*  Transcription factor GATA-3 (IPR029521) | InterPro | EMBL-EBI
Transcription factor GATA-3 (IPR029521). Short name: GATA-3 Family relationships *Transcription factor, GATA-2/3 (IPR016374) * ... GATA-3 belongs to the GATA transcription factor family, which consists of a group of vertebrate GATA factors that have two ... GATA-3 is a trans-acting T-cell-specific transcription factor required for several developmental steps in T-cells [PMID: ... GATA-3 regulates the self-renewal of long-term hematopoietic stem cells.. Nat. Immunol. 14 1037-44 2013 ...
  http://www.ebi.ac.uk/interpro/entry/IPR029521
*  JCI - Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs
Previous studies showed that Gata3 is regulated by transcription factors HEB (37, 38), T cell factor 1 (TCF-1) (39), and RBP-J/ ... The transcription factor GATA3 is essential for the genesis and maturation of the T cell lineage, and GATA3 dysregulation has ... TCF-1, HEB, and RBP-J regulate Gata3 transcription by binding within Tce1. Several transcription factors have been proposed as ... Prediction of putative transcription factor-binding sites. A search for putative transcription factor-binding sites in Tce1 was ...
  https://www.jci.org/articles/view/83894
*  Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells...
Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells ... T-box transcription factor (T-bet), GATA3 (GATA Binding Protein 3), and CD152 (CTLA-4) expression in BTBR mice. Our results ... An imbalance in the production of pro- and anti-inflammatory cytokines and transcription factors plays a role in ... The augmented levels of IL-21/IL-22 and GATA3/T-bet could be due to altered A2AR signaling. Our results indicate that A2AR ...
  https://www.sigmaaldrich.com/catalog/papers/28807491
*  The Diagnostic Value of Transcription Factors T-bet-GATA3 Ratio in Predicting Antibody-Mediated Rejection - pdf descargar
The Diagnostic Value of Transcription Factors T-bet-GATA3 Ratio in Predicting Antibody-Mediated Rejection. . Biblioteca virtual ... The Diagnostic Value of Transcription Factors T-bet-GATA3 Ratio in Predicting Antibody-Mediated Rejection - Descarga este ... The Diagnostic Value of Transcription Factors T-bet-GATA3 Ratio in Predicting Antibody-Mediated Rejection. ... We compared the intraglomerular T-bet-GATA3 ratio in ABMR and TCMR. The intragraft expression of T-bet and GATA3 was studied ...
  http://libros.duhnnae.com/2017/jun9/149862664350-The-Diagnostic-Value-of-Transcription-Factors-T-bet-GATA3-Ratio-in-Predicting-Antibody-Mediated-Rejection.php
*  The transcription factor XBP-1 is essential for the development and survival of dendritic cells | JEM
Transcription factor GATA-3 is required for development of the T-cell lineage. Nature. 384:474-478. ... several intracellular signaling molecules and transcription factors-including Gfi1, Id2, Ikaros, IFN regulatory factor 2 (IRF-2 ... The transcription factor XBP-1 is essential for the development and survival of dendritic cells. Neal N. Iwakoshi, Marc Pypaert ... Transcription factor PU.1 is necessary for development of thymic and myeloid progenitor-derived dendritic cells. J. Immunol. ...
  http://jem.rupress.org/content/204/10/2267
*  JCI - Volume 126, Issue 3
The transcription factor GATA3 is essential for the genesis and maturation of the T cell lineage, and GATA3 dysregulation has ... Gata3. transcription in vivo. Here, we determined that the canonical Gata3. promoter is insufficient for Gata3. transcriptional ... Gata3. expression in T cells. Instead, we demonstrated that multiple lineage-affiliated transcription factors bind to Tce1. and ... Lineage-affiliated transcription factors bind the Gata3 Tce1 enhancer to mediate lineage-specific programs. ...
  https://jci.org/126/3
*  Safety, Tolerability, and Pharmacokinetics After a Single Dose of Orally Inhaled DNAzyme Solution for Nebulisation in Male...
The transcription factor GATA-3 plays a key role in mediating the asthmatic immune response and has been shown to be necessary ... By cleaving GATA-3 mRNA, hgd40 reduces specific cytokine production and thereby reduces key features of allergic airway ... a Human GATA-3-specific DNAzyme Solution for Nebulisation - A Randomised, Double-blind, Placebo-controlled, Parallel-group (Per ...
  https://clinicaltrials.gov/ct2/show/NCT01577953
*  Transcription Factor ets-2 Plays an Important Role in the Pathogenesis of Pulmonary Fibrosis
The roles of transcription factors, such as Smad3 (4), Nrf2 (5), CEBPβ (6), GATA-3 (7), PPARs (8, 9), Fra-2 (10), and p53 (11 ... Overexpression of the transcription factor GATA-3 enhances the development of pulmonary fibrosis. Am J Pathol 2006;169:96-104 [ ... Transcription Factor ets-2 Plays an Important Role in the Pathogenesis of Pulmonary Fibrosis. Christopher P. Baran,1 Sara N. ... The transcription factor NRF2 protects against pulmonary fibrosis. FASEB J 2004;18:1258-1260 [PubMed] ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3262682/
*  The BTB-ZF Family of Transcription Factors: Key Regulators of Lineage Commitment and Effector Function Development in the...
PLZP was shown to interact directly with the Th2-promoting transcription factor GATA-3 and could antagonize GATA-3 binding to ... In a temporal and developmental sense, ThPOK functions downstream of GATA-3, an early CD4+ lineage transcription factor, and ... Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat. ... A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/ ...
  http://www.jimmunol.org/content/187/6/2841
*  Cytokines and Transcription Factors That Regulate T Helper Cell Differentiation: New Players and New Insights | SpringerLink
The transcription factors Stat6, GATA-3, c-Maf, NFATs, and the cytokine IL-4 promote TH2 differentiation. These key regulators ... Zhang DH, Cohn L, Ray P, Bottomly K, Ray A: Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells ... Zhang DH, Yang L, Ray A: Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. J Immunol 161(8 ... Ko LJ, Yamamoto M, Leonard MW, George KM, Ting P, Engel JD: Murine and human T-lymphocyte GATA-3 factors mediate transcription ...
  https://link.springer.com/article/10.1023%2FA%3A1023381027062
*  Related Articles by Review for PubMed (Select 10935639) - PubMed - NCBI
Transcription factor GATA3 and the human HDR syndrome.. Van Esch H, Devriendt K. ... GATA3 haplo-insufficiency causes human HDR syndrome.. Van Esch H, Groenen P, Nesbit MA, Schuffenhauer S, Lichtner P, ... Role of the vascular endothelial growth factor isoforms in retinal angiogenesis and DiGeorge syndrome. ...
  https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed_reviews&from_uid=10935639
*  A reverse-engineering approach to dissect post-translational modulators of transcription factor's activity from transcriptional...
An on-line web-tool enabling the user to use DMI to identify post-transcriptional modulators of a transcription factor of ... to infer post-translational modulators of a transcription factor from a compendium of gene expression profiles (GEPs). DMI is ... showing its predictive ability in correctly identifying kinases regulating the activity of 14 different transcription factors. ... Transcription factors (TFs) act downstream of the major signalling pathways functioning as master regulators of cell fate. ...
  https://bmcbioinformatics.biomedcentral.com/articles/10.1186/s12859-015-0700-3
*  GATA3 - GATA-binding factor 3 - Gallus gallus (Chicken) - GATA3 gene & protein
Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites ... RNA polymerase II transcription factor binding Source: GO_Central. *transcriptional activator activity, RNA polymerase II ... sp,P23825,GATA3_CHICK GATA-binding factor 3 OS=Gallus gallus GN=GATA3 PE=2 SV=1 ... R-GGA-8939236. RUNX1 regulates transcription of genes involved in differentiation of HSCs. R-GGA-983231. Factors involved in ...
  http://www.uniprot.org/uniprot/P23825
*  Plus it
Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 2003;19:863-75. ... GATA-binding protein 3 (GATA3) is a transcription factor and a putative tumor suppressor that is highly expressed in normal ... GATA-binding protein 3 (GATA3) is a transcription factor that is highly expressed in normal breast luminal epithelium and the ... have shown by targeted disruption of GATA3 in mice that GATA3 is required for proper hair follicle stem cell function (28). In ...
  http://cebp.aacrjournals.org/content/16/11/2269
*  Recombinant Human GATA3 protein (ab114297) | Abcam
Buy our Recombinant Human GATA3 protein. Ab114297 is a protein fragment produced in Wheat germ and has been validated in WB, ... Trans acting T cell specific transcription factor GATA 3. *Trans-acting T-cell-specific transcription factor GATA-3 ... Defects in GATA3 are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia (HDR) [MIM:146255]; also ...
  https://www.abcam.com/recombinant-human-gata3-protein-ab114297.html
*  The transcription factor lymphoid enhancer factor 1 controls invariant natural killer T cell expansion and Th2-type effector...
T cell factor 1 initiates the T helper type 2 fate by inducing the transcription factor GATA-3 and repressing interferon-γ. Nat ... A recent study revealed that activating transcription factor 2 family transcription factors (ATF2) can promote transcription ... and the transcription factor c-myc. LEF1 also directly augments expression of the effector fate-specifying transcription factor ... 5 A). When compared with other transcription factors, LEF1 expression was proportional to GATA3 and PLZF and was largely ...
  http://jem.rupress.org/content/early/2015/04/14/jem.20141849
*  Protein (RefSeq) Links for PubMed (Select 19700764) - Protein - NCBI
PREDICTED: trans-acting T-cell-specific transcription factor GATA-3 isoform X2 [Mus musculus] ... PREDICTED: trans-acting T-cell-specific transcription factor GATA-3 isoform X1 [Mus musculus] ... trans-acting T-cell-specific transcription factor GATA-3 isoform 3 [Mus musculus] ... trans-acting T-cell-specific transcription factor GATA-3 isoform 4 [Mus musculus] ...
  https://www.ncbi.nlm.nih.gov/protein?LinkName=pubmed_protein_refseq&from_uid=19700764
*  Similar articles for PubMed (Select 22685315) - PubMed - NCBI
The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3. ... The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma. ... The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells. ... Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. ...
  https://www.ncbi.nlm.nih.gov/pubmed?linkname=pubmed_pubmed&from_uid=22685315
*  Catalog | Mendeley
Copyright © 2017 Mendeley Ltd. All rights reserved. Cookies are set by this site. To decline them or learn more, visit our cookies page.. ...
  https://www.mendeley.com/research-papers/updated-view-transcription-factor-gata3-mediated-regulation-th1-th2-cell-differentiation/
*  Characterization of cis-regulatory elements and nuclear factors conferring Th2-specific expression of the IL-5 gene: a role for...
... indicating that transcription from the IL-5 promoter is Th2 specific. For the functioning of the IL-5 promoter in a Th2 clone, ... Taken together, our results provide evidence that GATA-related factors may be involved in Th2-specific expression of the IL-5 ... IL-5CLE0 interacted with both constitutive and inducible nuclear factors (designated NFIL-5CLE0), which existed in both Th1 and ... Th2 clones, whereas IL-5C interacted with a constitutive nuclear factor (designated NFIL-5C), which was found only in Th2 but ...
  https://www.semanticscholar.org/paper/Characterization-of-cis-regulatory-elements-and-of-Lee-O%27Garra/73209494ddef5ff167d8990582557aa7bbf7ae3b
*  Dynamic Repositioning of CD4 and CD8 Genes during T Cell Development | JEM
Other transcription factors have been implicated in the development of CD4 or CD8 lineage T cells, including GATA3, Tox, and ... and Runx transcription factors (5-7). Other transcription factors including SAF and HES have also been implicated in CD4 ... Critical roles for transcription factor GATA-3 in thymocyte development. Immunity. 19:863-875. ... Other transcription factors have been implicated in CD4 and CD8 T cell development including GATA3, which is required for CD4 T ...
  http://jem.rupress.org/content/200/11/1427
*  Selected Publications
Breast tumor specific mutation in GATA3 affects physiological mechanisms regulating transcription factor turnover. BMC cancer ... The transcription factors Snail and Slug activate the transforming growth factor-beta signaling pathway in breast cancer. PLoS ... Kajita, M., McClinic K.N., and Wade, P.A. (2004) Aberrant expression of the transcription factors Snail and Slug alter the ... Dhasarathy, A., Kajita, M., and Wade, P.A. (2007) The transcription factor snail mediates epithelial to mesenchymal transitions ...
  https://www.niehs.nih.gov/research/atniehs/labs/escbl/pi/etr/publications/
*  Frontiers | Regulation of murine natural killer cell commitment | Immunology
While a few important transcription factors have identified for NK genesis the mechanisms of how this is achieved is far from ... While a few important transcription factors have identified for NK genesis the mechanisms of how this is achieved is far from ... in vivo and it remains to be addressed if a common NK cell precursor seeds diverse niches and how transcription factors may ... in vivo and it remains to be addressed if a common NK cell precursor seeds diverse niches and how transcription factors may ...
  https://www.frontiersin.org/articles/10.3389/fimmu.2013.00014/full
*  Table of Contents - December 01, 2016, 197 (11) | The Journal of Immunology
Correction: Transcription Factors Directing Th2 Differentiation: Gata-3 Plays a Dominant Role Anne O'Garra and Leona Gabryšová ...
  http://www.jimmunol.org/content/197/11