myxovirus resistance proteins Summary Report | CureHunter
... contributes to resistance against influenza; MW 75,000; human equivalent of mo Mx protein; MxA(R645) has Glu to Arg ... myxovirus resistance proteins: induced by interferon-alpha/beta; accumulates in nucleus of IFN-treated Mx cells; ... "We examined the mRNA expression levels of TIPE2 and myxoma resistance protein (MX) 1 (one of type I interferon inducible genes ... resistance 2 protein, rat; myxovirus (influenza virus) resistance protein, rat; p78-related protein, human; protein Mx; protein ...http://www.curehunter.com/public/keywordSummaryC043999-myxovirus-resistance-proteins.do
MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjögren's syndrome | Annals of...
MxA (Myxovirus-resistance protein 1) is a key mediator of the IFN-induced antiviral response and is tightly regulated by type I ... A) Relative mRNA gene expression is shown for the five IFN type I inducible genes of the IFN type I signature in CD14 monocytes ... Upregulation of myxovirus-resistance protein A: a possible marker of type I interferon induction in systemic sclerosis. J ... Methods In a cohort of 35 pSS patients, myxovirus-resistance protein A (MxA) was assessed as a potential biomarker for type I ...http://ard.bmj.com/content/early/2013/07/05/annrheumdis-2012-202552
Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus | PNAS
... myxovirus resistance 1 (MX1), IFN-inducible protein with tetratricopeptide repeats 1 (IFIT1), and IFIT3 by real-time PCR in ... Expression levels of four type I IFN-regulated genes including LY6E, MX1, IFIT1, and IFIT3 were measured by real-time PCR in ... IFN score was calculated by combination of mRNA expression levels of four IFN-regulated genes including LY6E, MX1, IFIT1, and ... S1 showed that five of the six male G allele carriers had higher expression levels of TLR7 protein than the two C allele ...http://www.pnas.org/content/107/36/15838
Responsiveness to IL-7 but not to IFN-α is diminished in CD4+ T cells from treated HIV infected patients who experience poor...
CD127 expressing CD4 T cells were decreased, whereas expression of 2′-5′-oligoadenylate synthetase-1, myxovirus resistance A ... oligoadenylate synthetase-1 and myxovirus resistance A protein) by quantitative real-time PCR. Responses to IFN-α were assessed ... subsets by flow cytometry and sorted CD3 T cells were assessed for expression of IFN-α and interferon stimulated genes (2′-5′- ... protein, and IFN-α mRNA were increased in total CD3 T cells from immune failure patients. CD127 expression correlated with CD25 ...https://www.physiciansweekly.com/responsiveness-to-il-7-but-not-to-ifn-%CE%B1-is-diminished-in-cd4-t-cells-from-treated-hiv-infected-patients-who-experience-poor-cd4-t-cell-recovery/
ASMscience | Human Susceptibility and
... such as myxovirus resistance protein A (MxA), which is generally induced by viruses but not by bacteria. Host response analysis ... Host response pattern determination by expression analysis of a predefined set of genes is a novel strategy in the diagnosis of ... Certain host gene variants correlate with the prognosis of infection. Currently, for instance, interleukin (IL) 28B genotyping ... Notably, human populations from distinct geographic areas have different frequencies of immune gene variants. The genetic ...http://www.asmscience.org/content/book/10.1128/9781555819156.ch40
Protocols and Video Articles Authored by Francesca Gilli
The expression of the interferon acute-response protein, myxovirus resistance protein A (MxA) is a sensitive measure of the ... 2004 , Pubmed ID: 15771557 The gene expression of the myxovirus-resistant protein A (MxA) gene is a sensitive measure of the ... We quantitated by a real-time RT-PCR multi-gene system the expression of a pathway-focused panel of genes at 30 and 165 days ... With an MxA gene expression inhibition assay, NABs were detected in Betaferon treated wildtype hybrid mice, but not in ...https://www.jove.com/author/Francesca_Gilli
MxB binds to the HIV-1 core and prevents the uncoating process of HIV-1 | Retrovirology | Full Text
These results identify MxB as an endogenously expressed protein with the ability to inhibit HIV-1 uncoating. In addition, we ... Matzinger SR, Carroll TD, Dutra JC, Ma Z-M, Miller CJ: Myxovirus resistance gene A (MxA) expression suppresses influenza A ... The myxovirus resistance proteins (Mxs) represent a family of interferon-inducible factors with a wide range of antiviral ... Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein. J Virol. 1990, 64: ...https://retrovirology.biomedcentral.com/articles/10.1186/s12977-014-0068-x
OriGene - Mx1 (NM 010846) Human ORF cDNA Clone
... resistance 1 (Mx1) available for purchase from OriGene - Your Gene Company. ... MX1 (untagged)-Human myxovirus (influenza virus) resistance 1 interferon-inducible protein p78 (mouse) (MX1) transcript variant ... Expression varies depending on the nature of the gene.. OTI Disclaimer:. Due to the inherent nature of this plasmid, standard ... It has been shown to confer resistance to the influenza virus. This gene produces a functional protein in some feral mouse ...http://www.origene.com/Mouse_ORF/MG209610.aspx
MX1 Gene - GeneCards | MX1 Protein | MX1 Antibody
... proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... Protein Coding), MX Dynamin Like GTPase 1, including: function, ... Myxovirus resistance protein 1 (MX1_HUMAN). *MX1 protein ( ... Domains & Families for MX1 Gene Gene Families for MX1 Gene. Human Protein Atlas (HPA):. *Predicted intracellular proteins ... Protein Expression for MX1 Gene. See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB ...http://www.genecards.org/cgi-bin/carddisp.pl?gene=MX1
Antiviral and cytokine responses of human... | ERA
FluA treatment resulted in mast cell expression of antiviral proteins, namely myxovirus resistance protein A, protein kinase R ... interferon stimulated gene 15, viral stress inducible protein 56, and endothelial nitric oxide synthase. Next, we performed co- ... While expression of FluA mRNA and proteins followed similar time courses in both mast cells and epithelial cells, mast cells ... Our results showed that mast cells in co-culture inhibited the expression of the viral hemagglutinin protein in FluA-infected ...https://era.library.ualberta.ca/items/b2977f59-7702-4347-8ba1-e9302ab4e026
IRGs - Wikipedia
... inducible GTPases encompass four families of proteins including myxovirus resistant proteins (Mx), guanylate-binding proteins ( ... 2000). "Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP". Proc Natl Acad Sci U S A ... determined expression patterns of functional IFN-inducible GTPase genes in Branchiostoma japonicum at various immunologic sites ... GBP), immunity-related GTPase proteins (IRGs), and very large inducible GTPase proteins (VLIG). IRGs confer resistance from ...https://en.wikipedia.org/wiki/IRGs
Protocols and Video Articles Authored by Zvi G. Fridlender (Translated to German)
Î²-dependent proteins, such as myxovirus resistance 1 (Mx1) and 2',5'-oligoadenylate synthetase 1 (OAS1). Mice treated with ... Structural genes and genes related to cell-cytotoxicity (i.e. respiratory burst) were significantly down-regulated in TAN. In ... Expression of IFN-beta Enhances Both Efficacy and Safety of Oncolytic Vesicular Stomatitis Virus for Therapy of Mesothelioma ... Resistance to Adjuvant Arthritis is Due to Protective Antibodies Against Heat Shock Protein Surface Epitopes and the Induction ...https://www.jove.com/author/Zvi+G._Fridlender?language=German
Transcriptome profiling of antiviral immune and dietary fatty acid dependent responses of Atlantic salmon macrophage-like cells...
Although the different levels of dietary fish and vegetable oils involved in this study affected the expression of some ... Fatty acid-binding protein adipocyte (fabp4) and proteasome subunit beta type-8 (psmb8) were significantly up- and down- ... there was reduced leukocyte phagocytic activity and increased expression of the mx gene (i.e. myxovirus resistance, interferon- ... The expression of the rnf8 (ring finger protein 8, E3 ubiquitin protein ligase) and cflar (CASP8 and FADD-like apoptosis ...https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-4099-2
Joseph P[au] - PubMed - NCBI
Silica inhalation altered telomere length and gene expression of telomere regulatory proteins in lung tissue of rats. ... Outpatient Antibiotic Stewardship: A Growing Frontier-Combining Myxovirus Resistance Protein A With Other Biomarkers to Improve ... Role of age, Rho-kinase 2 expression, and G protein-mediated signaling in the myogenic response in mouse small mesenteric ... Pulmonary toxicity and global gene expression changes in response to sub-chronic inhalation exposure to crystalline silica in ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Joseph+P%5Bau%5D&dispmax=50
MX1 - Wikipedia
"Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)". Pavlovic J, Haller O, ... "Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein". J. Virol. 64 (7): ... The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction ... Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene. In mouse, the interferon- ...https://en.wikipedia.org/wiki/MX1
Meta-Analysis of Differential Connectivity in Gene Co-Expression Networks in Multiple Sclerosis
... another DC gene was myxovirus (influenza virus) resistance 1 (MX1) (. p. =. 0. .. 013. in GSE41846, p. =. 0. .. 029. in ... Moreover, this study suggests a loss of gene connectivity also for genes encoding for extracellular matrix proteins (matrisome ... 4.2.1. Gene Differential Expression. The gene differential expression (DE) p-values were evaluated by a two-tailed Student's t- ... We searched the Gene Expression Omnibus (GEO) repository  for the most numerous datasets of the gene expression of MS ...http://pubmedcentralcanada.ca/pmcc/articles/PMC4926469/
Early detection of neutralizing antibodies to interferon-beta in multiple sclerosis patients - Danish National Research...
... gene expression of MxA and protein concentrations of MMP-9, TIMP-1, sTRAIL, CXCL-10 and CCL-2. RESULTS: We found that 22 of 164 ... Myxovirus Resistance Proteins; Predictive Value of Tests; Prospective Studies; TNF-Related Apoptosis-Inducing Ligand; Time ...http://www.forskningsdatabasen.dk/catalog/262448658
METHOD FOR EVALUATING THE RESPONSE OF AN INDIVIDUAL TO A TREATMENT WITH A TYPE I INTERFERON (IFN) - Patent application
... the gene encoding myxovirus resistance protein A (M×A) in said whole blood sample. M×A protein is also known as the interferon- ... PCR of gene expression of M×A to determine the in vivo biological effect of administered IFNβ. The M×1 gene is expressed at ... proteins. Among these latter proteins, the "human myxovirus resistance protein" type A (M×A) is exclusively induced by type I ( ... The method can further comprise determining mRNA levels of the gene encoding myxovirus resistance protein A (M×A) in said blood ...http://www.patentsencyclopedia.com/app/20100129788
Publications | Mizuguchi Laboratory
"Integrating sequence and gene expression information predicts genome-wide DNA-binding proteins and suggests a cooperative ... "Classification of idiopathic interstitial pneumonias using anti-myxovirus resistance-protein 1 autoantibody. ". Sci Rep. 2017 ... "Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions. ". Proteins, 2013 ... "Exploring the evolutionary rate differences of party hub and date hub proteins in Saccharomyces cerevisiae protein-protein ...http://mizuguchilab.org/en_research/publications/
Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles | The Journal of Immunology
Deletion of the caspase-8 gene in hepatocytes endows them with resistance to Fas cytotoxicity. A-D, Comparison of Casp8F/+:Alb- ... Co-ordination of the expression of the protein tyrosine kinase p56lck with the pre-T cell receptor during thymocyte development ... To induce deletion of caspase-8 in mice expressing Cre under the control of the myxovirus resistance-1 (Mx1) promoter, mice ... Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods 25:402. ...http://www.jimmunol.org/content/173/5/2976.long
Consequence of HIV and HCV co-infection on host immune response, persistence and current treatment options | Springer for...
... and myxovirus resistance proteins 1 (Mx1) polymorphisms and severity of liver disease in human immunodeficiency virus (HIV)/ ... takes place with specific cell-surface receptors in virus-infected cells resulting in rapid gene activation by protein-protein ... In a recent study, the impact of HIV infection of hepatocytes on HCV expression was investigated and it was concluded that, the ... Like a retrovirus, total three structural proteins known as Gag, Pol and Env and six accessory proteins Tat, Rev, Nef, Vpr, Vpu ...https://rd.springer.com/article/10.1007/s13337-018-0424-x
Stevenson JL[au] - PubMed - NCBI
Correlation between reproductive status and steady-state messenger ribonucleic acid levels of the Myxovirus resistance gene, ... Use of a modified tryptophanase promoter to direct high-level expression of foreign proteins in E. coli. ... Cross-resistance to cisplatin in cells with acquired resistance to copper.. Safaei R, Katano K, Samimi G, Naerdemann W, ... Expression of GLUT12 in the fetal membranes of the human placenta.. Gude NM, Stevenson JL, Murthi P, Rogers S, Best JD, ...https://www.ncbi.nlm.nih.gov/pubmed?cmd=search&term=Stevenson+JL%5Bau%5D&dispmax=50
Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage | The Journal...
Myxovirus (influenza virus) resistance 2 (mouse). MX2. 879_at. 2.3. Interferon, gamma-inducible protein 16. IFI16. 1456_s_at. ... Confirmation of selected chemokine and adhesion molecule gene expression by RT-PCR. Monocytes were mock infected or HCMV ... Genes on the left represent the total set of genes probed for with the kit, and the genes on the right represent those genes ... Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse). MX1. 37014_at. 5.6. ...http://www.jimmunol.org/content/181/1/698/tab-figures-data
ANTIPROLIFERATIVE AGENT - Patent application
Ribosomal protein L27 (L27) was used as reference housekeeping gene. Detailed description of the genes and expression see Table ... mRNA level of 2'5'-oligoadenylate synthetase isoforms 1 and 2 (OAS1, OAS2), interferon-induced myxovirus resistance 1 (MX1 and ... Expression was related to the housekeeping gene 60S ribosomal protein L27 (RPL27) which did not change under any of the ... genes, whereas expression of cell proliferation genes were diminished (FIG. 11K; Table 1). Altogether, these observations ...http://www.patentsencyclopedia.com/app/20120207770
HIV-1 Tat second exon limits the extent of Tat-mediated modulation of interferon-stimulated genes in antigen presenting cells |...
Tat expression in cells deleted of the type I IFN locus or receptor resulted in a gene modulation pattern similar to that ... ISG activation depends on Tat interaction with MAP2K3, MAP2K6, and IRF7 promoters and a single exon Tat protein more strongly ... Mutants with reduced LTR transactivation had a substantially reduced effect on host gene expression modulation than wild type ... A cellular gene modulation similar to that induced by Tat and Tat mutants in immature dendritic cells could be observed in ...https://retrovirology.biomedcentral.com/articles/10.1186/1742-4690-11-30