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*  ASMscience | Transposable Elements as
The host variation associated with transposable elements can result from several interconnected aspects of transposable element ... Some features of both transposable elements and hosts suggest coadaptations to mitigate the reduction of fitness expected from ... Two mechanisms are considered most likely to be responsible for transposable element-induced karyotypic changes. The best known ... Estimates of the frequencies of new transposable element-induced mutations have been made under laboratory conditions and ...
  http://www.asmscience.org/content/book/10.1128/9781555817954.chap5
*  Short DNA sequence patterns accurately identify broadly active human enhancers | BMC Genomics | Full Text
EnhancerDinucleotide repeat motifMachine learningGene expression. Background. Enhancers are DNA regulatory elements distal to ... An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Sci. 2013;342(6155):253-7.View ... Enhancers are DNA regulatory elements that influence gene expression. There is substantial diversity in enhancers' activity ... For consistency with the enhancer prediction analyses, we analyzed 600 bp regions centered on each enhancer for all enhancer ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-3934-9
*  Unlinking an lncRNA from Its Associated cis Element. - Radcliffe Department of Medicine
Therefore, the Lockd gene positively regulates Cdkn1b transcription through an enhancer-like cis element, whereas the lncRNA ... We studied Lockd (lncRNA downstream of Cdkn1b), a 434-nt polyadenylated lncRNA originating 4 kb 3' to the Cdkn1b gene. Deletion ... RNAs can regulate gene expression and protein functions. However, the proportion of lncRNAs with biological activities among ... Enhancer Elements, Genetic, Gene Expression Regulation, Mice, Poly A, Promoter Regions, Genetic, RNA, Long Noncoding, ...
  https://www.rdm.ox.ac.uk/publications/614079
*  Modified binding of proteins from calcitonin-negative tumor cells to the neuroendocrine-specific CANNTG motif of the calcitonin...
... cell line TT is modulated by a neuroendocrine-specific enhancer fragment (nucleotides -965 to -905) containing two CANNTG ... Enhancer Elements, Genetic*. Gene Expression Regulation, Neoplastic*. Hela Cells. Humans. Molecular Sequence Data. ... In CT-negative MTC cells (RO-D81), the Ets response element was active but the two copies of E2 were not. Similar results were ... Previous Document: Identification of positive and negative regulatory elements involved in the retinoic acid/cAMP induc.... ...
  http://www.biomedsearch.com/nih/Modified-binding-proteins-from-calcitonin/8265349.html
*  NAVER Academic > Search...
Animals, Enhancer Elements, Genetic, Gene Expression Regulation, Humans, Promoter Regions, Genetic, Regulatory Sequences, ... Modularity in promoters and enhancers.. W S Dynan CELL cited 114 times ... Amino Acid Sequence, Animals, Cells, Cultured, Cercopithecus aethiops, DNA Mutational Analysis, Gene Expression Regulation, HIV ...
  https://academic.naver.com/search.naver?field=3&query=CELL+58%EA%B6%8C+1%ED%98%B8
*  NAVER Academic > Search...
Arabidopsis, chemistry, genetics, Chromosome Mapping, Chromosomes, Plant, Enhancer Elements, Genetic, Gene Expression ... Arabidopsis, genetics, growth & development, metabolism, Chromatin, DNA Methylation, DNA, Plant, Epigenesis, Genetic, Gene ... Arabidopsis, genetics, Arabidopsis Proteins, metabolism, Chromatin, DNA Methylation, Epigenesis, Genetic, Gene Expression ... Unraveling the Complex Epigenetic Mechanisms that Regulate Gene Activity.. 2018 Marian Bemer Methods in Molecular Biology cited ...
  https://academic.naver.com/search.naver?field=3&query=Methods+in+Molecular+Biology+1675%EA%B6%8C
*  NAVER Academic > Search...
Enhancer Elements, Genetic, Gene Expression... ... CCAAT-enhancer binding protein alpha is expressed in activated ... Phenylethanolamine N-methyltransferase gene expression: synergistic activation by Egr-1, AP-2 and the glucocorticoid receptor. ... Animals, Cell Line, DNA-Binding Proteins, physiology, Drug Synergism, Early Growth Response Protein 1, Gene Expression ... Animals, Brain Chemistry, Brain Injuries, genetics, CCAAT-Enhancer-Binding Proteins, DNA-Binding Proteins, biosynthesis, ...
  https://academic.naver.com/search.naver?field=3&query=Molecular+Brain+Research+61%EA%B6%8C+1-2%ED%98%B8
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Post-zygotic and inter-individual structural genetic variation in a presumptive enhancer element of the locus between the IL10R ... and we find that CpG-rich enhancers bound by EP300 in the bodies of expressed genes are unmethylated despite the dense gene- ... and point to an underlying genetic architecture in which several genes of moderate effect act together with many genes of small ... Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the ...
  https://www.jove.com/visualize?author=Devin+Absher
*  NAVER Academic > Search...
Enhancer Elements, Genetic, genetics, Gene Expression... ... Cx30.2 enhancer analysis identifies Gata4 as a novel regulator ... Animals, Cell Membrane, enzymology, Embryo, Mammalian, cytology, Epistasis, Genetic, Epithelial Cells, metabolism, Female, Gene ... Animals, Axons, metabolism, Cell Lineage, Cell Movement, Gene Expression Regulation, Developmental, Homeodomain Proteins, ... Enhancer Elements, Genetic, GATA4... ...
  https://academic.naver.com/search.naver?field=3&query=Development.+136%EA%B6%8C+15%ED%98%B8
*  Amyloidosis and Neoplasia Flashcards by Colby Passaro | Brainscape
... suggesting these genetic variants alter the function of enhancer elements regulating MYC expression ... Deletion on chrom 5 fuses part of ALK with part of EML4 gene in some lung adenocarcinomas -, EML4-ALK fusion gene encodes a ... In chronic myelogenous leukemia (CML), the ABL gene is translocated from chrom 9 to chrom 22, where it fuses with the BCR gene ... Multiple mechanisms, including point mutations, gene amplifications, and gene rearrangements:. 1. ERBB1: encodes epidermal ...
  https://www.brainscape.com/flashcards/amyloidosis-and-neoplasia-3407083/packs/5233706
*  Genetics, Gene Therapy & Genetic Disease | EMBO Molecular Medicine
Three enhancer elements were here identified to drive POLG expression in the central nervous system regions that degenerate in ... Three enhancer elements were here identified to drive POLG expression in the central nervous system regions that degenerate in ... Distal enhancer elements drive the expression of DNA polymerase gamma, mitochondrial DNA replicase, to specific neuronal ... enables genetic correction & provide evidence of translation of HAC technology into DMD muscle progenitors for ex vivo gene ...
  http://embomolmed.embopress.org/collection/genetics-gene-therapy-genetic-disease?page=2
*  Pluripotential reprogramming of the somatic genome in hybrid cells occurs with the first cell cycle.
Oct4-green fluorescent protein (GFP) transgenes that do not contain the proximal enhancer (PE) region are widely used to ... Enhancer Elements, Genetic. Female. Gene Expression Regulation. Genome. Green Fluorescent Proteins / genetics. Hybrid Cells / ... In addition, demethylation of the Oct4-GFP transgene and that of the endogenous Oct4 and Nanog genes was found to occur within ... We asked whether activation of the transgene actually reflects activation of the endogenous Oct4 gene. In the current study, we ...
  http://www.biomedsearch.com/nih/Pluripotential-reprogramming-somatic-genome-in/18065396.html
*  Model equations: protein-protein interactions.The mod | Open-i
Enhancer Elements, Genetic*. *Gene Rearrangement/genetics*. *Homeodomain Proteins/genetics*. *Transcription Factors/genetics* ... was able to correctly predict expression patterns driven by enhancers for other Drosophila genes; even-skipped enhancers not ... was able to correctly predict expression patterns driven by enhancers for other Drosophila genes; even-skipped enhancers not ... was able to correctly predict expression patterns driven by enhancers for other Drosophila genes; even-skipped enhancers not ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3585115_pgen.1003243.g003&req=4
*  Prioritization and functional assessment of noncoding variants associated with complex diseases | SpringerLink
PAFA integrates genetic elements, including annotated enhancer, TSS, exon, 3′-UTR, and 5′-UTR, from curated databases, ... in the gene, and 0.1 for the gene's open chromatin. si indicates the ith gene's frequency as it appears in gene-disease ... Assume that the target variant overlapped with m different genes and n different elements were influenced by each gene. Then, ... be the ith gene's jth element's length and \( {L}_{o_{ij}} \) be the overlapped length between variant and the ith gene's jth ...
  https://link.springer.com/article/10.1186%2Fs13073-018-0565-y
*  Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2 | Cancer Research
Schmitt C. A., Rosenthal C. T., Lowe S. W. Genetic analysis of chemoresistance in primary murine lymphomas. Nat. Med., 6: 1029- ... Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2. Caroline A. Heckman, ... Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2 ... Critical Elements of the Immunoglobulin Heavy Chain Gene Enhancers for Deregulated Expression of Bcl-2 ...
  http://cancerres.aacrjournals.org/content/63/20/6666.long
*  Genetic Basis of Hypertension | Hypertension
Nibu Y, Takahashi S, Tanimoto K, Murakami K, Fukamizu A. Identification of cell type-dependent enhancer core element located in ... The human AGT gene, a member of the serpin gene superfamily, stretches over only &12 kb on chromosome 1 (1q42-q43) and contains ... However, the most compelling early genetic evidence implicating this gene in essential hypertension in humans came from the ... The AGT Gene and Protein. Among candidate genes for essential hypertension, AGT was the first and remains perhaps "the most ...
  http://hyper.ahajournals.org/content/48/1/14.long
*  Limitations of the murine nose in the development of nonviral airway gene transfer. - Radcliffe Department of Medicine
The plasmids used were regulated by either (1) the commonly used short-acting cytomegalovirus promoter/enhancer or (2) the ... lung disease is currently being undertaken by the UK CF Gene Therapy Consortium. We have evaluated GL67A gene transfer to the ... At the current levels of gene transfer efficiency achievable with nonviral vectors, the murine nose is of limited value as a ... We then assessed whether CFTR gene transfer corrected a panel of CFTR-specific endpoint assays in the murine nose, including ...
  https://www.rdm.ox.ac.uk/publications/116955
*  Correction for Rietveld et al., Common genetic variants associated with cognitive performance identified using the proxy...
... chromosomal enhancer maps and element-gene interaction networks detected brain regions related associations between elements ... Improving genetic prediction by leveraging genetic correlations among human diseases and traits ... Common genetic variants associated with cognitive performance identified using the proxy-phenotype method ... Correction for Rietveld et al., Common genetic variants associated with cognitive performance identified using the proxy- ...
  http://www.pnas.org/content/112/4/E380/tab-article-info
*  Codon optimization: new safety concerns for gene therapy and genetic vaccines
Codon-optimization describes gene engineering approaches that use synonymous codon changes to increase protein production. It ... These applied studies have led to the identification of Translational Enhancer Elements (TEEs) and the generation of synthetic ... Codon optimization: new safety concerns for gene therapy and genetic vaccines. Presented At Genetics and Genomics 2013 ... Diet and gene interactions in the control of central cell metabolism DATE: June 29, 2018TIME: 09:00AM PDT, 12:00PM EDT There is ...
  https://www.labroots.com/webinar/codon-optimization-new-safety-concerns-for-gene-therapy-and-genetic-vaccines
*  MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L...
... and unmethylated CpG regions in the gene body. Compared to other H3K79me2/3 marked genes, MLL-AF4 spreading gene expression is ... Here, we find that at a subset of gene targets, MLL-AF4 binding spreads into the gene body and is associated with the spreading ... Translocations of the mixed-lineage leukemia (MLL) gene produce fusion proteins such as MLL-AF4 that disrupt epigenetic ... Enhancer Elements, Genetic, Gene Expression Regulation, Leukemic, Genome, Human, Histones, Humans, Intercellular Signaling ...
  https://www.rdm.ox.ac.uk/publications/670826
*  From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning. - PubMed - NCBI
The identification of regulatory elements of electrical activity genes helps to explain the impact of genetic variants in non- ... From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.. van den Boogaard M1 ... Genome-wide association studies of ECG parameters implicated genetic variants in the genes for these factors and ion channels ... Here, we review recent insights into the regulation of localized expression of ion channel genes and the mechanism by which a ...
  https://www.ncbi.nlm.nih.gov/pubmed/24360055?dopt=Abstract
*  Transposable Elements Are Key to Genome Regulation | The Institute for Creation Research
... enhancers' that modulate gene expression in placental cells.7 The placenta connects the developing embryo to the uterus in ... report in the journal Nature Genetics showing that a family of transposable elements in mammals contribute hundreds of genetic ... The fact that extensive research is showing that transposable elements are essential to many aspects of gene and genome ... Endogenous retroviruses function as species-specific enhancer elements in the placenta. Nature Genetics. 45 (2013): 325-329. ...
  https://www.icr.org/article/transposable-elements-are-key-genome/
*  "The chemotherapeutic agent DMXAA potently and specifically activates t" by Zachary J. Roberts, Nadege Goutagny et al.
... activation and elicited minimal nuclear factor kappaB-dependent gene expression. DMXAA-induced signaling was critically ... Animals; Antineoplastic Agents; Cells, Cultured; Cytokines; DNA; Enhancer Elements, Genetic; Female; Gene Expression Regulation ... activation and elicited minimal nuclear factor kappaB-dependent gene expression. DMXAA-induced signaling was critically ...
  https://escholarship.umassmed.edu/infdis_pp/79/
*  Medical Xpress - genetic mutations(... continued page 8)
Genetic mutations can increase a person's cancer risk, but other gene "enhancer" elements may also be responsible for disease ... Research asks why genetic mutation leads to decreased triglycerides in blood. Common knowledge says that genetic mutations are ... Genetic profile of treatment-resistant lung cancer more variable than previously thought. The genetic mutations underlying ... Researchers find gene Wt1 to impact women's fertility. It has been estimated that more than 80 million people in the world have ...
  https://medicalxpress.com/tags/genetic+mutations/page8.html
*  Imaging of flexor and extensor motoneurons targeted wit | Open-i
Enhancer Elements, Genetic. *Genes, Reporter. *Integrases/genetics. *Motor Neurons/cytology. *Rhodopsin/metabolism ... Bottom Line: Here we present a circuit-deciphering 'tool box' for fast, reliable and cheap genetic targeting of neuronal ... Bottom Line: Here we present a circuit-deciphering 'tool box' for fast, reliable and cheap genetic targeting of neuronal ... with ubiquitously-expressed PBase and Cre under the control of the chick motoneuron-specific enhancer of the TAG1/Axonin1 gene ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4231727_gku750fig6&req=4