*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The HIV-1 gp120 protein, a glycoprotein envelope on the surface of HIV-1, plays an important role in viral entry into CD4 cells ... Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1. ... The transmembrane envelope protein gp41 of the human immunodeficiency virus HIV-1 plays an important role during infection ... Proteins, Exosomes, HIV, Peptides, Exocytosis, protein trafficking, secretion, HIV-1, Nef, Secretion Modification Region, SMR, ...
  https://www.jove.com/visualize/abstract/23383108/modulation-cytokine-release-gene-expression-immunosuppressive-domain
*  Frontiers | Unusual Fusion Proteins of HIV-1 | Microbiology
... the regulatory genes rev and tat and the accessory genes vpu, nef, vpr and vif enables assembly of the viral particle, ... HIV-1 expresses 16 canonical proteins from only nine genes within its 10 kb genome. Expression of the structural genes gag, pol ... HIV-1 expresses 16 canonical proteins from only nine genes within its 10 kb genome. Expression of the structural genes gag, pol ... of these non-canonical viral proteins will help to dissect their potential role in viral replication and reveal how HIV-1 ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2016.02152/full
*  Lentivirus - Wikipedia
... encoded by the viral gene env. 120000 Da (Daltons). Gp41 transmembrane envelope protein TM, also encoded by the viral gene env ... The envelope proteins SU and TM are glycosylated in at least some lentiviruses (HIV, SIV), if not all of them. Glycosylation ... P24 capsid protein CA, encoded by the viral gene gag. 24000 Da. P17 matrix protein MA, also encoded by gag. 17000 Da. P9 capsid ... Protein size 32000 Da. Protease PR encoded by the pro gene. dUTPase DU encoded by the pro gene (part of pol gene in some ...
  https://en.wikipedia.org/wiki/Lentivirus
*  Lenti-gp41 T cell receptor Viral Particle vector - Creative Biolabs
Creative Biolabs provides Lenti-gp41 T cell receptor Viral Particle product for Biopharmaceutical research,preclinical and ... and to infiltrate the target cell membrane.Env is a viral gene that encodes the protein forming the viral envelope. The ... Human immunodeficiency virus type 1; HIV-1; Envelope glycoprotein GP41; gp41; HIV envelope ... that are required for infection of host cells.Env is a viral gene that encodes the protein forming the viral envelope. The ...
  https://www.creative-biolabs.com/car-t/lenti-gp41-tcr-vp-2306.htm
*  Genes and Genome of HIV-1 | OMICS International
There are currently various different tests for HIV infections such as HIV antibody test, P24 antigen test, Polymerase chain ... and envelope protein. Viral proteins are processed by viral proteases: some of the viral proteins are moved to the host plasma ... Surface envelope protein), gp41 (Trans membrane protein) and the host cell receptors (CD4, chemokine). Uncoating release the ... Structure and cytopathogenic activity of HIV Vpr/Vpx proteins and genes. The vpx and vpr genes are presented in the HIV-2 and ...
  https://www.omicsonline.org/open-access/genes-and-genome-of-hiv-2329-9002-2-126.php?aid=27166
*  HIV vaccine - Wikipedia
... various viral diseases by priming the adaptive immunity to recognize the viral envelope proteins have failed in the case of HIV ... V520 contains a weakened adenovirus that serves as a carrier for three subtype B HIV genes (gag / pol / nef). Subtype B is the ... Most research focused on gp120 rather than gp41/gp160, as the latter are generally more difficult to produce and did not ... Most initial approaches have focused on the HIV envelope protein. At least thirteen different gp120 and gp160 envelope ...
  https://en.wikipedia.org/wiki/HIV_vaccine
*  Table of Contents - January 15, 1996, 156 (2) | The Journal of Immunology
Implications for the mechanism of processing of viral envelope proteins. R L Ferris, C Buck, S A Hammond, A S Woods, R J Cotter ... Class I-restricted presentation of an HIV-1 gp41 epitope containing an N-linked glycosylation site. ... The Ikaros gene encodes a family of lymphocyte-restricted zinc finger DNA binding proteins, highly conserved in human and mouse ... Adjuvant-free hsp70 fusion protein system elicits humoral and cellular immune responses to HIV-1 p24. K Suzue and R A Young ...
  http://www.jimmunol.org/content/156/2
*  List of MeSH codes (D12.776) - Wikipedia
... hiv envelope protein gp41 MeSH D12.776.964.970.880.940 - viral matrix proteins MeSH D12.776.964.970.880.940.580 - gene products ... hiv envelope protein gp41 MeSH D12.776.964.775.325.350 - hiv envelope protein gp120 MeSH D12.776.964.775.325.380 - hiv envelope ... hiv envelope protein gp41 MeSH D12.776.964.970.880.325.350 - hiv envelope protein gp120 MeSH D12.776.964.970.880.325.380 - hiv ... fusion proteins, gag-pol MeSH D12.776.964.970.600.850.350.400 - hiv core protein p24 MeSH D12.776.964.970.600.850.375 - gene ...
  https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D12.776)
*  Molecular Signaling and Cellular Pathways for Virus Entry
... model of HIV entry involves the binding of viral envelope glycoprotein gp120/gp41 to cell surface receptor CD4 and G-protein- ... T. M. Williams and M. P. Lisanti, "The Caveolin genes: from cell biology to medicine," Annals of Medicine, vol. 36, no. 8, pp. ... Binding of viral envelope glycoprotein (Env) of HIV-1 with the primary receptor CD4 and one of two coreceptors, CXCR4 or CCR5, ... HIV-1 employs envelope-CXCR4 interaction to activate a cellular actin depolymerization factor, cofilin, to support viral latent ...
  https://www.hindawi.com/journals/isrn/2013/306595/
*  Gp41 - Wikipedia
gp41 Envelope Protein, HIV at the US National Library of Medicine Medical Subject Headings (MeSH). ... Gp41 is coded with gp120 as one gp160 by the env gene of HIV. Gp160 is then extensively glycosylated and proteolytically ... While gp120 sits on the surface of the viral envelope, gp41 is the transmembrane portion of the spike complex with a portion of ... "Inhibition of HIV Entry by Targeting the Envelope Transmembrane Subunit gp41". Current HIV research. 14 (3): 283-294. doi: ...
  https://en.wikipedia.org/wiki/Gp41
*  Øvelse: "The Phylogeny of HIV"
Embedded in this envelope are the surface glycoproteins of HIV: gp120; and, gp41. The gp120 protein is crucial for binding of ... The core particle also contains viral proteins that are essential for the early steps of the virus life cycle, such as reverse ... HIV-2, chimpanzee SIV, and sooty mangabey SIV. The Pol gene encodes three different polypeptides: integrase, reverse ... First, we will use the file gp120.fasta, which contains 27 gp120 envelope protein sequences from isolates of HIV-1, HIV-2, and ...
  http://www.cbs.dtu.dk/dtucourse/27611spring2008/Ex09_Phylo/Ex_Phylo.php
*  HIV Virus and Drugs Flashcards by Meghan May | Brainscape
Study HIV Virus and Drugs flashcards from Meghan May ... Cleavage product of envelope glycoproteins--, gp120 and gp41. ... ELISA/Western blot tests look for antibodies to viral proteins; these tests often are falsely negative in the first 1-2 months ... Assembly of virions depends on HIV-1 protease (pol gene), which cleaves the polypeptide products of HIV mRNA into their ... env (gp120 and gp41):: Formed from cleavage of gp160 to form envelope glycoproteins.. gp120-attachment to host CD4+ T cell ( ...
  https://www.brainscape.com/flashcards/hiv-virus-and-drugs-3836579/packs/4797827
*  Gene Report for G00001918 - Genes2Cognition Neuroscience Research Programme
For the human and simian immunodeficiency viruses (HIV and SIV), sorting of the viral envelope proteins (Env) to assembly sites ... is directed by trafficking signals located in the cytoplasmic domain of the transmembrane protein gp41 (TM). A membrane ... G2Cdb::Gene report. Gene id. G00001918. Gene symbol. AP2A2 (HGNC). Species. Homo sapiens. Description. adaptor-related protein ... Gene lists (8). Databases (7). Gene. ENSG00000183020 (Ensembl human gene). 161 (Entrez Gene). 1086 (G2Cdb plasticity & disease) ...
  http://www.genes2cognition.org/db/Gene/G00001918
*  Gene Report for G00001927 - Genes2Cognition Neuroscience Research Programme
For the human and simian immunodeficiency viruses (HIV and SIV), sorting of the viral envelope proteins (Env) to assembly sites ... is directed by trafficking signals located in the cytoplasmic domain of the transmembrane protein gp41 (TM). A membrane ... Gene lists (6). Databases (8). Curated Gene. OTTHUMG00000070491 (Vega human gene). Gene. ENSG00000042753 (Ensembl human gene). ... G2Cdb::Gene report. Gene id. G00001927. Gene symbol. AP2S1 (HGNC). Species. Homo sapiens. Description. adaptor-related protein ...
  http://www.genes2cognition.org/db/Gene/G00001927
*  Envelope glycoprotein GP120 - Wikipedia
HIV envelope gene HIV entry to the cell gp41 CD4 CCR5 Entry inhibitor Structure and genome of HIV https://www.nytimes.com/1989/ ... The HIV viral protein gp120 induces apoptosis of neuronal cells by inhibiting levels of furin and tissue plasminogen activator ... CS1 maint: Multiple names: authors list (link) Price TO, Ercal N, Nakaoke R, Banks WA (May 2005). "HIV-1 viral proteins gp120 ... Gp120 is anchored to the viral membrane, or envelope, via non-covalent bonds with the transmembrane glycoprotein, gp41. Three ...
  https://en.wikipedia.org/wiki/Envelope_glycoprotein_GP120
*  Viral Membrane Proteins: Structure, Function, and Drug Design
In Viral Membrane Proteins : Structure, Function, and Drug Design, Wolfgang Fischer summarizes the current structural and ... In addition, contributors to the book address questions about proteins as potential drug targets. The range of information ... www.MOLUNA.de Viral Membrane Proteins: Structure, Function, and Drug Design [4173896] - ... functional knowledge of membrane proteins encoded by viruses. ... Fusion Proteins 3. HIV gp41: A Viral Membrane Fusion Machine ...
  https://www.moluna.de/buch/4173896-viral+membrane+proteins%3A+structure%2C+function%2C+and+drug+design/
*  CCR5 - Wikipedia
The HIV-1 envelope glycoprotein structure is essential in enabling the viral entry of HIV-1 into a target host cell. The ... structure consists of two protein subunits cleaved from a Gp160 protein precursor encoded for by the HIV-1 env gene: the Gp120 ... This bind results in gp41, the other protein product of gp160, to be released from its metastable conformation and insert ... During HIV-1 infection, the Gp120 envelope glycoprotein subunit binds to a CD4 glycoprotein and a HIV-1 co-receptor expressed ...
  https://en.wikipedia.org/wiki/CCR5
*  Human Immunodeficiency Virus (HIV) - wikidoc
env (for "envelope"): Codes for the precursor to gp120 and gp41, proteins embedded in the viral envelope which enable the virus ... HIV's gag and pol genes do not produce their proteins in their final form, but as larger combination proteins; the specific ... Vpx protein (Viral Protein X). Two functions of Vpr in HIV-1 are split between Vpr and Vpx in HIV-2, with the HIV-2 Vpr protein ... Fusion of the HIV cell to the host cell surface.. * HIV RNA, reverse transcriptase, integrase, and other viral proteins enter ...
  https://www.wikidoc.org/index.php/HIV
*  Structure and genome of HIV - Wikipedia
As the only proteins on the surface of the virus, the envelope glycoproteins (gp120 and gp41) are the major targets for HIV ... within the env gene. Another RNA structure that has been identified is gag stem loop 3 (GSL3), thought to be involved in viral ... genes unique to HIV. The HIV genome contains three major genes, 5'gag-pol-env-3', encoding major structural proteins as well as ... and gp41 or TM, which embeds in the viral envelope to enable the virus to attach to and fuse with target cells. tat (HIV trans- ...
  https://en.wikipedia.org/wiki/Structure_and_genome_of_HIV
*  HIV, viral facts
... codes for the surface proteins gp120 and gp41 that protrude from the lipid envelope and attach to cellular receptors using ... Genetics of HIV. HIV contains nine genes made of 9749 base pairs. [SIV has ten genes.] All retroviruses contain the genes gag ( ... HIV is an abbreviation for Human Immunodeficiency Virus. There are two main forms of HIV: HIV-1 and HIV-2. HIV-1 was discovered ... number of genes in HIV, gp41, gp120, gp160 spikes, p17, p24; M, N, and O subtypes, clades of HIV, which are dominant where, ...
  http://uhavax.hartford.edu/bugl/hiv.htm
*  Viral protein - Wikipedia
An example of a Class I viral fusion protein is the HIV glycoprotein, gp41. Class II: Protein lacks the central coiled-coil ... These viral proteins control and influence viral gene expressions in the viral genome, including viral structural gene ... The viral envelope is made up of a lipid bilayer embedded with viral proteins, including viral glycoproteins. These viral ... viral regulatory proteins can enhance viral gene transcription, likewise, these proteins can also enhance host cellular gene ...
  https://en.wikipedia.org/wiki/Viral_protein
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The HIV-1 gp120 protein, a glycoprotein envelope on the surface of HIV-1, plays an important role in viral entry into CD4 cells ... Infectious Diseases, Issue 91, HIV-1, envelope glycoproteins, gp120, gp41, neutralizing antibodies, non-neutralizing antibodies ... Here we present a novel method for assessing the in vitro replication of HIV-1 as influenced by the gag gene isolated from ... This approach is not limited to resolving HIV Envelope structures, and can be extended to other viral membrane proteins and ...
  https://www.jove.com/visualize/abstract/24897520/the-variable-loop-3-envelope-glycoprotein-is-critical-for-atypical
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Amplifying viral genes and quantifying HIV-1 RNA in HIV-1 infected individuals with viral loads below the limit of detection by ... Infectious Diseases, Issue 91, HIV-1, envelope glycoproteins, gp120, gp41, neutralizing antibodies, non-neutralizing antibodies ... Proteins, Exosomes, HIV, Peptides, Exocytosis, protein trafficking, secretion, HIV-1, Nef, Secretion Modification Region, SMR, ... HIV-1 envelope glycoproteins (Env) mediate viral entry into target cells and are essential to the infectious cycle. ...
  https://www.jove.com/visualize/abstract/21858133/disparate-associations-hla-class-i-markers-with-hiv-1-acquisition
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Amplifying viral genes and quantifying HIV-1 RNA in HIV-1 infected individuals with viral loads below the limit of detection by ... Infectious Diseases, Issue 91, HIV-1, envelope glycoproteins, gp120, gp41, neutralizing antibodies, non-neutralizing antibodies ... Phenotypes are determined by a complex series of physical (e.g. protein-protein) and functional (e.g. gene-gene or genetic) ... Gene Targeting, Eukaryota, Toxoplasma gondii, genetic manipulation, gene targeting, gene deletion, gene replacement, gene ...
  https://www.jove.com/visualize/abstract/23593376/phylogenetic-structural-diversity-feline-leukemia-virus-env
*  Engineering recombinase enzymes to emulate the CCR5-∆32 mutation conferring resistance to HIV-1 infection - The Harvard...
Co-receptor binding allows viral glycoprotein gp41 to fuse the cell membrane and viral envelope together, allowing the HIV-1 ... Figure 4. Illustration depicting the full-length CCR5 gene (protein-coding sequence marked by the blue arrow) within a segment ... Gene therapy progress and prospects: non-viral gene therapy by systemic delivery. Gene Ther, 13(18), 1313-9. ... Figure 1. HIV-1 (top) infects a macrophage cell (bottom) via binding of viral protein gp120 to cell-surface molecule CD4 and to ...
  http://thurj.org/research/2011/02/1238/