*  Nav1.9 - Wikipedia
Sodium channel, voltage-gated, type XI, alpha subunit also known as SCN11A or Nav1.9 is a voltage-gated sodium ion channel ... Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the ... Menthol inhibits action potentials by dampening the Na+ channel activity without affecting normal neural activity in the ... Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action ...
  https://en.wikipedia.org/wiki/Nav1.9
*  Nav1.4 - Wikipedia
"Entrez Gene: SCN4A sodium channel, voltage-gated, type IV, alpha subunit". Rüdel R, Lehmann-Horn F, Ricker K, Küther G ( ... They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one ... which are the binding sites of the inactivation gate. In patients with these the channel is unable to inactivate, sodium ... glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits ...
  https://en.wikipedia.org/wiki/Nav1.4
*  Sodium channel - Wikipedia
Voltage-gated sodium channels play an important role in action potentials. If enough channels open when there is a change in ... In addition to regulating channel gating, sodium channel beta subunits also modulate channel expression and form links to the ... "Voltage-gated", "voltage-sensitive", or "voltage-dependent" sodium channel also called "VGSCs" or "Nav channel") or a binding ... The four-domain animal voltage-gated sodium channel likely evolved from a single-subunit ion channel, which was probably ...
  https://en.wikipedia.org/wiki/Sodium_channel
*  Provocation of an Autoimmune Response to Cardiac Voltage-Gated Sodium Channel NaV1.5 Induces Cardiac Conduction Defects in Rats...
... voltage-gated sodium channels are crucial for the initiation and conduction of action potentials. The alpha subunit of the ... and also by alterations in cellular electrophysiology such as altered sodium-channel gating. Functional INa density is further ... Among these, antibodies against beta1-adrenergic receptors and muscarinic M2-acetylcholine receptors have been associated with ... cardiac voltage-gated sodium channel α-subunit. SCN5A. cardiac voltage-gated sodium channel α-subunit gene. TIMP. tissue ...
  http://www.onlinejacc.org/content/62/4/340
*  Plakophilin-2 - Wikipedia
... the voltage-gated sodium channel Na(V)1.5 and its interacting subunit, ankyrin G; and the K(ATP). Decreased expression of ... and knockdown of plakophilin-2 in cardiomyocytes alters sodium current properties as well as velocity of action potential ... PKP2 has been shown to interact with: ankyrin G, beta catenin, desmocollin 1, desmocollin 2, desmoglein 1, desmoglein 2, ... as well as a shift in gating and kinetics; pharmacological challenge also induced ventricular arrhythmias. These findings ...
  https://en.wikipedia.org/wiki/Plakophilin-2
*  Generalized epilepsy with febrile seizures plus - Wikipedia
"An epilepsy mutation in the beta1 subunit of the voltage-gated sodium channel results in reduced channel sensitivity to ... "A novel epilepsy mutation in the sodium channel SCN1A identifies a cytoplasmic domain for beta subunit interaction". J Neurosci ... However, this mutation also yields channels that inactivate at more hyperpolarized potentials relative to wild-type channels, ... "Generalized epilepsy with febrile seizures plus type 2 mutation W1204R alters voltage-dependent gating of Na(v)1.1 sodium ...
  https://en.wikipedia.org/wiki/Generalized_epilepsy_with_febrile_seizures_plus
*  Voltage-gated potassium channel - Wikipedia
... potential role as beta subunit of cardiac transient outward channel?". Circ Res. 88 (10): 1012-9. doi:10.1161/hh1001.090839. ... The position of these arginines, known as gating arginines, are highly conserved in all voltage-gated potassium, sodium, or ... The voltage-gated K+ channels that provide the outward currents of action potentials have similarities to bacterial K+ channels ... Voltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in ...
  https://en.wikipedia.org/wiki/Voltage-gated_potassium_channel
*  Potassium channel, voltage-dependent, EAG/ELK/ERG (IPR003938) | InterPro | EMBL-EBI
... or hetero-associations of alpha subunits or association with auxiliary cytoplasmic beta subunits. K+ channel subunits ... Potassium channel, voltage-dependent, ERG (IPR003967). *Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated ... They are important in shaping the action potential, and in neuronal excitability and plasticity [PMID: 2451788]. The potassium ... with only small amino acid changes causing the diversity of the voltage-dependent gating mechanism, channel conductance and ...
  http://www.ebi.ac.uk/interpro/entry/IPR003938
*  Voltage-gated ion channel - Wikipedia
... this type of channel differs in function between cell types. Ca2+ channels produce action potentials similarly to Na+ channels ... ISBN 978-0-7167-3136-8. Gulbis JM, Mann S, MacKinnon R (June 1999). "Structure of a voltage-dependent K+ channel beta subunit ... Armstrong CM (July 1981). "Sodium channels and gating currents". Physiological Reviews. 61 (3): 644-83. PMID 6265962. Vassilev ... DB Voltage-gated ion channel subunits The IUPHAR Compendium of Voltage-gated Ion Channels 2005 Voltage-Dependent Anion Channels ...
  https://en.wikipedia.org/wiki/Voltage-gated_ion_channel
*  Frontiers | The Segregated Expression of Voltage-Gated Potassium and Sodium Channels in Neuronal Membranes: Functional...
... which is a prerequisite for an appropriate integration of synaptic inputs and the generation of adequate action potential ... review will focus on the signaling pathways leading to segmented expression of voltage-gated potassium and sodium ion channels ... review will focus on the signaling pathways leading to segmented expression of voltage-gated potassium and sodium ion channels ... molecular and functional identity of axonal and dendritic segments is the restricted expression of voltage-gated ion channels. ...
  https://www.frontiersin.org/articles/10.3389/fncel.2017.00115/full
*  SCN3B - Wikipedia
An additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics". ... "Entrez Gene: SCN3B sodium channel, voltage-gated, type III, beta". Hakim P, Gurung IS, Pedersen TH, Thresher R, Brice N, ... They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one ... Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more ...
  https://en.wikipedia.org/wiki/SCN3B
*  Cardiac action potential - Wikipedia
"SCN5A sodium channel, voltage-gated, type V, alpha subunit [Homo sapiens (human)]". National Center for Biotechnology ... this resets the sodium channels; opening the inactivation gate, but still leaving the channel closed. This means that it is ... kinetics by interaction between the alpha 1 and beta subunits of the skeletal muscle dihydropyridine-sensitive Ca2+ channel". ... and the threshold potential is not reached, the rapid sodium channels will not activate and an action potential will not be ...
  https://en.wikipedia.org/wiki/Cardiac_action_potential
*  Trpm4 - Transient receptor potential cation channel subfamily M member 4 - Mus musculus (Mouse) - Trpm4 gene & protein
Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical ... Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway (By similarity). Essential for the ... cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is ... voltage-gated ion channel activity Source: MGIInferred from sequence orthologyi*12799367 ...
  http://www.uniprot.org/uniprot/Q7TN37
*  Voltage-gated calcium channel - Wikipedia
"The I-II loop of the Ca2+ channel α1 subunit contains an endoplasmic reticulum retention signal antagonized by the beta subunit ... Zakon, H. H. (2012). "Adaptive evolution of voltage-gated sodium channels: The first 800 million years". Proceedings of the ... They are activated (i.e., opened) at depolarized membrane potentials and this is the source of the "voltage-gated" epithet. The ... The α2δ subunit is also a binding site of the central depressant and anxiolytic drug phenibut, in addition to actions at other ...
  https://en.wikipedia.org/wiki/Voltage-gated_calcium_channel
*  Neuron - Scholarpedia
In the specific case of action potentials voltage-gated channels, the inflow of sodium or calcium ions depolarizes the plasma ... Cav3 and Cav1 subunits), in conjunction with voltage and calcium gated potassium currents. The frequency of these oscillations ... of a neurotransmitter will gate ionic conductances allowing the generation of excitatory or inhibitory synaptic potentials. Yet ... can vary from high gamma band (80 Hz), Mu (25 Hz), beta (15 Hz), alpha (10 Hz), theta (6 Hz,) delta (3 Hz) and slow sleep ...
  http://scholarpedia.org/article/Neuron
*  Frontiers | Therapeutic Value of Voltage-Gated Sodium Channel Inhibitors in Breast, Colorectal, and Prostate Cancer: A...
Voltage-gated Na+ channels (VGSCs) are membrane proteins, which regulate membrane current and cellular migration during nervous ... Voltage-gated Na+ channels (VGSCs) are membrane proteins, which regulate membrane current and cellular migration during nervous ... Brackenbury, W. J., and Isom, L. L. (2008). Voltage-gated Na+ channels: potential for beta subunits as therapeutic targets. ... Instead, they modulate channel gating and function as cell adhesion molecules (Brackenbury and Isom, 2011). The influx of Na+ ...
  https://www.frontiersin.org/articles/10.3389/fphar.2015.00273/full
*  Consequences of Inhibiting Amyloid Precursor Protein Processing Enzymes on Synaptic Function and Plasticity
... β2 subunit of the voltage-gated sodium channel (Nav1) is a substrate of BACE1 [186, 187]. The β2 subunit of the Nav1 channel is ... which are critical for generating action potentials. Among the ten different types of Nav1 channels, Nav1.1, Nav1.2, Nav1.3, ... "Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of insP3 receptor channel gating," Neuron, vol. 58 ... H. Z. Nie, Z. Q. Li, Q. X. Yan et al., "Nicotine decreases beta-amyloid through regulating BACE1 transcription in SH-EP1-α4β2 ...
  https://www.hindawi.com/journals/np/2012/272374/
*  Marine Drugs | Free Full-Text | ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential | HTML
This review compares the action of three ω-conotoxins, GVIA, MVIIA and CVID, describing their structure-activity relationships ... channel inhibitors from cone snail venom (the ω-conotoxins) have emerged as a new class of therapeutics for the treatment of ... and potential as leads for the design of improved N-type therapeutics that are more useful in the treatment of chronic pain. ... Highly selective N-type voltage-gated calcium (CaV) ... the voltage-gated sodium (NaV) channel, the voltage-gated ...
  http://www.mdpi.com/1660-3397/4/3/193/htm
*  Plus it
... protein in various heterologous systems confirmed this protein to be a voltage-gated potassium channel protein subunit, which ... mechanism of chromosome 3-linked LQTS is persistent noninactivated sodium current in the plateau phase of the action potential ... 1998) Novel LQT-3 mutation affects Na+ channel activity through interactions between alpha- and beta 1-subunits. Circ Res 83: ... in channel gating was responsible for channel dysfunction.. Another interesting finding was reported by Nagatomo et al. (1998) ...
  http://dmd.aspetjournals.org/content/29/4/574
*  SCN8A - Wikipedia
Sodium channel, voltage gated, type VIII, alpha subunit also known as SCN8A or Nav1.6 is a membrane protein encoded by the ... Like other sodium ion channels, Nav1.6 facilitates action potential propagation when the membrane potential is depolarized by ... "Resurgent current and voltage sensor trapping enhanced activation by a beta-scorpion toxin solely in Nav1.6 channel. ... "Ankyrin-G regulates inactivation gating of the neuronal sodium channel, Nav1.6". Journal of Neurophysiology. 96 (3): 1347-57. ...
  https://en.wikipedia.org/wiki/SCN8A
*  Ion channel - Wikipedia
Voltage-gated sodium channels: This family contains at least 9 members and is largely responsible for action potential creation ... Ion channels may be classified by gating, i.e. what opens and closes the channels. Voltage-gated ion channels open or close ... For most voltage-gated ion channels, the pore-forming subunit(s) are called the α subunit, while the auxiliary subunits are ... T-cell activation and pancreatic beta-cell insulin release. In the search for new drugs, ion channels are a frequent target. ...
  https://en.wikipedia.org/wiki/Ion_channel
*  Potassium channel - Wikipedia
... "leak channels" that set the negative membrane potential of neurons. Voltage-gated potassium channel - are voltage-gated ion ... pH gating domain of KcsA, cyclic nucleotide gating domains, and voltage gated potassium channels. N-type inactivation is ... family Potassium uptake permease Sodium ion channel Calcium channel Littleton JT, Ganetzky B (Apr 2000). "Ion channels and ... By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may ...
  https://en.wikipedia.org/wiki/Potassium_channel
*  Resveratrol attenuates cortical neuron activity: roles of large conductance calcium-activated potassium channels and voltage...
... resveratrol on action potential firing rate may be mediated by opening BKCa channels and closing voltage-gated sodium channels ... some mutations in BKCa channel subunit can give rise to channel gain-of-function that leads to development of idiopathic ... of both acquired and inherited epilepsy is associated with abnormal expression or function of voltage-gate sodium currents [29 ... Resveratrol enhances insulin secretion by blocking K(ATP) and K(V) channels of beta cells. Eur J Pharmacol. 2007;568(1-3):269- ...
  https://jbiomedsci.biomedcentral.com/articles/10.1186/s12929-016-0259-y
*  Гришин Евгений Васильевич - ИБХ РАН
Scorpion α-toxins affect insect and/or mammalian voltage-gated sodium channels (Navs) and thereby modify the excitability of ... The toxin is therefore concluded to represent the first sodium channel gating modifier from an araneomorph spider and features ... as well as to characterize their affinity to Kv1.3 channel using the "mix and read" mode. To demonstrate the potential of the ... In addition, the action of Ltc on erythrocytes and cancer cells was investigated in detail with confocal laser scanning ...
  http://www.ibch.ru/about/history/personalia/7
*  Multiple molecular interactions determine the clustering of Caspr2 and Kv1 channels in myelinated axons
The distribution and targeting of neuronal voltage-gated ion channels. Nat Rev Neurosci. 2006;7:548-562. [PubMed] ... Axon initial segment kv1 channels control axonal action potential waveform and synaptic efficacy. Neuron. 2007;55:633-647. [ ... Generation and characterization of subtype-specific monoclonal antibodies to K+ channel alpha- and beta-subunit polypeptides. ... A targeting motif involved in sodium channel clustering at the axonal initial segment. Science. 2003;300:2091-2094. [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2859216/