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*  Cell Cycle - QIAGEN
Key genes that regulate cell cycle progression and checkpoints encode cullins, cyclins, and cyclin-dependent kinases and their ... How Can We Beat Cancer? * Want to Save 275,000 Lives Each Year? ... Key genes that regulate cell cycle progression and checkpoints ... For example, the G2-M DNA damage checkpoint ensures the fidelity of DNA replication, and arrests the cell cycle to allow time ... For example, the G2-M DNA damage checkpoint ensures the fidelity of DNA replication, and arrests the cell cycle to allow time ...
  https://www.qiagen.com/cn/shop/genes-and-pathways/complete-biology-list/cell-cycle/
*  Frontiers | DNA Damage Response and Immune Defense: Links and Mechanisms | Genetics
In response to genotoxic insults, the DNA damage response (DDR) orchestrates DNA damage checkpoint activation and facilitates ... transducer kinases, and effectors. In this review, we describe recent advances on the understanding of the role of DDR in ... In response to genotoxic insults, the DNA damage response (DDR) orchestrates DNA damage checkpoint activation and facilitates ... transducer kinases, and effectors. In this review, we describe recent advances on the understanding of the role of DDR in ...
  https://www.frontiersin.org/articles/10.3389/fgene.2016.00147/full
*  Frontiers | Pharmacodynamic Modeling of Cell Cycle Effects for Gemcitabine and Trabectedin Combinations in Pancreatic Cancer...
Extensive experimental data were obtained for two pancreatic cancer cell lines (MiaPaCa-2 and BxPC-3), including cell ... Extensive experimental data were obtained for two pancreatic cancer cell lines (MiaPaCa-2 and BxPC-3), including cell ... data and extend a prototype model framework were developed to characterize dynamic changes in cell cycle phase of cancer cell ... data and extend a prototype model framework were developed to characterize dynamic changes in cell cycle phase of cancer cell ...
  https://www.frontiersin.org/articles/10.3389/fphar.2016.00421/full
*  Spindle apparatus - Wikipedia
Failure of this spindle assembly checkpoint can result in aneuploidy and may be involved in aging and the formation of cancer. ... CDK1 (also called CDC2) is considered the main mitotic kinase in mammalian cells and is activated by Cyclin B1. Aurora kinases ... Hirano T (2012). "Condensins: universal organizers of chromosomes with diverse functions". Genes Dev. 26 (15): 1659-1678. doi: ... Spindle assembly is largely regulated by phosphorylation events catalyzed by mitotic kinases. Cyclin dependent kinase complexes ...
  https://en.wikipedia.org/wiki/Spindle_apparatus
*  Chek2 MGI Mouse Gene Detail - MGI:1355321 - checkpoint kinase 2
breast cancer DOID:1612. DOID:1648. DOID:4241. ICD10CM:C50. ICD10CM:C50-C50. ICD9CM:174.8. MESH:D001943. NCI:C2910. NCI:C9335. ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc ... prostate cancer DOID:10283. DOID:514. ICD10CM:C61. ICD9CM:185. KEGG:05215. MESH:D011471. NCI:C3343. NCI:C7378. OMIM:176807. ... VEGA Gene Model , MGI Sequence Detail. 34167. C57BL/6J. ± kb. transcript. OTTMUST00000134619. VEGA , MGI Sequence Detail. 2276 ...
  http://www.informatics.jax.org/marker/MGI:1355321
*  Patient survival and tumor characteristics associated with CHEK2:p.I157T - findings from the Breast Cancer Association...
Breast cancerCHEK2CHK2I157T1100delCSurvivalPathologyGene expression. Background. Checkpoint kinase 2 (CHEK2) is a moderate ... Enrichment of cancer associated gene signatures. In the GSEA analysis, several independent MSigDB [38] gene signatures related ... The clinical value of somatic TP53 gene mutations in 1,794 patients with breast cancer. Clin Cancer Res. 2006;12(4):1157-67. ... Gene expression profiling assigns CHEK2 1100delC breast cancers to the luminal intrinsic subtypes. Breast Cancer Res Treat. ...
  https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-016-0758-5
*  Cancers | Free Full-Text | Kinases and Cancer | HTML
The human genome contains 518 protein kinase genes, 478 of which belong to the classical protein kinase family and 40 are ... Protein kinases are a large family of enzymes catalyzing protein phosphorylation. ... Kim, D.S.; Kim, M.J.; Lee, J.Y.; Lee, S.M.; Choi, J.E.; Lee, S.Y.; Park, J.Y. Epigenetic inactivation of checkpoint kinase 2 ... Several families of kinases, such as tyrosine kinases [53], cycle-dependent kinases [54,55,56], aurora kinases [57,58], mTOR [ ...
  https://www.mdpi.com/2072-6694/10/3/63/htm
*  Effects of Selective Checkpoint Kinase 1 Inhibition on Cytarabine Cytotoxicity in Acute Myelogenous Leukemia Cells In Vitro |...
M checkpoint independently of p53 by targeting both of the checkpoint kinases, Chk2 and Chk1. Cancer Res 2002;62:5743-8. ... We have previously shown that disruption of the replication checkpoint by gene deletion or RNA interference increases the ... New insights into checkpoint kinase 1 in the DNA damage response signaling network. Clin Cancer Res 2010;16:376-83. ... Cancer Therapy: Preclinical Effects of Selective Checkpoint Kinase 1 Inhibition on Cytarabine Cytotoxicity in Acute Myelogenous ...
  http://clincancerres.aacrjournals.org/content/18/19/5364?rss=1
*  CHEK2 (Checkpoint Kinase 2) Gene Mutation Analysis
... cancer hospital, cancer treatment, breast cancer hospital, lymphoma treatment, city of hope, los angeles, cancer hospital ... california, cancer clinical trials, cancer doctors, oncologists, bone marrow transplant, hct, bmt ... Breast cancer. Prostate cancer. Li-Fraumeni /Li-Fraumeni-like Syndrome. CHEK2 encodes a Serine/threonine-protein kinase which ... It has been suggested that CHEK2 functions as a low-penetrance susceptibility gene for cancers and multiplies the risks ...
  https://www.cityofhope.org/clinical-molecular-diagnostic-laboratory/list-of-cmdl-tests/chek2-checkpoint-kinase-2-gene-mutation-analysis
*  Gene Manipulation May Overcome Infertility Caused by Cancer Treatments | BabyMed.com
In women, a protein called Chk2 (checkpoint kinase 2) destroys immature eggs damaged this way so no faulty DNA is passed ... They then manipulated the activity of the Chk2 gene so that it did not cull the faulty sex cells. When the damaged immature ... This effort of buying time may give her body the ability to repair the damage done by the cancer treatments and restore her ... Although similar experiments were done with sperm cells, turning off the expression of the Chk2 gene did not produce the same ...
  https://www.babymed.com/fertility-news/gene-manipulation-may-someday-overcome-infertility-caused-cancer-treatments
*  INT6/EIF3E Interacts with ATM and Is Required for Proper Execution of the DNA Damage Response in Human Cells | Cancer Research
Inherited mutations in the gene encoding checkpoint kinase 2 (CHK2), a major signal transducer of DDR, are associated with an ... Germline 657del5 mutation in the NBS1 gene in breast cancer patients. Int J Cancer 2003;106:379-81. ... Cancer Research Online ISSN: 1538-7445. Cancer Research Print ISSN: 0008-5472. Journal of Cancer Research ISSN: 0099-7013. ... and NBS1 genes are all considered as hereditary breast cancer susceptibility genes as well (16-18). However, approximately 70% ...
  http://cancerres.aacrjournals.org/content/72/8/2006.long
*  Difference between revisions of "BME103:T130 Group 3" - OpenWetWare
The SNP is located on the 22nd chromosome and affects the gene checkpoint kinase 2. The sequence of this gene is:. ... DNA can contain a certain sequence located on a gene that has been linked with having the disease of cancer. Only one copy of ... DNA can contain a certain sequence located on a gene that has been linked to the disease of cancer. Only one copy of this ... DNA can contain a certain sequence located on a gene that has been linked to the disease of cancer. Only one copy of this ...
  https://openwetware.org/wiki/?title=BME103:T130_Group_3&diff=656695&oldid=656607
*  BME103:T130 Group 3 - OpenWetWare
The SNP is located on the 22nd chromosome and affects the gene checkpoint kinase 2. The sequence of this gene is:. ... DNA can contain a certain sequence located on a gene that has been linked with having the disease of cancer. Only one copy of ... Proportion of cancer patients with positive results, within the group of ALL patients with positive results:. A/(A+C). =80/(80+ ... The presence of amplified DNA means that the patient is positive for the cancer marker. Reliability (Baye's Rule) Explanation: ...
  https://openwetware.org/wiki/?title=BME103:T130_Group_3&oldid=655673
*  Difference between revisions of "BME103 s2013:T900 Group2 L3" - OpenWetWare
Furthermore, This SNP is a variant of the CHEK2 gene (Checkpoint kinase 2) which if present in a person's genome may increase ... Cancer allele forward primer: -, TTGAGAATG[TCA]CGTATGTAT Cancer allele reverse primer: -, AACTCTTAC[AGT]GCATACATA ... Calculation 3: The probability that the patient will develop cancer, given a cancer DNA sequence.. ... For example, this mutation would alter the normal alelle ATT and the middle position resulting the cancer associated allele ACT ...
  https://openwetware.org/wiki/?title=BME103_s2013:T900_Group2_L3&diff=prev&oldid=691692
*  Integrated genomic analysis identifies the mitotic checkpoint kinase WEE1 as a novel therapeutic target in medulloblastoma |...
Gene expression profiling in 16 medulloblastoma patient samples and subsequent gene set enrichment analysis indicated that cell ... RNA interference (RNAi)-mediated knockdown of WEE1 kinase and other mitotic kinases was sufficient to reduce medulloblastoma ... In addition a kinome-wide small interfering RNA (siRNA) screen was performed to identify kinases that, when inhibited, could ... Taken together, these findings highlight mitotic kinases and, in particular, WEE1 as a rational therapeutic target for ...
  https://molecular-cancer.biomedcentral.com/articles/10.1186/1476-4598-13-72
*  Detecting differential allelic expression using high-resolution melting curve analysis: application to the breast cancer...
Though CHEK2 has been identified as an intermediate breast cancer susceptibility gene, only a small proportion of high-risk ... We aimed to assess whether CHEK2 was subject to DAE in lymphoblastoid cell lines (LCLs) from high-risk breast cancer patients ... Alteration in gene expression regulation provides a potential mechanism for generating disease susceptibility. The detection of ... This approach would be of great interest for high-throughput mutation screening projects aiming to identify genes carrying ...
  https://bmcmedgenomics.biomedcentral.com/articles/10.1186/1755-8794-4-39
*  Difference between revisions of "BME103 s2013:T900 Group4 L3" - OpenWetWare
CHEK2 is a gene located at chromosome 22. It provides instructions for making protein called checkpoint kinase 2, a tumor ... Mutations of CHEK2 gene can lead to breast cancer, Li-Fraumeni syndrome, and other type cancers and diseases. . The mutation ... CHEK2 is a gene located at chromosome 22. It provides instructions for making protein called checkpoint kinase 2, a tumor ... CHEK2 is a gene located at chromosome 22. It provides instructions for making protein called checkpoint kinase 2, a tumor ...
  https://openwetware.org/wiki/?title=BME103_s2013:T900_Group4_L3&diff=prev&oldid=691969
*  Plus it
The concomitant down-regulation of mitotic checkpoint genes and the induction of DNA damage by SDX-105 may amplify the ... Cancer Research Online ISSN: 1538-7445. Cancer Research Print ISSN: 0008-5472. Journal of Cancer Research ISSN: 0099-7013. ... and Aurora A kinase (AurkA) are down-regulated in SU-DHL-1, SU-DHL-9 and Daudi cells after 8 hours of exposure to clinically ... Your Name) has forwarded a page to you from Cancer Research Message Body (Your Name) thought you would be interested in this ...
  http://cancerres.aacrjournals.org/content/65/9_Supplement/538.1
*  DNA repair - Wikipedia
... and some genes are involved in both DNA damage repair and cell cycle checkpoint control, for example ATM and checkpoint kinase ... The gene designations shown in red, gray or cyan indicate genes frequently epigenetically altered in various types of cancers. ... An intra-S checkpoint also exists. Checkpoint activation is controlled by two master kinases, ATM and ATR. ATM responds to DNA ... Red-highlighted genes are frequently reduced or silenced by epigenetic mechanisms in various cancers. When these genes have low ...
  https://en.wikipedia.org/wiki/DNA_repair
*  BRCA and beyond: the genes that influence breast cancer risk
The next milestone in breast cancer genetics came in 2002 with the discovery of frameshift alteration in the checkpoint kinase ... BRCA and beyond: the genes that influence breast cancer risk. Figure 1. The loge of the breast cancer odds ratio (y-axis) is ... Although some of these putative target genes were well-known cancer genes others were not; in depth follow-up studies will be ... How many more breast cancer predisposition genes are there? Breast Cancer Res 1999; 1(1): 14-17.. 4. Kuchenbaecker KB, Hopper ...
  https://www.clinlabint.com/detail/clinical-laboratory/brca-and-beyond-the-genes-that-influence-breast-cancer-risk/
*  Gamma-synuclein - Wikipedia
"Breast cancer-specific gene 1 interacts with the mitotic checkpoint kinase BubR1". Oncogene. England. 22 (48): 7593-9. doi: ... "Blockade of AP1 transactivation abrogates the abnormal expression of breast cancer-specific gene 1 in breast cancer cells". J. ... "Identification of a breast cancer-specific gene, BCSG1, by direct differential cDNA sequencing". Cancer Res. 57 (4): 759-64. ... "Entrez Gene: SNCG synuclein, gamma (breast cancer-specific protein 1)". George JM (2002). "The synucleins". Genome Biology. 3 ( ...
  https://en.wikipedia.org/wiki/Gamma-synuclein
*  CHEK2 - Wikipedia
The CHEK2 gene encodes for checkpoint kinase 2 (CHK2), a protein that acts a tumor suppressor. CHK2 regulates cell division, ... Mutations to the CHEK2 gene have been linked to a wide range of cancers. The CHEK2 gene is located on the long (q) arm of ... "S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe". Genes ... Two more CHEK2 gene mutations, CHEK2*S428F, an amino-acid substitution to the kinase domain in exon 11 and CHEK2*P85L, an amino ...
  https://en.wikipedia.org/wiki/CHEK2
*  CKS2 CDC28 protein kinase regulatory subunit 2 [Homo sapiens (human)] - Gene - NCBI
The Cks2 gene may have potential as a biomarker for predicting superficial bladder cancer progression to muscle-invasive cancer ... leads to override of the intra-S-phase checkpoint. Title: Cyclin-dependent kinase subunit (Cks) 1 or Cks2 overexpression ... Small cell lung cancer, organism-specific biosystemLung cancer is a leading cause of cancer death among men and women in ... Small cell lung cancer, conserved biosystem (from KEGG) Small cell lung cancer, conserved biosystemLung cancer is a leading ...
  https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=1164
*  Plus it
... and radiotherapy resistance by several DNA repair and damage checkpoint genes (e.g. BRCA2 (breast cancer 2), CHEK1 (checkpoint ... Global gene expression profiling of pleural mesotheliomas: overexpression of aurora kinases and P16/CDKN2A deletion as ... Second cancers among 40,576 testicular cancer patients: focus on long-term survivors. J Natl Cancer Inst 2005; 97: 1354-1365. ... Gene expression profiling of malignant mesothelioma cell lines: cDNA array study. Int J Cancer 2001; 91: 492-496. ...
  http://err.ersjournals.com/content/24/135/115
*  Cancer cells - definition of Cancer cells by The Free Dictionary
Cancer cells synonyms, Cancer cells pronunciation, Cancer cells translation, English dictionary definition of Cancer cells. ... cells once believed to be peculiar to cancers, but now know to be epithelial cells differing in no respect from those found ... Nasdaq: ARQL) today announced that the direct activation of the human checkpoint kinase 2 (Chk2) caused the death of cancer ... The strategy is to introduce to a tumor site a gene encoding a toxin that can kill cancer cells.. Infectious Notion ...
  http://www.thefreedictionary.com/Cancer+cells