*  PLOS Genetics: A Comprehensive tRNA Deletion Library Unravels the Genetic Architecture of the tRNA Pool
When a deleted tRNA belongs to a family which contains multiple genes with the same anti-codon, the affected cells responded by ... Our tRNA deletion library is a unique resource that paves the way towards fully characterizing the tRNA pool and their role in ... Co-deletion of tRNA combinations revealed that tRNAs with essential function can be compensated by members of the same or ... We created a comprehensive tRNA deletion library in yeast and assessed the essentiality of each tRNA in multiple conditions. ...
  http://journals.plos.org/plosgenetics/article/figure?id=10.1371/journal.pgen.1004084.g004
*  久米 一規(大学院先端物質科学研究科)
Screening for a gene deletion mutant whose temperature sensitivity is suppressed by FK506 in budding yeast and its application ... Effect of ethanol on cell growth of budding yeast: Genes that are important for cell growth in the presence of ethanol, ... GENES TO CELLS, 20巻, 12号, pp.1046-pp.1058, DEC 2015. DOIを用いた論文検索結果へのリンク ...
  http://seeds.office.hiroshima-u.ac.jp/profile/ja.ea18e48d41ddec8c520e17560c007669.html
*  Strain sensitivity to different translation-inhibitory | Open-i
Wild type (WT) or gene deletion mutant strains (yploo9cΔ, yil137cΔ, ypl183w-aΔ, ydr056cCΔ and ... Wild type (WT) or gene deletion mutant strains (yploo9cΔ, yil137cΔ, ypl183w-aΔ, ydr056cCΔ and yjr111cΔ) were serially diluted ... Wild type (WT) or gene deletion mutant strains (yploo9cΔ, yil137cΔ, ypl183w-aΔ, ydr056cCΔ and yjr111cΔ) were serially diluted ... More than 70,000 strains were analyzed from the array of gene deletion mutant yeast strains. As expected, the overall profiles ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2925817_1472-6769-10-6-2&req=4
*  Multiplex polymerase chain reaction - Wikipedia
Multiplex-PCR was first described in 1988 as a method to detect deletions in the dystrophin gene. It has also been used with ... Ballabio A, Ranier JE, Chamberlain JS, Zollo M, Caskey CT (1990). "Screening for steroid sulfatase (STS) gene deletions by ... Gene Deletion Analysis 5. Template Quantitation 6. Linkage Analysis 7. RNA Detection 8. Forensic Studies 9. Diet Analysis ... "Analysis of quantitative PCR for the diagnosis of deletion and duplication carriers in the dystrophin gene". Journal of Medical ...
  https://en.wikipedia.org/wiki/Multiplex_polymerase_chain_reaction
*  Zygosaccharomyces bailii - Wikipedia
Targeted gene deletion in Zygosaccharomyces bailii. Yeast 18, 173-186. Kalathenos, P., Sutherland, J. P., Roberts, T. A., 1995 ...
  https://en.wikipedia.org/wiki/Zygosaccharomyces_bailii
*  Haptoglobin - Wikipedia
Koda Y, Soejima M, Yoshioka N, Kimura H (1998). "The haptoglobin-gene deletion responsible for anhaptoglobinemia". American ... Erickson LM, Kim HS, Maeda N (1993). "Junctions between genes in the haptoglobin gene cluster of primates". Genomics. 14 (4): ... Maeda N (1985). "Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene ... Mutations in this gene or its regulatory regions cause ahaptoglobinemia or hypohaptoglobinemia. This gene has also been linked ...
  https://en.wikipedia.org/wiki/Haptoglobin
*  Essential gene - Wikipedia
... targeted mutants are gene deletions; random mutants are transposon insertions. Methods: Clones indicate single gene deletions, ... Two main strategies have been employed to identify essential genes on a genome-wide basis: directed deletion of genes and ... Essential genes are those genes of an organism that are thought to be critical for its survival. However, being essential is ... While it may be difficult to prove that a gene is essential in humans, it can be demonstrated that a gene is not essential or ...
  https://en.wikipedia.org/wiki/Essential_gene
*  TMEM50A - Wikipedia
"RHD gene deletion occurred in the Rhesus box". Blood. 95 (12): 3662-8. PMID 10845894. "Entrez Gene: TMEM50A transmembrane ... This gene is located in the RH gene locus, between the RHD and RHCE genes. The function of its protein product is unknown; ... Its position between the RH genes suggests that polymorphisms in this gene may be tightly linked to RH haplotypes and may ... The TMEM50A gene is located on chromosome 1 p36.11 in the human (homo sapiens) genome. Its mRNA sequence is 2284 base pairs in ...
  https://en.wikipedia.org/wiki/TMEM50A
*  Janus Experiments - Wikipedia
Paunesku, Tatjana; Zhang, Yueru; Gemmell, M. Anne; Woloschak, Gayle E. (2000). "p53 gene deletions in radiation-induced tumors ...
  https://en.wikipedia.org/wiki/Janus_Experiments
*  Osteochondroprogenitor cell - Wikipedia
General Trsp gene deletion is lethal to the embryo. The results of this research was used as a model for Kashin-Beck disease. ... Deletion of the Trsp gene in osteochondroprogenitor cells results in abnormal bone growth, delayed ossification, ... Aug 2009). "Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and ... General gene knock out of the TGF-β resulted in death. Conditional inactivation of TGF-βr2 of osteochondroprogenitor cells in ...
  https://en.wikipedia.org/wiki/Osteochondroprogenitor_cell
*  KLRC2 - Wikipedia
... common occurrence of NKG2-C deletion in the general population". Genes and Immunity. 4 (2): 160-7. doi:10.1038/sj.gene.6363940 ... The KLRC (NKG2) gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially ... gene deletion". International Immunology. 16 (1): 163-8. doi:10.1093/intimm/dxh013. PMID 14688071. Ortega C, Romero P, Palma A ... and D receptor genes in the human natural killer gene complex". Immunogenetics. 48 (3): 163-73. doi:10.1007/s002510050420. PMID ...
  https://en.wikipedia.org/wiki/KLRC2
*  Cochliobolus heterostrophus - Wikipedia
This "facilitates functional analysis by site-specific gene deletion." "Cochliobolus heterostrophus C5". Retrieved 25 October ...
  https://en.wikipedia.org/wiki/Cochliobolus_heterostrophus
*  Complement component 4B - Wikipedia
A mechanism for gene deletions and disease associations". The Journal of Biological Chemistry. 274 (17): 12147-56. doi:10.1074/ ... Complement component 4B (Chido blood group) is a protein that in humans is encoded by the C4B gene. This gene encodes the basic ... or 3 copies of this gene. In addition, this gene exists as a long form and a short form due to the presence or absence of a 6.4 ... This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this ...
  https://en.wikipedia.org/wiki/Complement_component_4B
*  APOBEC3B - Wikipedia
2007). "Population Stratification of a Common APOBEC Gene Deletion Polymorphism". PLoS Genet. 3 (4): e63. doi:10.1371/journal. ... This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster ... This gene along with APOBEC3A have been in recent years found associated with mutagenesis of several cancers. The APOBEC3A and ... "Entrez Gene: APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B". Human APOBEC3B genome location and ...
  https://en.wikipedia.org/wiki/APOBEC3B
*  Mark Walport - Wikipedia
"Homozygous hereditary C3 deficiency due to a partial gene deletion". Proceedings of the National Academy of Sciences of the ...
  https://en.wikipedia.org/wiki/Mark_Walport
*  Epithelial cell adhesion molecule - Wikipedia
Deletion of a portion of the 3' end of the EpCAM gene causes epigenetic inactivation of the MSH2 gene by hypermethylating the ... Tomita, N; Yamano T; Matsubara N; Tamura K (2013). "[A Novel Genetic Disorder of Lynch Syndrome-EPCAM Gene Deletion]". Gan to ... This complex then binds to DNA and promotes the transcription of various genes. Targets of upregulation include c-myc, e-fabp, ... 2004). "EpCAM is overexpressed in breast cancer and is a potential target for breast cancer gene therapy". Cancer Res. 64 (16 ...
  https://en.wikipedia.org/wiki/Epithelial_cell_adhesion_molecule
*  HLA A1-B8-DR3-DQ2 - Wikipedia
Scully LJ, Toze C, Sengar DP, Goldstein R (May 1993). "Early-onset autoimmune hepatitis is associated with a C4A gene deletion ... one expects 1/2 of adjacent genes to have new gene-alleles, unless the genes are small and very close together. This dynamic ... More recent studies indicate that risk lies solely between B8-DR3 region, this includes 3 class I genes, the class III gene ... There are many genes that lie on either side of HLA-B, TNF alpha is over expressed. Closer to DR3, C4A is null in B8-DR3 ...
  https://en.wikipedia.org/wiki/HLA_A1-B8-DR3-DQ2
*  Fibrillin 1 - Wikipedia
"In frame fibrillin-1 gene deletion in autosomal dominant Weill-Marchesani syndrome". Journal of Medical Genetics. 40 (1): 34-6 ... Fibrillin-1 is a protein that in humans is encoded by the FBN1 gene, located on chromosome 15. FBN1 is a 230-kb gene with 65 ... The FBN-1 gene is involved in a variety of embryonic developmental programs. The microfibrils that are made from fibrillin-1 ... Marfan Syndrome is a congenital disease that arises from a mutation in the FBN-1 gene. This leads to the malformation and ...
  https://en.wikipedia.org/wiki/Fibrillin_1
*  Strictosidine - Wikipedia
This was accomplished by adding 21 genes and 3 gene deletions. Mizukami, H; Nordlöv, H; Lee, S. L.; Scott, A. I. (1979). " ...
  https://en.wikipedia.org/wiki/Strictosidine
*  Ayazi syndrome - Wikipedia
... a contiguous gene deletion syndrome in Xq21". Am J Hum Genet. 45 (4): 530-540. PMC 1683514 . PMID 2491012. http://www. ... Genes known to be deleted are CHM and POU3F4, both located on the Xq21 locus. "OMIM Entry - # 303110 - CHOROIDEREMIA, DEAFNESS ... Ayazi syndrome (or Chromosome 21 Xq21 deletion syndrome) is a syndrome characterized by choroideremia, congenital deafness and ...
  https://en.wikipedia.org/wiki/Ayazi_syndrome
*  IGHG3 - Wikipedia
... cDNA sequence supports partial gene deletion model". Proc Natl Acad Sci U S A. 79 (10): 3260-4. doi:10.1073/pnas.79.10.3260. ... Ig gamma-3 chain C region is a protein that in humans is encoded by the IGHG3 gene. "Human PubMed Reference:". Alexander A, ... "Entrez Gene: IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker)". Michaelsen TE, Frangione B, Franklin EC (1977). " ... 1986). "Sequence of a human immunoglobulin gamma 3 heavy chain constant region gene: comparison with the other human C gamma ...
  https://en.wikipedia.org/wiki/IGHG3
*  Hairy cell leukemia - Wikipedia
Vallianatou K, Brito-Babapulle V, Matutes E, Atkinson S, Catovsky D (1999). "p53 gene deletion and trisomy 12 in hairy cell ... The expression of genes is also dysregulated in a complex and specific pattern. The cells under express 3p24, 3p21, 3q13.3-q22 ... There is some evidence suggesting that a rearrangement of the immunoglobulin gene VH4-34, which is found in about 40% of HCL-V ... Hairy cells are nearly mature B cells, which are activated clonal cells with signs of VH gene differentiation. They may be ...
  https://en.wikipedia.org/wiki/Hairy_cell_leukemia
*  Yuet Wai Kan - Wikipedia
Kan was the first to discover the gene deletion in human alpha-thalassemia; he was the first to discover a point-mutation ...
  https://en.wikipedia.org/wiki/Yuet_Wai_Kan
*  X-linked intellectual disability - Wikipedia
"A novel 2 bp deletion in the TM4SF2 gene is associated with MRX58". J Med Genet. 39 (6): 430-3. doi:10.1136/jmg.39.6.430. PMC ... This gene is involved in CNS and pancreas development. Mutations in this gene cause X-linked intellectual disability and ... This gene is a homeobox-containing gene expressed during development. The expressed protein contains two conserved domains, a C ... "Familial intellectual disability and autistic behavior caused by a small FMR2 gene deletion". Am. J. Med. Genet. A. 155A (8): ...
  https://en.wikipedia.org/wiki/X-linked_intellectual_disability
*  Hemoglobin, alpha 2 - Wikipedia
Coelho A, Picanço I, Seuanes F, Seixas MT, Faustino P (Aug 2010). "Novel large deletions in the human alpha-globin gene cluster ... Deletion of 1 or 2 alleles is clinically silent. Deletion of 3 alleles causes HbH disease, resulting in anemia and ... The human alpha globin gene cluster is located on chromosome 16 and spans about 30 kb, including seven alpha like globin genes ... "Hemoglobin H disease due to a de novo mutation at the α2-globin gene and an inherited common α-thalassemia deletion found in a ...
  https://en.wikipedia.org/wiki/Hemoglobin,_alpha_2