JCI - Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs
Previous studies showed that Gata3 is regulated by transcription factors HEB (37, 38), T cell factor 1 (TCF-1) (39), and RBP-J/ ... The transcription factor GATA3 is essential for the genesis and maturation of the T cell lineage, and GATA3 dysregulation has ... TCF-1, HEB, and RBP-J regulate Gata3 transcription by binding within Tce1. Several transcription factors have been proposed as ... Prediction of putative transcription factor-binding sites. A search for putative transcription factor-binding sites in Tce1 was ...https://www.jci.org/articles/view/83894
RCSB PDB - Protein Feature View - Trans-acting T-cell-specific transcription factor GATA-3 - P23771 (GATA3 HUMAN)
Trans-acting T-cell-specific transcription factor GATA-3 - P23771 (GATA3_HUMAN) ...http://www.rcsb.org/pdb/protein/P23771
Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4(+) T...
Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4(+) T ... T-box transcription factor (T-bet), GATA3 (GATA Binding Protein 3), and CD152 (CTLA-4) expression in BTBR mice. Our results ... An imbalance in the production of pro- and anti-inflammatory cytokines and transcription factors plays a role in ... The augmented levels of IL-21/IL-22 and GATA3/T-bet could be due to altered A2AR signaling. Our results indicate that A2AR ...https://www.physiciansweekly.com/adenosine-a2a-receptor-signaling-affects-il-21il-22-cytokines-and-gata3t-bet-transcription-factor-expression-in-cd4-t-cells-from-a-btbr-t-itpr3tfj-mouse-model-of-autism/
The transcription factor XBP-1 is essential for the development and survival of dendritic cells | JEM
Transcription factor GATA-3 is required for development of the T-cell lineage. Nature. 384:474-478. ... several intracellular signaling molecules and transcription factors-including Gfi1, Id2, Ikaros, IFN regulatory factor 2 (IRF-2 ... The transcription factor XBP-1 is essential for the development and survival of dendritic cells. Neal N. Iwakoshi, Marc Pypaert ... Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells. J. Immunol. ...http://jem.rupress.org/content/204/10/2267
JCI - Volume 126, Issue 3
The transcription factor GATA3 is essential for the genesis and maturation of the T cell lineage, and GATA3 dysregulation has ... Gata3. transcription in vivo. Here, we determined that the canonical Gata3. promoter is insufficient for Gata3. transcriptional ... Gata3. expression in T cells. Instead, we demonstrated that multiple lineage-affiliated transcription factors bind to Tce1. and ... Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs. ...https://jci.org/126/3
Safety, Tolerability, and Pharmacokinetics After a Single Dose of Orally Inhaled DNAzyme Solution for Nebulisation in Male...
The transcription factor GATA-3 plays a key role in mediating the asthmatic immune response and has been shown to be necessary ... By cleaving GATA-3 mRNA, hgd40 reduces specific cytokine production and thereby reduces key features of allergic airway ... a Human GATA-3-specific DNAzyme Solution for Nebulisation - A Randomised, Double-blind, Placebo-controlled, Parallel-group (Per ...https://clinicaltrials.gov/ct2/show/NCT01577953
Cytokines and Transcription Factors That Regulate T Helper Cell Differentiation: New Players and New Insights | SpringerLink
The transcription factors Stat6, GATA-3, c-Maf, NFATs, and the cytokine IL-4 promote TH2 differentiation. These key regulators ... Zhang DH, Cohn L, Ray P, Bottomly K, Ray A: Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells ... Zhang DH, Yang L, Ray A: Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. J Immunol 161(8 ... Ko LJ, Yamamoto M, Leonard MW, George KM, Ting P, Engel JD: Murine and human T-lymphocyte GATA-3 factors mediate transcription ...https://link.springer.com/article/10.1023%2FA%3A1023381027062
Related Articles by Review for PubMed (Select 10935639) - PubMed - NCBI
Transcription factor GATA3 and the human HDR syndrome.. Van Esch H, Devriendt K. ... GATA3 haplo-insufficiency causes human HDR syndrome.. Van Esch H, Groenen P, Nesbit MA, Schuffenhauer S, Lichtner P, ... Role of the vascular endothelial growth factor isoforms in retinal angiogenesis and DiGeorge syndrome. ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed_reviews&from_uid=10935639
A reverse-engineering approach to dissect post-translational modulators of transcription factor's activity from transcriptional...
An on-line web-tool enabling the user to use DMI to identify post-transcriptional modulators of a transcription factor of ... to infer post-translational modulators of a transcription factor from a compendium of gene expression profiles (GEPs). DMI is ... showing its predictive ability in correctly identifying kinases regulating the activity of 14 different transcription factors. ... Transcription factors (TFs) act downstream of the major signalling pathways functioning as master regulators of cell fate. ...https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-015-0700-3
GATA3 - GATA-binding factor 3 - Gallus gallus (Chicken) - GATA3 gene & protein
Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites ... RNA polymerase II transcription factor binding Source: GO_Central. *transcriptional activator activity, RNA polymerase II ... sp,P23825,GATA3_CHICK GATA-binding factor 3 OS=Gallus gallus GN=GATA3 PE=2 SV=1 ... R-GGA-8939236. RUNX1 regulates transcription of genes involved in differentiation of HSCs. R-GGA-983231. Factors involved in ...http://www.uniprot.org/uniprot/P23825
Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 2003;19:863-75. ... GATA-binding protein 3 (GATA3) is a transcription factor and a putative tumor suppressor that is highly expressed in normal ... GATA-binding protein 3 (GATA3) is a transcription factor that is highly expressed in normal breast luminal epithelium and the ... have shown by targeted disruption of GATA3 in mice that GATA3 is required for proper hair follicle stem cell function (28). In ...http://cebp.aacrjournals.org/content/16/11/2269
CD4-Transgenic Zebrafish Reveal Tissue-Resident Th2- and Regulatory T Cell-like Populations and Diverse Mononuclear Phagocytes ...
Transcription factor GATA-3 in Atlantic salmon (Salmo salar): molecular characterization, promoter activity and expression ... Sequence and expression analysis of two T helper master transcription factors, T-bet and GATA3, in rainbow trout Oncorhynchus ... transcription factor. TIL. tumor-infiltrating lymphocyte. Treg. regulatory T cell. t-SNE. t-distributed stochastic neighbor ... Identification and characterization of the transcription factors involved in T-cell development, t-bet, stat6 and foxp3, within ...http://www.jimmunol.org/content/197/9/3520.long
Recombinant Human GATA3 protein (ab114297) | Abcam
Buy our Recombinant Human GATA3 protein. Ab114297 is a protein fragment produced in Wheat germ and has been validated in WB, ... Trans acting T cell specific transcription factor GATA 3. *Trans-acting T-cell-specific transcription factor GATA-3 ... Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also ...https://www.abcam.com/recombinant-human-gata3-protein-ab114297.html
The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector...
T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-γ. Nat ... A recent study revealed that activating transcription factor 2 family transcription factors (ATF2) can promote transcription ... and the transcription factor c-myc. LEF1 also directly augments expression of the effector fate-specifying transcription factor ... 5 A). When compared with other transcription factors, LEF1 expression was proportional to GATA3 and PLZF and was largely ...http://jem.rupress.org/content/early/2015/04/14/jem.20141849
Similar articles for PubMed (Select 22685315) - PubMed - NCBI
The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. ... The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. ... The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells. ... Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. ...https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=22685315
Anti-GATA1 antibody (ab11852) | Abcam
GATA (GATA1, GATA2, GATA3) Transcription Factor Assay Kit (Colorimetric) (ab207205) * ChIP Related Products ... Epigenetics and Nuclear Signaling Transcription Domain Families Zinc Finger Share by email ... Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites ...https://www.abcam.com/gata1-antibody-ab11852.html
Catalog | Mendeley
Copyright © 2017 Mendeley Ltd. All rights reserved. Cookies are set by this site. To decline them or learn more, visit our cookies page.. ...https://www.mendeley.com/research-papers/updated-view-transcription-factor-gata3-mediated-regulation-th1-th2-cell-differentiation/
Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for...
... indicating that transcription from the IL-5 promoter is Th2 specific. For the functioning of the IL-5 promoter in a Th2 clone, ... Taken together, our results provide evidence that GATA-related factors may be involved in Th2-specific expression of the IL-5 ... IL-5CLE0 interacted with both constitutive and inducible nuclear factors (designated NFIL-5CLE0), which existed in both Th1 and ... Th2 clones, whereas IL-5C interacted with a constitutive nuclear factor (designated NFIL-5C), which was found only in Th2 but ...https://www.semanticscholar.org/paper/Characterization-of-cis-regulatory-elements-and-of-Lee-O%27Garra/73209494ddef5ff167d8990582557aa7bbf7ae3b
Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC cancer ... The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer. PLoS ... Kajita, M., McClinic K.N., and Wade, P.A. (2004) Aberrant expression of the transcription factors Snail and Slug alter the ... Dhasarathy, A., Kajita, M., and Wade, P.A. (2007) The transcription factor snail mediates epithelial to mesenchymal transitions ...https://www.niehs.nih.gov/research/atniehs/labs/escbl/pi/etr/publications/
FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy. - Semantic Scholar
Loss of WASP was phenotypically associated with increased GATA3 expression in effector memory FOXP3+ Tregs, but not in naive- ... Dynamic expression of transcription factors T-bet and GATA-3 by regulatory T cells maintains immunotolerance. *Fang Yu, Suveena ...https://www.semanticscholar.org/paper/FOXP3%2B-Tregs-require-WASP-to-restrain-Th2-mediated-Lexmond-Goettel/1f5ddbb6c0c8d8bc0d78b39efdb59396403f49d5
Table of Contents - December 01, 2016, 197 (11) | The Journal of Immunology
Correction: Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role Anne O'Garra and Leona Gabryšová ...http://www.jimmunol.org/content/197/11
Immune Modulatory Treatment of Trinitrobenzene Sulfonic Acid Colitis with Calcitriol Is Associated with a Change of a T Helper ...
A representative immunoblot (IB) of the relevant Th1 or Th2 transcription factors T-bet (A) and GATA3 (C) are shown. T-bet: 1, ... GATA family of transcription factors 3, a Th2 master regulator (GATA3), Foxp3, cytotoxic T-lymphocyte-associated antigen 4 ( ... GATA3, GATA family of transcription factors 3, a Th2 master regulator; CTLA, cytotoxic T-lymphocyte-associated antigen. ... DC-derived factors, including augmentation of the transcription factor T-bet following activation by DC-derived IL-12. The ...http://jpet.aspetjournals.org/content/324/1/23.long
Atoh1 null mice show directed afferent fiber growth to undifferentiated ear sensory epithelia followed by incomplete fiber...
Transcription factor GATA-3 alters pathway selection of olivocochlear neurons and affects morphogenesis of the ear. J Comp ... A-J: The expression of brain-derived neurotrophic factor (Bdnf) -LacZ in the ear and the effect of Bdnf null mutation on the ... A-C: The expression of brain-derived neurotrophic factor (Bdnf; A,B) and Atoh1 (C) is shown in embryonic day (E) 12.5 wild-type ... 7, 8). It is also conceivable that other as yet unknown factor(s) can be produced by these cells. Together, Bdnf and such ...http://onlinelibrary.wiley.com/doi/10.1002/dvdy.20370/full
Immune physiologic D/C Flashcards by Lorne Runge | Brainscape
GATA-3 is the transcription factor inTh2 cells that stimulates the production of IL-4, IL 13, and IL-8. ... The precursor is modified into a 17-kDa transcription factor, and cytosolic protein which acts as a damage-associated molecular ... IL-1 alpha precursor protein contains a transcription factor (ppIL-1 alpha) released via calpain (calcium activated protease). ... Helios (IZKF2) is a zinc finger transcription factor important in lymphocyte maturation.Other family members include Ikaros, ...https://www.brainscape.com/flashcards/immune-physiologic-d-c-2484247/packs/4392200
Anti-beta Actin antibody [mAbcam 8226] - Loading Control (ab8226) References
Adomas AB et al. Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor ... transcription factor MafB antagonizes antiviral responses by blocking recruitment of coactivators to the transcription factor ... Landeras-Bueno S et al. The splicing factor proline-glutamine rich (SFPQ/PSF) is involved in influenza virus transcription. ... Chen H et al. Inducing goat pluripotent stem cells with four transcription factor mRNAs that activate endogenous promoters. BMC ...http://www.abcam.com/beta-actin-antibody-mabcam-8226-loading-control-ab8226-references.html