Role for 17-beta-HSDXI in androgen metabolism during steroidogenesis. Title: 17 beta-hydroxysteroid dehydrogenase type XI ... 17-beta-hydroxysteroid dehydrogenase type XI. CTCL tumor antigen HD-CL-03. CTCL-associated antigen HD-CL-03. cutaneous T-cell ... 17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs. ... Gene Ontology Provided by GOA Function. Evidence Code. Pubs. enables estradiol 17-beta-dehydrogenase [NAD(P)] activity IDA ...

Two different polymorphisms of the HSD11B2 gene were observed. The association of both polymorphisms was significantly higher ... Structural analysis and evaluation of the 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) gene in human essential ... Analysis of the 11beta-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) in human essential hypertension Barbara Mariniello 1 ... Analysis of the 11beta-hydroxysteroid dehydrogenase type 2 gene (HSD11B2) in human essential hypertension Barbara Mariniello et ...

... hydroxysteroid 11-beta dehydrogenase 2 (human). Find diseases associated with this biological target and compounds tested ... Rhythm of Fetoplacental 11beta-Hydroxysteroid Dehydrogenase Type 2 - Fetal Protection From Morning Maternal Glucocorticoids. ... Gene neighbors Overlapping genes and two nearest non-overlapping genes on either side ... Gene. Interaction. Pubs. Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of ...

... insA polymorphism in HSD1181 gene may have a protective effect against insulin resistance. ... Association between 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in Bosnian population ... Association between 11beta-hydroxysteroid dehydrogenase type 1 gene polymorphisms and metabolic syndrome in Bosnian population ... Introduction: The enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) catalyzes the conversion of the hormonally ...

... adrenal cortex and aldosterone secreting adenomas express both 11beta-hydroxysteroid dehydrogenase type 1 and type 2 genes". ... Pácha J, Lisá V, Miksík I (February 2002). "Effect of cellular differentiation on 11beta-hydroxysteroid dehydrogenase activity ... Wake DJ, Walker BR (February 2006). "Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 in obesity". Endocrine. 29 (1): ... Agarwal AK (November 2003). "Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I ...

3-beta-hydroxysteroid dehydrogenase (3BHSD) deficiency is a rare genetic disorder of steroid biosynthesis that results in ... identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional ... Type I 3-beta-hydroxysteroid dehydrogenase isoenzyme is normal in patients with type II 3-beta-hydroxysteroid dehydrogenase ... 3-Beta-Hydroxysteroid Dehydrogenase Deficiency. 3-beta-hydroxysteroid dehydrogenase (3BHSD) is required for the synthesis of ...

Gene Expression Regulation, Enzymologic*; Humans; Kinetics; Oxidoreductases/chemistry*; Oxidoreductases/genetics; ... MeSH Terms: 11-beta-Hydroxysteroid Dehydrogenase Type 1/antagonists & inhibitors; 11-beta-Hydroxysteroid Dehydrogenase Type 1/ ... 11-beta-Hydroxysteroid Dehydrogenase Type 1/genetics; 11-beta-Hydroxysteroid Dehydrogenase Type 1/metabolism; Enzyme Inhibitors ...

A number of approaches have been taken to finding "obesity genes." Transgenic overexpression and gene deletion models have ... "candidate genes" in humans with obesity. Genome linkage studies in human populations have been less successful. The genes ... Obesity: Genes vs Environment. Note: This is the first in an occasional series of articles by Zachary T. Bloomgarden, MD, ... Genes, he pointed out, control 50% to 90% of the variation in body weight and fat content in human populations, according to ...

Mutation analysis of ARVCF gene on chromosome 22q11 as a candidate for a schizophrenia gene. Schizophr Res 72(2-3):275- ... Effect of metallothionein 2A gene polymorphism on allele-specific gene expression and metal content in prostate cancer. Toxicol ... Placenta-imprinted gene expression association of infant neurobehavior. J Pediatr 160(5):854-860.e222153677. Crossref, Medline ... Zinc finger genes Fezf1 and Fezf2 control neuronal differentiation by repressing Hes5 expression in the forebrain. Development ...

Cortisol-secreting adrenal adenomas express 11beta-hydroxysteroid dehydrogenase type-2 gene yet possess low 11beta-HSD2 ... 6. Inhibition of 11beta-hydroxysteroid dehydrogenase eliminates impaired glucocorticoid suppression and induces apoptosis in ... 3. Expression of genes related to corticotropin production and glucocorticoid feedback in corticotroph adenomas of dogs with ... Role of local 11 beta-hydroxysteroid dehydrogenase type 2 expression in determining the phenotype of adrenal adenomas.. Mune T ...

Three genes separately encode the "tissue-specific" ALPs whereas the fourth gene encodes ubiquitous homodimeric "tissue- ... We analyzed tissue myeloperoxidase (MPO) activity, serum pro-inflammatory cytokines (IL-1 beta, IL-6 and TNF), mRNA and protein ... lactate dehydrogenase, and magnesium compared with gel tubes. Maximal allowable bias for phosphate was exceeded after 68 hours ... A significant dysregulation of gene expression for CRH, AVP, and HSD11B2 genes was seen in the Index group, compared to ...

Study the regulatory genes and pathways that control embryonic development *Evolution of the Hox gene, which has undergone ... Global analysis of gene expression in the neuroendocrine system. * Identifying those genes involved in regulating growth and ... Nutrient control of gene expression. *Elucidation of the mechanisms responsible for the altered gene expression modulated by ... to detecting gene-gene interactions, and to integrating a variety of biological knowledge from genetic, genomic, and epigenetic ...

3-beta hydroxysteroid dehydrogenase deficiency, and 17 alpha-hydroxylase/17,20-lyase deficiency are generally not characterized ... Type 1 GFND maps to chromosome 1q32, but the gene is unknown at this time. Type 2 GFND is caused by mutations in the FN1 gene ... Beta-adrenergic agonists enhance potassium entry into cells, whereas beta-blockers and alpha-adrenergic agonists inhibit it. ... The genes causing this disorder code for protein kinases that are localized to the distal tubule and that regulate ion ...

GENE-EXPRESSION, SEPTIC SHOCK, GLUCOCORTICOID METABOLISM, BRAIN 5-ALPHA-REDUCTASE", ... keywords = "glucocorticoids, 5 alpha-reductases, adrenal insufficiency, HPA axis, CORTICOTROPIN-RELEASING HORMONE, 11-BETA- ... HYDROXYSTEROID DEHYDROGENASE TYPE-1, CORTISONE REDUCTASE DEFICIENCY, POLYCYSTIC-OVARY-SYNDROME, HYPOTHALAMIC PARAVENTRICULAR ...

hydroxysteroid 11-beta dehydrogenase 1 163 0.520. 0.731. 0.42. 0.600. None 0.970. 33 5 2002. 2019. ... Gene UniProt Gene Full Name Protein Class N. diseases g DSI g DPI g pLI Score gda EL gda EI gda N. PMIDs N. SNPs gda First Ref. ...

Mutants of 11beta-hydroxysteroid dehydrogenase (11-HSD2) with partial activity: improved correlations between genotype and ... A new compound heterozygous mutation in the 11 beta-hydroxysteroid dehydrogenase type 2 gene in a case of apparent ... Highest score: 11 (high probability of substitution).. More information can be found on the following page Variant description: ...

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary ... Gestational age dependence of 11 beta-hydroxysteroid dehydrogenase and its relationship to the enzymes of phosphatidylcholine ... knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound ...

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 ... hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 ... steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) ... steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) ...

... in the HSD3B2 gene, which results in decreased activity of the enzyme 3-beta-hydroxysteroid dehydrogenase. The clinical ... C120203 17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency 17-Beta-Hydroxysteroid Dehydrogenase 3 Deficiency 17 beta HSD3 ... C131088 3-Beta-Hydroxysteroid Dehydrogenase Deficiency 3-Beta-Hydroxysteroid Dehydrogenase Deficiency 3-beta HSD Deficiency ... 17-beta-hydroxysteroid dehydrogenase, associated with mutation(s) in the HSD17B3 gene, leading to reduced testosterone ...

3-beta-hydroxysteroid dehydrogenase (3BHSD) deficiency is a rare genetic disorder of steroid biosynthesis that results in ... identification of eight mutations in the HSD3B2 gene eleven patients from seven new families and comparison of the functional ... encoded search term (3-Beta-Hydroxysteroid Dehydrogenase Deficiency) and 3-Beta-Hydroxysteroid Dehydrogenase Deficiency What to ... and frameshift mutations in the type II 3-beta-hydroxysteroid dehydrogenase gene with no mutation in the type I gene. Such ...

... hydroxysteroid dehydrogenase type 2 gene in a case of apparent mineralocorticoid excess Carvajal C.A.; González A.A.; Mosso L.M ... Molecular Basis of Ligand Dissociation in beta-Adrenergic Receptors González A; Perez-Acle, T; Pardo, L; Deupi X. Article ISI ... An eleven amino acid residue deletion expands the substrate specificity of acetyl xylan esterase II (AXE II) from Penicillium ... Nuclear Receptor Genes: Evolution Saez, JP; Lange S.; Perez-Acle, T; Owen, GI BookSection (2010) ...

Global expression of Wnt signalling and target genes in response to TNFα and glucocorticoids was assessed using a custom array ... However, TNFα and IL-1β indirectly stimulated DKK1 production through increased expression of 11β-HSD1. CONCLUSIONS: These ... The ability of inflammatory cytokine-induced expression of the glucocorticoid-activating enzyme 11beta-hydroxysteroid ... dehydrogenase type 1 (11β-HSD1) to sensitise fibroblasts to endogenous glucocorticoids was explored. ...

... with smaller compacted muscle fibres and increased proinflammatory gene expression relative to TNF-Tg mice with normal 11β-HSD1 ... The contributions of 11β-HSD1 to muscle inflammation and wasting were assessed in vivo with the TNF-Tg mouse on an 11β-HSD1 ... The expression of 11β-HSD1 in response to proinflammatory stimuli was determined in a transgenic murine model of chronic ... 11β-HSD1 was significantly upregulated within the tibialis anterior and quadriceps muscles from TNF-Tg mice. In human and ...

We recently established that cortisone reductase deficiency is a digenic disease requiring mutations in both the gene encoding ... hexose-6-phosphate dehydrogenase (H6PDH). This latter enzyme generates NADPH, the co-factor required for oxo-reductase activity ... glucose-6-phosphate dehydrogenase (G6PD) affect 11 beta-HSD1 oxo-reductase activity. Conversely in HEK 293 cells stably ... acts only as a dehydrogenase, converting cortisol to cortisone. 11 beta-HSD1 (liver) is a bi-directional enzyme in cell ...

Microenvironment-associated gene HSD11B1 may serve as a prognostic biomarker in clear cell renal cell carcinoma: a study based ... Subsequently, hydroxysteroid 11-beta dehydrogenase-1 (HSD11B1) was identified by univariate Cox regression analysis, protein- ... Furthermore, Gene Set Enrichment Analysis (GSEA) and TME suggested that HSD11B1 was involved in TME immune-related status. ... Redes Reguladoras de Genes/genética , Humanos , Imuno-Histoquímica/métodos , Estimativa de Kaplan-Meier , Neoplasias Renais/ ...

Caused by homozygous or compound heterozygous loss-of-function mutations or deletions in the HSD11B2 gene (16q22). In all cases ... 11-beta-hydroxysteroid dehydrogenase deficiency type 2 Active Synonym false false 3968448016 Ulick syndrome Active Synonym ... 11-beta-HSD2), an enzyme involved in the conversion of cortisol to cortisone. Transmission is autosomal recessive.. ... these mutations lead to abolition or a marked decrease in the activity of 11-beta-hydroxysteroid dehydrogenase type 2 ( ...

Endorsing these findings, 11β-HSD1 mRNA and immunostaining was markedly increased in NASH patients in peri septal hepatocytes ... In contrast, in patients with NASH, 11β-HSD1 activity was increased both in comparison to patients with steatosis, and controls ... RESULTS: In patients with steatosis 5αR activity was increased, with a decrease in hepatic 11β-HSD1 activity. Total cortisol ... With progression to NASH, increased 11β-HSD1 activity and consequent cortisol regeneration may serve to limit hepatic ...

Search for genes and functional terms extracted and organized from over a hundred publicly available resources. ... hydroxysteroid (17-beta) dehydrogenase 12 -1.49415 NDUFS8 NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme ... signal sequence receptor, beta (translocon-associated protein beta) -1.9056 AVEN apoptosis, caspase activation inhibitor - ... PDK1_knockout_265_GSE42187 Gene Set. Dataset. GEO Signatures of Differentially Expressed Genes for Kinase Perturbations ...

occasionally) due to excessive beta-sympathetic stimulation (hypokalemic thyrotoxic periodic paralysis Familial Periodic ... disorder caused by unrestrained sodium reabsorption in the distal nephron due to one of several mutations found in genes ... Stimulation of the sympathetic nervous system, particularly with beta 2-agonists (eg, albuterol, terbutaline), which may ... After acidosis and other causes of intracellular potassium shift (increased beta-adrenergic effect, hyperinsulinemia) have been ...

Other very rare types of CAH include 3-beta-hydroxy-steroid dehydrogenase deficiency, lipoid CAH, and 17-hydroxylase deficiency ... The genes for CAH are passed down from parents to their children. In general, people have two copies of every gene in their ... If each parent carries one affected gene and one normal gene (called a "carrier"), there is a one-in-four chance of their child ... CAH is caused by changes (mutations) in one of several genes. These changes lead to deficiencies in 21-hydroxylase or, less ...