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*  Short Hairpin RNA-mediated Selective Knockdown of NaV1.8 Tetrodotoxin-resistant Voltage-gated Sodium Channel in Dorsal Root...
These two channels are encoded by different VGSC genes, but tetrodotoxin alone can not distinguish currents flowing through ... NaV1.2 expressed in the brain is known to associate with accessory proteins such as contactin,32 and this association prolongs ... VOLTAGE-GATED sodium channels (VGSCs) play a critical role in determining excitability by supporting the upstroke of the action ... Akopian AN, Sivilotti L, Wood JN: A tetrodotoxin-resistant voltage-gated sodium channel expressed by sensory neurons. Nature ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1923738
*  SCN2A2 (Human) Recombinant Protein (Q01) - (H00006326-Q01) - Products - Abnova
Gene Summary:. *Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with ... voltage-gated, type II, alpha,sodium channel, voltage-gated, type II, alpha 1 polypeptide,sodium channel, voltage-gated, type ... Gene Alias:. *HBA,HBSCI,HBSCII,NAC2,Na(v)1.2,Nav1.2,SCN2A1,SCN2A2 ... Gene Description:. *sodium channel, voltage-gated, type II, ... This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and ...
  http://www.abnova.com/products/products_detail.asp?catalog_id=H00006326-Q01
*  Clinical whole-genome sequencing in severe early-onset epilepsy reveals new genes and improves molecular diagnosis. - Oxford...
... which produced a substantial increase in potassium channel current. The fourth OS patient had a recessive mutation in PIGQ that ... Mutations in these genes were not found among 500 additional individuals with epilepsy. This work reveals two novel genes for ... Molecular diagnosis has historically been confined to sequential testing of candidate genes known to be associated with ... we found de novo non-synonymous mutations in the genes KCNQ2 and SCN2A. In a third OS case, WGS revealed paternal isodisomy for ...
  https://www.bdi.ox.ac.uk/publications/447735
*  Nav1.2 - Wikipedia
... voltage-gated, type II, alpha subunit is a protein that in humans is encoded by the SCN2A gene. Functional sodium channels ... Sodium channels which contain the Navα1.2 subunit are called Nav1.2 channels. Voltage-gated sodium channels are transmembrane ... "Entrez Gene: SCN2A sodium channel, voltage-gated, type II, alpha subunit". Sanders SJ,, Stephan J.; Murtha MT; Gupta AR; ... This gene encodes one member of the sodium channel alpha subunit gene family. It is heterogeneously expressed in the brain, and ...
  https://en.wikipedia.org/wiki/Nav1.2
*  Paralytic (gene) - Wikipedia
Paralytic is a gene in the fruit fly, Drosophila melanogaster, which encodes a voltage gated sodium channel within D. ... Voltage-gated ion channel Nav1.2 SCN8A SCN1A "Dmel\para". FlyBase. Retrieved 28 March 2017. "D. melanogaster chrX:16,455,230- ... Voltage-gated sodium channels are highly conserved across lineages. The exons in specific, are conserved across many diverged ... Lin WH, Wright DE, Muraro NI, Baines RA (September 2009). "Alternative splicing in the voltage-gated sodium channel DmNav ...
  https://en.wikipedia.org/wiki/Paralytic_(gene)
*  Gene Report for G00001826 - Genes2Cognition Neuroscience Research Programme
Ankyrin-G, a modular protein, plays a critical role in clustering voltage-gated sodium channels (Nav channels) in nodes of ... Interaction of the Nav1.2a subunit of the voltage-dependent sodium channel with nodal ankyrinG. In vitro mapping of the ... Gene lists (6). Databases (8). Curated Gene. OTTHUMG00000018288 (Vega human gene). Gene. ENSG00000151150 (Ensembl human gene). ... Voltage-gated sodium channels are composed of a pore-forming alpha subunit and at least one auxiliary beta subunit. Both beta1 ...
  http://www.genes2cognition.org/db/Gene/G00001826
*  Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia | Journal of Medical...
Sangameswaran L, Fish LM, Koch BD, et al. A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and ... Claes L, Del-Favero J, Ceulemans B, et al.De novo mutations in the sodium-channel gene SCN1A cause severe myoclonic epilepsy of ... Nav1.2 (encoded by SCN2A), Nav1.3 (encoded by SCN3A), Nav1.4 (encoded by SCN4A), Nav1.5 (encoded by SCN5A), Nav1.6 (encoded by ... SCN9A encodes Nav1.7, a voltage gated sodium channel alpha subunit expressed primarily in sensory and sympathetic ganglia,14 ...
  http://jmg.bmj.com/content/41/3/171
*  Nav1.1 - Wikipedia
... is a protein which in humans is encoded by the SCN1A gene. The vertebrate sodium channel is a voltage-gated ion channel ... Nav1.2), and III (Nav1.3). There are also several distinct sodium channel alpha subunit isoforms in skeletal and cardiac muscle ... "Entrez Gene: SCN1A sodium channel, voltage-gated, type I, alpha subunit". Malo MS, Blanchard BJ, Andresen JM, Srivastava K, ... Spampanato J, Escayg A, Meisler MH, Goldin AL (Oct 2001). "Functional effects of two voltage-gated sodium channel mutations ...
  https://en.wikipedia.org/wiki/Nav1.1
*  APETx1 - Wikipedia
... channel, a type of voltage-gated potassium channel, and as a blocker of voltage-gated sodium channels, including Nav1.2 and ... blocks voltage-gated human ether-a-go-go-related gene potassium channels". Molecular Pharmacology. 64 (1): 59-69. doi:10.1124/ ... of the hERG channels at maximum affinity suggests that APETx1 is a gating modifier. APETx1 blocks voltage-gated sodium channels ... In addition, APETx1 blocks several mammalian voltage-gated sodium channels, including Nav1.2 with an IC50 of 31 nM, and Nav1.8 ...
  https://en.wikipedia.org/wiki/APETx1
*  Nav1.5 - Wikipedia
SCN5A is part of a family of 10 genes that encode different types of sodium channels, i.e. brain-type (NaV1.1, NaV1.2, NaV1.3, ... NaV1.5 is an integral membrane protein and tetrodotoxin-resistant voltage-gated sodium channel subunit. NaV1.5 is found ... SCN5A is the gene that encodes the cardiac sodium channel NaV1.5. SCN5A is a highly conserved gene located on human chromosome ... NaV1.6), neuronal channels (NaV1.7, NaV1.8 and NaV1.9), skeletal muscle channels (NaV1.4) and the cardiac sodium channel NaV1.5 ...
  https://en.wikipedia.org/wiki/Nav1.5
*  Beta-hexatoxin-Mg1a precursor - Macrothele gigas (Spider)
... sodium channels and shifts the activation voltage of the mammalian Nav1.2a/SCN2A channel to more hyperpolarized voltages, ... whereas the insect channel, DmNav1 (para), is not affected. Competes for binding at site 3 of the insect sodium channel. Causes ... Voltage-gated sodium channel impairing toxin. ,p>This section provides information about the protein and gene name(s) and ... Binds to site 4 of mammalian voltage-gated sodium channels and shifts the activation voltage of the mammalian Nav1.2a/SCN2A ...
  http://www.uniprot.org/uniprot/P83561
*  SCN8A - Wikipedia
Nav1.6 is encoded by the SC8NA gene which contains 27 exons and measures 170 kb. The voltage gated sodium channel is composed ... However, in MS models, sodium channel conversion from mature Nav1.6 to Nav1.2 is observed. Sodium channel paralytic - SCN8A ... Nav1.6 is one sodium channel isoform and is the primary voltage-gated sodium channel at the nodes of Ranvier. The channels are ... "Entrez Gene: SCN8A sodium channel, voltage gated, type VIII, alpha subunit". Caldwell JH, Schaller KL, Lasher RS, Peles E, ...
  https://en.wikipedia.org/wiki/SCN8A
*  DERIVATIVES FOR MODULATION OF ION CHANNELS - Patent application
... useful as inhibitors of voltage-gated sodium ion channels or calcium channels, preferably N-type calcium channels. In one ... and NaV1.2 (See Sugawara, T., Y. Tsurubuchi, et al. (2001) "A missense mutation of the Na+ channel alpha II subunit gene Na(v) ... 0062]In one embodiment, the inhibitors of voltage-gated sodium channels and calcium channels have the structure of formula I: ... 0117]Specific inhibitors of voltage-gated sodium channels and calcium channels are listed in Table 1 below. TABLE-US-00003 ...
  http://www.patentsencyclopedia.com/app/20110077269
*  SCN1B - Wikipedia
Sodium channel subunit beta-1 is a protein that in humans is encoded by the SCN1B gene. Voltage-gated sodium channels are ... 2004). "Sodium channel beta1 subunit-mediated modulation of Nav1.2 currents and cell surface density is dependent on ... "Entrez Gene: SCN1B sodium channel, voltage-gated, type I, beta". Hartshorne RP, Catterall WA (1984). "The sodium channel from ... 1995). "Genomic organization and chromosomal assignment of the human voltage-gated Na+ channel beta 1 subunit gene (SCN1B)". ...
  https://en.wikipedia.org/wiki/SCN1B
*  Clinical spectrum of SCN2A mutations. - PubMed - NCBI
NAV1.2 Voltage-Gated Sodium Channel. *Nerve Tissue Proteins/genetics*. *Seizures, Febrile/genetics ... Mutations in SCN2A, the gene encoding α2 subunit of the neuronal sodium channel, are associated with a variety of epilepsies: ... Recently, microduplication of chromosome 2q24.3 (containing eight genes including SCN2A, SCN3A, and the 3' end of SCN1A) was ...
  https://www.ncbi.nlm.nih.gov/pubmed/22029951
*  Co-expression of β Subunits with the Voltage-Gated Sodium Channel NaV1.7: the Importance of Subunit Association and...
We examined how auxiliary β2 and β3 subunits and the phosphorylation state of the channel influence its biophysical... ... The voltage-gated sodium ion channel NaV1.7 is crucial in pain signaling. ... Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations. Clin ... Das S, Gilchrist J, Bosmans F, Van Petegem F (2016) Binary architecture of the Nav1.2-β2 signaling complex. elife 5. https:// ...
  https://link.springer.com/article/10.1007%2Fs12031-018-1082-6
*  M-theraphotoxin-Gr1a precursor - Grammostola rosea (Chilean rose tarantula)
... without affecting channel gating. It has also a medium toxicity on a large spectra of sodium channels (Nav1.1/SCN1A, Nav1.2/ ... It also binds to the voltage sensor of voltage-gated potassium channels from the archaebacterium Aeropyrum pernix (KvAP) ... It blocks mechanosensitive ion channels (also named stretch-activated channels or SACs), without having effect on whole-cell ... voltage-sensitive currents. Acts by partitioning into the membrane and perturbing the interface between the channel and the ...
  http://www.uniprot.org/uniprot/Q7YT39
*  Sodium channels
... voltage-gated type 1 α subunit sodium channel) up to Nav1.9. The number following the subscript indicates the gene subfamily ( ... Nav1.2 (Central neurons, peripheral neurons). *Nav1.3 (Central neurons, peripheral neurons and cardiac myocytes) ... STRUCTURE AND BEHAVIOUR OF SODIUM CHANNELS. Voltage-gated sodium channels consist one long polypeptide chain - comprising 1840 ... SODIUM CHANNELS GENE MUTATION. As far as the mutations in such genes as those encoding the making and behaviour of sodium ...
  http://flipper.diff.org/app/pathways/info/3240
*  Frontiers | Ankyrin G Membrane Partners Drive the Establishment and Maintenance of the Axon Initial Segment | Frontiers in...
... voltage-gated sodium channels (Nav) or neurofascin-186) led to a decrease of ankG concentration and perturbed the AIS formation ... rescued by expressing a recombinant AIS-targeted Nav or by a minimal construct containing the ankyrin-binding domain of Nav1.2 ... voltage-gated sodium channels (Nav) or neurofascin-186) led to a decrease of ankG concentration and perturbed the AIS formation ... rescued by expressing a recombinant AIS-targeted Nav or by a minimal construct containing the ankyrin-binding domain of Nav1.2 ...
  https://www.frontiersin.org/articles/10.3389/fncel.2017.00006/full
*  CK2-An Emerging Target for Neurological and Psychiatric Disorders
NAv1.2 and 1.6) [57]. CK2 was further found to directly phosphorylate the voltage gated sodium channel NAv1, thereby enhancing ... A CamKIIalpha iCre BAC allows brain-specific gene inactivation. Genesis. 2001;31:37-42. doi: 10.1002/gene.1078. [PubMed] [Cross ... CK2 activity is required for the interaction of FGF14 with voltage-gated sodium channels and neuronal excitability. FASEB J. ... Another family of membrane proteins that modulate synaptic activity are the voltage gated sodium channels (NAvs). Recently, the ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC5374411/
*  Equilibrative Nucleoside Transporters
Voltage-gated sodium (Nav) channels are required for impulse conductance in excitable. 8 May 2017 ovarian ... CNS Nav1.1-Nav1.2 Nav1.6; PNS Nav1.7-Nav1.9) [5]. Navs mediate sodium influx to generation action potentials which are critical ... Navs are users of a single gene family with at least nine isotypes (Nav1.1-1.9) which are commonly found in excitable cells ... Voltage-gated sodium (Nav) channels are required for impulse conductance in excitable tissues. cells. Nav1.5 and Nav1.6 were ...
  http://www.ovarian-cancersymptoms.com/category/equilibrative-nucleoside-transporters/
*  The Role of Non-pore-Forming β Subunits in Physiology and Pathophysiology of Voltage-Gated Sodium Channels | SpringerLink
Voltage-gated sodium channel β1 and β2 subunits were discovered as auxiliary proteins that co-purify with pore-forming α ... A homozygous mutation of voltage-gated sodium channel beta(I) gene SCN1B in a patient with Dravet syndrome. Epilepsia 53(12): ... McEwen DP, Meadows LS, Chen C, Thyagarajan V, Isom LL (2004) Sodium channel beta1 subunit-mediated modulation of Nav1.2 ... Brackenbury WJ (2012) Voltage-gated sodium channels and metastatic disease. Channels 6(5):352-361PubMedCentralPubMedGoogle ...
  https://link.springer.com/chapter/10.1007/978-3-642-41588-3_4
*  Huwentoxin-IV precursor - Haplopelma schmidti (Chinese bird spider)
These data indicate that mHwTx-IV strongly binds to voltage sensor of sodium channel even at extreme depolarization voltages ( ... It inhibits activation of sodium channel by trapping the voltage sensor of domain II (DIIS4) in the closed configuration ( ... It does not slow fast-inactivation of hNav1.7 channels (PubMed:20855463). In addition, it has only a weak affinity for lipid ... and unmodified toxins is that moderate or high depolarization voltages (200 mV) permit the unmodified toxin to dissociate, ...
  http://www.uniprot.org/uniprot/P83303
*  A knock-in model of human epilepsy in Drosophila reveals a novel cellular mechanism associated with heat-induced seizure
Out-cold mutants of Drosophila melanogaster have novel missense mutations in the voltage-gated sodium channel gene paralytic. ... reported a hyperpolarizing shift in activation voltage of sodium currents in HEK293 cells expressing wild-type Nav1.2 channels ... Many human seizure disorders are caused by mutations in ion channel genes. The SCN1A sodium channel gene alone has in excess of ... Epilepsy-associated dysfunction in the voltage-gated neuronal sodium channel SCN1A. J Neurosci. 2003;23:11289-11295. [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3482260/?lang=en-ca
*  Genetics of Pain - Neurowiki 2014
SCN9A is a gene that encodes for a type IX alpha subunit of a voltage gated sodium channel, generally found in nociceptors.18 ... The endocanabinoid anandamide inhibits voltage-gated sodium channels nav1.2, nav 1.6, nav 1.7, and nav 1.8 in Xenopus oocytes. ... There are a variety of proteins that these genes code for, such as different ion channels (potassium8, sodium9, calcium10), ... Peripheral neurons with this voltage-gated sodium channel are essential for pain and olfaction in both mice and humans.19. ...
  http://neurowiki2014.wikidot.com/individual:genetics-of-pain