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8B). This model is homozygous for a mutation in pituitary transcription factor-1 (Pit-1), which plays a key role in the ... Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. Nature347 :528 -533, ... pituitary transcription factor-1; PND, postnatal day; SSC, sodium chloride-sodium citrate. ... Elevated levels of some of these factors, including tumor necrosis factor-α (2), plasminogen-activator inhibitor-1 (3), ...
  http://diabetes.diabetesjournals.org/content/52/2/268
*  The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3, Mammalian Genome | 10.1007...
"The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3, Mammalian Genome" on DeepDyve, ... Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1 ... The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3. The costimulatory genes Cd80 ... The costimulatory genes Cd80 and Cd86 are linked on mouse chromosome 16 and human chromosome 3. Reeves, Roger; Patch, David; ...
  https://www.deepdyve.com/lp/springer_journal/the-costimulatory-genes-cd80-and-cd86-are-linked-on-mouse-chromosome-olJox1SFja
*  Pituitary-specific positive transcription factor 1 - Wikipedia
"Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1". Gene. 122 (2): 387-8. doi:10.1016/ ... is a transcription factor for growth hormone. PIT1 is a pituitary-specific transcription factor responsible for pituitary ... PIT1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Transcription Factor Pit-1 at the US ... Lew AM, Elsholtz HP (1991). "Cloning of the human cDNA for transcription factor Pit-1". Nucleic Acids Res. 19 (22): 6329. doi: ...
  https://en.wikipedia.org/wiki/Pituitary-specific_positive_transcription_factor_1
*  NAVER Academic | Parathyroid hormone regulation of bone sialoprotein (BSP) gene transcription is mediated through a pituitary...
... a pituitary-specific transcription factor-1 (Pit-1) regulatory element (nts −111 to −105) was identified as the target of ... that PTH acts through a protein kinase A pathway involving cAMP to stimulate BSP transcription by blocking the action of a Pit- ... The increased transcription was mimicked by both forskolin (10 −6 M) and isoproterenol (10 −7 M), and was also increased by 3- ... Thus, we have identified a novel Pit-1 suppressor element in the rat BSP gene promoter that is the target of PTH-stimulated ...
  https://academic.naver.com/article.naver?doc_id=141297555
*  A Large PROP1 Gene Deletion in a Turkish Pedigree
Transcription factor genes playing a role in the development of hypothalamus and pituitary are pituitary transcription factor 1 ... In familial or sporadic CPHD cases, the most common causes are PIT1 and PROP1 gene defects [2]. ... CPHD occurs due to recognized mutations of transcription factors such as HESX1, PROP1, POU1F1, LHX3, and LHX4. PROP1 mutations ... Phenotypic characteristics may be variable in CPHD result from these transcription factors' mutations, including PROP1. ...
  https://www.hindawi.com/journals/crie/2018/2403430/
*  Immunocompetence - definition of immunocompetence by The Free Dictionary
Genetic polymorphisms of pituitary-specific transcription factor-1 (Pit-1) gene from Indonesian local goat population reared in ... Phenotypic diversity, major genes and production potential of local chickens and guinea fowl in Tamale, northern Ghana ... Risk factors include baseline immunocompetence of the patient, presence of comorbid conditions, and patient age (Kleinpell & ... Local chicken breeds are often endowed with major genes that confer adaptability and improve performances or immunocompetence ...
  http://www.thefreedictionary.com/immunocompetence
*  JCI - Volume 120, Issue 12
This role for RB1 was linked to both E2F transcription factor 1-driven upregulation of the androgen receptor (AR) and increased ... Here, we show that RI-BPI induces a particular gene expression signature in human DLBCL cell lines that included genes ... Increased expression of Pit-1 has been reported in human tumorigenic breast cells. Here, we found that Pit-1 overexpression or ... Moreover, mitogenic stimuli such as serum, FGF, and HGF increased Enigma transcription via induction of serum response factor ( ...
  https://www.jci.org/120/12
*  Hypothyroidism in children: diagnosis and treatment
... linked to gene mutations of transcription factors involved in hypothalamic-pituitary embriogenesis. POU1F1 (previously Pit1) ... TH receptor proteins are coded by two genes: a gene, located in chromosome 17, and b gene, located in chromosome 3. The ... Kambe E, Seo H. Thyroid specific transcription factors. Endocr J. 1997; 44:775-84. [ Links ]. 15. Ares S, Escobar-Morreale, HF ... The binding of TH with their nuclear receptors allows the transcription of specific mRNA (nuclear receptors are transcription ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0021-75572007000700013&lng=en&nrm=iso&tlng=en
*  PROP1 - Wikipedia
"Entrez Gene: PROP1 prophet of Pit1, paired-like homeodomain transcription factor". Osorio MG, Kopp P, Marui S, et al. (2000). " ... Homeobox protein prophet of PIT-1 is a protein that in humans is encoded by the PROP1 gene. PROP1 has both DNA-binding and ... 2001). "PROP1 gene screening in patients with multiple pituitary hormone deficiency reveals two sites of hypermutability and a ... Rodriguez R, Andersen B (2003). "Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes ...
  https://en.wikipedia.org/wiki/PROP1
*  Hypophysenspezifischer Transkriptionsfaktor 1
al. (1996) A new mutation of the gene encoding the transcription factor Pit-1 is responsible for combined pituitary hormone ... al. (1992) Characterization of the gene encoding human pituitary-specific transcription factor, Pit-1. ... al. (1999) The tissue-specific transcription factor Pit-1/GHF-1 binds to the c-fos serum response element and activates c-fos ... al. (1990) Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene pit-1. ...
  http://www.moldiag.com/moldiag/de/id/G0410
*  POU1F1 | Cancer Genetics Web
... by using a dominant-negative form of this gene involved in human pituitary deficiencies: transcription factor Pit-1 (POU1F1) ... Transcription factor (gene : POUF1) essential for transcription of Pituitary hormones GH, PRL and TSHb], which in turn leads to ... The transcription factor Pit-1/Pou1f1 regulates GH and prolactin (PRL) secretion in the pituitary gland. Pit-1 expression and ... Inactivation of transcription factor pit-1 to target tumoral somatolactotroph cells.. Hum Gene Ther. 2012; 23(1):104-14 [PubMed ...
  http://www.cancerindex.org/geneweb/POU1F1.htm
*  POU1F1 Gene - GeneCards | PIT1 Protein | PIT1 Antibody
Complete information for POU1F1 gene (Protein Coding), POU Class 1 Homeobox 1, including: function, proteins, disorders, ... Entrez Gene Summary for POU1F1 Gene. * This gene encodes a member of the POU family of transcription factors that regulate ... Gene-Enhancer Score. TSS distance (kb). Number of Genes Away. Size (kb). Transcription Factor Binding Sites within enhancer. ... RNA polymerase II transcription factor binding. IPI. 26612202. GO:0001102. RNA polymerase II activating transcription factor ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=POU1F1&genscript_clones_seq=2
*  General Information | Richard Maurer, Ph.D. | OHSU People | OHSU
"The pituitary-specific transcription factor, Pit-1, can direct changes in the chromatin structure of the prolactin promoter." ... "Expression of the synaptotagmin I gene is enhanced by binding of the pituitary-specific transcription factor, POU1F1." ... "In Vivo mutational analysis of the DNA binding domain of the tissue-specific transcription factor, Pit-1." Journal of ... "Thyrotropin releasing hormone stimulates transient phosphorylation of the tissue-specific transcription factor, Pit-1." Journal ...
  http://www.ohsu.edu/people/richard-maurer/BFD4C89E55524FEFA6F336D4AF82D60C
*  Molecular Cloning and Characterization of Human Cardiac Homeobox Gene CSX1 | Circulation Research
For example, the MyoD gene family of skeletal muscle-specific transcription factors plays a critical role in skeletal muscle ... differentiation.12 13 Many non-Hox class homeobox genes have been identified to date, and some of them, eg, Pit-1,14 TTF-1 ( ... 3 4 5 Mammalian homeobox genes could be divided into two classes, Hox class genes and non-Hox class genes. Hox class genes ... tk-luc gene was significantly higher than that of tk-luc (pT81luc), it is possible that some other transcription factors that ...
  http://circres.ahajournals.org/content/79/5/920
*  The Pou1f1 gene and its possible relation to ageing in mice
Transcription factor that regulates pituitary development. Potential relevance to longevity and/or ageing. Observations. ... Gene information (ID: 506). Symbol. Pou1f1. Aliases. dw; Hmp1; Pit1; GHF-1; Pit-1; dwarf; Pit1-rs1. Name. POU domain, class 1, ... Entrez Gene. View on Entrez Gene database (18736). Homologues. Search HomoloGene. UniProt. Search. Internet. Search Google or ... Gene Expression Projects focused on gene expression profiling of ageing and of dietary manipulations of ageing, such as caloric ...
  http://genomics.senescence.info/genes/details.php?id=506
*  September, 2016 | Cholesterol Absorption Inhibitors cholesterol-absorption.com
Pit1 is important but not ample for basal transcription of the TSHb gene, in truth, the basal activity of the TSHb promoter was ... A pituitary-precise transcription factor, Pit1, was initially postulated as a applicant protein that influences TRH-induced ... Pit1 has also been claimed to be essential for regulation of the TSHb gene by TRH [13]. TRHdependent phosphorylation of Pit1 ... NP and NS genes of classical swine virus origin, the PB2 and PA genes from North American avian viruses, the PB1 gene from ...
  http://www.cholesterol-absorption.com/2016/09/
*  IJMS | Free Full-Text | Tailoring the Models of Transcription | HTML
... study of transcriptional regulation has been greatly facilitated by the development of reporter genes and transcription factor ... as well as transcription factors in order to examine their function. The understanding of promoter complexity and transcription ... Transcription is the first step in protein expression and the major point of regulation of the components that determine the ... on some of the many applications of molecular cut-and-paste tools for the manipulation of promoters and transcription factors ...
  http://mdpi.com/1422-0067/14/4/7583/htm
*  IGF-1 | Insulin Like Growth Factor 1 | Growth Hormone
odent T. Perhaps Editor's note: The HESX1 gene was among the new generation of transcription factors associated with ... developmental pituitary defects following the early characterization of Pit-1 and POUF-1. most pediatric endocrine units work ... GH receptor gene mutations The gene encoding the GH receptor contains 10 exons. and a partial deletion of the GH receptor gene ... and bind to DNA to induce transcription of target genes. and GH-IGF axis abnormalities of the patient described by Kofoed et al ...
  https://www.scribd.com/document/85704870/IGF-1
*  The glucocorticoid receptor inhibits the human prolactin gene expression by interference with Pit-1 activity - Nalda Asunción M
Transcription Factor Pit-1 ; Transcription Factors/drug effects/*metabolism/physiology ; Tumor Cells, Cultured. ... We conclude that the activated GR functionally interferes with the pituitary specific factor Pit-1, thereby leading to the ... The glucocorticoid receptor inhibits the human prolactin gene expression by interference with Pit-1 activity. ... Immunoprecipitation studies show that either anti-GR or anti-Pit-1 antibodies are able to co-precipitate GR and Pit-1, ...
  http://orbi.ulg.ac.be/handle/2268/31656
*  POU3F2 - Wikipedia
POU domain, class 3, transcription factor 2 is a protein that in humans is encoded by the POU3F2 gene. N-Oct-3 is a protein ... PIT1; MIM 173110). Class III POU genes are expressed predominantly in the CNS. It is likely that CNS-specific transcription ... "Entrez Gene: POU3F2 POU domain, class 3, transcription factor 2". Mühleisen TW, Leber M, Schulze TG, Strohmaier J, Degenhardt F ... "The POU domain transcription factor Brn-2: elevated expression in malignant melanoma and regulation of melanocyte-specific gene ...
  https://en.wikipedia.org/wiki/POU3F2
*  Molecular analysis of the PROP1 and HESX1 genes in patients with septo-optic dysplasia and/or pituitary hormone deficiency
A series of transcription factors such as Pit1 (pituitary specific transcription factor 1), PROP1 (prophet of Pit1), HESX1 ( ... Lim homeobox gene 4), Pitx1/2 (Paired-like homeodomain transcription factor 1/2), and TPIT (T Box transcription factor), act in ... in other transcription factors such as PROP1; PIT1, LHX3 and LHX4 can cause CPHD, whereas mutations in the growth hormone ... For example, mutations in the SOX3 and SOX2 genes in combination with environmental factors such as very young maternal age, ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27302010000500009&lng=en&tlng=en
*  Frontiers | Mechanisms and Clinical Consequences of Vascular Calcification | Endocrinology
Chondro-osseous and calcification promoting genes reported in calcifying VSMCs include the transcription factor Msx2 which ... Phosphate increases PiT-1 expression, which leads to increased levels of intracellular phosphate. This induces Runx2 expression ... Risk Factors for Vascular Calcification. Elevated serum phosphate levels are recognized as a major risk factor for ... Doherty, M. J., and Canfield, A. E. (1999). Gene expression during vascular pericyte differentiation. Crit. Rev. Eukaryot. Gene ...
  https://www.frontiersin.org/articles/10.3389/fendo.2012.00095/full
*  Hypopituitarism - Wikipedia
This requires particular transcription factors that induce the expression of particular genes. Some of these transcription ... For instance, POU1F1 (also known as Pit-1) mutations cause specific deficiencies in growth hormone, prolactin and TSH. In ... Each transcription factor acts in particular groups of cells. Therefore, various genetic mutations are associated with specific ... some of the transcription factors are also required for the development of other organs; some of these mutations are therefore ...
  https://en.wikipedia.org/wiki/Hypopituitarism
*  POU1F1 recombinant protein | Pituitary-specific positive transcription factor 1 (POU1F1) Recombinant Protein-NP 001036325.1
Pituitary-specific positive transcription factor 1 (POU1F1) Recombinant Protein-NP_001036325.1 (MBS1353963) product datasheet ... Product Gene Name POU1F1 recombinant protein. [Similar Products] Product Synonym Gene Name POU1F1; GHF1; PIT1 [Similar Products ... This gene encodes a member of the POU family of transcription factors that regulate mammalian development. The protein ... UniProt Synonym Gene Names GHF1; PIT1; PIT-1; GHF-1 [Similar Products] ...
  https://www.mybiosource.com/prods/Recombinant-Protein/Pituitary-specific-positive-transcription-factor-1-POU1F1/POU1F1/datasheet.php?products_id=1353963
*  Rare thyroid non-neoplastic diseases | Thyroid Research | Full Text
In most of the rare thyroid diseases genetic factors play a key role, many of them can be classified as monogenic disorders. ... Thyroid hormone resistance is most commonly found in THRB gene mutations and more rarely in THRA mutations; in some cases both ... Rare causes of hyperthyroidism are: activating mutations in TSHR or GNAS genes, pituitary adenomas, differentiated thyroid ... genes are unchanged (non-TR RTH). Recently the term 'reduced sensitivity to thyroid hormones' was introduced, which encompass ...
  https://thyroidresearchjournal.biomedcentral.com/articles/10.1186/s13044-015-0017-3