*  Fibrinogen alpha chain - Wikipedia
Alternative splicing results in two isoforms that vary in the carboxy-terminus. Fibrinogen alpha chain has been shown to ... Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene. The protein encoded by this gene is the alpha ... Fibrinogen Fibrinogen gamma chain GRCh38: Ensembl release 89: ENSG00000171560 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... "Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and ...
  https://en.wikipedia.org/wiki/Fibrinogen_alpha_chain
*  FGL1 - Wikipedia
FGL-1 is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved ... In humans, FLG-1 is encoded by the FGL1 gene. Four splice variants exist for this gene. Fibrinogen-like protein 1 is a member ... "Entrez Gene: FGL1 fibrinogen-like 1". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure ... Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. ...
  https://en.wikipedia.org/wiki/FGL1
*  ICAM-1 - Wikipedia
... and a carboxy-terminus cytoplasmic domain. The structure of ICAM-1 is characterized by heavy glycosylation, and the protein's ... is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically ... and fibrinogen. These three proteins are generally expressed on endothelial cells and leukocytes, and they bind to ICAM-1 to ... "Entrez Gene: intercellular adhesion molecule 1". Bella J, Kolatkar PR, Marlor CW, Greve JM, Rossmann MG (Apr 1998). "The ...
  https://en.wikipedia.org/wiki/ICAM-1
*  FGL2 - Wikipedia
Fibrinogen-like protein 2, also known as FGL2, is a protein which in humans is encoded by the FGL2 gene. FGL2 is a 439 amino ... The protein exists as both a Type II transmembrane protein (with the carboxy terminus on the extracellular side of the plasma ... The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a ... "Entrez Gene: FGL2 fibrinogen-like 2". Rüegg C, Pytela R (July 1995). "Sequence of a human transcript expressed in T-lymphocytes ...
  https://en.wikipedia.org/wiki/FGL2
*  Undergraduate Research Symposium Abstracts from Biology 2006 A-K
A multi-step cloning strategy was used to add the HA coding sequence to the carboxy terminus of the human gene already cloned ... As the concentration of Fibrinogen increased the absorbance of the B7 cells at 485 nm increased. Beyond 50 g/mL of Fibrinogen ... The goal of this research was to clone genes from the common garden snail Helix aspersa in the hopes of finding a gene ... Gene Expression in Rat Brain Following Exposure to Synthetic Fox Odor - 2,4,5-Trimethylthiazoline. Bisola C. Awoyemi and ...
  http://www1.udel.edu/chem/white/HHMI2/Symp06/BiolAbst06A-K.html
*  New Mechanisms for Vascular Control of Inflammation Mediated by Natural Anticoagulant Proteins | JEM
Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J. Biol. Chem ... TM is a complex membrane protein with a lectin-like domain from the amino terminus, six epidermal growth factor (EGF)-like ... but also blocks the ability of thrombin to clot fibrinogen and participate in platelet and endothelial cell activation (25). An ... this class of enzymes removes carboxy terminal arginine and lysine residues. It was originally thought that this enzyme's major ...
  http://jem.rupress.org/content/196/5/561
*  Overview of MMP Biology and Gene Associations in Human Diseases | IntechOpen
Overview of MMP Biology and Gene Associations in Human Diseases , IntechOpen, Published on: 2017-12-20. Authors: Tamara Djuric ... MMP-23 has a unique carboxy terminal domain rich in cysteine and an immunoglobulin-like domain after the C terminus of the ... Casein, fibrinogen and fibronectin. MMP-26. Collagen type IV and gelatin. Casein. α1-antitrypsin. ... There are 24 genes encoding MMPs in humans, including duplicated MMP-23 gene. So, there are 23 different MMPs in humans [8]. ...
  https://www.intechopen.com/books/the-role-of-matrix-metalloproteinase-in-human-body-pathologies/overview-of-mmp-biology-and-gene-associations-in-human-diseases/
*  US5719041A - DNA encoding ecotin homologs - Google Patents
USA 82:5132 1985!). Solid phase synthesis begins at the carboxy-terminus of the putative peptide by coupling a protected amino ... Gene Fusions. A variation on the above procedures contemplates the use of gene fusions, wherein the gene encoding the ecotin or ... Factor Xa activates prothrombin to thrombin which cleaves fibrinogen to fibrin and ultimately results in the formation of a ... In addition, a gene fusion consisting of two tandem copies of the ecotin or ecotin homolog gene may be used. The ecotin ...
  https://patents.google.com/patent/US5719041?oq=patent%3A5992892
*  WikiGenes - leucine - (2R)-2-amino-4-methyl-pentanoic acid
... and a carboxy terminus with high homology to cyclophilin [39]. ... wikigene or wiki gene protein drug chemical gene disease author ... Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. Benson, M.D., Liepnieks, J., Uemichi, T., Wheeler ... Gene context of leucine. *The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site ... The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich ...
  http://www.wikigenes.org/e/chem/e/439524.html
*  Method of Measuring Amyloid-Beta Peptides - Patent application
For example, Aβ(1-43) is an Aβ species or variant, whose amino terminus begin at amino acid number 1 and carboxy terminus ends ... Because plasma is serum plus the clotting protein fibrinogen, the term "plasma" is used broadly herein to encompass "serum." [ ... The transgenic animals express the Swedish mutation APP gene of the transgene (or homologously recombined targeting construct ... Aβ whose carboxy termini extend beyond amino acid 40; but it may also detect AD whose amino termini do not extend to amino acid ...
  http://www.patentsencyclopedia.com/app/20090123952
*  A Heterotrimeric G Protein of the Gi Family is Required for cAMP-triggered Trafficking of Aquaporin 2 in Kidney Epithelial...
Introduction of a synthetic peptide corresponding to the C terminus of the Gi3 alpha subunit into permeabilized CD8 cells ... C-terminus DEFINITION: The intracellular carboxy-terminus or tail of the vasopressin-2 receptor (V2R). See diagram. ... 1. Showing a detectable effect of a gene.. 2. Made known; shown.. 3. Squeezed out; extracted by pressing. ... fibrinogen and other coagulation factors, complement components, immunoglobulins, enzyme inhibitors, precursors of substances ...
  http://www.ndif.org/articles/22-A_Heterotrimeric_G_Protein_of_the_Gi_Family_is_Required_for_cAMPtriggered_Trafficking_of_Aquaporin_2_in_Kidney_Epithelial_Cells/body
*  Regulation by Fibrinogen and Its Products of Intercellular Adhesion Molecule-1 Expression in Human Saphenous Vein Endothelial...
... sequences at the carboxy terminus and the middle section of the 2 Aα chains of fibrinogen17 are able to bind to endothelial ... Mouse anti-human tumor necrosis factor-α (TNF-α)-neutralizing antibody, recombinant human IL-1β, and ICAM-1 gene probe cocktail ... at 1 μmol/L fibrinogen, to 171±18% at 2 μmol/L fibrinogen, and to 210±20% at 4 μmol/L fibrinogen (ANOVA, P,0.05; n=4). After ... of basal levels at 0.3 μmol/L fibrinogen, to 112±8% at 1 μmol/L fibrinogen, to 109±10% at 2 μmol/L fibrinogen, and to 94±4% at ...
  http://atvb.ahajournals.org/content/20/3/652
*  MODULATION OF SYNAPTOGENESIS - Patent application
Peptides may be truncated by 1, 2, 3, 4, 5, or more amino acids from the amino terminus, the carboxy terminus, or both. [0137] ... Gene Delivery [0191] One approach for modulating synaptogenesis involves gene therapy. In such methods, sequences encoding an ... It contains binding sites for thrombin, fibrinogen, heparin, fibronectin, plasminogen, plasminogen activator, collagen, laminin ... Both terms refer to a process which introduces a foreign gene (also called an "exogenous" gene) into one or more preexisting ...
  http://www.patentsencyclopedia.com/app/20110104181
*  The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function
Exopeptidases cleave the peptide bond proximal to the amino (NH2)or carboxy (COOH) termini of the proteinaceous substrate, ... 1993) have demonstrated the presence of a gene from C. fasciculata with homology to the gp63 metalloprotease gene of Leishmania ... fibrinogen, hemoglobin and immunoglobulins (Bouvier et al. 1990), as well as extracellular matrix components such as type IV ... The C. fasciculata gene homologue is arranged as a multicopy family comprised of approximately 7 distinct genes, where the ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000400006&lng=en&tlng=en
*  COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY - Patent application
The paxillin binding sequence (PBS) on GIT1 is found at the carboxy-terminus of the protein and has been shown to prevent ... of Oregon Press, Eugene). [0392]Wilkinson D G, Bhatt S, Herrmann B G. Expression pattern of the mouse T gene and its role in ... Additionally, cells expressing αIIb:β3 or αIIb-Robo4:β3 were plated on fibronectin and fibrinogen, and Rac-GTP levels were ... To clarify which Lim domain is required for binding to Robo4, serial deletions were made from the carboxy terminus of paxillin ...
  http://www.patentsencyclopedia.com/app/20100222401
*  Analytical Enzyme Factor Xa | Sigma-Aldrich
Further hydrolysis of a small glycopeptide from the carboxy-terminus of the heavy chain yields factor Xaβ, which has equal ... Activation of factor X involves the hydrolysis of a 9.5 KDa peptide from the amino terminus of the heavy chain of the zymogen. ... Gene Search * Metabolomics * Metabolomics Products * Learning Center * Enzymes & Proteins * Enzyme Products * Learning Center ... Fibrinogen & Fibrin * Luciferase * BioUltra Proteins * Cell Signaling Enzymes, Proteins and Peptides * Enzyme Reagents ...
  https://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/factor-xa.html
*  Matrix Metalloproteinases (MMPs) Regulate Fibrin-invasive Activity via MT1-MMP-dependent and -independent Processes | JEM
... or MT3-MMPs containing a His-tag epitope at their carboxy termini in the absence or presence of an α1PDX expression vector. In ... to fibrin(ogen), the major component of the provisional matrix (3, 22, 23, 25, 26). Nonetheless, fibrin(ogen)olytic activity ... Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction. Am. J. Pathol. 156:1865-1873. ... To vary fibrin fiber size, polymerization rates were varied by incubating thrombin-fibrinogen mixtures at pH 6.9, 7.4, or 8.0 ( ...
  http://jem.rupress.org/content/195/3/295
*  Proteases in angiogenesis - Wikipedia
The hemopexin like domain in the carboxy terminus of MMP-2 is able to block this interaction of active MMP-2 and integrin αvβ3 ... For example, MMP-3, 7, 8, 12 and 13 can cleave fibrinogen. MMP activity is one of the earliest and most sustained processes ... "Specific interference of urokinase type plasminogen activatior receptor and matrix metalloproteinase 9 gene expression induced ... Lastly, endorepellin is a recently described inhibitor of angiogenesis derived from the carboxy terminus of perlecan. Nanomolar ...
  https://en.wikipedia.org/wiki/Proteases_in_angiogenesis
*  Clinical value of serum transferrin measurements - IFCC
The gene for the human transferrin receptor is 32 Kb long and located on chromosome 3. It shows some similarities to the gene ... a 28-residue transmembrane region and a 671-residue extracellular carboxyl-terminus (McClelland et al 1984, Schneider et al ... The structure of the ectodomain has striking similarities to the membranebound carboxy peptidase II (Lawrence et al 1999), ... to recombinant human erythropoietin in patients with the anemia of renal failure by serum transferrin receptor and fibrinogen. ...
  http://www.ifcc.org/ifcc-communications-publications-division-cpd/ifcc-publications/ejifcc-journal/e-journal-volumes/ejifcc-2002-vol-13/vol-13-no-2/clinical-value-of-serum-transferrin-measurements/
*  Clotting Factor-Fc Chimeric Proteins to Treat Hemophilia - Patent application
The portion of an immunoglobulin constant region will have both an N, or an amino terminus, and a C, or carboxy terminus. In ... Because this gene is present in germline tissues, it is passed from parent to offspring. Exogenous genes are introduced into ... Factor Xa is required to convert prothrombin to thrombin, which converts fibrinogen to fibrin as a final stage in forming a ... wherein X is linked at its C terminus to the N terminus of L, and L is linked at its C terminus to the N terminus of F and ...
  http://www.patentsencyclopedia.com/app/20130273047
*  renin-angiotensin-aldosterone system (RAAS) - Endocrinology / Hormones
Angiotensin III is a hexapeptide formed as a result of a cleavage at the N-terminus of Angiotensin II, a key factor in the ... Angiotensin (1-7) is an endogenous peptide fragment that can be produced from Ang I or Ang II via endo- or carboxy-peptidases ... Acetyl Angiotensinogen (1-14),porcine, The protein encoded by the Angiotensinogen gene is known as pre-angiotensinogen or ... It also can effectively reduce the plasma fibrinogen level.. A11122 Rosuvastatin HMG-CoA reductase inhibitor Rosuvastatin is a ...
  http://www.adooq.com/renin-angiotensin-aldosterone-system-raas.html
*  US6103888A - Mammalian cationic proteins having lipopolysaccharide binding and anti-coagulant activity - Google Patents
... fragment found at the carboxy-terminus of CAP18. Polypeptides are capable of binding to LPS and inhibiting LPS-mediated ... The sequence derived from Edman degradation is found at the carboxy-terminus of the protein beginning at amino acid position ... Homologous CAP18 genes from other species may be identified and cloned using probes based on the rabbit and/or CAP18 genes. ... Prothrombinase converts prothrombin (factor II) to thrombin (IIa). Thrombin generates fibrin monomers from fibrinogen. Because ...
  https://patents.google.com/patent/US6103888
*  Biology of periodontal regeneration
The IGFs, which are synthesized primarily by the liver, retain the C peptide and have an extended carboxy terminus 54. ... There are two types of receptors for TNF-α encoded by distinct genes: TNF receptor with a molecular mass of 55 kDa (TNF-Rp55) ... These include factors like albumin, fibrinogen, fibronectin , IgG, and coagulation factors V and VIII, as well as platelet- ... To date, five α, three β and three γ chains have been characterized. They represent the products of distinct genes that evolved ...
  http://periobasics.com/biology-of-periodontal-regeneration.html
*  Patente US6025194 - Nucleic acid sequence of senescence asssociated gene - Google Patentes
... such agents as well as GC6 gene and gene products and products corresponding thereto can be used to prevent and treat diseases ... Isolated, purified, and recombinant nucleic acids and proteins corresponding to the human GC6 gene and its mRNA and protein ... identify agents that alter senescent gene expression generally and GC6 expression specifically; ... Human gene GC6 is expressed more abundantly in senescent cells than young cells. ...
  http://www.google.es/patents/US6025194
*  Application # 2018/0142210. MODIFIED STEM CELLS AND USES THEREOF - Patents.com
A stem cell or differentiated cell of claim 1 wherein the chimeric molecule comprises from amino-terminus to carboxy-terminus: ... gene, the adenosine deaminase gene (ADA), and the multi-drug resistance (MDR) gene. [0103] In particular embodiments, ... 8,361,794), fibrinogen domains (see, e.g., Weisel, et al., 1985, Science 230:1388), Kunitz domains (see, e.g., U.S. Pat. No. ... A stem cell or differentiated cell of claim 1 wherein the chimeric molecule comprises from amino-terminus to carboxy-terminus: ...
  http://patents.com/us-20180142210.html