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*  KAKEN - Research Projects | Separation and analysis of genes highly expressed in macrophages (KAKENHI-PROJECT-07457061)
Publications] M.Kataoka: 'leukocyte Typing VI.White Cell Differentiation Antigens' Oxford Univ.Press ( in press),. *. Related ... cDNA for human CD156 was isolated from cDNA libraries from the human macrophage cell line THP-1 and from human granulocytes. ... Cloning of the genes : We have cloned a variety of cDNA which are highly expressed in myelomonocytic cells. These includes CD14 ... The nucleotide sequence of the CD156 cDNA showed 65.6% homology with Less ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457061/
*  Bancroft GJ (1993). The role of natural killer cells in innate resistance to infection. Curr Opin Immunol 5: - PDF
www.iqproducts.nl PRODUCT INFORMATION SHEET Monoclonal antibodies detecting human antigens IFN- γ PURE [RUO] [REF] IQP-160P s ... A novel bacterial virulence gene in Listeria monocytogenes required for host cell microfilament interaction with homology to ... T Cell Maturation,Activation and Differentiation T Cell Maturation,Activation and Differentiation Positive Selection- In thymus ... Exacerbation of murine listeriosis by a monoclonal antibody specific for the type 3 complement receptor of myelomonocytic cells ...
  http://docplayer.net/1915664-Bancroft-gj-1993-the-role-of-natural-killer-cells-in-innate-resistance-to-infection-curr-opin-immunol-5-503-510.html
*  Prognostic significance of macrophage infiltration in leiomyosarcomas. - PubMed - NCBI
Antigens, CD. *Antigens, Differentiation, Myelomonocytic. *Biomarkers, Tumor. *CD163 antigen. *CD68 antigen, human ... Gene expression profiling revealed high-level expression of several macrophage-associated genes such as CD163 and CD68 in a ... Homology*BLAST (Basic Local Alignment Search Tool). *BLAST (Stand-alone). *BLAST Link (BLink) ... Global gene expression profiling data of a series of soft tissue tumors were analyzed for macrophage-associated gene expression ...
  https://www.ncbi.nlm.nih.gov/pubmed/18316565
*  Frontiers | Molecular Recognition of Paired Receptors in the Immune System | Microbiology
The LILR family genes are encoded within the LRC on human chromosome 19q13 (Figure 1A). In the syntenic region of the mouse, at ... Beck, S., and Barrell, B. G. (1988). Human cytomegalovirus encodes a glycoprotein homologous to MHC class-I antigens. Nature ... 1997). A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic ... The extracellular Ig-like domain is classified into three types, D0, D1, and D2, dependent on the sequence homology. KIR2DL4 ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2012.00429/full
*  Adiponectin | ProSpec
The human Adiponectin gene spans 17 kb on chromosome 3q27 (Saito et al, 1999), consisting of three exons and two introns. ... The protein possesses significant homology to collagens VIII, X and complement factor C1q and has been described also as adipoQ ... Adiponectin predominantly inhibits proliferation of myelomonocytic lineage cells (see also: hematopoiesis). Some of the effects ... secreted by 3T3-L1 cells in the course of their differentiation into adipocytes are homologous proteins. ...
  https://www.prospecbio.com/adiponectin
*  Interleukin - Wikipedia
... and expression of the gene encoding human eosinophil differentiation factor (interleukin 5)". Proceedings of the National ... Boulay JL, Paul WE (Sep 1993). "Hematopoietin sub-family classification based on size, gene organization and sequence homology ... IL3 is produced by T lymphocytes and T-cell lymphomas only after stimulation with antigens, mitogens, or chemical activators ... However, IL3 is constitutively expressed in the myelomonocytic leukaemia cell line WEHI-3B. It is thought that the genetic ...
  https://en.wikipedia.org/wiki/Interleukin
*  Cytomegaloviruses: Molecular Biology and Immunology
... regulation of viral gene expression, regulation of viral mRNA export, animal models of infection, novel therapeutics, vaccine ... the molecular events regulating macrophage differentiation and the molecular mechanisms of how specific macrophage-tropic genes ... Finally, the development and physiology of non-human primates are reasonably well understood, at least in the context of human ... In this chapter we argue in favour of a model involving acquisition of CMV antigens by non-infected dendritic cells from ...
  https://www.caister.com/cmv
*  Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL | The EMBO Journal
1991) A human Hox1 homeobox gene exhibits myeloid‐specific expression of alternative transcripts in human hematopoietic cells. ... 1993) Genes on chromosomes 4, 9, and 19 involved in 11q23 abnormalities in acute leukemia share sequence homology and/or common ... Recent studies have shown that during hematopoietic differentiation, expression of 3′ HOX genes is extinguished earlier than 5 ... 2Kb antigens (Thy‐1loSca‐1+H‐2Khi) were enriched by FACS as described previously (Szilvassy et al., 1996b). In experiment 2, 5‐ ...
  http://emboj.embopress.org/content/16/14/4226
*  Application # 2017/0315132. MULTIPLEXED TOTAL ANTIBODY AND ANTIBODY-CONJUGATED DRUG QUANTIFICATION ASSAY - Patents.com
Methods are disclosed to detect, characterize, measure, and quantify human and humanized antibodies, and their conjugates, that ... may be present in pre-clinical animal biological samples, or human biol ... differentiation), pI: 4.84, MW: 25028 TM: 2 [P] Gene Chromosome: 19q13.2, Genbank accession No. NP_001774.10); WO2003088808, ... 0105] "Tumor-associated antigens" (TAA) are known in the art, and can prepared for use in generating human or humanized ...
  http://patents.com/us-20170315132.html
*  Joseph (Joe) Lipsick | Stanford Medicine Profiles
Retinoic acid (RA) is capable of inducing the differentiation of various myelomonocytic cell lines. During this differentiation ... We have found that transcriptional activation of a Myb-responsive reporter gene can be inhibited by RA in a human monocytic ... Cells expressing viral antigens are first seen in the diffuse cortex of lymph nodes and the periarteriolar white sheath of the ... The c-Myb protein is a transcriptional regulator initially identified by homology to the v-Myb oncoprotein, and has since been ...
  https://med.stanford.edu/profiles/joseph-lipsick
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
In summary, we provide a comprehensive and easily accessible resource of gene expression and gene regulation in human Treg and ... Abs against five human nuclear antigens that were difficult to purify as full-length recombinant proteins were detected in the ... All the experiments are performed in a differentiation time course of the THP-1 human leukemic cell line. Furthermore, we ... The remaining sequences revealed the presence of 92 novel transcribed loci, of which 79 did not show homology to known RNA ...
  https://www.jove.com/visualize?author=Yoshihide+Hayashizaki
*  Protocols and Video Articles Authored by Maher Albitar
Although abnormalities in the neurofibromatosis 1 (NF1) gene, which is a gene involved in the ras pathway, have been observed ... ligand-binding domain of the human p75 TNF receptor linked to the Fc portion of human IgG1. Ten patients with refractory MM ... to cytoplasmic and nuclear antigens. The analysis of surface antigens is performed on cells selected (gated) based on light- ... Sep, 2002 , Pubmed ID: 12209693 Interleukin 6 (IL-6) is a B-cell growth and differentiation factor, which may promote the ...
  https://www.jove.com/author/Maher_Albitar
*  METHODS OF IMMUNE OR HEMATOLOGICAL ENHANCEMENT, INHIBITING TUMOUR FORMATION OR GROWTH, AND TREATING OR PREVENTING CANCER,...
Butyric acid and tributyrin induce apoptosis in human hepatic tumour cells. J Dairy Res. 1999;66:559-67. Weinberg ED. Human ... in the promoter/enhancer regions of genes including but not limited to genes that exert antiproliferative effects on tumour ... differentiation, and migration. Other reported therapies rely on the use of cytokines and other modifiers of inflammation (such ... myelomonocytic, monocytic, erythroleukemia leukemia and myelodysplastic syndrome, chronic leukemia such as but not limited to, ...
  http://www.sumobrain.com/patents/wipo/Methods-immune-hematological-enhancement-inhibiting/WO2008140335A2.html
*  Functionally diverse human T cells recognize non-microbial antigens presented by MR1 | eLife
MR1T cells are human polyclonal T cells endowed with diverse effector functions in response to endogenous antigens presented by ... the mediator of lymphocyte functional differentiation JUN-B (Li et al., 1999), and the SREBF1, a member of the SREBP gene ... The following cell lines were obtained from American Type Culture Collection: A375 (human melanoma), THP-1 (myelomonocytic ... with human and mouse MR1 sharing ,90% sequence homology at the protein level (Riegert et al., 1998). To date, the MR1-bound ...
  https://elifesciences.org/articles/24476
*  RECOMBINANT HCMV AND RHCMV VECTORS AND USES THEREOF - Patent application
35), and thus any individual gene or gene group in these dispensable regions can clearly be replaced with heterologous antigens ... and directed differentiation of human embryonic stem cells towards kidney precursors. Differentiation 78:45-56; Abenes, G., Lee ... Early work revealed high homology between the HCMV genes gB, IE1 and UL121-117 and their RhCMV homologues (Kravitz et al., J ... myelomonocytic, monocytic and erythroleukemia), chronic leukemias (such as chronic myelocytic (granulocytic) leukemia, chronic ...
  http://www.patentsencyclopedia.com/app/20160114027
*  Interleukin Expression - Proteins > Extracellular Proteins > Extracellular Ligands > Interleukins - Reviews - Review Articles...
The human GM-CSF and IL-3 genes map to the long arm of chromosome 5, show similar genomic structures, and share several ... cDNA clones encoding murine and human interleukin-10 exhibit a strong homology to BCRFI in Epstein-Barr virus. BCRFI conserves ... also show profound defects in lymphocyte differentiation. Transgenic mice over-expressing the IL-7 gene also show profound ... Recently, we have found that a few MPC-1- immature myeloma cells express CD45 antigens while most myeloma cells do not express ...
  http://biologicalworld.com/articles/modules/smartsection/item.php?itemid=138
*  Patent US6139832 - Leukocyte adhesion inhibitor-1 (LAI-1) Polypeptides - Google Patents
... polypeptide and a human leukocyte adhesion inhibitor-1 (LAI-1) polypeptide (previously termed chemokine α1(CKα1 or ckα-1), as ... There are disclosed therapeutic compositions and methods using isolated nucleic acid molecules encoding a human chemokine beta- ... the ampicillin resistance gene of E. coli and S. cerevisiae TRPL gene, and a promoter derived from a highly-expressed gene to ... "Purification and Characterization of a Novel Monocyte Chemotactic and Activating Factor Produced By a Human Myelomonocytic Cell ...
  http://www.google.com/patents/US6139832?dq=6650327
*  Polymeric carriers of therapeutic agents and recognition moieties for antibody-based targeting of disease sites - Immunomedics,...
The transgenic mice can synthesize human antibodies specific for human antigens, and the mice can be used to produce human ... 2001) examined the degree of sequence homology between different AKAP-binding DDD sequences from human and non-human proteins ... the mouse antibody genes have been inactivated and replaced by functional human antibody genes, while the remainder of the ... Luft et al., "Type I IFNs Enhance the Terminal Differentiation of Dendritic Cells", J. Immunol. 161:1947-1953 (1998). Mason, ...
  http://www.freepatentsonline.com/8889835.html
*  IMMUNOMODULATING COMPOSITIONS AND USES THEREFOR - Patent application
158: 97-129; Kotin, R. M., 1994, Human Gene Therapy 5: 793-801; Shelling and Smith, 1994, Gene Therapy 1: 165-169; and Zhou et ... Illustrative examples of melanoma-related antigens include melanocyte differentiation antigen (e.g., gp100, MART, Melan-A/MART- ... having homology to a target gene. Alternatively, RNA molecules of about 21 to about 23 nucleotides, which direct cleavage of ... myelomonocytic, monocytic and erythroleukemia); chronic leukemia (chronic myelocytic (granulocyte) leukemia and chronic ...
  http://www.patentsencyclopedia.com/app/20090136546
*  CONSTITUTIVE EXPRESSION OF COSTIMULATORY LIGANDS ON ADOPTIVELY TRANSFERRED T LYMPHOCYTES - Patent application
4a-d, peripheral blood human T lymphocytes were transduced with Pzl and restimulated with LNCaP-CD80 cells before a second gene ... Human Immunodeficiency Virus (HIV), and influenza virus antigens. [0008] In yet another aspect, the invention provides a tumor ... 0119] Expansion and differentiation agents can be provided prior to, during or after administration of the cells to increase ... acute myelomonocytic leukemia, acute monocytic leukemia, acute erythroleukemia, chronic leukemia, chronic myelocytic leukemia, ...
  http://www.patentsencyclopedia.com/app/20130121960
*  Hematopoietic Growth Factor Inducible Neurokinin-1 Gene and Uses Thereof - Patent application
0214] Cell Differentiation. Cell differentiation was performed with a myelomonocytic cell line, HL-60, or bone marrow ... significant homology to any human gene. The 19 nucleotide (nt) sequence (sense) was placed in tandem with the loop structure ... cells also respond to antigens. Some of them (CD4+) secrete lymphokines that act on other cells, thus regulating the complex ... gene and/or a reporter gene. [0098] The term "selectable marker gene" refers to a gene encoding a product that, when expressed ...
  http://www.patentsencyclopedia.com/app/20110237519
*  Cancer as a metabolic disease | Nutrition & Metabolism | Full Text
Besides HIF-1α function, the human MYC transcription factor also shows homology to the yeast Rtg3 transcription factor [112]. ... granulocyte/macrophage colony-stimulating factor inhibit growth and induce antigens characteristic of myeloid differentiation ... Gene. 2005, 354: 22-27. 10.1016/j.gene.2005.03.040.View ArticleGoogle Scholar. ... Willenbring H, Bailey AS, Foster M, Akkari Y, Dorrell C, Olson S, Finegold M, Fleming WH, Grompe M: Myelomonocytic cells are ...
  https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-7-7
*  ANTIBODIES THAT BIND COLONY STIMULATING FACTOR 1 RECEPTOR (CSF1R) - Patent application
... from a human framework region of a first human antibody or encoded by a first human immunoglobulin gene, one or more of the non ... In some embodiments, a human framework region is selected that has the highest level of homology to the non-human framework ... antibodies that bind to both human and cynomolgus monkey antigens with similar affinity. The three chimeric antibodies chosen ... Both CSF1 and IL34 stimulate monocyte survival, proliferation, and differentiation into macrophages. [0004] Many tumor cells ...
  http://www.patentsencyclopedia.com/app/20140322757
*  Plus it
Human subjects and blood sample preparation. Blood samples were obtained from patients with renal tumors before surgery or ... Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J 1992;11: ... It has been shown that monocyte-presented antigens can effectively prime T cells to kill renal tumor cells (38), and monocytes ... Increased PD-1 expression on CD14bright myelomonocytic cells, effector T cells, and natural killer (NK) cells correlated to ...
  http://cancerimmunolres.aacrjournals.org/content/2/4/320
*  HIP1 Gene - GeneCards | HIP1 Protein | HIP1 Antibody
Complete information for HIP1 gene (Protein Coding), Huntingtin Interacting Protein 1, including: function, proteins, disorders ... HIP1_HUMAN *Note=A chromosomal aberration involving HIP1 is found in a form of chronic myelomonocytic leukemia (CMML). ... May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors (PubMed:11007801, ... Suggested Antigen Peptide Sequences for HIP1 Gene. GenScript: Design optimal peptide antigens:. *HIP1 protein (A4VCI6_HUMAN) ...
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=HIP1