*  Novel and existing mutations in the tyrosine kinase domain of the epidermal growth factor receptor are predictors of optimal...
a change; a change in a gene.. oncology. (on-call-o-jee) the branch of medicine concerned with the diagnosis and treatment of ... The EGFR mutations identified included the L858R activating mutation, as well as eight novel EGFR-TK catalytic domain point ... epidermal growth factor receptor. The process of cell division, growth, differentiation and death is a highly regulated process ... Several class of trans membrane receptors play a pivot role in this process, of these, epidermal growth factor receptor (EGFR) ...
  http://www.mesothelioma-line.com/2008/11/11/novel-and-existing-mutations-in-the-tyrosine-kinase-domain-of-the-epidermal-growth-factor-receptor-are-predictors-of-optimal-resectability-in-malignant-peritoneal-mesothelioma/
*  Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and New Therapeutic...
MET is overexpressed, activated and sometimes mutated in NSCLC cell lines and tumor tissues. MET increased gene copy number has ... Title: Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and New Therapeutic ... Mechanisms of Acquired Resistance to Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors and New Therapeutic ... MET increased gene copy number has also been documented in NSCLC and has been studied as negative prognostic factor. It has ...
  http://www.eurekaselect.com/73933/article
*  Clinical Utility of Serum Human Epidermal Growth Factor Receptor Type 2 Testing as a Marker of Therapeutic Response In Tissue...
Human Epidermal growth factor Receptor type 2 (HER2) is over expressed in 20.0-30.0% of breast cancers and is currently ... HER2 functions as a transmembrane receptor and tyrosine kinase that is activated by the binding of its ligand to the ECD and ... HER2 overexpression occurs in 20.0-30.0% of breast cancers, usually as a result of gene amplification [4,5], and is associated ... Human epidermal growth factor receptor type 2, Serum marker, Therapeutic response Abbreviations. HER2: Human Epidermal Growth ...
  https://www.clinmedjournals.org/articles/ijccr/international-journal-of-cancer-and-clinical-research-ijccr-4-089.php?jid=ijccr
*  Lysophosphatidylcholine Increases Expression of Heparin-Binding Epidermal Growth Factor-Like Growth Factor in Human T...
To examine whether IL-2 is necessary for HB-EGF and IL-2 receptor gene upregulation elicited by lyso-PC in T cells, we excluded ... Platelet-activating factor stimulates transcription of the heparin-binding epidermal growth factor-like growth factor in ... Tumor necrosis factor increases transcription of the heparin-binding epidermal growth factor-like growth factor gene in ... can upregulate gene expression and secretion of heparin-binding epidermal growth factor-like growth factor (HB-EGF) in cultured ...
  http://circres.ahajournals.org/content/80/5/638
*  Study of Erlotinib (Tarceva®) in Combination With OSI-906 in Patients With Advanced Non-small Cell Lung Cancer (NSCLC) With...
With Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene. The safety and scientific validity of this study ... With Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene. Official Title ICMJE A Randomized, Double-Blind ... with Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene who are Chemonaive.. ... OSI-906 or Placebo in Chemonaive Patients With Advanced NSCLC With Activating Mutations of the Epidermal Growth Factor Receptor ...
  https://clinicaltrials.gov/ct2/show/record/NCT01221077
*  Challenges to targeting epidermal growth factor receptor in glioblastoma: escape mechanisms and combinatorial treatment...
Epidermal growth factor receptor (EGFR) gene amplification and activating mutations are common findings in glioblastomas. EGFR ... Epidermal growth factor receptor (EGFR) gene amplification and activating mutations are common findings in glioblastomas. EGFR ... Roth, P; Weller, M (2014). Challenges to targeting epidermal growth factor receptor in glioblastoma: escape mechanisms and ... Challenges to targeting epidermal growth factor receptor in glioblastoma: escape mechanisms and combinatorial treatment ...
  http://www.zora.uzh.ch/id/eprint/100316/
*  Plus it
Top1 has also been suggested to activate transcription of specific genes [including epidermal growth factor receptor (EGFR)] by ... in the case of the epidermal growth factor receptor (EGFR) gene, whose expression has been reported to be positively regulated ... DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell ... The two other up-regulated genes, CD59 and GIP3, both encode factors that protect cells ( 44, 45). We also found the ...
  http://cancerres.aacrjournals.org/content/67/18/8752
*  Gene Info
BP] negative regulation of epidermal growth factor-activated receptor activity *[BP] negative regulation of neuron apoptotic ... BP] nerve growth factor receptor signaling pathway *[BP] neuron apoptotic process *[BP] neuron development *[BP] neuron ... Entrez Gene. OMIM. Ensembl Gene. HPRD. Vega. DTP. SNP. SNP: GeneView. SNP: VarView. Assemblies. RNAi. ... Gene Expression Data. *This gene is found in these cDNA libraries from the following tissue types: b-cell, bone, bone marrow, ...
  https://cgap.nci.nih.gov/Genes/GeneInfo?ORG=Hs&CID=3260
*  Medline ® Abstract for Reference 8 of 'Overview of the treatment of advanced non-small cell lung cancer'
... the efficacy of erlotinib in this setting and its association with activating mutations in the epidermal growth factor receptor ... this clinical benefit is related to the presence of activating mutations in exons 19 or 21 of the EGFR gene. ... EGFR) gene. We retrospectively identified patients with NSCLC and brain metastases treated with erlotinib. EGFR mutations in ...
  http://www.uptodate.com/contents/overview-of-the-treatment-of-advanced-non-small-cell-lung-cancer/abstract/8
*  Ncf1 - Neutrophil cytosol factor 1 - Mus musculus (Mouse) - Ncf1 gene & protein
positive regulation of epidermal growth factor-activated receptor activity Source: MGI. *positive regulation of JNK cascade ... Neutrophil cytosol factor 1Add BLAST. 390. Amino acid modifications. Feature key. Position(s). DescriptionActions. Graphical ... GO (Gene Ontology) annotation. *. Cytosol. *cytosol 1 Publication. ,p>Manually curated information for which there is published ... p>This subsection of the 'Names and taxonomy' section indicates the name(s) of the gene(s) that code for the protein sequence(s ...
  http://www.uniprot.org/uniprot/Q09014
*  Amphiregulin activates PTHrP gene expression through the P1-promoter in hypercalcemia inducing lung squamous cell carcinomas |...
The epidermal growth factor receptor (EGFR) has been implicated in activating PTHrP gene expression in lung and breast cancer, ... transforming growth factor-α (TGFα), and heparin binding-epidermal growth factor (HB-EGF). AREG transcript levels were at least ... Amphiregulin activates PTHrP gene expression through the P1-promoter in hypercalcemia inducing lung squamous cell carcinomas. ... Gene Regulation and Promoter Studies: Poster Presentations - Proffered Abstracts. *. KLF8 activates transcription by recruiting ...
  http://cancerres.aacrjournals.org/content/68/9_Supplement/82
*  Frontiers | Historical Evolution of Second-Line Therapy in Non-Small Cell Lung Cancer | Medicine
Patients who carry activating mutations in the epidermal growth factor receptor gene (EGFR) or translocations in the anaplastic ... Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to ... Table 2. Clinical trials exploring epidermal growth factor receptor gene-tyrosine kinase inhibitors with second-line ... hindering the vascular endothelial growth factor receptor (VEGFR1-3), the FGFR1-3, the platelet-derived growth factor receptors ...
  https://www.frontiersin.org/articles/10.3389/fmed.2017.00004/full
*  MEK Inhibitor for Gastric Cancer with MEK1 Gene Mutations | Molecular Cancer Therapeutics
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to ... Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung ... The identification of additional oncogenes with influences similar to those of epidermal growth factor receptor gene mutations ... Fibroblast growth factor receptor 2 gene (FGFR2) or MET gene (MET) amplification has been also regarded as a potential target ...
  http://mct.aacrjournals.org/content/13/12/3098
*  Highly parallel identification of essential genes in cancer cells | Proceedings of the National Academy of Sciences
2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to ... Amplification of CRKL Induces Transformation and Epidermal Growth Factor Receptor Inhibitor Resistance in Human Non-Small Cell ... S11). The second-best-scoring gene was CDK4 (P = 0.014; Fig. 3B), which modulates the p16INK4a-cyclin D1-CDK4-RB growth ... For example, 530 genes ranked in the top 5% for essentiality in 5 or more cell lines, whereas only 2 genes would be expected if ...
  http://www.pnas.org/content/105/51/20380
*  Genes associated with progression of melanoma identified
Examples included the pathways mediated by mitogen-activated protein (MAP) kinase and epidermal growth factor receptor (EGFR). ... "This yeast's genome has 6,000 genes, and a different gene has been knocked out in each of these mutants, so we were able to ... Genes associated with progression of melanoma identified. December 7, 2017, FAPESP Screening used synthetic curcumin-like ... and the Gene Expression Omnibus (GEO), to understand how these genes talked to each other," Oliveira said. ...
  https://medicalxpress.com/news/2017-12-genes-melanoma.html
*  SNX1 Gene - GeneCards | SNX1 Protein | SNX1 Antibody
Complete information for SNX1 gene (Protein Coding), Sorting Nexin 1, including: function, proteins, disorders, pathways, ... This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role ... Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/ ... No data available for DME Specific Peptides for SNX1 Gene Domains & Families for SNX1 Gene Gene Families for SNX1 Gene. HGNC:. ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=SNX1
*  Personalizing Cancer Treatment in the Age of Global Genomic Analyses: PALB2 Gene Mutations and the Response to DNA Damaging...
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to ... Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the ... best exemplified by the observation that patients with lung cancer harboring mutations in the epidermal growth factor receptor ... EGFR) gene respond rather dramatically to agents that target this receptor (6). This relationship was discovered only after ...
  http://mct.aacrjournals.org/content/10/1/3
*  Cancers | Free Full-Text | Reinventing Diagnostics for Personalized Therapy in Oncology | HTML
Both factors are giving rise to attempts to correlate tumor characteristics and response to specific adjuvant and neoadjuvant ... Only 25% of cancer patients, on average, benefit from therapy as most therapies do not account for individual factors that ... Mutation of Tyrosine Kinase Domains in the Epidermal Growth Factor Receptor (EGFR) Gene. Acquired activating mutations in the ... Approximately 60 loci containing genes associated with the epidermal growth factor family (epidermal growth factor receptor, ...
  http://www.mdpi.com/2072-6694/2/2/1066/htm
*  Overcoming Drug Resistance to Targeted Cancer Therapies - Massachusetts General Hospital, Boston, MA
... mitogen-activated protein kinase/Erk kinase), and EGFR (epidermal growth factor receptor) genes. ... 2010). BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E ... For example, approximately half of patients with lung cancers that have the ALK gene rearrangement relapse within 10 months. ... 60%: Approximate percentage of patients with tumors known to harbor rearrangements of the ALK (anaplastic lymphoma kinase) gene ...
  http://www.massgeneral.org/cancer/news/newsarticle.aspx?id=2971
*  CA2069900C - Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor - Google Patents
... and erbB-2 genes was detected by reduced stringency hybridization of v-erbB to normal genomic human DNA. Characterization of ... prompting designation of the new gene as erbB-3. It was mapped to human chromosome 12q11-13 and was shown to be expressed as ... A DNA fragment distinct from the epidermal growth factor receptor (EGF-R) ... In g~articular, both the erbB and erbB-2 genes have been shown to be activated as oncogenes by mechanisms involving over- ...
  https://patents.google.com/patent/CA2069900C
*  Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients | Cancer Research
Activating epidermal growth factor receptor (EGFR) mutations are common in many cancers including glioblastoma. However, ... promoting tumor growth and motility. Gene silencing of Fyn and Src limited EGFR- and EGFRvIII-dependent tumor cell motility. ... mouse model can be achieved by targeting epidermal growth factor receptor but not vascular endothelial growth factor receptor-2 ... Phosphorylation of platelet-derived growth factor receptor and c-Met by platelet-derived growth factor and hepatocyte growth ...
  http://cancerres.aacrjournals.org/content/69/17/6889
*  Detection of Mutations in EGFR in Circulating Lung-Cancer Cells
Tumor-associated activating mutations in the epidermal growth factor receptor (EGFR) gene identify patients with non-small-cell ... Presence of epidermal growth factor receptor gene T790M mutation as a minor clone in non-small cell lung cancer. Cancer Res. ... Epidermal growth factor receptor mutations and gene amplification in non-small-cell lung cancer: molecular analysis of the ... Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3551471/?lang=en-ca
*  EP0502927A4 - Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor - Google...
Activated her3 as a marker for predicting therapeutic efficacy KR101598229B1 (en) * 2007-02-16. 2016-02-26. 메리맥 파마슈티컬즈, 인크.. ... Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor Info. Publication number. ... EP19910900108 1989-12-01 1990-11-30 Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor ... Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor ...
  https://patents.google.com/patent/EP0502927A4
*  Plus it
This gene encodes the receptor of the growth factors epidermal growth factor and TGF-α. Ligand binding to the extracellular ... domain of the EGFR causes receptor dimerization, which activates tyrosine kinase function. This leads to autophosphorylation ... Grandis J. R., Tweardy D. J. Elevated levels of transforming growth factor α and epidermal growth factor receptor messenger RNA ... epidermal growth factor receptor; TGF-α, transforming growth factor α; LOH, loss of heterozygosity; CDK, cyclin-dependent ...
  http://cebp.aacrjournals.org/content/9/3/249
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Receptor, Epidermal Growth Factor, Actins, Fluorescence, Endocytosis, Microscopy, STORM, super-resolution microscopy, nanoscopy ... Neural immune gene expression variables are measured with qPCR screening, qPCR arrays, and, importantly, use of cDNA ... thereby activating intracellular Ca2+ release units (CRUs). In contrast to VMs, the organization and functional role of TATS ... cell biology, fluorescence microscopy, test samples, resolution, actin filaments, fiducial markers, epidermal growth factor, ...
  https://www.jove.com/visualize/abstract/23300962/long-term-in-vivo-imaging-of-multiple-organs-at-the-single-cell-level