*  Biomedicines | Free Full-Text | Decoding the Pluripotency Network: The Emergence of New Transcription Factors | HTML
Nanog and Sall4 co-occupied both Nanog and Sall4 enhancer regions in ESCs and activated the gene expression [102]. The direct ... Similar to the Oct4-Sox2 element, the Esrrb-Sox2 element possesses a spacer of 2 to 8 bp [45]. A recent study demonstrated that ... Genetic ablation of GCNF caused embryonic lethality in mice, in which Oct4 expression was no longer restricted to the germ cell ... Genes Cells 2009, 14, 683-694. [Google Scholar] [CrossRef]. *Yang, J.; Corsello, T.R.; Ma, Y. Stem cell gene SALL4 suppresses ...
  http://www.mdpi.com/2227-9059/1/1/49/htm
*  ASMscience | Transposable Elements as
The host variation associated with transposable elements can result from several interconnected aspects of transposable element ... Some features of both transposable elements and hosts suggest coadaptations to mitigate the reduction of fitness expected from ... Two mechanisms are considered most likely to be responsible for transposable element-induced karyotypic changes. The best known ... Estimates of the frequencies of new transposable element-induced mutations have been made under laboratory conditions and ...
  http://www.asmscience.org/content/book/10.1128/9781555817954.chap5
*  The genomic landscape shaped by selection on transposable elements across 18 mouse strains | Genome Biology | Full Text
It is thus plausible that TEVs contribute substantially to the genetic load and gene expression variation among inbred and wild ... effects of TE insertions include their regulation of transcription by acting as alternative promoters or as enhancer elements ... Transposable element (TE)-derived sequence dominates the landscape of mammalian genomes and can modulate gene function by ... Warnefors M, Pereira V, Eyre-Walker A: Transposable elements: insertion pattern and impact on gene expression evolution in ...
  https://genomebiology.biomedcentral.com/articles/10.1186/gb-2012-13-6-r45
*  Short DNA sequence patterns accurately identify broadly active human enhancers | BMC Genomics | Full Text
EnhancerDinucleotide repeat motifMachine learningGene expression. Background. Enhancers are DNA regulatory elements distal to ... An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Sci. 2013;342(6155):253-7.View ... Enhancers are DNA regulatory elements that influence gene expression. There is substantial diversity in enhancers' activity ... For consistency with the enhancer prediction analyses, we analyzed 600 bp regions centered on each enhancer for all enhancer ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-3934-9
*  Modified binding of proteins from calcitonin-negative tumor cells to the neuroendocrine-specific CANNTG motif of the calcitonin...
... cell line TT is modulated by a neuroendocrine-specific enhancer fragment (nucleotides -965 to -905) containing two CANNTG ... Enhancer Elements, Genetic*. Gene Expression Regulation, Neoplastic*. Hela Cells. Humans. Molecular Sequence Data. ... In CT-negative MTC cells (RO-D81), the Ets response element was active but the two copies of E2 were not. Similar results were ... Previous Document: Identification of positive and negative regulatory elements involved in the retinoic acid/cAMP induc.... ...
  http://www.biomedsearch.com/nih/Modified-binding-proteins-from-calcitonin/8265349.html
*  NAVER Academic > Search...
Animals, Enhancer Elements, Genetic, Gene Expression Regulation, Humans, Promoter Regions, Genetic, Regulatory Sequences, ... Modularity in promoters and enhancers.. W S Dynan CELL cited 114 times ... Amino Acid Sequence, Animals, Cells, Cultured, Cercopithecus aethiops, DNA Mutational Analysis, Gene Expression Regulation, HIV ...
  https://academic.naver.com/search.naver?field=3&query=CELL+58%EA%B6%8C+1%ED%98%B8
*  NAVER Academic > Search...
Enhancer Elements, Genetic, Gene Expression... ... CCAAT-enhancer binding protein alpha is expressed in activated ... Phenylethanolamine N-methyltransferase gene expression: synergistic activation by Egr-1, AP-2 and the glucocorticoid receptor. ... Animals, Cell Line, DNA-Binding Proteins, physiology, Drug Synergism, Early Growth Response Protein 1, Gene Expression ... Animals, Brain Chemistry, Brain Injuries, genetics, CCAAT-Enhancer-Binding Proteins, DNA-Binding Proteins, biosynthesis, ...
  https://academic.naver.com/search.naver?field=3&query=Molecular+Brain+Research+61%EA%B6%8C+1-2%ED%98%B8
*  NAVER Academic > Search...
Enhancer Elements, Genetic, genetics, Gene Expression... ... Cx30.2 enhancer analysis identifies Gata4 as a novel regulator ... Animals, Cell Membrane, enzymology, Embryo, Mammalian, cytology, Epistasis, Genetic, Epithelial Cells, metabolism, Female, Gene ... Animals, Axons, metabolism, Cell Lineage, Cell Movement, Gene Expression Regulation, Developmental, Homeodomain Proteins, ... Enhancer Elements, Genetic, GATA4... ...
  https://academic.naver.com/search.naver?field=3&query=Development.+136%EA%B6%8C+15%ED%98%B8
*  Amyloidosis and Neoplasia Flashcards by Colby Passaro | Brainscape
... suggesting these genetic variants alter the function of enhancer elements regulating MYC expression ... Deletion on chrom 5 fuses part of ALK with part of EML4 gene in some lung adenocarcinomas -, EML4-ALK fusion gene encodes a ... In chronic myelogenous leukemia (CML), the ABL gene is translocated from chrom 9 to chrom 22, where it fuses with the BCR gene ... Multiple mechanisms, including point mutations, gene amplifications, and gene rearrangements:. 1. ERBB1: encodes epidermal ...
  https://www.brainscape.com/flashcards/amyloidosis-and-neoplasia-3407083/packs/5233706
*  Pluripotential reprogramming of the somatic genome in hybrid cells occurs with the first cell cycle.
Oct4-green fluorescent protein (GFP) transgenes that do not contain the proximal enhancer (PE) region are widely used to ... Enhancer Elements, Genetic. Female. Gene Expression Regulation. Genome. Green Fluorescent Proteins / genetics. Hybrid Cells / ... In addition, demethylation of the Oct4-GFP transgene and that of the endogenous Oct4 and Nanog genes was found to occur within ... We asked whether activation of the transgene actually reflects activation of the endogenous Oct4 gene. In the current study, we ...
  http://www.biomedsearch.com/nih/Pluripotential-reprogramming-somatic-genome-in/18065396.html
*  Model equations: protein-protein interactions.The mod | Open-i
Enhancer Elements, Genetic*. *Gene Rearrangement/genetics*. *Homeodomain Proteins/genetics*. *Transcription Factors/genetics* ... was able to correctly predict expression patterns driven by enhancers for other Drosophila genes; even-skipped enhancers not ... was able to correctly predict expression patterns driven by enhancers for other Drosophila genes; even-skipped enhancers not ... was able to correctly predict expression patterns driven by enhancers for other Drosophila genes; even-skipped enhancers not ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3585115_pgen.1003243.g003&req=4
*  Prioritization and functional assessment of noncoding variants associated with complex diseases | SpringerLink
PAFA integrates genetic elements, including annotated enhancer, TSS, exon, 3′-UTR, and 5′-UTR, from curated databases, ... in the gene, and 0.1 for the gene's open chromatin. si indicates the ith gene's frequency as it appears in gene-disease ... Assume that the target variant overlapped with m different genes and n different elements were influenced by each gene. Then, ... be the ith gene's jth element's length and \( {L}_{o_{ij}} \) be the overlapped length between variant and the ith gene's jth ...
  https://link.springer.com/article/10.1186%2Fs13073-018-0565-y
*  Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2 | Cancer Research
Schmitt C. A., Rosenthal C. T., Lowe S. W. Genetic analysis of chemoresistance in primary murine lymphomas. Nat. Med., 6: 1029- ... Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2. Caroline A. Heckman, ... Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2 ... Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2 ...
  http://cancerres.aacrjournals.org/content/63/20/6666.long
*  Genetic Basis of Hypertension | Hypertension
Nibu Y, Takahashi S, Tanimoto K, Murakami K, Fukamizu A. Identification of cell type-dependent enhancer core element located in ... The human AGT gene, a member of the serpin gene superfamily, stretches over only &12 kb on chromosome 1 (1q42-q43) and contains ... However, the most compelling early genetic evidence implicating this gene in essential hypertension in humans came from the ... The AGT Gene and Protein. Among candidate genes for essential hypertension, AGT was the first and remains perhaps "the most ...
  http://hyper.ahajournals.org/content/48/1/14.long
*  Limitations of the murine nose in the development of nonviral airway gene transfer. - Radcliffe Department of Medicine
The plasmids used were regulated by either (1) the commonly used short-acting cytomegalovirus promoter/enhancer or (2) the ... lung disease is currently being undertaken by the UK CF Gene Therapy Consortium. We have evaluated GL67A gene transfer to the ... At the current levels of gene transfer efficiency achievable with nonviral vectors, the murine nose is of limited value as a ... We then assessed whether CFTR gene transfer corrected a panel of CFTR-specific endpoint assays in the murine nose, including ...
  https://www.rdm.ox.ac.uk/publications/116955
*  Correction for Rietveld et al., Common genetic variants associated with cognitive performance identified using the proxy...
... chromosomal enhancer maps and element-gene interaction networks detected brain regions related associations between elements ... Improving genetic prediction by leveraging genetic correlations among human diseases and traits ... Common genetic variants associated with cognitive performance identified using the proxy-phenotype method ... Correction for Rietveld et al., Common genetic variants associated with cognitive performance identified using the proxy- ...
  http://www.pnas.org/content/112/4/E380/tab-article-info
*  MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L...
... and unmethylated CpG regions in the gene body. Compared to other H3K79me2/3 marked genes, MLL-AF4 spreading gene expression is ... Here, we find that at a subset of gene targets, MLL-AF4 binding spreads into the gene body and is associated with the spreading ... Translocations of the mixed-lineage leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic ... Enhancer Elements, Genetic, Gene Expression Regulation, Leukemic, Genome, Human, Histones, Humans, Intercellular Signaling ...
  https://www.rdm.ox.ac.uk/publications/670826
*  "The chemotherapeutic agent DMXAA potently and specifically activates t" by Zachary J. Roberts, Nadege Goutagny et al.
... activation and elicited minimal nuclear factor kappaB-dependent gene expression. DMXAA-induced signaling was critically ... Animals; Antineoplastic Agents; Cells, Cultured; Cytokines; DNA; Enhancer Elements, Genetic; Female; Gene Expression Regulation ... activation and elicited minimal nuclear factor kappaB-dependent gene expression. DMXAA-induced signaling was critically ...
  https://escholarship.umassmed.edu/infdis_pp/79/
*  Medical Xpress - genetic mutations(... continued page 8)
Genetic mutations can increase a person's cancer risk, but other gene "enhancer" elements may also be responsible for disease ... Research asks why genetic mutation leads to decreased triglycerides in blood. Common knowledge says that genetic mutations are ... Genetic profile of treatment-resistant lung cancer more variable than previously thought. The genetic mutations underlying ... Researchers find gene Wt1 to impact women's fertility. It has been estimated that more than 80 million people in the world have ...
  https://medicalxpress.com/tags/genetic+mutations/page8.html
*  Imaging of flexor and extensor motoneurons targeted wit | Open-i
Enhancer Elements, Genetic. *Genes, Reporter. *Integrases/genetics. *Motor Neurons/cytology. *Rhodopsin/metabolism ... Bottom Line: Here we present a circuit-deciphering 'tool box' for fast, reliable and cheap genetic targeting of neuronal ... Bottom Line: Here we present a circuit-deciphering 'tool box' for fast, reliable and cheap genetic targeting of neuronal ... with ubiquitously-expressed PBase and Cre under the control of the chick motoneuron-specific enhancer of the TAG1/Axonin1 gene ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4231727_gku750fig6&req=4
*  Patent US6242570 - Production and use of recombinant protein multimers with increased ... - Google Patents
... a genetic element or elements having a regulatory role in gene expression, for example, promoters or enhancers; (2) a ... Gene 42:133, 1986); Bauer et al. (Gene 37:73, 1985); Craik (BioTechniques, Jan. 12-19, 1985); Smith et al. (Genetic Engineering ... the ampicillin resistance gene of E. coli and S. cerevisiae trpl gene, which provides a selection marker for a mutant strain of ... viral or insect genes. Such regulatory elements include a transcriptional promoter, an optional operator sequence to control ...
  http://www.google.com/patents/US6242570
*  Chromatin landscapes and genetic risk for juvenile idiopathic arthritis | Arthritis Research & Therapy | Full Text
We examined human neutrophils and CD4 primary T cells to identify genes and functional elements located within those risk loci ... To gain a better understanding of this phenomenon, we studied known JIA genetic risk loci, the majority of which are located in ... In CD4+ T cells, multiple genes, including HLA-DQA1, HLA-DQB2, TRAF1, and IRF1 were associated with the long-distance ... In neutrophils, none of the genes that were differentially expressed between untreated patients with JIA and healthy children ...
  https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-017-1260-x
*  Tissue-specific CTCF-cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo. - Radcliffe...
The α-globin enhancers now interact with the flanking chromatin, upregulating expression of genes within this extended sub-TAD ... Whereas the α-globin regulatory elements normally act solely on promoters downstream of the enhancers, removal of a conserved ... containing the mouse α-globin gene cluster, lying within a ∼1 Mb TAD. We find that the sub-TAD is flanked by predominantly ... CTCF-cohesin boundaries in this sub-TAD delimit the region of chromatin to which enhancers have access and within which they ...
  https://www.rdm.ox.ac.uk/publications/709225
*  Researchers inhibit cancer metastases via novel steps
Genetic mutations can increase a person's cancer risk, but other gene "enhancer" elements may also be responsible for disease ... There are tens of thousands of gene enhancers in each cell, far more than the number of genes; they will be in different "on" ... enhancer elements endow tumor cells with metastatic capacity and that targeted inhibition of genes associated with enhancer ... the mechanisms that control these genes are not well defined. Our findings demonstrate that altered gene-enhancer activity is ...
  https://medicalxpress.com/news/2018-02-inhibit-cancer-metastases.html
*  ZFIN Publication: Lee et al., 2015
Enhancer Elements, Genetic*; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental*; Gene Library; Gene ... are associated with developmental genes and are marked with active enhancer histone posttranslational modifications. Their ... Lee, H.J., Lowdon, R.F., Maricque, B., Zhang, B., Stevens, M., Li, D., Johnson, S.L., Wang, T. (2015) Developmental enhancers ... However, developmental DNA methylation dynamics of the majority of the genomic CpGs outside gene promoters and CpG islands has ...
  http://zfin.org/ZDB-PUB-150224-20