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*  Primed to Understand Fibrinogen in Cardiovascular Disease | Arteriosclerosis, Thrombosis, and Vascular Biology
Genetic variation in the fibrinogen gamma gene increases the risk for deep venous thrombosis by reducing plasma fibrinogen ... Fibrinogen gamma′ chain carboxy terminal peptide selectively inhibits the intrinsic coagulation pathway. Br J Haematol. 2007; ... chain containing a unique 20-amino acid sequence at the C terminus. Between 8% and 15% of circulating fibrinogen in healthy ... to-total fibrinogen ratio7-11 suggests that γA/γ′ fibrinogen is not simply a biomarker for increased total fibrinogen. Together ...
  http://atvb.ahajournals.org/content/36/1/4
*  Fibrinogen alpha chain - Wikipedia
Alternative splicing results in two isoforms that vary in the carboxy-terminus. Fibrinogen alpha chain has been shown to ... Fibrinogen alpha chain is a protein that in humans is encoded by the FGA gene. The protein encoded by this gene is the alpha ... Fibrinogen Fibrinogen gamma chain GRCh38: Ensembl release 89: ENSG00000171560 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... "Carboxy-terminal-extended variant of the human fibrinogen alpha subunit: a novel exon conferring marked homology to beta and ...
  https://en.wikipedia.org/wiki/Fibrinogen_alpha_chain
*  FGL1 Gene - GeneCards | FGL1 Protein | FGL1 Antibody
Fibrinogen Like 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen ... No data available for DME Specific Peptides for FGL1 Gene Domains & Families for FGL1 Gene Gene Families for FGL1 Gene. HGNC:. ... Publications for FGL1 Gene * Molecular cloning and initial characterization of a novel fibrinogen-related gene, HFREP-1. (PMID ...
  https://www.genecards.org/cgi-bin/carddisp.pl?gene=FGL1
*  fgl1, fibrinogen-like 1 - Creative Biogene
Fibrinogen-like 1 is a member of the fibrinogen family. This protein is homologous to the carboxy terminus of the fibrinogen ... DNA Methylation AnalysisPlasmid DNA Production ServiceGene Expression ServiceGene Synthesis and Cloning ServiceGene Mutagenesis ... FGL1; fibrinogen-like 1; fibrinogen-like protein 1; HFREP 1; FGL 1; FGL1_HUMAN; Fibrinogen like 1; Fibrinogen like protein 1; ... Gene OverexpressionGene Knockout Stable Cell LinesGene Knockdown Stable Cell Lines ...
  https://www.creative-biogene.com/symbolsearch_fgl1.html
*  FGL1 - Wikipedia
FGL-1 is homologous to the carboxy terminus of the fibrinogen beta- and gamma- subunits which contains the four conserved ... In humans, FLG-1 is encoded by the FGL1 gene. Four splice variants exist for this gene. Fibrinogen-like protein 1 is a member ... "Entrez Gene: FGL1 fibrinogen-like 1". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure ... Fibrinogen-like protein 1 (FGL-1) is a protein that is structurally related to fibrinogen. ...
  https://en.wikipedia.org/wiki/FGL1
*  Immune physiologic D/C Flashcards by Lorne Runge | Brainscape
The carboxy terminus is similar to fibrinogen. Binds to syndecan. Multiple disulfide bonds and glycosylation sites. The C form ... SMAD (mothers against decapentaplegic- a Drosophila gene, small body size- a worm gene) proteins transduce extracellular ... T-bet from gene TBX21, binds to a T-box promoter producing T-bet which stimulates Th1 and NK cells to produce interferon gamma ... The S100A7 gene codes for psoriasin which is an inflammatory cytokine in autoimmune skin conditions including psoriasis. S-100 ...
  https://www.brainscape.com/flashcards/immune-physiologic-d-c-2484247/packs/4392200
*  ICAM-1 - Wikipedia
... and a carboxy-terminus cytoplasmic domain. The structure of ICAM-1 is characterized by heavy glycosylation, and the protein's ... is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically ... and fibrinogen. These three proteins are generally expressed on endothelial cells and leukocytes, and they bind to ICAM-1 to ... "Entrez Gene: intercellular adhesion molecule 1". Bella J, Kolatkar PR, Marlor CW, Greve JM, Rossmann MG (Apr 1998). "The ...
  https://en.wikipedia.org/wiki/ICAM-1
*  FGL2 - Wikipedia
Fibrinogen-like protein 2, also known as FGL2, is a protein which in humans is encoded by the FGL2 gene. FGL2 is a 439 amino ... The protein exists as both a Type II transmembrane protein (with the carboxy terminus on the extracellular side of the plasma ... The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a ... "Entrez Gene: FGL2 fibrinogen-like 2". Rüegg C, Pytela R (July 1995). "Sequence of a human transcript expressed in T-lymphocytes ...
  https://en.wikipedia.org/wiki/FGL2
*  Undergraduate Research Symposium Abstracts from Biology 2006 A-K
A multi-step cloning strategy was used to add the HA coding sequence to the carboxy terminus of the human gene already cloned ... As the concentration of Fibrinogen increased the absorbance of the B7 cells at 485 nm increased. Beyond 50 g/mL of Fibrinogen ... The goal of this research was to clone genes from the common garden snail Helix aspersa in the hopes of finding a gene ... Gene Expression in Rat Brain Following Exposure to Synthetic Fox Odor - 2,4,5-Trimethylthiazoline. Bisola C. Awoyemi and ...
  http://www1.udel.edu/chem/white/HHMI2/Symp06/BiolAbst06A-K.html
*  New Mechanisms for Vascular Control of Inflammation Mediated by Natural Anticoagulant Proteins | JEM
Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J. Biol. Chem ... TM is a complex membrane protein with a lectin-like domain from the amino terminus, six epidermal growth factor (EGF)-like ... but also blocks the ability of thrombin to clot fibrinogen and participate in platelet and endothelial cell activation (25). An ... this class of enzymes removes carboxy terminal arginine and lysine residues. It was originally thought that this enzyme's major ...
  http://jem.rupress.org/content/196/5/561
*  Overview of MMP Biology and Gene Associations in Human Diseases | IntechOpen
Overview of MMP Biology and Gene Associations in Human Diseases , IntechOpen, Published on: 2017-12-20. Authors: Tamara Djuric ... MMP-23 has a unique carboxy terminal domain rich in cysteine and an immunoglobulin-like domain after the C terminus of the ... Casein, fibrinogen and fibronectin. MMP-26. Collagen type IV and gelatin. Casein. α1-antitrypsin. ... There are 24 genes encoding MMPs in humans, including duplicated MMP-23 gene. So, there are 23 different MMPs in humans [8]. ...
  https://www.intechopen.com/books/the-role-of-matrix-metalloproteinase-in-human-body-pathologies/overview-of-mmp-biology-and-gene-associations-in-human-diseases/
*  US5719041A - DNA encoding ecotin homologs - Google Patents
USA 82:5132 1985!). Solid phase synthesis begins at the carboxy-terminus of the putative peptide by coupling a protected amino ... Gene Fusions. A variation on the above procedures contemplates the use of gene fusions, wherein the gene encoding the ecotin or ... Factor Xa activates prothrombin to thrombin which cleaves fibrinogen to fibrin and ultimately results in the formation of a ... In addition, a gene fusion consisting of two tandem copies of the ecotin or ecotin homolog gene may be used. The ecotin ...
  https://patents.google.com/patent/US5719041?oq=patent%3A5992892
*  WikiGenes - leucine - (2R)-2-amino-4-methyl-pentanoic acid
... and a carboxy terminus with high homology to cyclophilin [39]. ... wikigene or wiki gene protein drug chemical gene disease author ... Hereditary renal amyloidosis associated with a mutant fibrinogen alpha-chain. Benson, M.D., Liepnieks, J., Uemichi, T., Wheeler ... Gene context of leucine. *The A. thaliana disease resistance gene RPS2 encodes a protein containing a nucleotide-binding site ... The complete form of X-linked congenital stationary night blindness is caused by mutations in a gene encoding a leucine-rich ...
  http://www.wikigenes.org/e/chem/e/439524.html
*  Method of Measuring Amyloid-Beta Peptides - Patent application
For example, Aβ(1-43) is an Aβ species or variant, whose amino terminus begin at amino acid number 1 and carboxy terminus ends ... Because plasma is serum plus the clotting protein fibrinogen, the term "plasma" is used broadly herein to encompass "serum." [ ... The transgenic animals express the Swedish mutation APP gene of the transgene (or homologously recombined targeting construct ... Aβ whose carboxy termini extend beyond amino acid 40; but it may also detect AD whose amino termini do not extend to amino acid ...
  http://www.patentsencyclopedia.com/app/20090123952
*  Hybridoma Center
Ndonwi M, Girard TJ, Broze GJ Jr. The carboxy-terminus of TFPI alpha is required for its interaction with factor V and Va. J. ... Fibrinogen-specific antibody induces abdominal aortic aneurysm in mice through complement lectin pathway activation. Proc. Natl ... Localization of a yeast phase specific gene product to the cell wall in Histoplasma capsulatum. Infect and Immun 1996;64:3048- ... Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. ...
  https://pathology.wustl.edu/research/core-facilities/hybridoma-center/
*  Experimental Evolution: Foot-and-Mouth Disease Virus - Immunology and Evolution of Infectious Disease - NCBI Bookshelf
12.3). In serotype C, the carboxyl terminus of VP1 also contributes to this site, and in serotype O, the EF loop of VP2 is ... A second discontinuous epitope occurs in serotype O. The GH loop and the carboxy-terminal (COOH) end of VP1 jointly form the ... 1997) sequenced the capsid genes from the original line, from the serially passaged line, and from an escape mutant of the ... fibrinogen, and type I collagen (Fox et al. 1989). All field isolates of FMDV have the conserved RGD motif needed for ...
  https://www.ncbi.nlm.nih.gov/books/NBK2393/
*  A Heterotrimeric G Protein of the Gi Family is Required for cAMP-triggered Trafficking of Aquaporin 2 in Kidney Epithelial...
Introduction of a synthetic peptide corresponding to the C terminus of the Gi3 alpha subunit into permeabilized CD8 cells ... C-terminus DEFINITION: The intracellular carboxy-terminus or tail of the vasopressin-2 receptor (V2R). See diagram. ... 1. Showing a detectable effect of a gene.. 2. Made known; shown.. 3. Squeezed out; extracted by pressing. ... fibrinogen and other coagulation factors, complement components, immunoglobulins, enzyme inhibitors, precursors of substances ...
  http://www.ndif.org/articles/22-A_Heterotrimeric_G_Protein_of_the_Gi_Family_is_Required_for_cAMPtriggered_Trafficking_of_Aquaporin_2_in_Kidney_Epithelial_Cells/body
*  Regulation by Fibrinogen and Its Products of Intercellular Adhesion Molecule-1 Expression in Human Saphenous Vein Endothelial...
... sequences at the carboxy terminus and the middle section of the 2 Aα chains of fibrinogen17 are able to bind to endothelial ... Mouse anti-human tumor necrosis factor-α (TNF-α)-neutralizing antibody, recombinant human IL-1β, and ICAM-1 gene probe cocktail ... at 1 μmol/L fibrinogen, to 171±18% at 2 μmol/L fibrinogen, and to 210±20% at 4 μmol/L fibrinogen (ANOVA, P,0.05; n=4). After ... of basal levels at 0.3 μmol/L fibrinogen, to 112±8% at 1 μmol/L fibrinogen, to 109±10% at 2 μmol/L fibrinogen, and to 94±4% at ...
  http://atvb.ahajournals.org/content/20/3/652
*  MODULATION OF SYNAPTOGENESIS - Patent application
Peptides may be truncated by 1, 2, 3, 4, 5, or more amino acids from the amino terminus, the carboxy terminus, or both. [0137] ... Gene Delivery [0191] One approach for modulating synaptogenesis involves gene therapy. In such methods, sequences encoding an ... It contains binding sites for thrombin, fibrinogen, heparin, fibronectin, plasminogen, plasminogen activator, collagen, laminin ... Both terms refer to a process which introduces a foreign gene (also called an "exogenous" gene) into one or more preexisting ...
  http://www.patentsencyclopedia.com/app/20110104181
*  The ubiquitous gp63-like metalloprotease from lower trypanosomatids: in the search for a function
Exopeptidases cleave the peptide bond proximal to the amino (NH2)or carboxy (COOH) termini of the proteinaceous substrate, ... 1993) have demonstrated the presence of a gene from C. fasciculata with homology to the gp63 metalloprotease gene of Leishmania ... fibrinogen, hemoglobin and immunoglobulins (Bouvier et al. 1990), as well as extracellular matrix components such as type IV ... The C. fasciculata gene homologue is arranged as a multicopy family comprised of approximately 7 distinct genes, where the ...
  http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652006000400006&lng=en&tlng=en
*  Human Coronavirus NL63 Open Reading Frame 3 encodes a virion-incorporated N-glycosylated membrane protein | Virology Journal |...
... analysis and subsequent endoglycosidase H digestion we showed that ORF 3 protein is N-glycosylated at the N-terminus. Analysis ... Using N-terminally FLAG-tagged ORF 3 protein and an antiserum specific to the C-terminus we verified the proposed topology of ... an extracellular N-terminus and a cytosolic C-terminus. By in-vitro translation ... Escors D, Ortego J, Laude H, Enjuanes L: The membrane M protein carboxy terminus binds to transmissible gastroenteritis ...
  https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-7-6
*  COMPOSITIONS AND METHODS FOR TREATING PATHOLOGIC ANGIOGENESIS AND VASCULAR PERMEABILITY - Patent application
The paxillin binding sequence (PBS) on GIT1 is found at the carboxy-terminus of the protein and has been shown to prevent ... of Oregon Press, Eugene). [0392]Wilkinson D G, Bhatt S, Herrmann B G. Expression pattern of the mouse T gene and its role in ... Additionally, cells expressing αIIb:β3 or αIIb-Robo4:β3 were plated on fibronectin and fibrinogen, and Rac-GTP levels were ... To clarify which Lim domain is required for binding to Robo4, serial deletions were made from the carboxy terminus of paxillin ...
  http://www.patentsencyclopedia.com/app/20100222401
*  Analytical Enzyme Factor Xa | Sigma-Aldrich
Further hydrolysis of a small glycopeptide from the carboxy-terminus of the heavy chain yields factor Xaβ, which has equal ... Activation of factor X involves the hydrolysis of a 9.5 KDa peptide from the amino terminus of the heavy chain of the zymogen. ... Gene Search * Metabolomics * Metabolomics Products * Learning Center * Enzymes & Proteins * Enzyme Products * Learning Center ... Fibrinogen & Fibrin * Luciferase * BioUltra Proteins * Cell Signaling Enzymes, Proteins and Peptides * Enzyme Reagents ...
  https://www.sigmaaldrich.com/life-science/metabolomics/enzyme-explorer/analytical-enzymes/factor-xa.html
*  Matrix Metalloproteinases (MMPs) Regulate Fibrin-invasive Activity via MT1-MMP-dependent and -independent Processes | JEM
... or MT3-MMPs containing a His-tag epitope at their carboxy termini in the absence or presence of an α1PDX expression vector. In ... to fibrin(ogen), the major component of the provisional matrix (3, 22, 23, 25, 26). Nonetheless, fibrin(ogen)olytic activity ... Disruption of the plasminogen gene in mice abolishes wound healing after myocardial infarction. Am. J. Pathol. 156:1865-1873. ... To vary fibrin fiber size, polymerization rates were varied by incubating thrombin-fibrinogen mixtures at pH 6.9, 7.4, or 8.0 ( ...
  http://jem.rupress.org/content/195/3/295
*  Clotting Factor-Fc Chimeric Proteins to Treat Hemophilia - Patent application
The portion of an immunoglobulin constant region will have both an N, or an amino terminus, and a C, or carboxy terminus. In ... Because this gene is present in germline tissues, it is passed from parent to offspring. Exogenous genes are introduced into ... Factor Xa is required to convert prothrombin to thrombin, which converts fibrinogen to fibrin as a final stage in forming a ... wherein X is linked at its C terminus to the N terminus of L, and L is linked at its C terminus to the N terminus of F and ...
  http://www.patentsencyclopedia.com/app/20130273047