Vitamin D receptor activation down-regulates the small heterodimer partner and increases CYP7A1 to lower cholesterol
Gene Expression Regulation, Enzymologic * HEK293 Cells * Hepatocytes / drug effects* * Hepatocytes / enzymology * Humans ... 15 expression, as well as levels of cholesterol, were measured. We studied the regulation of Shp by Vdr using reporter and ... Results: We first confirmed the presence of Vdr mRNA and protein expression in livers of mice. In mice fed normal diets and ... Changes in hepatic Cyp7a1 messenger RNA (mRNA) correlated with those of Cyp24a1 (a Vdr target gene) and inversely with Shp mRNA ...
The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis
Marked species differences have been demonstrated in the catalytic activities and regulation of this subfamily. In humans, the ... CYP2A genes are found as a cluster on the lo … ... Gene Expression Regulation, Enzymologic * Humans * Liver / ... The CYP2A gene subfamily: species differences, regulation, catalytic activities and role in chemical carcinogenesis ... Marked interindividual differences in expression of the CYP2A6 gene was found in livers analyzed in vitro and in humans ...
Biblio | Page 6 | Linus Pauling Institute | Oregon State University
AKR1C3 | Cancer Genetics Web
Enzymologic Gene Expression Regulation. *Racemases and Epimerases. *Prostate Cancer. *Hydroxyprostaglandin Dehydrogenases. * ... Gene expression analysis showed that galeterone altered the expression of HSD3B2 but orteronel did not change the expression of ... Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. ... Gene expression data-sets have been processed using A-MADMAN. Common differentially expressed gene (DEG) were identified ...
List of MeSH codes (G05) - Wikipedia
... gene expression regulation, developmental MeSH G05.315.320 - gene expression regulation, enzymologic MeSH G05.315.320.200 - ... gene expression regulation, leukemic MeSH G05.315.375 - gene expression regulation, plant MeSH G05.315.385 - gene expression ... gene amplification MeSH G05.315.290 - gene expression regulation, archaeal MeSH G05.315.300 - gene expression regulation, ... gene expression regulation, fungal MeSH G05.315.370 - gene expression regulation, neoplastic MeSH G05.315.370.500 - ...
Estrogen up-regulates cyclooxygenase-2 via estrogen receptor in human uterine microvascular endothelial cells.
Gene Expression Regulation, Enzymologic. *Fulvestrant. Citation. APA Chicago ICMJE MLA NLM Tamura, M., Deb, S., Sebastian, S., ... To investigate the effects of 17beta-estradiol (E(2)) on cyclooxygenase-2 (COX-2) expression and prostaglandin E(2) (PGE(2)) ... can significantly increase COX-2 expression and PGE(2) synthesis in HUMEC via the estrogen receptor. ...
Enzyme Repression | Profiles RNS
Dong-Young Ryu - Citation Index - NCSU Libraries
Gene Expression Regulation, Enzymologic; Isoenzymes / metabolism; Liver / drug effects; Liver / enzymology; Male; Mice; Mice, ... Gene Expression Regulation, Enzymologic; Immunohistochemistry; Isoenzymes / genetics; Liver / enzymology; Male; Mice; Mice, ... Gene Expression Regulation, Neoplastic; Hepcidins; Immunoblotting; Injections, Subcutaneous; Iron / blood; Iron / metabolism; ... Regulation of iron metabolism-related genes in diethylnitrosamine-induced mouse liver tumors ...
Angeles Ribera's research topics | Colorado PROFILES
L-Dopa stimulates expression of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO) in cultured astroglial cells<...
Gene Expression Regulation, Enzymologic, Indomethacin, Journal Article, Levodopa, NAD(P)H Dehydrogenase (Quinone), Polymerase ... L-Dopa stimulates expression of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO) in cultured astroglial cells. In: ... L-Dopa stimulates expression of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO) in cultured astroglial cells. Free ... L-Dopa stimulates expression of the antioxidant enzyme NAD(P)H:quinone oxidoreductase (NQO) in cultured astroglial cells. / van ...
Scholars
Gene Expression Regulation, Enzymologic * Biological Transport * RNA, Messenger * Adrenodoxin * Fmn Reductase * Saccharomyces ... Ferredoxin Yah1p is involved in Fe/S cluster assembly, and Aft1p-targeted iron regulon genes are also upregulated in Yah1p- ... It indirectly senses cytosolic Fe status and responds by activating or repressing iron regulon genes. Aft1p within the Aft1-1( ... up) strain has a single amino acid mutation which causes it to constitutively activate iron regulon genes regardless of ...
Telomerase. Medical search
Gene Expression Regulation, Enzymologic. Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence ... TelomereTelomere HomeostasisCell AgingTelomere ShorteningCatalytic DomainGene Expression Regulation, EnzymologicBase Sequence ... ProtozoanDNA NucleotidylexotransferaseCoiled BodiesCatalytic DomainGene Expression Regulation, EnzymologicBase SequenceTumor ... suggesting that the regulation of hTERT gene expression occurs mainly at the transcriptional level. Additional luciferase ...
Hypoxia-inducible factor 1α induces corticosteroid-insensitive inflammation via reduction of histone deacetylase-2...
Gene Expression Regulation, Enzymologic, Glucocorticoids, Histone Deacetylase 2, Humans, Hypoxia-Inducible Factor 1, alpha ... gene deletion, gene expression, gene function, human, human cell, hypoxia, inflammation, lung alveolus epithelium, macrophage, ... protein expression, transcription initiation, transcription regulation, Basic Helix-Loop-Helix Transcription Factors, Cell ... HDAC2 mRNA and protein expression was reduced under hypoxic conditions (1% O2). Hypoxia enhanced interleukin-1β-induced ...
Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. · NEOMED Bibliography...
Gene Expression Regulation, 2012, Animals, Bile Acids and Salts/*biosynthesis, Boehme Shannon, Chiang John Y L, Cholesterol 7- ... Enzymologic, Epigenesis, Erickson Sandra K, Experimental/genetics/*metabolism, Fasting/metabolism, Francl Jessica M, Genetic/ ... Gene Expression Regulation; Animals; Bile Acids and Salts/*biosynthesis; Cholesterol 7-alpha-Hydroxylase/genetics/*metabolism; ... Glucose induces CYP7A1 gene expression mainly by epigenetic mechanisms. In diabetic mice, CYP7A1 chromatin is hyperacetylated, ...
yhm phantom suppressor review
The effect of inhibition of the tumor suppressor p53 on the antioxidant system genes expression under the influence of ... Gene Expression Regulation, Enzymologic / drug effects. *Gene Expression Regulation, Neoplastic. *MCF-7 Cells ... which attested to the p53-dependent regulation of these genes.. Keywords: antioxidant system; gene expression of the ... which was confirmed by an increase in the expression of the P21 gene, the target gene of the p53 protein. It was shown that the ...
AKR1C3 | Cancer Genetics Web
Enzymologic Gene Expression Regulation. *Racemases and Epimerases. *Prostate Cancer. *Hydroxyprostaglandin Dehydrogenases. * ... Gene expression analysis showed that galeterone altered the expression of HSD3B2 but orteronel did not change the expression of ... Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. ... Gene expression data-sets have been processed using A-MADMAN. Common differentially expressed gene (DEG) were identified ...
Kathleen Mary Buchheit, M.D. | Harvard Catalyst Profiles | Harvard Catalyst
Membrane-type matrix metalloproteinases: Their functions and regulations. - Nuffield Department of Orthopaedics, Rheumatology...
... and this cell surface expression provides those enzymes with unique functionalities affecting various cellular behaviours. ... Among the 6 MT-MMPs, MT1-MMP is the most investigated enzyme and many of its roles and regulations have been revealed to date, ... Gene Expression Regulation, Enzymologic, Humans, Matrix Metalloproteinases, Membrane-Associated, Neoplasms ... Among the 6 MT-MMPs, MT1-MMP is the most investigated enzyme and many of its roles and regulations have been revealed to date, ...
Diesel exhaust particles activate the matrix-metalloproteinase-1 gene in human bronchial epithelia in a beta-arrestin...
Gene Expression Regulation, Enzymologic. Humans. Immunohistochemistry. Matrix Metalloproteinase 1. Respiratory Mucosa. Reverse ... which led to striking up-regulation of MMP-1 transcriptional activation. CONCLUSION: Our results confirm up-regulation of MMP-1 ... Transcriptional regulation of the human MMP-1 promoter was strongly influenced by the presence of the -1607GG polymorphism, ... OBJECTIVE: We elucidated the molecular mechanisms of DEPs up-regulation of MMP-1. METHODS/RESULTS: Using permanent and primary ...
Lysozyme is an inducible marker of macrophage activation in murine tissues as demonstrated by in situ hybridization. - Nuffield...
This study demonstrates the induction of lysozyme mRNA expression in situ in tissue macrophages (M phi) of mice following in ... Animals, Gene Expression Regulation, Enzymologic, Macrophage Activation, Macrophages, Mice, Mice, Inbred BALB C, Mice, Inbred ... This study demonstrates the induction of lysozyme mRNA expression in situ in tissue macrophages (M phi) of mice following in ...
Inheritance, gene expression, and lignin characterization in a mutant pine deficient in cinnamyl alcohol dehydrogenase. -...
... in which expression of the gene encoding cinnamyl alcohol dehydrogenase (CAD; EC 1.1.1.195) is severely reduced. The products ... Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Plant, Homozygote, Lignin, Mutation, Phenotype, Substrate ... Inheritance, gene expression, and lignin characterization in a mutant pine deficient in cinnamyl alcohol dehydrogenase. ... Inheritance, gene expression, and lignin characterization in a mutant pine deficient in cinnamyl alcohol dehydrogenase. ...
The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation. | Profiles RNS
Gene Expression Regulation, Enzymologic. * Genome, Human. * Hematopoietic Stem Cells. * Humans. * Induced Pluripotent Stem ...
Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. -...
To understand the organization of cis-acting sequences that are responsible for oxygen-regulated gene expression, we have ... which were crucial for oxygen-regulated expression. The most important of these, although not capable of driving hypoxic ... Deletional and mutational analysis of the function of mouse LDH-reporter fusion gene constructs in transient transfection ... cells and operates on other genes, including those involved in energy metabolism. ...
Lysozyme is an inducible marker of macrophage activation in murine tissues as demonstrated by in situ hybridization. -...
This study demonstrates the induction of lysozyme mRNA expression in situ in tissue macrophages (M phi) of mice following in ... Animals, Gene Expression Regulation, Enzymologic, Macrophage Activation, Macrophages, Mice, Mice, Inbred BALB C, Mice, Inbred ... This study demonstrates the induction of lysozyme mRNA expression in situ in tissue macrophages (M phi) of mice following in ...
Expression and gene variation studies deny association of human HSD3B1 gene with aldosterone production or blood pressure. -...
Expression of HSD3B1 and HSD3B2 was investigated in various adrenocortical tissues (n = 15) and in primary adrenal cell ... No variants in the HSD3B1 gene were associated with blood pressure or the occurrence of hypertension. CONCLUSIONS: We found no ... Six tagging single nucleotide polymorphisms within the HSD3B1 gene were studied for association with blood pressure and ... a steroidogenic enzyme encoded by the HSD3B1 gene, could be involved in aldosterone production and that genetic variation in ...
Male germ cells require polyenoic sphingolipids with complex glycosylation for completion of meiosis: a link to ceramide...
... longevity assurance genes), and out of six members of this gene family, only Cers3 mRNA expression was limited to germ cells, ... Their synthesis is most likely driven by ceramide synthase-3. This enzyme is encoded by the Cers3/Lass3 gene ( ... Aging, Animals, Cell-Free System, Gene Expression Regulation, Enzymologic, Germ Cells, Glycosylation, Glycosyltransferases, ... longevity assurance genes), and out of six members of this gene family, only Cers3 mRNA expression was limited to germ cells, ...
JAK2 is required for induction of the murine DUB-1 gene - Oxford Cardiovascular Science
The DUB-1 gene contains a 112-bp enhancer element that is specifically induced by the beta c subunit of the interleukin-3 (IL-3 ... We have recently identified a hematopoietic cell-specific immediate-early gene, DUB-1, that encodes a growth-regulatory ... resulting in the induction of specific target genes. ... Gene Expression Regulation, Enzymologic Growth Inhibitors/ ... JAK2 is required for induction of the murine DUB-1 gene Jaster R., Zhu Y., Pless M., Bhattacharya S., Mathey-Prevot B., ...