GHF1; PIT1; PIT-1; GHF-1 [Similar Products] ...
  https://www.mybiosource.com/prods/Recombinant-Protein/Pituitary-specific-positive-transcription-factor-1-POU1F1/POU1F1/datasheet.php?products_id=1353963
*  Pou4f1 - PCR Primer Pair - SYBR | PrimePCR | Bio-Rad
Gene Information. transcription factor containing the Pit1-Oct1-Unc86 (POU) domain; regulates expression of Trk receptors and ... Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene ... and sensitive first-strand cDNA synthesis kit for gene expression analysis by reverse-transcription qPCR. ... Home , Life Science Research , Products , PCR Amplification , PrimePCR™ PCR Primers, Assays, and Arrays , Gene: Pou4f1, Rat , ...
  http://www.bio-rad.com/en-us/prime-pcr-assays/assay/qrnoced0053962-primepcr-sybr-green-assay-pou4f1-rat
*  A Molecular Circuit Composed of CPEB-1 and c-Jun Controls Growth Hormone-Mediated Synaptic Plasticity in the Mouse Hippocampus ...
We examined the GH promoter for binding sites of transcription factors whose mRNAs contain CPEs. One primary candidate was Pit- ... 2006) Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease. Neurobiol Dis 22: ... 3A). The two consensus c-Jun sites also reside near putative nuclear factor of activated T-cells (NFAT) transcription factor ... are products of immediate early genes that heterodimerize to form the transcription factor AP-1. AP-1 controls the expression ...
  http://www.jneurosci.org/content/28/34/8502
*  LHX3 gene - Genetics Home Reference
The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. ... and synergistically enhances transcription from the prolactin promoter in cooperation with POU1F1/Pit-1 (By similarity). ... From NCBI Gene:. This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich ... LHX3 gene. LIM homeobox 3. Enable Javascript to view the expand/collapse boxes.. Open All Close All ...
  https://ghr.nlm.nih.gov/gene/LHX3
*  Significant quantitative and qualitative transition in pituitary stem / progenitor cells occurs during the postnatal...
We reported recently that a pituitary-specific transcription factor PROP1 is present in SOX2-positive cells and disappears at ... Prop1 encodes a paired-like homeodomain transcription factor, and is a heritable responsive gene for the combined pituitary ... prophet of PIT1), PIT1 and SF1, have been discovered and characterised (1), although their precise functions in pituitary ... Recent studies have demonstrated that cells expressing the gene for the HMG-box transcription factor SOX2, a marker of stem/ ...
  http://www.biomedsearch.com/nih/Significant-Quantitative-Qualitative-Transition-in/21815952.html
*  Melittin inhibits osteoclast formation through the downregulation of the RANKL-RANK signaling pathway and the inhibition of...
Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) for analysis of gene expression. To evaluate the mRNA ... Receptor activator of nuclear factor-κB ligand activates nuclear factor-κB in osteoclast precursors. Endocrinology. 2001;142: ... F-actin staining and pit formation methods. The gene expression of TRAP, cathepsin K, matrix metalloproteinase-9 (MMP-9) and ... The expression of these genes decreased thereafter. The increased expression of these osteoclastogenic genes in the RAW 264.7 ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5360391/
*  Multiple Pituitary Deficiency Essay - 6874 Words
Mutations of transcription factor genes that are also expressed in other embryonic tissues give rise to more complex phenotypes ... POU1F1 (PIT1) was originally identified as a nuclear protein that bound to the GH and PRL promoters. Mutations in POU1F1 are ... Mutations of transcription factor genes that are only expressed in the anterior pituitary lead to simple phenotypes with ... rendering the mutant proteins incapable of binding to promoter sites or activating transcription of target genes. Missense, ...
  http://www.studymode.com/essays/Multiple-Pituitary-Deficiency-1383139.html
*  Capacity for Purinergic Control of Renin Promoter via P2Y11 Receptor and cAMP Pathways | Hypertension
... and a factor binding a pituitary-specific trans-acting factor (Pit-1) motif. Biochem J. 1996;316:107-113. ... Germain S, Philippe J, Fuchs S, Lengronne A, Corvol P, Pinet F. Regulation of human renin secretion and gene transcription in ... Renin gene promoter activity in GC cells is regulated by cAMP and thyroid hormone through Pit-1-dependent mechanisms. J Biol ... This revealed a time-dependent phosphorylation of both CREB and activating transcription factor-1 (ATF-1) to 10- and 5-fold, ...
  http://hyper.ahajournals.org/content/36/6/1093
*  GATA2 - Wikipedia
GATA2 is a human gene which makes a protein called GATA binding protein 2 - a transcription factor. The GATA family of ... "Reciprocal interactions of Pit1 and GATA2 mediate signaling gradient-induced determination of pituitary cell types". Cell. 97 ( ... Towatari M, Kanei Y, Saito H, Hamaguchi M (1998). "Hematopoietic transcription factor GATA-2 activates transcription from HIV-1 ... "Transcription factor GATA-2 gene is located near 3q21 breakpoints in myeloid leukemia". Biochem. Biophys. Res. Commun. 273 (1 ...
  https://en.wikipedia.org/wiki/GATA2