RFA-ES-04-008: METABOLOMICS: APPLICATION TO ENVIRONMENTAL HEALTH RESEARCH
APPLICATION TO ENVIRONMENTAL HEALTH RESEARCH RFA-ES-04-008. NIEHS ... catalog metabolite expression patterns in response to exposure ... Thus, the application of metabolomics provides a new approach for defining gene-environment interactions in disease and for ... metabolic and regulatory pathways that are perturbed by environmental exposures and can lead to the development of toxicity and ... susceptibility to toxicity or disease resulting from exposure to environmental factors. o Studies to assess changes in ...https://grants.nih.gov/grants/guide/rfa-files/RFA-ES-04-008.html
2004 Annual Report | Center for Child Environmental Health Risks Research| Research Project Database | Grantee Research...
Gene expression profiling analysis reveals arsenic-induced cell cycle arrest and apoptosis in p53-proficient and p53-deficient ... A framework for assessing risks to children from exposure to environmental agents. Environmental Health Perspectives 2004;112(2 ... children's environmental health, diesel exhaust, environmental risks, exposure assessment, genetic mechanisms, genetic risk ... Journal of Exposure Analysis and Environmental Epidemiology 2005;15(2):164-171. R831709 (2005). R831709 (2007). *Abstract from ...https://cfpub.epa.gov/ncer_abstracts/index.cfm/fuseaction/display.abstractDetail/abstract/8038/report/2004
Signatures of Environmental Exposures Using Peripheral Leukocyte Gene Expression: Tobacco Smoke | Cancer Epidemiology,...
Signatures of Environmental Exposures Using Peripheral Leukocyte Gene Expression: Tobacco Smoke. Johanna W. Lampe, Sergey B. ... Signatures of Environmental Exposures Using Peripheral Leukocyte Gene Expression: Tobacco Smoke. Johanna W. Lampe, Sergey B. ... Signatures of Environmental Exposures Using Peripheral Leukocyte Gene Expression: Tobacco Smoke. Johanna W. Lampe, Sergey B. ... Signatures of Environmental Exposures Using Peripheral Leukocyte Gene Expression: Tobacco Smoke Message Subject (Your Name) has ...http://cebp.aacrjournals.org/content/13/3/445
The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression |...
Department of Environmental Health, Rollins School of Public Health at Emory University, Atlanta, USA ... The aquaglyceroporin AQP9 contributes to the sex-specific effects of in utero arsenic exposure on placental gene expression. ...https://ehjournal.biomedcentral.com/articles/10.1186/s12940-017-0267-8/open-peer-review
Association between In Utero arsenic exposure, placental gene expression, and infant birth weight: a US birth cohort study |...
Environmental exposure to arsenic, AS3MT polymorphism and prevalence of diabetes in Mexico. Journal of exposure science & ... AQP9 expression and the expression of other genes, and (C) infant birth weight and gene expression. All analyses were adjusted ... between AQP9 expression and the expression of the other candidate genes as well as the association between gene expression and ... The expression of arsenic-related genes was further normalized to the geometric mean of the expression of 5 house-keeping genes ...https://ehjournal.biomedcentral.com/articles/10.1186/1476-069X-12-58
Exposure to the pesticide linuron affects androgen‐dependent gene expression in the three‐spined stickleback (Gasterosteus...
... dependent gene expression in the three‐spined stickleback (Gasterosteus aculeatus). Previous research demonstrated that ... exposure to exogenous androgens and effluents with androgenic activity ... ... Article Exposure to the pesticide linuron affects androgen‐ ... About Environmental XPRT. Environmental XPRT is a global ... No comments were found for Exposure to the pesticide linuron affects androgen‐dependent gene expression in the three‐spined ...https://www.environmental-expert.com/articles/exposure-to-the-pesticide-linuron-affects-androgen-dependent-gene-expression-in-the-three-spined-sti-291845
Gene expression network analyses in response to air pollution exposures in the trucking industry | Environmental Health | Full...
To better understand the cellular responses induced by air pollution exposures, we performed genome-wide gene expression ... were common to all three exposure measures and were differentially expressed in two previous studies assessing gene expression ... We defined genes and gene networks that were differentially activated in response to PM2.5 (particulate matter ≤ 2.5 microns in ... including 63 that were statistically significantly correlated with at least two out of the three exposures. These genes ...https://0-ehjournal-biomedcentral-com.brum.beds.ac.uk/articles/10.1186/s12940-016-0187-z
Stephen Friend - Wikipedia
"Signatures of environmental exposures using peripheral leukocyte gene expression: Tobacco smoke". Cancer epidemiology, ... "A gene-expression signature as a predictor of survival in breast cancer". New England Journal of Medicine. 347 (25): 1999-2009 ... "Gene expression changes associated with progression and response in chronic myeloid leukemia". Proceedings of the National ... Van 't Veer, L. J.; Dai, H; Van De Vijver, M. J.; He, Y. D.; Hart, A. A.; Bernards, R; Friend, S. H. (2003). "Expression ...https://en.wikipedia.org/wiki/Stephen_Friend
NIH study suggests immune system could play a central role in AMD | National Eye Institute
Changes in how genes in the immune system function may result in age-related macular degeneration (AMD), the leading cause of ... One explanation may be that environmental exposures influence DNA methylation, which regulates gene expression. Changes in this ... finding is consistent with the hypothesis that environmental exposures may epigenetically regulate expression of many genes and ... meaning that the underlying DNA is normal but gene expression has been modified, likely by environmental factors, in an adverse ...https://nei.nih.gov/news/pressreleases/112712
Autism, Addiction and MeCP2 | National Institute on Drug Abuse (NIDA)
In 1999, the MeCP2 gene was discovered to be altered in many cases of the autism spectrum disorder Rett syndrome. Since then, ... can be influenced by gene expression and environmental factors, including exposure to drugs. Dr. LaSalle began her presentation ... MeCP2, a binding protein known for regulating gene expression, produces one of the essential "readers" of the DNA methylation ... MeCP2 regulates the genes involved in changes to neural activity and growth, as well as the genes that control anxiety and ...https://www.drugabuse.gov/frontiers-in-addiction-research-mini-conventions/frontiers-in-addiction-research-2011/autism-addiction-mecp2
Epigenetics: A Molecular Link Between Environmental Factors and Type 2 Diabetes | Diabetes
Environmental exposures to nutrients may change gene expression and alter disease susceptibility through epigenetic ... Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins. J Clin ... Effects of DNA methylation on gene expression. A: Whereas low levels of DNA methylation at gene promoters have been proposed to ... gene silencing of SUV39H1 in normal human vascular smooth muscle cells increased the expression of inflammatory genes (104). NF ...http://diabetes.diabetesjournals.org/content/58/12/2718.full?cited-by=yes&legid=diabetes
RFA-MH-09-171: Recovery Act Limited Competition: Research to Address the Heterogeneity in Autism Spectrum Disorders ...
... exposures. Environmental exposures are thought to mediate gene expression through epigenetic modification at all levels ( ... exposures.. *Research to determine feasibility of adding new data collection efforts for environmental exposures in existing ... environmental exposures and specific subtypes of ASD.. *Studies that link existing environmental monitoring data to existing ... Research exploring relationships between environmental exposures and epigenetic alterations in ASD. *Studies examining defects ...https://grants.nih.gov/grants/guide/rfa-files/RFA-MH-09-171.html
SYSTEMS MAKING SENSE - Harpers Wine & Spirit Trade News
Occasionally, environmental exposures to certain odours can influence gene expression, turning on receptors in the olfactory ... An example of the latter is habituation'. Repeated or constant exposure to an odour reduces people's ability to detect it. Dr ... This sensitivity is thought to be genetic, although no gene has yet been implicated. Anatomically, Bartoshuk has shown that ... short exposures to the odorant over a few weeks'. The implication for wine tasting ability here would be that we can learn to ...http://www.harpers.co.uk/news/fullstory.php/aid/1777/SYSTEMS_MAKING_SENSE.html
Stress-induced inhibition of translation independently of eIF2α phosphorylation | Journal of Cell Science
All types of cells activate mechanisms to regulate gene expression after exposure to environmental stress, and to a large ... Translation elongation is proposed to represent a rich source for the regulation of gene expression (Chu et al., 2013), and ... J.H.J.K.: all experiments involving S. pombe and UV; G.E.R.: experiments with S. cerevisiae and exposure of S. pombe to H2O2; C ... when added immediately after exposure to UV (marked 'UV'; open symbols) or without exposure (marked 'Controls'; filled symbols ...http://jcs.biologists.org/content/128/23/4420
Obesity linked to the expression of genes that code for enzymes involved in sex steroid biosynthesis | RTI
2) Testing for an association between a change in the gene expressions of aromatase (CYP19, 17? dehydroxylase (CYP17), and ... Providing groundwork for future studies relating PCB and DDE exposure to changes in gene expression and the consequent ... intermediate for our investigation of a link between exposure to environmental contaminants and changes in gene expression in ... Objectives: 1) Providing groundwork for future studies relating PCB and DDE exposure to changes in gene expression and the ...https://www.rti.org/publication/obesity-linked-expression-genes-code-enzymes-involved-sex-steroid-biosynthesis
Identification of proteomic signatures of exposure to marine pollutants in mussels (Mytilus edulis)
Animals, Electrophoresis; Gel; Two-Dimensional, Environmental Exposure, Gene Expression Profiling, Multivariate Analysis, ... Application of two-dimensional electrophoresis (2-DE) provided protein expression signatures (PES) for exposure to these ... Environmental Sciences Pharmacology and Toxicology Research subject Biochemistry Identifiers. urn:nbn:se:su:diva-26150 (URN)978 ... Identification of proteomic signatures of exposure to marine pollutants in mussels (Mytilus edulis). Apraiz, Itxaso Stockholm ...http://su.diva-portal.org/smash/record.jsf?pid=diva2:177773
Eating Disorders and Epigenetics | SpringerLink
... and epigenetic mechanisms are believed to link environmental exposures to gene expression. This chapter provides an overview of ... Maternal care, gene expression, and the transmission of individual differences in stress reactivity across generations. Annu ... Prenatal exposure to maternal depression, neonatal methylation of human glucocorticoid receptor gene (NR3C1) and infant ... Promoter specific DNA methylation and gene expression of POMC in acutely underweight and recovered patients with anorexia ...https://link.springer.com/chapter/10.1007/978-3-319-53889-1_5
Gene-Environment Interactions and Airway Disease in Children | SUPPLEMENT ARTICLES | Pediatrics
... understanding how environmental exposures affect gene expression is critical to understanding these diseases. Genomic ... coupled with environmental exposures. Understanding the precise role of environmental exposures in the development of asthma is ... additional research is needed to clarify the interactions between these genes and the multiple environmental exposures that ... ENVIRONMENTAL EXPOSURES AND ASTHMA. A comparison of urban and rural children suggests that the pathogenesis of airway disease ...http://pediatrics.aappublications.org/content/123/Supplement_3/S151.full
Gene expression profiling in rat kidney after intratracheal exposure to cadmium-doped nanoparticles | SpringerLink
... very limited information exists on renal effects of exposure to cadmium-containing nanomaterials. In this work, ... This article is part of the Topical Collection on Nanotechnology, Occupational and Environmental Health ... Gene expression profiling in rat kidney after intratracheal exposure to cadmium-doped nanoparticles. ... The number of differentially expressed genes being 139 and 153 at the post exposure days 7 and 30, respectively. Renal gene ...https://link.springer.com/article/10.1007%2Fs11051-012-0925-2
Medical Xpress - environmental health sciences
Prenatal exposure to BPA at low levels can affect gene expression in developing rat brain. New research from North Carolina ... at levels below those currently considered safe for humans affects gene expression related to sexual differentiation and ... ... Defending against environmental stressors may shorten lifespan. A shorter life may be the price an organism pays for coping ... Exposure to specific toxins and nutrients during late pregnancy and early life correlates with autism risk. Using evidence ...https://medicalxpress.com/tags/environmental+health+sciences/sort/rank/all/
Expression of allograft inflammatory factor-1 in kidneys: A novel molecular component of podocyte. - Semantic Scholar
... was one of the highly expressed genes. Here, we explored the pathological significance of AIF-1 expression in the kidneys. The ... Furthermore, the expression of AIF-1 in human kidneys and urinary sediments was examined. AIF-1 was expressed at both mRNA and ... The expression of AIF-1 in podocytes was constitutive; positive in podocytes of both normal and diseased rats. In humans, AIF-1 ... and that the upregulation of AIF-1 in an anti-GBM nephritis model may mainly be a consequence of its expression in infiltrating ...https://www.semanticscholar.org/paper/Expression-of-allograft-inflammatory-factor-1-in-A-Tsubata-Sakatsume/78f10646f6408f9d6edbd71deeca58d308d9e0f1
Brain Sciences | Free Full-Text | The Neurodevelopmental Impact of Neonatal Morphine Administration | HTML
... and spatial recognition memory following morphine exposure. This comprehensive review examines existing preclinical and ... morphine exposure had different effects on hippocampal gene expression depending on the severity of environmental stress. ... Mild stress led to decreased expression of genes related to cell maintenance, while severe stress lead to increased expression ... Treatment of mild stress with morphine led to increased expression of specific gene sets related to neurodevelopment. In ...http://www.mdpi.com/2076-3425/4/2/321/htm
The Brain, Drugs, and Behavior - The New Science of Addiction
We can cite a growing number of examples in which specific types of environmental exposure can affect gene expression directly ... SWT: Can you briefly explain how environment affects addiction-related gene expression and function? ... Our environment can affect gene expression and its functional consequences directly or indirectly. ... The fact that genes, environment, and developmental stage all interact to play important roles in the onset, establishment, and ...http://www.socialworktoday.com/archive/janfeb2008p12.shtml
Health Effects - ccceh.org
The Center's research focuses on how early exposure to environmental pollutants could alter gene expression, thereby affecting ... any environmental exposure that perturbs the signals controlling for gene expression while the child is developing can be ... The disease develops from multiple factors, some unknown, including environmental pollutants, genes, nutrition, immunologic and ... Environmental Health Resources*Center Health Education Materials. Health tips developed by the Center and our community board ...http://ccceh.org/our-research/health-effects
Search of: 'environmental health' OR 'environmental exposure' | Recruiting, Not yet recruiting, Available Studies - List...
Change in TSLP Gene Expression. 300. All. 18 Years to 80 Years (Adult, Senior). NCT02740543. 10-01191. December 2013. December ... environmental health' OR 'environmental exposure' , Recruiting, Not yet recruiting, Available Studies. Need help? See RSS Feeds ... environmental health' OR 'environmental exposure' , Recruiting, Not yet recruiting, Available Studies (96 records) ... 96 Studies found for: 'environmental health' OR 'environmental exposure' , Recruiting, Not yet recruiting, Available Studies ...https://clinicaltrials.gov/search/open/term=%22environmental+health%22+OR+%22environmental+exposure%22