*  Development and Structure of the Cardiac Conduction System | SpringerLink
Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. N Engl J Med. 2001;344:1823-31.PubMedCrossRef ... Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage ... tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome ... postnatal development of ventricular pre-excitation in a mouse model of cardiac hypertrophy and Wolff-Parkinson-White syndrome ...
  https://link.springer.com/chapter/10.1007/978-1-4939-2739-5_1
*  Wolff-Parkinson-White Syndrome Guidelines: Guidelines Summary
Wolff-Parkinson-White (WPW) syndrome is defined as a congenital condition involving abnormal conductive cardiac tissue between ... Parkinson, and White described a series of young patients who experienced paroxysms of tachycardia and had characteristic ... Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. N Engl J Med. 2001 Jun 14. 344(24):1823-31. [ ... encoded search term (Wolff-Parkinson-White%20Syndrome) and Wolff-Parkinson-White Syndrome What to Read Next on Medscape. ...
  https://emedicine.medscape.com/article/159222-guidelines
*  JCI - The blooming of the French lilac
Identification of a gene responsible for a familial Wolff-Parkinson-White syndrome. N Engl J Med 2001. 344:1823-1831. View this ... 2 subunit has been pinpointed as a molecular defect underlying ventricular pre-excitation in the Wolff-Parkinson-White syndrome ... Each AMPK subunit is represented in an isoform family, derived from different genes. The binding of the β/γ subunits to the α ... and lipogenic gene expression, and to increase skeletal muscle glucose uptake (9, 17-19). ...
  https://www.jci.org/articles/view/14178
*  AMPK activation-protean potential for boosting healthspan | SpringerLink
Gollob MH, Green MS, Tang AS et al (2001) Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. N ... Transgenic mice overexpressing mutant PRKAG2 define the cause of Wolff-Parkinson-White syndrome in glycogen storage ... Mehenni H, Gehrig C, Nezu J et al (1998) Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and ... Hearle N, Schumacher V, Menko FH et al (2006) Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res ...
  https://link.springer.com/article/10.1007%2Fs11357-013-9595-y
*  Genomics in Cardiovascular Disease | JACC: Journal of the American College of Cardiology
2001) Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. N Engl J Med 344:1823-1831. ... Rare variants that cause single gene diseases such as hypertrophic cardiomyopathy (3) and Wolff-Parkinson-White syndrome (49) ... tachycardia induced by an AMP-activated protein kinase loss-of-function mutation responsible for Wolff-Parkinson-White syndrome ... Single Gene Disorders: The Success of Genetic Linkage Analysis. Single gene disorders are the phenotypic consequences of rare ...
  http://www.onlinejacc.org/content/61/20/2029
*  The Year in Clinical Cardiac Electrophysiology | JACC: Journal of the American College of Cardiology
2001) Identification of a gene responsible for familial Wolff-Parkinson-White syndrome. N Engl J Med 344:1823-1831, (erratum in ... The Wolff-Parkinson-White (WPW) syndrome. An intriguing paper by Lalani et al. (45) describes a new genetic abnormality ... 2009) 20p12.3 microdeletion predisposes to Wolff-Parkinson-White syndrome with variable neurocognitive deficits. J Med Genet 46 ... To date, although familial clustering of the WPW syndrome has been described, only 1 gene (PRKAG2) has been identified as being ...
  http://www.onlinejacc.org/content/56/8/667
*  PRKAG2 - Wikipedia
Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive ... 2001). "Identification of a gene responsible for familial Wolff-Parkinson-White syndrome". N. Engl. J. Med. 344 (24): 1823-31. ... 1995). "Familial Hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3". J. Clin. ... "Entrez Gene: PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit". Cheung, P C; Salt I P; Davies S P; Hardie D ...
  https://en.wikipedia.org/wiki/PRKAG2
*  PRKAG2 - 5'-AMP-activated protein kinase subunit gamma-2 - Homo sapiens (Human) - PRKAG2 gene & protein
"Identification of a gene responsible for familial Wolff-Parkinson-White syndrome.". Gollob M.H., Green M.S., Tang A.S.-L., ... "Identification of a gene responsible for familial Wolff-Parkinson-White syndrome.". Gollob M.H., Green M.S., Tang A.S.-L., ... Wolff-Parkinson-White syndrome (WPWS)3 Publications. Manual assertion based on experiment ini ... CMH6 patients present Wolff-Parkinson-White ventricular preexcitation, enlarged myocytes without myofiber disarray, and ...
  https://www.uniprot.org/uniprot/Q9UGJ0
*  Produktübersicht anti-PRKAG2 Antikörper
Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive ... Overexpression of G100S mutation in PRKAG2 causes Wolff-Parkinson-White syndrome in transgenic zebrafish. ... levels can induce beneficial metabolic effects but that this is accompanied by Wolff-Parkinson-White Syndrome syndrome. ... the PRKAG2 gene can be used for marker-assisted selection to improve the body measurement and meat quality traits in the ...
  http://www.antikoerper-online.de/ampk-signaling-pathway-15/prkag2-antibody-1337/
*  AMPK gamma-2 chain / PRKAG2 antibody | acris-antibodies.com
Mutations in this gene have been associated with ventricular pre-excitation (Wolff-Parkinson-White syndrome), progressive ... This gene is a member of the AMPK gamma subunit family and encodes a protein with four cystathionine beta-synthase domains. ... Various forms of each of these subunits exist, encoded by different genes. AMPK is an important energy-sensing enzyme that ...
  https://www.acris-antibodies.com/target/ampk-gamma-2-chain-antibody-prkag2-antibody.htm
*  A Newly Created Splice Donor Site in Exon 25 of the MyBP-C Gene Is Responsible for Inherited Hypertrophic Cardiomyopathy With...
Familial hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7q3. J Clin Invest. 1995 ... Genomic DNA of the exon 25 region of the MyBP-C gene was cloned using a similar protocol. After blue-white selection, ... Episodes of supraventricular tachycardia were recorded in 7 of 19 gene carriers. A total of 8 of the 27 gene carriers had a ... Fractional shortening was within normal limits in all gene carriers. In 17 of the 27 gene carriers, 24-hour Holter monitoring ...
  http://circ.ahajournals.org/content/101/12/1396
*  Cardiac Memory in Patients With Wolff-Parkinson-White Syndrome | Circulation
... as a result of altered gene transcription by continued downregulation of the cAMP response element binding protein, altered ... The Wolff-Parkinson-White (WPW) syndrome3 involves a long-standing altered activation sequence, different from normal sinus ... Cardiac Memory in Patients With Wolff-Parkinson-White Syndrome. Subham Ghosh, Edward K. Rhee, Jennifer N. Avari, Pamela K. ... Cardiac Memory in Patients With Wolff-Parkinson-White Syndrome. Subham Ghosh, Edward K. Rhee, Jennifer N. Avari, Pamela K. ...
  http://circ.ahajournals.org/content/118/9/907
*  Wolff-Parkinson-White syndrome - Wikipedia
A small number of cases are due to a mutation of the PRKAG2 gene which may be inherited from a person's parents in an autosomal ... Wolff-Parkinson-White syndrome (WPW) is a disorder due to a specific type of problem with the electrical system of the heart ... "Wolff-Parkinson-White Syndrome". 8 Dec 2009. Archived from the original on 2015-02-07. Fengler BT, Brady WJ, Plautz CU (June ... Wolff-Parkinson-White Syndrome and the Risk of Sudden Cardiac Death. Doctors Lounge Website. Available at: "Archived copy". ...
  https://en.wikipedia.org/wiki/Wolff%E2%80%93Parkinson%E2%80%93White_syndrome
*  5'-AMP-activated protein kinase subunit gamma-2
Mutations in this gene have been associated with Wolff-Parkinson-White syndrome, familial hypertrophic cardiomyopathy, and ... Overexpression of G100S mutation in PRKAG2 causes Wolff-Parkinson-White syndrome in transgenic zebrafish.. ... Overexpression of G100S mutation in PRKAG2 causes Wolff-Parkinson-White syndrome in zebrafish.. ... Its mutation causes AMPK signaling abnormality which leads to cardiac syndrome.. 23115293. The authors found that the gene ...
  https://pharos.nih.gov/idg/targets/Q9UGJ0
*  AMP-kinase α2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high...
... interfere with AMP activation of AMPK and cause hypertrophic cardiomyopathy associated with Wolff-Parkinson-White syndrome.13 ... Recently, Xu et al12 found that rare homozygotes of an intronic SNP in the regulatory AMPK γ2 subunit gene PRKAG2 had ... To this end, we have examined association of a set of five tSNPs spanning the AMPK catalytic α2 subunit gene PRKAA2, with a ... Multilocus (or gene-wide) tests, including all tSNPs, were significant for total cholesterol (p = 0.004) and LDL-cholesterol (p ...
  http://jmg.bmj.com/content/43/12/936
*  Wolff-Parkinson-White Syndrome in New Delhi Gurgaon Noida
... Faridabad NCR or Online Treatment of Wolff-Parkinson-White Syndrome ... Causes of Wolff-Parkinson-White syndrome. *An abnormal gene. *Congenital heart disease ... What is Wolff-Parkinson-White syndrome. Wolff-Parkinson-White syndrome is a condition characterized by abnormal electrical ... Homeopathic Treatment of Wolff-Parkinson-White syndrome. *Acupuncture & Acupressure Treatment of Wolff-Parkinson-White syndrome ...
  http://ethosbodyandmindclinic.com/wolff-parkinson-white-syndrome
*  A familial form of conduction defect related to a mutation in the PRKAG2 gene : EP Europace - oi
... previously described as associated with this gene as neither left ventricular hypertrophy nor Wolff-Parkinson-White syndrome ... A mutation in the γ2 subunit of the AMP activated protein kinase gene (PRKAG2) was identified in the four members of the family ... A mutation in the γ2 subunit of the AMP activated protein kinase gene (PRKAG2) was identified in the four members of the family ... Keywords: Conduction defect; PRKAG2 gene; Preexcitation; AMP activated protein kinase Journal Article. 1592 words. Illustrated. ...
  http://oxfordindex.oup.com/view/10.1093/europace/eum071
*  Canonical Wnt Signaling Regulates Atrioventricular Junction Programming and Electrophysiological Properties | Circulation...
Aberrant AVC development can lead to ventricul¬¬ar preexcitation, a characteristic feature of Wolff-Parkinson-White syndrome. ... Stabilization of β-catenin protein levels can rescue Notch-mediated ventricular preexcitation and dysregulated ion channel gene ...
  http://circres.ahajournals.org/content/early/2014/11/06/CIRCRESAHA.116.304731
*  Most recent papers with the keyword Ipsc derived cardiomyopathy | Read by QxMD
... and familial Wolff-Parkinson-White (WPW) syndrome. Patients carrying the R302Q mutation in PRKAG2 present with sinus ... Gene therapy is a promising option for severe forms of genetic diseases. We previously provided evidence for the feasibility of ... Mutations in the BAG3 gene, which encodes a co-chaperone protein, have been associated with heart failure due to both inherited ... The onset of NLSDM is caused by autosomal recessive mutations in the PNPLA2 gene, which encodes adipose triglyceride lipase ( ...
  https://www.readbyqxmd.com/keyword/110608
*  Role of Imaging in the Evaluation of Patients at Risk for Sudden Cardiac Death | JACC: Cardiovascular Imaging
With respect to the diagnosis of Danon disease, the presence of massive LVH, Wolff-Parkinson-White syndrome findings on ECG, ... Although HCM is an example of a monogenic disorder, it is increasingly recognized that gene-gene interactions, as well as gene- ... Long QT syndrome (LQTS), Brugada syndrome, short QT syndrome, and catecholaminergic ventricular tachycardia all cause SCD. ... DCM can be an isolated finding or part of a clinical syndrome in which other organs are affected. These syndromes include Emery ...
  http://imaging.onlinejacc.org/content/8/7/828
*  Most recent papers with the keyword micro electrode array | Read by QxMD
... and familial Wolff-Parkinson-White (WPW) syndrome. Patients carrying the R302Q mutation in PRKAG2 present with sinus ... BACKGROUND: Mutations in the PRKAG2 gene encoding the γ-subunit of adenosine monophosphate kinase (AMPK) cause hypertrophic ... CRISPR correction of the PRKAG2 gene mutation in the patient's induced pluripotent stem cell-derived cardiomyocytes eliminates ... The link between glycogen storage, WPW syndrome, HCM, and arrhythmias remains unknown... ...
  https://www.readbyqxmd.com/keyword/49341
*  What is the drug warfarin used to treat : Dvt treatment guidelines 2017
Wolff-Parkinson-White syndrome is caused by mutations in the PRKAG2 gene.In order for us to create your customized HealthSavvy ... Wolff-Parkinson-White syndrome is a common cause of paroxysmal supraventricular tachycardia.Several forms of vitamin K are used ...
  http://www.geolectica.com/dihu/what-is-the-drug-warfarin-used-to-treat-648.php
*  Genetic and Molecular Basis of Cardiac Arrhythmias: Impact on Clinical Management Parts I and II | Circulation
Familial hypertrophic cardiomyopathy with Wolff-Parkinson-White syndrome maps to a locus on chromosome 7p3. J Clin Invest. 1995 ... At least 1 variant of the Brugada syndrome is caused by defects in the sodium channel gene (SCN5A), ie, the same gene ... Depending on the size of the gene and on the number of genes to be screened, costs may be substantial (,$1000 US per gene ... contiguous gene syndrome) and thus frequently cosegregate. In the latter case, familial WPW could be caused by a single gene ...
  http://circ.ahajournals.org/content/99/4/518
*  Distinct early signaling events resulting from the expression of the PRKAG2 R302Q mutant of AMPK contribute to increased...
Wolff-Parkinson-White Syndrome. Abstract. BACKGROUND: Humans with an R302Q mutation in AMPKgamma(2) (the PRKAG2 gene) develop a ... glycogen storage cardiomyopathy characterized by a familial form of Wolff-Parkinson-White syndrome and cardiac hypertrophy. ... AMP-Activated Protein Kinases, Animals, Cells, Cultured, Disease Models, Animal, Female, Gene Expression, Glycogen, Humans, ...
  https://www.hli.ubc.ca/publication/distinct-early-signaling-events-resulting-expression-prkag2-r302q-mutant-ampk-contribute
*  Genetics of Glycogen-Storage Disease Type II (Pompe Disease) Treatment & Management: Medical Care, Consultations, Diet
Pompe's disease presenting as hypertrophic myocardiopathy with Wolff-Parkinson-White syndrome. Am Heart J. 1978 Aug. 96(2):246- ... Identification of the first deletion-insertion involving the complete structure of GAA gene and part of CCDC40 gene mediated by ... Galehdari H, Emami M, Mohammadian G, Khodadadi A, Azmoon S, Baradaran M. Detection of a novel mutation in the GAA gene in an ... Mutation profile of the GAA gene in 40 Italian patients with late onset glycogen storage disease type II. Hum Mutat. 2006 Oct. ...
  https://emedicine.medscape.com/article/947870-treatment