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*  CSHLPress.com
COLD SPRING HARBOR, N.Y.- How many genes are in the human genome? Which genes are commonly associated with genetic diseases? ... "dosage compensation". If male flies fail to compensate, they die! ... Researchers have discovered a key gene that influences genetic recombination during sexual reproduction in wild plant ... The latter carries very few genes, while the X chromosome has thousands of genes. Male fruit flies compensate for this short- ...
  https://www.cshlpress.com/press.tpl?cart=13395071701389163
*  The Caenorhabditis elegans Dosage Compensation Machinery Is Recruited to X Chromosome DNA Attached to an Autosome | Genetics
1994 Sex-specific regulation of the male-specific lethal-1 dosage compensation gene in Drosophila. Genes Dev. 8: 698-706. ... 1999 Genetic analysis of the mouse X inactivation center defines an 80-kb multifunction domain. Proc. Natl. Acad. Sci. USA 96: ... 1989 Genes that implement the hermaphrodite mode of dosage compensation in Caenorhabditis elegans. Genetics 121: 57-76. ... X-linked genes are fully expressed because the dosage compensation proteins are prevented from localizing to the single X. ...
  http://www.genetics.org/content/156/4/1603
*  Gene dosage - Wikipedia
Copy-number variation Dosage compensation Genetic association Polyploidy, Aneuploidy Leland H. Hartwell; et al. (2011), ... Gene dosage is the number of copies of a particular gene present in a genome. Gene dosage is known to be related to the amount ... These slight gene dosage differences are responsible for variation in gene expression depending on the position on the ... Nonetheless, changes in gene dosage (copy number variations) due to gene insertions or deletions can have significant ...
  https://en.wikipedia.org/wiki/Gene_dosage
*  Stephen B. Montgomery | Stanford Medicine Profiles
X-chromosome inactivation (XCI) is a dosage compensation mechanism that silences the majority of genes on one X chromosome in ... Here we describe genetic effects on gene expression levels across 44 human tissues. We find that local genetic variation ... Furthermore, we found that robustness to heterozygous gene inactivation is not due to dosage compensation. Our results ... Genetic variation influences gene expression, and this variation in gene expression can be efficiently mapped to specific ...
  https://med.stanford.edu/profiles/stephen-montgomery
*  Rapid regulatory evolution of a nonrecombining autosome linked to divergent behavioral phenotypes | PNAS
... gene expression divergence and dosage compensation can prevail before large-scale genetic degeneration. Our results show ... Our work with this chromosome reveals that rapid changes in gene expression and dosage compensation, not necessarily large- ... expression divergence between ZAL2 and ZAL2m alleles and signatures of dosage compensation for highly expressed genes. These ... Patterns of protein evolution exhibited only weak signals of genetic degeneration, and few genes harbored signatures of ...
  http://www.pnas.org/content/115/11/2794.short?rss%3D1
*  Chloride conductance in mouse muscle is subject to post-transcriptional compensation of the functional Cl- channel 1 gene dosage
Genetic CLC-1 chloride channel deficiency modifies diaphragm muscle isometric contractile properties.. van Lunteren E, Moyer M ... 3. Despite a halved functional gene dosage, heterozygous muscles display an average G(Cl), which is not significantly different ... Chloride conductance in mouse muscle is subject to post-transcriptional compensation of the functional Cl- channel 1 gene ... Chloride conductance in mouse muscle is subject to post-transcriptional compensation of the functional Cl- channel 1 gene ...
  https://pub.uni-bielefeld.de/record/1627314
*  A System for Dosage-Based Functional Genomics in Poplar | Plant Cell
2013). Gene dosage effects: nonlinearities, genetic interactions, and dosage compensation. Trends Genet. 29: 385-393. ... 2001). Dosage-dependent gene regulation in multicellular eukaryotes: implications for dosage compensation, aneuploid syndromes ... Altering gene dosage through variation in gene copy number is a powerful approach to addressing questions regarding gene ... Variation in gene dosage can have important consequences on phenotypes. Gene dosage is particularly important to variation ...
  http://www.plantcell.org/content/27/9/2370.full?sid=94ff4db9-637d-41ed-acb6-4d2a6a3e9c10
*  A new strategy for isolating genes controlling dosage compensation in Drosophilausing a simple epigenetic mosaic eye phenotype ...
A genetic screen for dominant modifiers of dosage compensation. We carried out a dominant F1 enhancer screen (Figure 1a) on a ... Polytene ChromosomeDosage CompensationPosition Effect VariegationDosage Compensation ComplexMale Specific Lethal ... Chromosome-wide gene-specific targeting of the Drosophila dosage compensation complex. Genes Dev. 2006, 20: 858-870. 10.1101/ ... The two roX genes were found in screens for sex-specific transcripts and later found to act in dosage compensation [34, 35]. ...
  https://preview-bmcbiol.biomedcentral.com/articles/10.1186/1741-7007-8-80
*  Interactive Fly, Drosophila
First of all, genetic destruction of the complex does not eliminate dosage compensation of most X-linked genes. However, one ... The collective data indicate that models that posit an association of the Msl complex with a gene for dosage compensation to ... In this way, the twofold inverse-dosage effect of the X is used to achieve a proper level of dosage compensation, but the ... 3) Autosomal insertions of many X-derived genes still exhibit some degree of compensation despite the fact that these genes ...
  http://www.sdbonline.org/sites/fly/gene/sexlthl4.htm
*  NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM‐related cofactor...
MOF was discovered in a genetic screen for genes necessary for dosage compensation in Drosophila (Hilfiker et al., 1997). It is ... Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila. Genes Dev, 8, 96-104. ... a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for ... Reifsnyder C, Lowell J, Clarke A and Pillus L (1996) Yeast SAS silencing genes and human genes associated with AML and HIV‐1 ...
  http://emboj.embopress.org/content/18/18/5108
*  This Week in Science | Science
... explore how the activity of a gene network can be invariant despite alterations in network dosage. A two-component genetic ... stoichiometry between the activating and inhibiting agents also represented essential elements for network-dosage compensation. ... The number of copies of a gene network in a cell, or network dosage, is altered in a variety of situations, including switching ... Now, Johnson et al. (p. 1641; see the Perspective by Packer) provide comprehensive genetic and demographic analyses of a ...
  http://science.sciencemag.org/content/329/5999/twis
*  Establishing coordinate gene regulation during Drosophila dosage compensation - Erica Larschan
However, significant gene copy number variation exists a... ... All organisms must regulate their genes precisely for normal ... We used an innovative genetic screen for new regulators of dosage compensation that function in both males and females and ... Dosage compensation is one of the best model systems for studying this process because all of the genes on a single chromosome ... Establishing coordinate gene regulation during Drosophila dosage compensation Larschan, Erica Nicole Brown University, ...
  http://grantome.com/grant/NIH/R01-GM098461-02
*  Human genomics. Effect of predicted protein-truncating genetic variants on the human transcriptome. - Radcliffe Department of...
Furthermore, we found that robustness to heterozygous gene inactivation is not due to dosage compensation. Our results ... a class of variants expected to have profound effects on gene function, using data from the Genotype-Tissue Expression (GTEx) ... Accurate prediction of the functional effect of genetic variation is critical for clinical genome interpretation. We ... illustrate the value of transcriptome data in the functional interpretation of genetic variants. ...
  https://www.rdm.ox.ac.uk/publications/523212
*  Sex Chromosomes - Definition and Types | Biology Dictionary
... primarily because of a large difference in their genetic content and size. ... This modification of gene expression is called dosage compensation. Recently, dosage compensation has also been observed for ... Genetic Disorders in Sex Chromosomes. Heterogametic individuals are more susceptible to genetic disorders involving the sex ... where some genes are turned on or off depending on the ambient temperature. These genes give rise to the external male or ...
  https://biologydictionary.net/sex-chromosomes/
*  Hyperactivation - Wikipedia
... and the acrosome reaction Hyperactivation is a term also used to express an X chromosome gene dosage compensation mechanism and ... Here, a complex of proteins bind to the X-linked genes to effectively double their genetic activity. This allows males (XY) to ... have equal genetic activity as females (XX), whose X's are not hyperactivated. Mammalian sperm cells become more active when ...
  https://en.wikipedia.org/wiki/Hyperactivation
*  Pallister-Killian syndrome: cytogenetic and molecular studies - Peltomäki - 1987 - Clinical Genetics - Wiley Online Library
... analyses of Pallister-Killian syndrome reveal partial dosage compensation of tetrasomy 12p and hypomethylation of gene-poor ... Harold Chen, Atlas of Genetic Diagnosis and Counseling, 2017, 2289. CrossRef. *2. Mi-Na Lee, Jiwon Lee, Hee Joon Yu, Jeehun Lee ... Harold Chen, Atlas of Genetic Diagnosis and Counseling, 2016, 1. CrossRef. *4. Josef Davidsson, Bertil Johansson, Methylation ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1399-0004.1987.tb02832.x/abstract
*  Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage...
... a gene implicated in cartilage development, show evidence for a lack of dosage compensation. This observation is further ... By using a linear mixed model, we estimate that on average 2.6% of the additive genetic variance in these twelve traits is ... The lines show the regions of the expected values of the effects under either full dosage compensation (FDC) or no dosage ... Posterior probability of no dosage compensation (NDC) model at the three lead SNPs when the other candidate is full dosage ...
  https://www.ncbi.nlm.nih.gov/pubmed/24516404
*  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles | PNAS
... we would not expect to see enrichment for bands on chromosome X because most X linked genes are subject to dosage compensation ... and 50 sets containing genes coregulated in response to genetic and chemical perturbations, as reported in various experimental ... for interpreting gene expression data. The method derives its power by focusing on gene sets, that is, groups of genes that ... We compared the gene set from one data set, SBoston, to the entire ranked gene list from the other. The set SBoston shows a ...
  http://www.pnas.org/content/102/43/15545
*  Searle Scholars Program : Mitzi I. Kuroda (1992)
Drosophila, dosage compensation increases transcription of X-linked genes in males, is essential for male viability, and is ... We are currently pursuing genetic and biochemical studies to determine how these regulators function to increase transcription ... To define the biochemical mechanism responsible for dosage compensation we study the trans-acting factors required in males to ... these data suggest that altered chromatin structure is involved in dosage compensation. Consistent with this hypothesis, we ...
  https://searlescholars.net/person/253
*  Relationships between the most commonly used Dictyostel | Open-i
The expression level of many duplicated genes is increased with dosage, but for others it appears that some form of dosage ... compensation occurs.. Conclusion: The genetic variation described here must underlie some of the phenotypic variation observed ... The expression level of many duplicated genes is increased with dosage, but for others it appears that some form of dosage ... but for others it appears that some form of dosage compensation occurs.We suggest courses of action to alleviate the problem. ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2643946_gb-2008-9-4-r75-1&req=4
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... a gene implicated in cartilage development, show evidence for a lack of dosage compensation. This observation is further ... Genetic studies have recently begun to elucidate its molecular aetiology. The authors investigated candidate genes of monoamine ... These genes show megakaryocyte-specific gene expression patterns and extensive network connectivity. Using gene silencing in ... Several infrequent genetic polymorphisms in the SERPINA1 gene are known to substantially reduce concentration of alpha1- ...
  https://www.jove.com/visualize?author=Marjo-Riitta+J%C3%A4rvelin
*  Whole-genome sequencing of cultivated and wild peppers provides insights into Capsicum domestication and specialization | PNAS
We also found that dosage compensation effect of tandem duplication genes probably contributed to the pungent diversification ... of 3.48-Gb scaffolds containing 34,476 protein-coding genes were anchored to chromosomes by a high-density genetic map. ... aKey Laboratory of Biology and Genetic Improvement of Maize in Southwest Region, Ministry of Agriculture, Maize Research ... aKey Laboratory of Biology and Genetic Improvement of Maize in Southwest Region, Ministry of Agriculture, Maize Research ...
  https://www.pnas.org/content/111/14/5135.abstract
*  Genetic Data Preserved by Two Vital Proteins
... cohesin and condensin were found in the organization of chromosome which could aid in better understanding of genetic diseases. ... The protein is called Dosage Compensation Complex (DCC). The binding of DCC to specific sites on the promoter correlates with ... Quiz on Genetic Disorders. genetic mutations and these mutations may be small, affecting just one gene or affecting entire ... Role of SMC in Expression of Genes Studies on Caenorhabditis elegans have shown that SMC play an important role in gene ...
  http://www.medindia.net/news/healthinfocus/genetic-data-preserved-by-two-vital-proteins-162820-1.htm
*  Precision IFX: Using a Dashboard to Individualize Infliximab Dosage
... by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms ... Etiology may be genetic or environmental. This term includes CROHN DISEASE and ULCERATIVE COLITIS. ... Gene Dosage. The number of copies of a given gene present in the cell of an organism. An increase in gene dosage ( ... result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage. ...
  https://www.bioportfolio.com/resources/trial/149209/Precision-IFX-Using-a-Dashboard-to-Individualize-Infliximab-Dosage.html
*  What's hot today: Current papers in developmental biology and gene function
1.688 g/cm satellite-related repeats: a missing link to dosage compensation and speciation. Mol Ecol [Epub ahead of print]. ... of genes known to be involved in human genetic diseases), this study looked for genes in Drosophila that alter their nicotine ... A DNA glycosylase encoded by the Ogg1 gene removes oxidized guanine bases and is widely conserved. In this study a genetic ... It was shown that a Hox induced genetic cascade transforms into a robust gene network during organogenesis due to the repeated ...
  http://www.sdbonline.org/sites/fly/aimain/model-organisms-august2015.htm