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*  Novel and existing mutations in the tyrosine kinase domain of the epidermal growth factor receptor are predictors of optimal...
a change; a change in a gene.. oncology. (on-call-o-jee) the branch of medicine concerned with the diagnosis and treatment of ... The EGFR mutations identified included the L858R activating mutation, as well as eight novel EGFR-TK catalytic domain point ... epidermal growth factor receptor. The process of cell division, growth, differentiation and death is a highly regulated process ... Several class of trans membrane receptors play a pivot role in this process, of these, epidermal growth factor receptor (EGFR) ...
  http://www.mesothelioma-line.com/2008/11/11/novel-and-existing-mutations-in-the-tyrosine-kinase-domain-of-the-epidermal-growth-factor-receptor-are-predictors-of-optimal-resectability-in-malignant-peritoneal-mesothelioma/
*  Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and New Therapeutic...
MET is overexpressed, activated and sometimes mutated in NSCLC cell lines and tumor tissues. MET increased gene copy number has ... Title: Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and New Therapeutic ... Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and New Therapeutic ... MET increased gene copy number has also been documented in NSCLC and has been studied as negative prognostic factor. It has ...
  http://www.eurekaselect.com/73933/article
*  Clinical Utility of Serum Human Epidermal Growth Factor Receptor Type 2 Testing as a Marker of Therapeutic Response In Tissue...
Human Epidermal growth factor Receptor type 2 (HER2) is over expressed in 20.0-30.0% of breast cancers and is currently ... HER2 functions as a transmembrane receptor and tyrosine kinase that is activated by the binding of its ligand to the ECD and ... HER2 overexpression occurs in 20.0-30.0% of breast cancers, usually as a result of gene amplification [4,5], and is associated ... Human epidermal growth factor receptor type 2, Serum marker, Therapeutic response Abbreviations. HER2: Human Epidermal Growth ...
  https://www.clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-4-089.php?jid=ijccr
*  Lysophosphatidylcholine Increases Expression of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Human T...
To examine whether IL-2 is necessary for HB-EGF and IL-2 receptor gene upregulation elicited by lyso-PC in T cells, we excluded ... Platelet-activating factor stimulates transcription of the heparin-binding epidermal growth factor-like growth factor in ... Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in ... can upregulate gene expression and secretion of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in cultured ...
  http://circres.ahajournals.org/content/80/5/638
*  Study of Erlotinib (Tarceva®) in Combination With OSI-906 in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) With...
With Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene. The safety and scientific validity of this study ... With Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene. Official Title ICMJE A Randomized, Double-Blind ... with Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene who are Chemonaive.. ... OSI-906 or Placebo in Chemonaive Patients With Advanced NSCLC With Activating Mutations of the Epidermal Growth Factor Receptor ...
  https://clinicaltrials.gov/ct2/show/record/NCT01221077
*  Plus it
Top1 has also been suggested to activate transcription of specific genes [including epidermal growth factor receptor (EGFR)] by ... in the case of the epidermal growth factor receptor (EGFR) gene, whose expression has been reported to be positively regulated ... DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell ... The two other up-regulated genes, CD59 and GIP3, both encode factors that protect cells ( 44, 45). We also found the ...
  http://cancerres.aacrjournals.org/content/67/18/8752
*  Challenges to targeting epidermal growth factor receptor in glioblastoma: escape mechanisms and combinatorial treatment...
Epidermal growth factor receptor (EGFR) gene amplification and activating mutations are common findings in glioblastomas. EGFR ... Epidermal growth factor receptor (EGFR) gene amplification and activating mutations are common findings in glioblastomas. EGFR ... Roth, P; Weller, M (2014). Challenges to targeting epidermal growth factor receptor in glioblastoma: escape mechanisms and ... Challenges to targeting epidermal growth factor receptor in glioblastoma: escape mechanisms and combinatorial treatment ...
  http://www.zora.uzh.ch/id/eprint/100316/
*  Medline ® Abstract for Reference 8 of 'Overview of the treatment of advanced non-small cell lung cancer'
... the efficacy of erlotinib in this setting and its association with activating mutations in the epidermal growth factor receptor ... this clinical benefit is related to the presence of activating mutations in exons 19 or 21 of the EGFR gene. ... EGFR) gene. We retrospectively identified patients with NSCLC and brain metastases treated with erlotinib. EGFR mutations in ...
  http://www.uptodate.com/contents/overview-of-the-treatment-of-advanced-non-small-cell-lung-cancer/abstract/8
*  Gene Info
BP] negative regulation of epidermal growth factor-activated receptor activity *[BP] negative regulation of neuron apoptotic ... BP] nerve growth factor receptor signaling pathway *[BP] neuron apoptotic process *[BP] neuron development *[BP] neuron ... Entrez Gene. OMIM. Ensembl Gene. HPRD. Vega. DTP. SNP. SNP: GeneView. SNP: VarView. Assemblies. RNAi. ... Gene Expression Data. *This gene is found in these cDNA libraries from the following tissue types: b-cell, bone, bone marrow, ...
  https://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=3260
*  CHMP6 Gene - GeneCards | CHMP6 Protein | CHMP6 Antibody
Complete information for CHMP6 gene (Protein Coding), Charged Multivesicular Body Protein 6, including: function, proteins, ... negative regulation of epidermal growth factor-activated receptor activity. IMP. 16973552. Genes that share ontologies with ... No data available for DME Specific Peptides for CHMP6 Gene Domains & Families for CHMP6 Gene Gene Families for CHMP6 Gene. HGNC ... Summaries for CHMP6 Gene Entrez Gene Summary for CHMP6 Gene. * This gene encodes a member of the chromatin-modifying protein/ ...
  https://www.genecards.org/cgi-bin/carddisp.pl?id_type=entrezgene&id=79643
*  Ncf1 - Neutrophil cytosol factor 1 - Mus musculus (Mouse) - Ncf1 gene & protein
positive regulation of epidermal growth factor-activated receptor activity Source: MGI. *positive regulation of JNK cascade ... Neutrophil cytosol factor 1Add BLAST. 390. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ... GO (Gene Ontology) annotation. *. Cytosol. *cytosol 1 Publication. ,p>Manually curated information for which there is published ... p>This subsection of the 'Names and taxonomy' section indicates the name(s) of the gene(s) that code for the protein sequence(s ...
  http://www.uniprot.org/uniprot/Q09014
*  Zfyve28 - Lateral signaling target protein 2 homolog - Mus musculus (Mouse) - Zfyve28 gene & protein
Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when ... negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB. *negative regulation of epidermal ... Negative regulator of epidermal growth factor receptor (EGFR) signaling. Acts by promoting EGFR degradation in endosomes when ... Gene expression databases. Bgee dataBase for Gene Expression Evolution. More...Bgeei. ENSMUSG00000037224 Expressed in 104 organ ...
  https://www.uniprot.org/uniprot/Q6ZPK7
*  VPS25 - Vacuolar protein-sorting-associated protein 25 - Homo sapiens (Human) - VPS25 gene & protein
negative regulation of epidermal growth factor-activated receptor activity Source: UniProtKB ,p>Inferred from Mutant Phenotype ... Gene expression databases. Bgee dataBase for Gene Expression Evolution. More...Bgeei. ENSG00000131475 Expressed in 193 organ(s ... based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.,p>,a href='/help/gene_centric_isoform_ ... Gene expression databases. Bgeei. ENSG00000131475 Expressed in 193 organ(s), highest expression level in cortex of kidney. ...
  https://www.uniprot.org/uniprot/Q9BRG1
*  Frontiers | Historical Evolution of Second-Line Therapy in Non-Small Cell Lung Cancer | Medicine
Patients who carry activating mutations in the epidermal growth factor receptor gene (EGFR) or translocations in the anaplastic ... Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to ... Table 2. Clinical trials exploring epidermal growth factor receptor gene-tyrosine kinase inhibitors with second-line ... hindering the vascular endothelial growth factor receptor (VEGFR1-3), the FGFR1-3, the platelet-derived growth factor receptors ...
  https://www.frontiersin.org/articles/10.3389/fmed.2017.00004/full
*  Epidermal growth factor receptor signalling in keratinocyte biology: implications for skin toxicity of tyrosine kinase...
... and its ligands have been long recognized as centrally involved in the growth and repair process of epithelia, as well as in ... Taus A, Vollmer I, Arriola E (2011) Activating and resistance mutations of the epidermal growth factor receptor (EGFR) gene and ... The epidermal growth factor receptor (EGFR) and its ligands have been long recognized as centrally involved in the growth and ... Pastore S, Mascia F, Mariani V, Girolomoni G (2002) Epidermal growth factor receptor ligands and tumor necrosis factor-alpha ...
  https://link.springer.com/article/10.1007%2Fs00204-014-1244-4
*  Amphiregulin activates PTHrP gene expression through the P1-promoter in hypercalcemia inducing lung squamous cell carcinomas |...
The epidermal growth factor receptor (EGFR) has been implicated in activating PTHrP gene expression in lung and breast cancer, ... transforming growth factor-α (TGFα), and heparin binding-epidermal growth factor (HB-EGF). AREG transcript levels were at least ... Amphiregulin activates PTHrP gene expression through the P1-promoter in hypercalcemia inducing lung squamous cell carcinomas. ... Gene Regulation and Promoter Studies: Poster Presentations - Proffered Abstracts. *. KLF8 activates transcription by recruiting ...
  http://cancerres.aacrjournals.org/content/68/9_Supplement/82
*  A gene-alteration profile of human lung cancer cell lines. - Semantic Scholar
... epidermal growth factor receptor (EGFR), NRAS, and ERBB2 were seen. Moreover, in non-small-cell lung cancer (NSCLC), ... In conclusion, our gene-alteration landscape of lung cancer cell lines provides insights into how gene alterations accumulate ... Here we derived a comprehensive gene-alteration profile of lung cancer cell lines. We tested 17 genes in a panel of 88 lung ... Cells with single activation of ERBB2, PTEN, or MET signaling showed greater sensitivity to cell-growth inhibition induced by ...
  https://www.semanticscholar.org/paper/A-gene-alteration-profile-of-human-lung-cancer-cell-Blanco-Iwakawa/8fc249404e23a3d515787a4ac7cb382d2dfbee7f
*  MEK Inhibitor for Gastric Cancer with MEK1 Gene Mutations | Molecular Cancer Therapeutics
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to ... Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung ... The identification of additional oncogenes with influences similar to those of epidermal growth factor receptor gene mutations ... Fibroblast growth factor receptor 2 gene (FGFR2) or MET gene (MET) amplification has been also regarded as a potential target ...
  http://mct.aacrjournals.org/content/13/12/3098
*  Highly parallel identification of essential genes in cancer cells | Proceedings of the National Academy of Sciences
2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to ... Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non-Small Cell ... S11). The second-best-scoring gene was CDK4 (P = 0.014; Fig. 3B), which modulates the p16INK4a-cyclin D1-CDK4-RB growth ... For example, 530 genes ranked in the top 5% for essentiality in 5 or more cell lines, whereas only 2 genes would be expected if ...
  http://www.pnas.org/content/105/51/20380
*  Organizing knowledge to enable personalization of medicine in cancer | Genome Biology | Full Text
To list just two groundbreaking examples, activating mutations in the epidermal growth factor receptor gene EGFR were linked to ... Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to ... Genomic events and the genes or pathways that they affect must be placed in the context of drug-gene or drug-variant ... Good BM, Clarke EL, de Alfaro L, Su AI: The Gene Wiki in 2011: community intelligence applied to human gene annotation. Nucleic ...
  https://genomebiology.biomedcentral.com/articles/10.1186/s13059-014-0438-7
*  Genes associated with progression of melanoma identified
Examples included the pathways mediated by mitogen-activated protein (MAP) kinase and epidermal growth factor receptor (EGFR). ... "This yeast's genome has 6,000 genes, and a different gene has been knocked out in each of these mutants, so we were able to ... Genes associated with progression of melanoma identified. December 7, 2017, FAPESP Screening used synthetic curcumin-like ... and the Gene Expression Omnibus (GEO), to understand how these genes talked to each other," Oliveira said. ...
  https://medicalxpress.com/news/2017-12-genes-melanoma.html
*  Overcoming Drug Resistance to Targeted Cancer Therapies - Massachusetts General Hospital, Boston, MA
... mitogen-activated protein kinase/Erk kinase), and EGFR (epidermal growth factor receptor) genes. ... 2010). BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E ... For example, approximately half of patients with lung cancers that have the ALK gene rearrangement relapse within 10 months. ... 60%: Approximate percentage of patients with tumors known to harbor rearrangements of the ALK (anaplastic lymphoma kinase) gene ...
  http://www.massgeneral.org/cancer/news/newsarticle.aspx?id=2971
*  Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging...
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to ... Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the ... best exemplified by the observation that patients with lung cancer harboring mutations in the epidermal growth factor receptor ... EGFR) gene respond rather dramatically to agents that target this receptor (6). This relationship was discovered only after ...
  http://mct.aacrjournals.org/content/10/1/3
*  Role of nitric oxide, Src kinases in lung cancer could provide treatment answer - Healthcanal.com : Healthcanal.com
... and they found the gene for Src in the cell becomes activated when it associates with epidermal growth factor receptor. The ... Such cancers require activation of the epidermal growth factor receptor, said Dr. Tony Eissa, professor of medicine - pulmonary ... In particular, patients who become resistant to erlotinib (the drug that blocks epidermal growth factor receptor) might be ... "This response is often followed by disease recurrence because the epidermal growth factor receptors mutate and become resistant ...
  https://www.healthcanal.com/medical-breakthroughs/4804-role-of-nitric-oxide-src-kinases-in-lung-cancer-could-provide-treatment-answer.html
*  Detection of Mutations in EGFR in Circulating Lung-Cancer Cells
Tumor-associated activating mutations in the epidermal growth factor receptor (EGFR) gene identify patients with non-small-cell ... Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer. Cancer Res. ... Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the ... Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3551471/?lang=en-ca