*  myxovirus resistance proteins Summary Report | CureHunter
... contributes to resistance against influenza; MW 75,000; human equivalent of mo Mx protein; MxA(R645) has Glu to Arg ... myxovirus resistance proteins: induced by interferon-alpha/beta; accumulates in nucleus of IFN-treated Mx cells; ... "We examined the mRNA expression levels of TIPE2 and myxoma resistance protein (MX) 1 (one of type I interferon inducible genes ... resistance 2 protein, rat; myxovirus (influenza virus) resistance protein, rat; p78-related protein, human; protein Mx; protein ...
  http://www.curehunter.com/public/keywordSummaryC043999-myxovirus-resistance-proteins.do
*  MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjögren's syndrome | Annals of...
MxA (Myxovirus-resistance protein 1) is a key mediator of the IFN-induced antiviral response and is tightly regulated by type I ... A) Relative mRNA gene expression is shown for the five IFN type I inducible genes of the IFN type I signature in CD14 monocytes ... Upregulation of myxovirus-resistance protein A: a possible marker of type I interferon induction in systemic sclerosis. J ... Methods In a cohort of 35 pSS patients, myxovirus-resistance protein A (MxA) was assessed as a potential biomarker for type I ...
  http://ard.bmj.com/content/early/2013/07/05/annrheumdis-2012-202552
*  Responsiveness to IL-7 but not to IFN-α is diminished in CD4+ T cells from treated HIV infected patients who experience poor...
CD127 expressing CD4 T cells were decreased, whereas expression of 2′-5′-oligoadenylate synthetase-1, myxovirus resistance A ... oligoadenylate synthetase-1 and myxovirus resistance A protein) by quantitative real-time PCR. Responses to IFN-α were assessed ... subsets by flow cytometry and sorted CD3 T cells were assessed for expression of IFN-α and interferon stimulated genes (2′-5′- ... protein, and IFN-α mRNA were increased in total CD3 T cells from immune failure patients. CD127 expression correlated with CD25 ...
  https://www.physiciansweekly.com/responsiveness-to-il-7-but-not-to-ifn-%CE%B1-is-diminished-in-cd4-t-cells-from-treated-hiv-infected-patients-who-experience-poor-cd4-t-cell-recovery/
*  ASMscience | Human Susceptibility and
... such as myxovirus resistance protein A (MxA), which is generally induced by viruses but not by bacteria. Host response analysis ... Host response pattern determination by expression analysis of a predefined set of genes is a novel strategy in the diagnosis of ... Certain host gene variants correlate with the prognosis of infection. Currently, for instance, interleukin (IL) 28B genotyping ... Notably, human populations from distinct geographic areas have different frequencies of immune gene variants. The genetic ...
  http://www.asmscience.org/content/book/10.1128/9781555819156.ch40
*  Protocols and Video Articles Authored by Francesca Gilli
The expression of the interferon acute-response protein, myxovirus resistance protein A (MxA) is a sensitive measure of the ... 2004 , Pubmed ID: 15771557 The gene expression of the myxovirus-resistant protein A (MxA) gene is a sensitive measure of the ... We quantitated by a real-time RT-PCR multi-gene system the expression of a pathway-focused panel of genes at 30 and 165 days ... With an MxA gene expression inhibition assay, NABs were detected in Betaferon treated wildtype hybrid mice, but not in ...
  https://www.jove.com/author/Francesca_Gilli
*  OriGene - Mx1 (NM 010846) Human ORF cDNA Clone
... resistance 1 (Mx1) available for purchase from OriGene - Your Gene Company. ... MX1 (untagged)-Human myxovirus (influenza virus) resistance 1 interferon-inducible protein p78 (mouse) (MX1) transcript variant ... Expression varies depending on the nature of the gene.. OTI Disclaimer:. Due to the inherent nature of this plasmid, standard ... It has been shown to confer resistance to the influenza virus. This gene produces a functional protein in some feral mouse ...
  http://www.origene.com/Mouse_ORF/MG209610.aspx
*  MX1 Gene - GeneCards | MX1 Protein | MX1 Antibody
... proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... Protein Coding), MX Dynamin Like GTPase 1, including: function, ... Myxovirus resistance protein 1 (MX1_HUMAN). *MX1 protein ( ... Domains & Families for MX1 Gene Gene Families for MX1 Gene. Human Protein Atlas (HPA):. *Predicted intracellular proteins ... Protein Expression for MX1 Gene. See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=MX1
*  IRGs - Wikipedia
... inducible GTPases encompass four families of proteins including myxovirus resistant proteins (Mx), guanylate-binding proteins ( ... 2000). "Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP". Proc Natl Acad Sci U S A ... determined expression patterns of functional IFN-inducible GTPase genes in Branchiostoma japonicum at various immunologic sites ... GBP), immunity-related GTPase proteins (IRGs), and very large inducible GTPase proteins (VLIG). IRGs confer resistance from ...
  https://en.wikipedia.org/wiki/IRGs
*  MX1 - Wikipedia
"Entrez Gene: MX1 myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse)". Pavlovic J, Haller O, ... "Resistance to influenza virus and vesicular stomatitis virus conferred by expression of human MxA protein". J. Virol. 64 (7): ... The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction ... Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene. In mouse, the interferon- ...
  https://en.wikipedia.org/wiki/MX1
*  Meta-Analysis of Differential Connectivity in Gene Co-Expression Networks in Multiple Sclerosis
... another DC gene was myxovirus (influenza virus) resistance 1 (MX1) (. p. =. 0. .. 013. in GSE41846, p. =. 0. .. 029. in ... Moreover, this study suggests a loss of gene connectivity also for genes encoding for extracellular matrix proteins (matrisome ... 4.2.1. Gene Differential Expression. The gene differential expression (DE) p-values were evaluated by a two-tailed Student's t- ... We searched the Gene Expression Omnibus (GEO) repository [16] for the most numerous datasets of the gene expression of MS ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4926469/
*  Early detection of neutralizing antibodies to interferon-beta in multiple sclerosis patients - Danish National Research...
... gene expression of MxA and protein concentrations of MMP-9, TIMP-1, sTRAIL, CXCL-10 and CCL-2. RESULTS: We found that 22 of 164 ... Myxovirus Resistance Proteins; Predictive Value of Tests; Prospective Studies; TNF-Related Apoptosis-Inducing Ligand; Time ...
  http://www.forskningsdatabasen.dk/catalog/262448658
*  METHOD FOR EVALUATING THE RESPONSE OF AN INDIVIDUAL TO A TREATMENT WITH A TYPE I INTERFERON (IFN) - Patent application
... the gene encoding myxovirus resistance protein A (M×A) in said whole blood sample. M×A protein is also known as the interferon- ... PCR of gene expression of M×A to determine the in vivo biological effect of administered IFNβ. The M×1 gene is expressed at ... proteins. Among these latter proteins, the "human myxovirus resistance protein" type A (M×A) is exclusively induced by type I ( ... The method can further comprise determining mRNA levels of the gene encoding myxovirus resistance protein A (M×A) in said blood ...
  http://www.patentsencyclopedia.com/app/20100129788
*  Publications | Mizuguchi Laboratory
"Integrating sequence and gene expression information predicts genome-wide DNA-binding proteins and suggests a cooperative ... "Classification of idiopathic interstitial pneumonias using anti-myxovirus resistance-protein 1 autoantibody. ". Sci Rep. 2017 ... "Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions. ". Proteins, 2013 ... "Exploring the evolutionary rate differences of party hub and date hub proteins in Saccharomyces cerevisiae protein-protein ...
  http://mizuguchilab.org/en_research/publications/
*  Caspase-8 Serves Both Apoptotic and Nonapoptotic Roles | The Journal of Immunology
Deletion of the caspase-8 gene in hepatocytes endows them with resistance to Fas cytotoxicity. A-D, Comparison of Casp8F/+:Alb- ... Co-ordination of the expression of the protein tyrosine kinase p56lck with the pre-T cell receptor during thymocyte development ... To induce deletion of caspase-8 in mice expressing Cre under the control of the myxovirus resistance-1 (Mx1) promoter, mice ... Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods 25:402. ...
  http://www.jimmunol.org/content/173/5/2976.long
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... and essential gene hypomorphic mutations (i.e. alleles conferring reduced protein expression, stability, or activity9, 12, 13) ... protocol allows to demonstrate and further investigate the interaction between the antiviral myxovirus resistance protein 1 ( ... Phenotypes are determined by a complex series of physical (e.g. protein-protein) and functional (e.g. gene-gene or genetic) ... Nonhost Resistance, Virus-induced gene silencing, VIGS, disease resistance, gene silencing, Pseudomonas, GFPuv, sequencing, ...
  https://www.jove.com/visualize/abstract/26147769/assorted-processing-synthetic-trans-acting-sirnas-its-activity
*  Transcriptome Analysis Reveals Human Cytomegalovirus Reprograms Monocyte Differentiation toward an M1 Macrophage | The Journal...
Myxovirus (influenza virus) resistance 2 (mouse). MX2. 879_at. 2.3. Interferon, gamma-inducible protein 16. IFI16. 1456_s_at. ... Confirmation of selected chemokine and adhesion molecule gene expression by RT-PCR. Monocytes were mock infected or HCMV ... Genes on the left represent the total set of genes probed for with the kit, and the genes on the right represent those genes ... Myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse). MX1. 37014_at. 5.6. ...
  http://www.jimmunol.org/content/181/1/698/tab-figures-data
*  ANTIPROLIFERATIVE AGENT - Patent application
Ribosomal protein L27 (L27) was used as reference housekeeping gene. Detailed description of the genes and expression see Table ... mRNA level of 2'5'-oligoadenylate synthetase isoforms 1 and 2 (OAS1, OAS2), interferon-induced myxovirus resistance 1 (MX1 and ... Expression was related to the housekeeping gene 60S ribosomal protein L27 (RPL27) which did not change under any of the ... genes, whereas expression of cell proliferation genes were diminished (FIG. 11K; Table 1). Altogether, these observations ...
  http://www.patentsencyclopedia.com/app/20120207770
*  Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver
... the expression of Fbxw7; (b) the expression and activation of protein kinases that phosphorylate the Cdc4 phosphodegron, an ... crossed these Fbxw7F/F mice with mice harboring a Cre transgene under the control of the promoter for the myxovirus resistance ... CDC4 gene expression as potential biomarker for targeted therapy in prostate cancer. Cancer Biol Ther. 2006;5(1):78-83. [PubMed ... and the adaptor protein S-phase kinase-associated protein 1 (Skp1) in addition to an F-box protein (2-4). F-box- and WD repeat ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3007132/
*  MxA/Mx1 Antibody (H00004599-B01P): Novus Biologicals
myxovirus (influenza virus) resistance 1, interferon-inducible protein p78(mouse). Background. In mouse, the interferon- ... The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction ... Western Blot: MxA/Mx1 Antibody [H00004599-B01P] - Analysis of MX1 expression in transfected 293T cell line by MX1 polyclonal ... human interferon-regulated resistance GTP-binding protein MXA10IFI-78Khomolog of murine (interferon-inducibleprotein p78) ...
  https://www.novusbio.com/products/mxa-mx1-antibody_h00004599-b01p
*  METHODS AND KITS FOR PREDICTING CANCER METASTASIS - Patent application
... at ring finger protein 44 [0120]The present inventors hypothesized that increased expression of certain genes in primary NSCLC ... 006251.2 protein kinase, AMP-activated, alpha 1 catalytic subunit NM_002463.1 myxovirus (influenza virus) resistance 2 (mouse) ... Gene Expression Levels in Primary Tumors [0101]Materials and Methods [0102]Gene Expression Real Time RT PCR (RQ-PCR) Study [ ... these genes. The relative gene expression for all analyzed genes was calculated using the "Relative Quantification Study" ...
  http://www.patentsencyclopedia.com/app/20100145131
*  Past Funding Archive | Integrated Natural Sciences Center | Haverford College
France performing mutagenesis and expression experiments on proteins from mature and emerging myxoviruses (2012 - 2014). ... She has worked on a project using in situ hybridization to analyze the level of expression of the T48 gene involved in ... As a Kovaric Fellow, Chloe worked in Walter Smith's nanoscale physics lab on measuring the electrical conductivity of DNA with ... Grace Thiele '17 -Investigating Protein-Protein Interactions of Acyl Carrier Proteins using a Site-Specific Vibrational ...
  https://www.haverford.edu/integrated-natural-sciences-center/archive
*  Preserved in vivo response to interferon-alpha in multiple sclerosis patients with neutralising antibodies against interferon...
... including Myxovirus Resistance Protein A (encoded by the MX1 gene), resulting in a loss of bioactivity and therapeutic benefit ... We measured the gene expression index of immune system genes in blood cells from the 10 NAb-positive patients after IFN-α ... We found a significantly increased expression of a number of genes, including MX1, IFI27, IL10 and TNFSF10 (encoding TRAIL) in ... We used in vivo induction of MX1 mRNA and other IFN-inducible genes as measure of the biological response. The primary endpoint ...
  http://www.forskningsdatabasen.dk/catalog/235205961
*  HCV Research and News: July 2010
... interferon stimulated genes, Mx1, myxovirus (influenza virus) resistance 1 interferon-inducible protein p78 (mouse), NR, no ... Gene expression profiles in the livers of 91 patients were analyzed using an Affymetrix genechip (Affymetrix, Santa Clara, CA ... Gene expression profiling of the liver differentiated patients into 2 groups: patients with up-regulated ISGs and patients with ... More recently, other scientists have achieved the same result in human cells by delivering the proteins encoded by those genes ...
  http://hepatitiscresearchandnewsupdates.blogspot.com.au/2010/07/
*  Medical Virology
VIRAL GENES NOT REQUIRED FOR VIRAL REPLICATION Viruses frequently have genes encoding proteins that are not directly involved ... Transcription and expression of adenovirus and herpesvirus immediateearly genes turn on the promoters for early genes, whereas ... RESISTANCE TO VIRAL INFECTIONS Resistance to viral infections is initially provided by factors that are not virus-specific. ... myxoviruses, and bunyaviruses. ... Most early genes encode proteins that are necessary for viral ...
  http://www.gkhub.info/medical-virology.html
*  MYST Histone Acetyltransferase 2 (MYST2) Antikörper
anti-Myxovirus (Influenza Virus) Resistance 1, Interferon-Inducible Protein p78 (Mouse) Antikörper ... which is indispensable for H3K14 acetylation and for the normal expression of essential genes regulating embryonic development ... anti-Myxovirus (Influenza Virus) Resistance 2 (Mouse) Antikörper * anti-N-6 Adenine-Specific DNA Methyltransferase 1 (Putative ... MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2 , MYST histone acetyltransferase 2 , MYST protein 2 , MYST-2 , histone ...
  http://www.antikoerper-online.de/abstract/MYST+Histone+Acetyltransferase+2+