myxovirus resistance proteins Summary Report | CureHunter
... contributes to resistance against influenza; MW 75,000; human equivalent of mo Mx protein; MxA(R645) has Glu to Arg ... myxovirus resistance proteins: induced by interferon-alpha/beta; accumulates in nucleus of IFN-treated Mx cells; ... "We examined the mRNA expression levels of TIPE2 and myxoma resistance protein (MX) 1 (one of type I interferon inducible genes ... resistance 2 protein, rat; myxovirus (influenza virus) resistance protein, rat; p78-related protein, human; protein Mx; protein ...http://www.curehunter.com/public/keywordSummaryC043999-myxovirus-resistance-proteins.do
Frontiers | IFN-λ: A New Inducer of Local Immunity against Cancer and Infections | Immunology
... including myxovirus resistance 1, protein kinase R, melanoma differentiation-associated protein 5, verpin, and 2′-5′- ... are induced to allow IFN-λ gene expression and subsequent release of IFN-λ proteins outside the infected cell. Dependent on the ... Wang Y, Xu H, Zheng X, Wei H, Sun R, Tian Z. High expression of NKG2A/CD94 and low expression of granzyme B are associated with ... the induction of interferon-stimulated gene factor leading to the expression of specific antiviral interferon-stimulated genes ...https://www.frontiersin.org/articles/10.3389/fimmu.2016.00598/full
MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjögren's syndrome | Annals of...
MxA (Myxovirus-resistance protein 1) is a key mediator of the IFN-induced antiviral response and is tightly regulated by type I ... A) Relative mRNA gene expression is shown for the five IFN type I inducible genes of the IFN type I signature in CD14 monocytes ... Upregulation of myxovirus-resistance protein A: a possible marker of type I interferon induction in systemic sclerosis. J ... Methods In a cohort of 35 pSS patients, myxovirus-resistance protein A (MxA) was assessed as a potential biomarker for type I ...http://ard.bmj.com/content/early/2013/07/05/annrheumdis-2012-202552
Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus | PNAS
... myxovirus resistance 1 (MX1), IFN-inducible protein with tetratricopeptide repeats 1 (IFIT1), and IFIT3 by real-time PCR in ... Expression levels of four type I IFN-regulated genes including LY6E, MX1, IFIT1, and IFIT3 were measured by real-time PCR in ... IFN score was calculated by combination of mRNA expression levels of four IFN-regulated genes including LY6E, MX1, IFIT1, and ... S1 showed that five of the six male G allele carriers had higher expression levels of TLR7 protein than the two C allele ...http://www.pnas.org/content/107/36/15838
Responsiveness to IL-7 but not to IFN-α is diminished in CD4+ T cells from treated HIV infected patients who experience poor...
CD127 expressing CD4 T cells were decreased, whereas expression of 2′-5′-oligoadenylate synthetase-1, myxovirus resistance A ... oligoadenylate synthetase-1 and myxovirus resistance A protein) by quantitative real-time PCR. Responses to IFN-α were assessed ... subsets by flow cytometry and sorted CD3 T cells were assessed for expression of IFN-α and interferon stimulated genes (2′-5′- ... protein, and IFN-α mRNA were increased in total CD3 T cells from immune failure patients. CD127 expression correlated with CD25 ...https://www.physiciansweekly.com/responsiveness-to-il-7-but-not-to-ifn-%CE%B1-is-diminished-in-cd4-t-cells-from-treated-hiv-infected-patients-who-experience-poor-cd4-t-cell-recovery/
Tula hantavirus isolate with the full-length ORF for nonstructural protein NSs survives for more consequent passages in...
... which contains the ORF for truncated NSs protein (66-67 aa). Our data show that expression of a full-length NSs protein is ... In contrast, in IFN-competent MRC5 cells TULV/Lodz isolate, that possesses the NSs ORF for the full-length protein of 90 aa, ... The two isolates differ in the length of the open reading frame (ORF) encoding the nonstructural protein NSs, which has ... These results suggest that the N-terminal aa residues are important for the full activity of the NSs protein. ...https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-5-3
JCI - Resolution of immune activation defines nonpathogenic SIV infection
Myxovirus influenza virus resistance protein 1 (MX1) and IP10 are antiviral factors. Melanoma differentiation-associated ... To this end, we longitudinally assessed the gene expression profiles of blood- and lymph node-derived CD4+ cells from AGMs and ... Lower expression of CCR5, the SIV coreceptor, on CD4+ T cells of natural hosts (11) and reduced expression of T cell-homing ... RMs have chronic expression of ISGs, accompanied by enhanced expression of proapoptotic factors (purple), as well as markers of ...https://www.jci.org/articles/view/41509
The goose genome sequence leads to insights into the evolution of waterfowl and susceptibility to fatty liver | Genome Biology ...
Myxovirus resistance, Retinoic acid-inducible gene I, and other genes related to disease resistance in geese. In addition, ... A draft sequence of the whole-goose genome was obtained by shotgun sequencing, and 16,150 protein-coding genes were predicted. ... The results of this study show that deletion of the goose lep gene might be the result of positive selection, thus allowing the ... Geese are capable of rapid growth, disease resistance, and high liver lipid storage capacity, and can be easily fed coarse ...https://genomebiology.biomedcentral.com/articles/10.1186/s13059-015-0652-y
ASMscience | Human Susceptibility and
... such as myxovirus resistance protein A (MxA), which is generally induced by viruses but not by bacteria. Host response analysis ... Host response pattern determination by expression analysis of a predefined set of genes is a novel strategy in the diagnosis of ... Certain host gene variants correlate with the prognosis of infection. Currently, for instance, interleukin (IL) 28B genotyping ... Notably, human populations from distinct geographic areas have different frequencies of immune gene variants. The genetic ...http://www.asmscience.org/content/book/10.1128/9781555819156.ch40
A Triple-Arginine Motif in the Amino-Terminal Domain and Oligomerization Are Required for HIV-1 Inhibition by Human MX2 |...
Structure of myxovirus resistance protein a reveals intra- and intermolecular domain interactions required for the antiviral ... infection and evoke an antiviral state in susceptible cells through the expression of a diverse array of IFN-stimulated genes ( ... We have employed molecular genetic approaches to understand the domain organization of the HIV-1 resistance factor myxovirus ... Protein levels of Flag-tagged MX2 proteins were determined, and Hsp90 served as a loading control. (B) Effect of individual- ...https://jvi.asm.org/content/89/8/4676
Protocols and Video Articles Authored by Francesca Gilli
The expression of the interferon acute-response protein, myxovirus resistance protein A (MxA) is a sensitive measure of the ... 2004 , Pubmed ID: 15771557 The gene expression of the myxovirus-resistant protein A (MxA) gene is a sensitive measure of the ... We quantitated by a real-time RT-PCR multi-gene system the expression of a pathway-focused panel of genes at 30 and 165 days ... With an MxA gene expression inhibition assay, NABs were detected in Betaferon treated wildtype hybrid mice, but not in ...https://www.jove.com/author/Francesca_Gilli
MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1 | Retrovirology | Full Text
These results identify MxB as an endogenously expressed protein with the ability to inhibit HIV-1 uncoating. In addition, we ... Matzinger SR, Carroll TD, Dutra JC, Ma Z-M, Miller CJ: Myxovirus resistance gene A (MxA) expression suppresses influenza A ... The myxovirus resistance proteins (Mxs) represent a family of interferon-inducible factors with a wide range of antiviral ... Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. J Virol. 1990, 64: ...https://retrovirology.biomedcentral.com/articles/10.1186/s12977-014-0068-x
Human endogenous retrovirus expression is inversely related with the up-regulation of interferon-inducible genes in the skin of...
Myxovirus resistance A) mRNA expression level was identified in the LP skin specimens. Other transcript expressions, such as ... Previous Document: A Molluscum contagiosum fusion protein inhibits CCL1-induced chemotaxis of cells expressing CCR8 and.... ... Human endogenous retrovirus expression is inversely related with the up-regulation of interferon-inducible genes in the skin of ... The expressions of HERV-K18 and HERV-W env were also inhibited in the skin of LP patients. We observed a strong correlation ...http://www.biomedsearch.com/nih/Human-endogenous-retrovirus-expression-inversely/25384438.html
Antiviral and cytokine responses of human... | ERA
FluA treatment resulted in mast cell expression of antiviral proteins, namely myxovirus resistance protein A, protein kinase R ... interferon stimulated gene 15, viral stress inducible protein 56, and endothelial nitric oxide synthase. Next, we performed co- ... While expression of FluA mRNA and proteins followed similar time courses in both mast cells and epithelial cells, mast cells ... Our results showed that mast cells in co-culture inhibited the expression of the viral hemagglutinin protein in FluA-infected ...https://era.library.ualberta.ca/items/b2977f59-7702-4347-8ba1-e9302ab4e026
Whole Blood Transcriptome Sequencing Reveals Gene Expression Differences between Dapulian and Landrace Piglets
... interferon-induced expression of the Mx2 protein from the feral mouse gene confers resistance to vesicular stomatitis virus," ... For instance, myxovirus resistance 2 (MX2), a novel innate immunity restriction factor with important roles in defensing virus ... qRT-PCR Confirmation of the Gene Expression Data from RNA-seq. To verify the gene expression data by RNA-seq, qRT-PCR was ... The input data for gene differential expression are the readcount data obtained from the gene expression level analysis. The ...https://www.hindawi.com/journals/bmri/2016/7907980/
IRGs - Wikipedia
... inducible GTPases encompass four families of proteins including myxovirus resistant proteins (Mx), guanylate-binding proteins ( ... 2000). "Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP". Proc Natl Acad Sci U S A ... determined expression patterns of functional IFN-inducible GTPase genes in Branchiostoma japonicum at various immunologic sites ... GBP), immunity-related GTPase proteins (IRGs), and very large inducible GTPase proteins (VLIG). IRGs confer resistance from ...https://en.wikipedia.org/wiki/IRGs
MX1 Gene - GeneCards | MX1 Protein | MX1 Antibody
... proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... Protein Coding), MX Dynamin Like GTPase 1, including: function, ... Myxovirus resistance protein 1 (MX1_HUMAN). *MX1 protein ( ... Domains & Families for MX1 Gene Gene Families for MX1 Gene. Human Protein Atlas (HPA):. *Predicted intracellular proteins ... Protein Expression for MX1 Gene. See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=MX1
OriGene - Mx1 (NM 010846) Human ORF cDNA Clone
... resistance 1 (Mx1) available for purchase from OriGene - Your Gene Company. ... MX1 (untagged)-Human myxovirus (influenza virus) resistance 1 interferon-inducible protein p78 (mouse) (MX1) transcript variant ... Expression varies depending on the nature of the gene.. OTI Disclaimer:. Due to the inherent nature of this plasmid, standard ... It has been shown to confer resistance to the influenza virus. This gene produces a functional protein in some feral mouse ...http://www.origene.com/Mouse_ORF/MG209610.aspx
MX1 - Wikipedia
"Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)". Pavlovic J, Haller O, ... "Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein". J. Virol. 64 (7): ... The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction ... Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene. In mouse, the interferon- ...https://en.wikipedia.org/wiki/MX1
Protocols and Video Articles Authored by Zvi G. Fridlender (Translated to German)
Î²-dependent proteins, such as myxovirus resistance 1 (Mx1) and 2',5'-oligoadenylate synthetase 1 (OAS1). Mice treated with ... Structural genes and genes related to cell-cytotoxicity (i.e. respiratory burst) were significantly down-regulated in TAN. In ... Expression of IFN-beta Enhances Both Efficacy and Safety of Oncolytic Vesicular Stomatitis Virus for Therapy of Mesothelioma ... Resistance to Adjuvant Arthritis is Due to Protective Antibodies Against Heat Shock Protein Surface Epitopes and the Induction ...https://www.jove.com/author/Zvi+G._Fridlender?language=German
Joseph P[au] - PubMed - NCBI
Silica inhalation altered telomere length and gene expression of telomere regulatory proteins in lung tissue of rats. ... Outpatient Antibiotic Stewardship: A Growing Frontier-Combining Myxovirus Resistance Protein A With Other Biomarkers to Improve ... Role of age, Rho-kinase 2 expression, and G protein-mediated signaling in the myogenic response in mouse small mesenteric ... Pulmonary toxicity and global gene expression changes in response to sub-chronic inhalation exposure to crystalline silica in ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Joseph+P%5Bau%5D&dispmax=50
METHOD FOR EVALUATING THE RESPONSE OF AN INDIVIDUAL TO A TREATMENT WITH A TYPE I INTERFERON (IFN) - Patent application
... the gene encoding myxovirus resistance protein A (M×A) in said whole blood sample. M×A protein is also known as the interferon- ... PCR of gene expression of M×A to determine the in vivo biological effect of administered IFNβ. The M×1 gene is expressed at ... proteins. Among these latter proteins, the "human myxovirus resistance protein" type A (M×A) is exclusively induced by type I ( ... The method can further comprise determining mRNA levels of the gene encoding myxovirus resistance protein A (M×A) in said blood ...http://www.patentsencyclopedia.com/app/20100129788
Transcriptome profiling of antiviral immune and dietary fatty acid dependent responses of Atlantic salmon macrophage-like cells...
Although the different levels of dietary fish and vegetable oils involved in this study affected the expression of some ... Fatty acid-binding protein adipocyte (fabp4) and proteasome subunit beta type-8 (psmb8) were significantly up- and down- ... there was reduced leukocyte phagocytic activity and increased expression of the mx gene (i.e. myxovirus resistance, interferon- ... The expression of the rnf8 (ring finger protein 8, E3 ubiquitin protein ligase) and cflar (CASP8 and FADD-like apoptosis ...https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-4099-2
Consequence of HIV and HCV co-infection on host immune response, persistence and current treatment options | Springer for...
... and myxovirus resistance proteins 1 (Mx1) polymorphisms and severity of liver disease in human immunodeficiency virus (HIV)/ ... takes place with specific cell-surface receptors in virus-infected cells resulting in rapid gene activation by protein-protein ... In a recent study, the impact of HIV infection of hepatocytes on HCV expression was investigated and it was concluded that, the ... Like a retrovirus, total three structural proteins known as Gag, Pol and Env and six accessory proteins Tat, Rev, Nef, Vpr, Vpu ...https://rd.springer.com/article/10.1007/s13337-018-0424-x
Meta-Analysis of Differential Connectivity in Gene Co-Expression Networks in Multiple Sclerosis
... another DC gene was myxovirus (influenza virus) resistance 1 (MX1) (. p. =. 0. .. 013. in GSE41846, p. =. 0. .. 029. in ... Moreover, this study suggests a loss of gene connectivity also for genes encoding for extracellular matrix proteins (matrisome ... 4.2.1. Gene Differential Expression. The gene differential expression (DE) p-values were evaluated by a two-tailed Student's t- ... We searched the Gene Expression Omnibus (GEO) repository  for the most numerous datasets of the gene expression of MS ...http://pubmedcentralcanada.ca/pmcc/articles/PMC4926469/