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*  GATA1 - Wikipedia
Reduced levels of GATA1 due to reductions in the translation of GATA1 mRNA into its transcription factor product are associated ... transcription factor regulating cell cycle progression),[25] TAL1 (a transcription factor),[26] FOG2 (a transcription factor ... greatly reduced levels of GATA1 as a result of a ribosomal deficiency in translating GATA1 mRNA into GATA1 transcription factor ... GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of ...
  https://en.wikipedia.org/wiki/GATA1
*  Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA...
PU.1 and ETS-1 expression were induced in correlation with miR-155 inhibition; however, the GATA-1/PU.1 interaction was ... GATA-2 and miR-27a expression were increased in correlation with a decrease in RUNX1 mRNA expression, suggesting megakaryocyte ... In Epo-stimulated CD34(+)/HSCs, VPA induced the expression of the ETS family transcription factors PU.1, ETS-1, GABP-α, Fli-1 ... Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA ...
  https://www.sigmaaldrich.com/catalog/papers/25241289
*  Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages | The EMBO Journal
Erythroid GATA1 function revealed by genome‐wide analysis of transcription factor occupancy, histone modifications, and mRNA ... binding transcription factors, including GATA3 in leukaemic T cells (Ono et al, 1998), and SP1 (Lecuyer et al, 2002) or GATA1 ( ... GATA1 and TAL1 cooccupancy appears to correlate with active genes in erythroid cells, although these two transcription factors ... binding selectivity of transcription factors and suggest how changing the cellular context can render a transcription factor ...
  http://emboj.embopress.org/content/30/3/494
*  Ribosomopathies: There's strength in numbers | Science
... transcription factors, certain Hox proteins, and GATA1) will be poor substrates for translation when ribosome availability is ... stable mRNA structures (87), oxidized mRNAs (88), or truncated mRNAs (89). These circumstances, along with tRNA shortages (90 ... An illustrative example comes from the discovery that inherited mutations in GATA1-an important erythroid transcription factor ... 2B, GATA1 and Hox mRNAs). As a corollary to this point, alternative start site usage is similarly increased during ...
  http://science.sciencemag.org/content/358/6363/eaan2755
*  AGGF1 - Wikipedia
GATA1 and another unknown factor. To form a protein, an mRNA transcript must be transcribed from the DNA. For AGGF1, the mRNA ... the only known transcription factor that regulates AGGF1 is GATA1. GATA1 binds upstream of the AGGF1 gene promoter at -295 and ... For the gene to be fully expressed, both of the activator sites must be bound by the transcription factors, ... "Novel roles of GATA1 in regulation of angiogenic factor AGGF1 and endothelial cell function". The Journal of Biological ...
  https://en.wikipedia.org/wiki/AGGF1
*  Lmo2 and Scl/Tal1 convert non-axial mesoderm into haemangioblasts which differentiate into endothelial cells in the absence of...
This restriction correlates well with activation of gata1 transcription and co-injection of gata1 mRNA along with scl/tal1 and ... We additionally show that other Gata factors, in particular Gata2, cannot replace Gata1. Furthermore, gata1-scl/tal1-lmo2- ... mRNAs (100 pg of each mRNA in all experiments except the gata1-scl/tal1-lmo2 injections where 25 pg of each mRNA were injected ... could not replace gata1. (E,F) gata1-scl/tal1-lmo2 injection (F) induced anterior expression of gata1end.. (G,H) gata1-scl/tal1 ...
  http://dev.biologists.org/content/130/25/6187.full
*  JCI - Welcome
RNH1 binds to ribosomes and regulates erythropoiesis by controlling translation of the erythroid transcription factor GATA1. ... In Rnh1-deficient embryos, mRNA levels of Gata1 are normal, but GATA1 protein levels are decreased. At the molecular level, we ... Little is known about the molecular mechanisms of selective mRNA translation and involvement of ribosomal-associated factors in ... In response to oscillatory shear stress, the transcription factors Tal1, Gata2, and Ets1/2 physically interacted with and ...
  https://www.jci.org/tags/19
*  Jason Gotlib | Stanford Medicine Profiles
Here, we identify mutations in GATA1, encoding the critical hematopoietic transcription factor GATA-binding protein-1, that ... We show that ribosomal protein haploinsufficiency, the more common cause of DBA, can lead to decreased GATA1 mRNA translation, ... The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted ... Confocal fluorescence microscopy and a lymphoid enhancer factor/T-cell factor reporter assay were used to detect nuclear beta- ...
  https://med.stanford.edu/profiles/jason-gotlib
*  JCI - Welcome
In both mice and humans, mutations in the gene-encoding transcription factor GATA1 cause an accumulation of proliferating, ... developed a protocol that restores endogenous GATA1 levels in MEPs derived from murine ES cells in which Gata1 mRNA is ... and mutations in the gene encoding the transcription factor GATA1 lead to the MEP accumulation in both mice and humans. While ... stem cells can be used to produce platelets on a clinical scale by controlling the level of the transcription factor GATA1. ...
  https://www.jci.org/posts/289
*  WikiGenes - GATA1 - GATA binding protein 1 (globin...
Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1. Pal, S., ... Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Zon ... Neurokinin-B transcription in erythroid cells: direct activation by the hematopoietic transcription factor GATA-1 [23]. ... High impact information on GATA1. *Acquired somatic mutations in exon 2 of the hematopoietic transcription factor GATA-1 have ...
  https://www.wikigenes.org/e/gene/e/2623.html
*  ERG Is a Megakaryocytic Oncogene | Cancer Research
Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet 2005; 37: 613-9. ... C, relative level of megakaryocytic mRNA expression (CD41, CD42, and PF4), measured by quantitative reverse transcription-PCR, ... Somatic mutations acquired during fetal hematopoiesis in the GATA1 transcription factor are detected in megakaryoblasts from ... Ets-related gene (ERG) is a member of the ETS transcription factor gene family located on Hsa21. ERG is known to have a crucial ...
  http://cancerres.aacrjournals.org/content/69/11/4665.full
*  JCI - Welcome
RNH1 binds to ribosomes and regulates erythropoiesis by controlling translation of the erythroid transcription factor GATA1. ... In Rnh1-deficient embryos, mRNA levels of Gata1 are normal, but GATA1 protein levels are decreased. At the molecular level, we ... Factor XII does double duty in wound healing In this issue, Stavrou et al. pursue coagulation factor FXII's functions in ... Little is known about the molecular mechanisms of selective mRNA translation and involvement of ribosomal-associated factors in ...
  https://minfengtang.net.insight.mobile.jci.org/
*  JCI - Latest articles
RNH1 binds to ribosomes and regulates erythropoiesis by controlling translation of the erythroid transcription factor GATA1. ... In Rnh1-deficient embryos, mRNA levels of Gata1 are normal, but GATA1 protein levels are decreased. At the molecular level, we ... Little is known about the molecular mechanisms of selective mRNA translation and involvement of ribosomal-associated factors in ... Our results reveal an unsuspected role for RNH1 in the control of GATA1 mRNA translation and erythropoiesis. ...
  https://minfengtang.net.insight.mobile.jci.org/just-published
*  JCI - Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation
Regulation of the erythroid Kruppel-like factor (EKLF) gene promoter by the erythroid transcription factor GATA-1. J Biol Chem ... In Rnh1-deficient embryos, mRNA levels of Gata1 are normal, but GATA1 protein levels are decreased. At the molecular level, we ... Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci ... Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature ...
  https://m.jci.org/articles/view/94956
*  Plus it
Because acetylation has been shown to affect the DNA binding activity of several transcription factors (e.g., p53 and GATA-1; ... GAPDH mRNA expression was used as the loading control. The Her-2/neu/GAPDH mRNA level ratio as a percentage of untreated ... Boyes, J., Byfield, P., Nakatani, Y., and Ogryzko, V. Regulation of activity of the transcription factor GATA-1 by acetylation ... We investigated whether treatment with LAQ824 could induce a transcription factor(s) that represses the transcription of Her-2/ ...
  http://mct.aacrjournals.org/content/2/10/971
*  ZFPM2 - Wikipedia
Svensson, E C; Tufts R L; Polk C E; Leiden J M (Feb 1999). "Molecular cloning of FOG-2: a modulator of transcription factor ... A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. ... Mutations in ZFPM2 cause Congenital Diaphragmatic Hernia . ZFPM2 has been shown to interact with GATA4, GATA1 and CTBP2. GRCh38 ... The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The ...
  https://en.wikipedia.org/wiki/ZFPM2
*  RPS19 ribosomal protein S19 [Homo sapiens (human)] - Gene - NCBI
Data indicate that GATA1 transcription factor is downregulated in ribosomal protein S19 (RPS19)-deficient cells through ... Viral mRNA Translation, organism-specific biosystemSpliced and unspliced viral mRNA in the cytoplasm are translated by host ... organism-specific biosystemThe 80S ribosome bound to the mRNA moves along the mRNA molecule from its initial site to the ... Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S, organism-specific ...
  https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=6223
*  Germ cell expression of the transcriptional co-repressor TIF1β is required for the maintenance of spermatogenesis in the mouse ...
... and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells. Development 120, 1759-1766. ... regulation by germ cells of the stage-specific expression of CP-2/cathepsin L mRNA by Sertoli cells. Dev. Genet. 16, 104-113. ... Central players in this elaborate process are sequence-specific transcription factors that activate and/or repress ... a novel AP-2-related transcription factor induced by retinoic acid during differentiation of P19 embryonal carcinoma cells. Exp ...
  http://dev.biologists.org/content/129/10/2329.long
*  mutations of mortality: How stem cells become B cells
HSCs express not only transcription factors that maintain their self-renewal capacity, but also transcription factors closely ... Erythroid and megakaryoctye required factors such as Gata1, EpoR and MPL are also expressed in the most primitive of bone ... Upon differentiation into MPPs and LMPPs, the mRNA levels of the erythroid specific genes decrease, while the levels of the ... The transcription factor Pax5 is regulated by E2A, EBF, IRF4, IRF8 as well as PU.1. It plays an essential role in B-lineage ...
  http://mutated-unmuated.blogspot.com/2011/11/how-stem-cells-become-b-cells.html
*  MicroRNAs and their roles in mammalian stem cells | Journal of Cell Science
... the miR-144-miR-451 locus is directly activated by a key erythroid transcription factor, Gata-1 (Dore et al., 2008). Loss-of- ... miR-145 directly targets and suppresses the mRNAs encoding the transcription factors Oct4, Sox2 and Klf4, which are required to ... Both miR-1 and miR-133 are muscle-specific miRNAs that are induced by serum response factor (SRF), a transcription factor that ... Because transcription mediated by RNA polymerase II is under extensive regulation by transcription factors and diverse ...
  http://jcs.biologists.org/content/124/11/1775
*  KAKEN - Research Projects | Cloning and functional analysis of molecules for eosinophil differentiation (KAKENHI-PROJECT...
We demonstarted a major positive regulatory role for GATA-1 and a negative regulatory role for GATA-2 in MBP gene transcription ... to identify transcription factors involved in regulating the commitment and terminal differentiation of myeloid progenitors to ... In the eosinophilic cell line, HT93A, C/EBPα mRNA expression decreased significantly concomitant with eosinophilic ... We show that both C/EBPβand GATA-1 can bind simultaneously to the C/EBP- and GATA-1 binding sites in the MBP promoter and that ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670959/
*  JCI - Welcome
RNH1 binds to ribosomes and regulates erythropoiesis by controlling translation of the erythroid transcription factor GATA1. ... In Rnh1-deficient embryos, mRNA levels of Gata1 are normal, but GATA1 protein levels are decreased. At the molecular level, we ... The transcription factor PU.1 is often impaired in patients with acute myeloid leukemia (AML). Here, we used AML cells that ... Little is known about the molecular mechanisms of selective mRNA translation and involvement of ribosomal-associated factors in ...
  https://taoyantao.com.www.mobile.jci.org/tags/23
*  Tmem261 - Wikipedia
2004). "Global regulation of erythroid gene expression by transcription factor GATA-1". Blood. 104 (10): 3136-3147. doi:10.1182 ... TMEM261 has 2 exons and 1 intron, and 6 primary transcript variants; the largest mRNA transcript variant consisting of 742bp ... 2004). "Global regulation of erythroid gene expression by transcription factor GATA-1". Blood. 104 (10): 3136-3147. doi:10.1182 ... regulation particularly in the cardiovascular system and two binding sites for GATA1 which is a globin transcription factor 1 ...
  https://en.wikipedia.org/wiki/Tmem261
*  SIGLEC8 - Wikipedia
... whereas the transcription factor GATA-1 peaks at day 2 and the secondary granule protein MBP-1 peaks at day 4 in this ... kinetic analysis of GATA-1, MBP1 and IL-5R alpha mRNA expression". Pediatric Allergy and Immunology. 21 (4 Pt 1): 640-8. doi: ... Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Siglec-8 is expressed by human ...
  https://en.wikipedia.org/wiki/SIGLEC8