Pde1c - Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C - Mus musculus (Mouse) - Pde1c gene & protein
Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators ... Type I PDE are activated by the binding of calmodulin in the presence of Ca2+. ... calmodulin-dependent cyclic-nucleotide phosphodiesterase activity Source: MGIInferred from sequence orthologyi*7568196 ... Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators ...http://www.uniprot.org/uniprot/Q64338
NAVER Academic | Association between a variation in the phosphodiesterase 4D gene and bone mineral density.
Cyclic Nucleotide Phosphodiesterases, Type 4, Female, Gene Frequency, Genome, Human, Great Britain, Humans, Male, Middle Aged, ... Association between a variation in the phosphodiesterase 4D gene and bone mineral density.. Author. Richard H Reneland, Steven ... High-throughput development and characterization of a genomewide collection of gene-based single nucleotide polymorphism ... The Sp1 COLIA1 gene polymorphism, and not vitamin D receptor or estrogen receptor gene polymorphisms, determines bone mineral ...http://academic.naver.com/article.naver?doc_id=146478858
Human Metabolome Database: Showing Protein Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C ...
Gene Name. PDE1C. Protein Type. Unknown. Biological Properties. General Function. Involved in catalytic activity. ... cyclic nucleotide phosphodiesterase 1C (HMDBP00605). IdentificationBiological propertiesGene propertiesProtein properties ... Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators ... cyclic nucleotide phosphodiesterases. J Biol Chem. 1996 Jan 12;271(2):796-806. [PubMed:8557689 ] ...http://www.hmdb.ca/proteins/HMDBP00605
PDE9A polyclonal antibody - (PAB16427) - Products - Abnova
... cyclic phosphodiesterase type 9,OTTHUMP00000109390,OTTHUMP00000109391,OTTHUMP00000109393,OTTHUMP00000109394,OTTHUMP00000109397, ... Gene Summary:. *The protein encoded by this gene catalyzes the hydrolysis of cAMP and cGMP to their corresponding ... encoded protein plays a role in signal transduction by regulating the intracellular concentration of these cyclic nucleotides. ... Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq ...http://www.abnova.com/products/products_detail.asp?catalog_id=PAB16427
Patente US7660631 - Methods and systems for electrical and/or drug stimulation as a therapy for ... - Google Patentes
Cyclic nucleotide phosphodiesterases, specifically Type 5, break down cGMP to GMP by catalyzing a reaction that breaks the ... genes, gene products, and other intracellular and intercellular chemical signals and messengers, and the like. In addition, ... on the Relaxation of Human Corpus Cavernosum Tissue in Vitro and on the Activities of Cyclic Nucleotide Phosphodiesterase ... Carter, et al., "Effect of the Selective Phosphodiesterase Type Inhibitor Sildenafil on Erectile Function in the Anesthetized ...http://www.google.es/patents/US7660631?dq=flatulence
Cyclic GMP-Dependent Protein Kinases and the Cardiovascular System | Circulation Research
8 Two cGK genes, coding for cGK type I (cGKI) and type II (cGKII), have been identified in mammals. The N-terminus (≈amino ... Cyclic nucleotide research: still expanding after half a century. Nat Rev Mol Cell Biol. 2002; 3: 710-718. ... Cyclic GMP phosphodiesterases and regulation of smooth muscle function. Circ Res. 2003; 93: 280-291. ... Cyclic AMP- and cyclic GMP-dependent protein kinases differ in their regulation of cyclic AMP response element-dependent gene ...http://circres.ahajournals.org/content/93/10/907.full
PDE1C - Wikipedia
... cyclic nucleotide phosphodiesterase 1C is an enzyme that in humans is encoded by the PDE1C gene. GRCh38: Ensembl release 89: ... 2006). "Subcellular localization and regulation of type-1C and type-5 phosphodiesterases". Biochem. Biophys. Res. Commun. 341 ( ... cyclic nucleotide phosphodiesterases". J Biol Chem. 271 (2): 796-806. doi:10.1074/jbc.271.2.796. PMID 8557689. "Entrez Gene: ... 2007). "Cyclic nucleotide phosphodiesterase PDE1C1 in human cardiac myocytes". J. Biol. Chem. 282 (45): 32749-57. doi:10.1074/ ...https://en.wikipedia.org/wiki/PDE1C
thpR - RNA 2',3'-cyclic phosphodiesterase - Escherichia coli (strain K12) - thpR gene & protein
... cyclic phosphodiester to an RNA 2'-phosphomonoester (PubMed:25239919). In vitro, can also ligate 5' and 3' half-tRNA molecules ... cyclic phosphate and 5'-hydroxyl termini, respectively, to the product containing the 2'-5' phosphodiester linkage. This ... cyclic-nucleotide 3'-phosphodiesterase activity Source: EcoCyc ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct ... These various submissions may originate from different sequencing projects, different types of experiments, or different ...http://www.uniprot.org/uniprot/P37025
Pde11a - Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A - Mus musculus (Mouse) - Pde11a gene & protein
Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. ... cGMP-stimulated cyclic-nucleotide phosphodiesterase activity Source: UniProtKB. *cyclic-nucleotide phosphodiesterase activity ... p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding ,a href ... Belongs to the cyclic nucleotide phosphodiesterase family.Curated. Keywords - Domaini. Repeat. Phylogenomic databases. ...https://www.uniprot.org/uniprot/P0C1Q2
Whole blood gene expression in adolescent chronic fatigue syndrome: an exploratory cross-sectional study suggesting altered B...
Gene set enrichment analyses suggested impairment of B cell differentiation and survival, as well as enhancement of innate ... We identified 176 genes as differentially expressed in patients compared to controls, adjusting for age and gender factors. ... A pattern of co-expression could be identified, and this pattern, as well as single gene transcripts, was significantly ... This study compared whole blood gene expression in adolescent CFS patients and healthy controls, and explored associations ...https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1201-0
P19 cell - Wikipedia
Cyclic-nucleotide 3'-phosphodiesterase. Moreover, oligodendrocytes also developed and migrated into fiber bundles in mice when ... including generating the mutant allele of retinoic acid receptor genes and studying the expression of receptor genes, Hox genes ... The cell line is pluripotent and can differentiate into cell types of all three germ layers. Also, it is the most characterized ... Notch pathway and hedgehog pathway are investigated either using gene expression or generating alleles for related genes. Same ...https://en.wikipedia.org/wiki/P19_cell
IJMS | Free Full-Text | Hyaluronan and Fibrin Biomaterial as Scaffolds for Neuronal Differentiation of Adult Stem Cells...
Gene expression, morphological feature and chromosomal imbalance (kariotype) were analyzed and compared. Adipose and skin ... without any chromosomal imbalance in two scaffold types, useful for tissue engineering application: hyaluronan based membrane ... Neurospheres from skin and adipose tissue were seeded onto two scaffold types: hyaluronan based membrane and fibrin-glue meshes ... Cyclic Nucleotide 3′-Phosphodiesterase) is expressed at high levels by oligodendrocytes in the CNS and by Schwann cells in the ...http://www.mdpi.com/1422-0067/12/10/6749/htm
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
We solved crystal structures of the phosphodiesterase domain of mouse CNPase, showing the binding mode of nucleotide ligands in ... Controlled gene deletion allows the investigation of gene function in specific tissues and at distinct time points. Analysis of ... Bacterial F-type ATP synthase is the target of a new, FDA-approved antibiotic to combat drug-resistant tuberculosis. ... cyclic phosphate termini. ... Here the gene of interest is flanked with Cre target sites loxP ...https://www.jove.com/visualize/abstract/22393399/myelin-23-cyclic-nucleotide-3-phosphodiesterase-active-site-ligand
3',5'-Ciklični-AMP fosfodiestaraza - Wikipedia
Johner, A., Kunz, S., Linder, M., Shakur, Y. and Seebeck, T. (2006). "Cyclic nucleotide specific phosphodiesterases of ... "Identification of the cpdA gene encoding cyclic 3′,5′-adenosine monophosphate phosphodiesterase in Escherichia coli". J. Biol. ... http://www.garlandscience.com/textbooks/0815323042.asp?type=reviews. *Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of ... B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 18.104.22.168, 3.4.21/22/23/24, ...https://sh.wikipedia.org/wiki/3
anti-PDE7A antibody | Rabbit PDE7A Polyclonal Antibody-NP 001229247.1
The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE7 subfamily. This PDE ... Protein type: Nucleotide Metabolism - purine; EC 22.214.171.124; Phosphodiesterase. Chromosomal Location of Human Ortholog: 8q13. ... Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily. 3 isoforms of the human protein are produced by ... cyclic phosphodiesterase 7A; TM22; phosphodiesterase isozyme 7 UniProt Protein Name High affinity cAMP-specific 3',5'-cyclic ...https://www.mybiosource.com/prods/Antibody/Polyclonal/PDE7A/datasheet.php?products_id=240106
Altered Phosphodiesterase 3-Mediated cAMP Hydrolysis Contributes to a Hypermotile Phenotype in Obese JCR:LA-cp Rat Aortic...
Beavo JA: Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol Rev75 :725 -748,1995. ... Of the many animal models used in the study of non-insulin-dependent (type 2) diabetes, the JCR:LA-cp rat is unique in that it ... Four PDE4 genes have been identified, PDE4A, PDE4B, PDE4C, and PDE4D (25). Perhaps owing to the weak vasorelaxation caused by ... Polson JB, Strada SJ: Cyclic nucleotide phosphodiesterases and vascular smooth muscle. Annu Rev Pharmacol Toxicol36 :403 -427, ...http://diabetes.diabetesjournals.org/content/51/4/1194
GNAT3 - Guanine nucleotide-binding protein G(t) subunit alpha-3 - Homo sapiens (Human) - GNAT3 gene & protein
Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible ... Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; ... Gustducin heterotrimer transduces response to bitter and sweet compounds via regulation of phosphodiesterase for alpha subunit ... Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as ...https://www.uniprot.org/uniprot/A8MTJ3
Persistent Newborn Pulmonary Hypertension: Practice Essentials, Overview, Etiology
Among the 11 isoforms of phosphodiesterases (PDEs), the most important are the PDE3 and PDE5 isoforms, which degrade cyclic ... leading to the conversion of guanosine triphosphate nucleotide into cyclic guanosine monophosphate (cGMP). The increase in ... Strong links between PPHN and polymorphisms of the carbamoyl phosphate synthase gene have been reported.  However, the ... or nitric oxide synthase type 3) is the most extensively studied enzyme in persistent pulmonary hypertension of the newborn ( ...https://emedicine.medscape.com/article/898437-overview
IL12B | Cancer Genetics Web
... cyclic-nucleotide phosphodiesterase). Enriched pathways include hsa04512 (ECM-receptor interaction), hsa04510 (Focal adhesion ... The HBV targeted genes include 7 genes (PTPRJ, CNTN6, IL12B, MYOM1, FNDC3B, LRFN2, FN1) containing IPR003961 (Fibronectin, type ... METHODS: We genotyped IL-12A gene rs568408, IL-12B gene rs3212227, IL-12Rβ1 gene 378 C/G, IL-27 gene rs153109, rs17855750, and ... Overall 3,610 single nucleotide polymorphisms (SNPs) in 133 genes were genotyped as part of the Collaborative Oncological Gene- ...http://www.cancerindex.org/geneweb/IL12B.htm
Autocrine Activation of Neuronal NMDA Receptors by Aspartate Mediates Dopamine- and cAMP-Induced CREB-Dependent Gene...
... neurons stimulated CREB-dependent gene transcription and this effect was potentiated by the cyclic nucleotide phosphodiesterase ... 1999) L-type Ca2+ channels are essential for glutamate-mediated CREB phosphorylation and c-fos gene expression in striatal ... L-type Cav antagonists blocked stimulation of CREB-dependent gene transcription by cAMP (Fig. 3) and D1 DA receptor activation ... 1989) Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59:675-680. ...http://www.jneurosci.org/content/29/40/12702.long
All-Trans Retinoic Acid and Sodium Butyrate Enhance Natriuretic Peptide Receptor A Gene Transcription: Role of Histone...
... phosphodiesterases, and cyclic nucleotide-gated ion channels, mediates the cellular and physiologic effects of NPRA (Garbers et ... 2006) Association of atrial natriuretic peptide and type a natriuretic peptide receptor gene polymorphisms with left ... Generation of Npr1 Gene-Targeted Mice.. Npr1 gene-disrupted and gene-duplicated mice were produced by homologous recombination ... Effect of ATRA, NaBu, and TTNPB on renal Npr1 gene expression in gene-targeted mice and MMCs. (A) Relative mRNA expression of ...http://molpharm.aspetjournals.org/content/85/6/946
Neuronal calcium sensor-1 - Wikipedia
... cyclic nucleotide phosphodiesterases ARF1 (ADP Ribosylation factor 1) A type (Kv4.3; Shal-related subfamily, member 3) voltage- ... is a protein that is encoded by the FREQ gene in humans. NCS-1 is a member of the neuronal calcium sensor family, a class of EF ... The designation 'NCS-1' came from the assumption that the protein was expressed only in neuronal cell types, which is not the ... type III phosphatidylinositol 4-kinase β) IP3 receptor (this activity is inhibited by lithium - a drug used for the treatment ...https://en.wikipedia.org/wiki/Neuronal_calcium_sensor-1
ABCC5 - Wikipedia
This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. ... "Entrez Gene: ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5". Kool M, de Haas M, Scheffer GL, Scheper RJ, van ... "cDNA cloning of a short type of multidrug resistance protein homologue, SMRP, from a human lung cancer cell line". Biochemical ... This protein functions in the cellular export of its substrate, cyclic nucleotides. ...https://en.wikipedia.org/wiki/ABCC5
PDE4B - Wikipedia
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic ... The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a ... cyclic phosphodiesterase 4B is an enzyme that in humans is encoded by the PDE4B gene. ... "The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family". Gene. 129 (2): 239-47. doi: ...https://en.wikipedia.org/wiki/PDE4B
Protocols and Video Articles Authored by Rohini Kuner (Translated to Italian)
In Vivo trasfezione di siRNA e Gene Knockdown in Spinal Cord via rapida non invasiva lombare spinale iniezioni nei topi' ... In silico analyses revealed that their predicted targets include key pain-related genes and we identified Clcn3, a gene ... Presynaptically Localized Cyclic GMP-dependent Protein Kinase 1 is a Key Determinant of Spinal Synaptic Potentiation and Pain ... We deleted the type 1 cannabinoid receptor (CB1) specifically in nociceptive neurons localized in the peripheral nervous system ...https://www.jove.com/author/Rohini_Kuner?language=Italian