*  GATA1 - Wikipedia
"Erythroid GATA1 function revealed by genome-wide analysis of transcription factor occupancy, histone modifications, and mRNA ... Erythroid transcription factor also known as GATA-binding factor 1 or GATA-1 is a protein that in humans is encoded by the ... "Entrez Gene: GATA1 GATA binding protein 1 (globin transcription factor 1)". Crispino JD (Feb 2005). "GATA1 in normal and ... GATA-1 is a member of the GATA transcription factor family and is a key mediator of the development of specific types of blood ...
  https://en.wikipedia.org/wiki/GATA1
*  Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA...
PU.1 and ETS-1 expression were induced in correlation with miR-155 inhibition; however, the GATA-1/PU.1 interaction was ... GATA-2 and miR-27a expression were increased in correlation with a decrease in RUNX1 mRNA expression, suggesting megakaryocyte ... In Epo-stimulated CD34(+)/HSCs, VPA induced the expression of the ETS family transcription factors PU.1, ETS-1, GABP-α, Fli-1 ... Valproic acid regulates erythro-megakaryocytic differentiation through the modulation of transcription factors and microRNA ...
  https://www.sigmaaldrich.com/catalog/papers/25241289
*  Differential genomic targeting of the transcription factor TAL1 in alternate haematopoietic lineages | The EMBO Journal
Erythroid GATA1 function revealed by genome‐wide analysis of transcription factor occupancy, histone modifications, and mRNA ... binding transcription factors, including GATA3 in leukaemic T cells (Ono et al, 1998), and SP1 (Lecuyer et al, 2002) or GATA1 ( ... GATA1 and TAL1 cooccupancy appears to correlate with active genes in erythroid cells, although these two transcription factors ... binding selectivity of transcription factors and suggest how changing the cellular context can render a transcription factor ...
  http://emboj.embopress.org/content/30/3/494
*  AGGF1 - Wikipedia
GATA1 and another unknown factor. To form a protein, an mRNA transcript must be transcribed from the DNA. For AGGF1, the mRNA ... the only known transcription factor that regulates AGGF1 is GATA1. GATA1 binds upstream of the AGGF1 gene promoter at -295 and ... For the gene to be fully expressed, both of the activator sites must be bound by the transcription factors, ... "Novel roles of GATA1 in regulation of angiogenic factor AGGF1 and endothelial cell function". The Journal of Biological ...
  https://en.wikipedia.org/wiki/AGGF1
*  JCI - Welcome
RNH1 binds to ribosomes and regulates erythropoiesis by controlling translation of the erythroid transcription factor GATA1. ... In Rnh1-deficient embryos, mRNA levels of Gata1 are normal, but GATA1 protein levels are decreased. At the molecular level, we ... Little is known about the molecular mechanisms of selective mRNA translation and involvement of ribosomal-associated factors in ... In response to oscillatory shear stress, the transcription factors Tal1, Gata2, and Ets1/2 physically interacted with and ...
  https://www.jci.org/tags/19
*  Jason Gotlib | Stanford Medicine Profiles
Here, we identify mutations in GATA1, encoding the critical hematopoietic transcription factor GATA-binding protein-1, that ... We show that ribosomal protein haploinsufficiency, the more common cause of DBA, can lead to decreased GATA1 mRNA translation, ... The purpose of this study is to investigate risk factors associated with depression and how such factors might be transmitted ... Confocal fluorescence microscopy and a lymphoid enhancer factor/T-cell factor reporter assay were used to detect nuclear beta- ...
  https://med.stanford.edu/profiles/jason-gotlib
*  JCI - Welcome
In both mice and humans, mutations in the gene-encoding transcription factor GATA1 cause an accumulation of proliferating, ... developed a protocol that restores endogenous GATA1 levels in MEPs derived from murine ES cells in which Gata1 mRNA is ... and mutations in the gene encoding the transcription factor GATA1 lead to the MEP accumulation in both mice and humans. While ... stem cells can be used to produce platelets on a clinical scale by controlling the level of the transcription factor GATA1. ...
  https://www.jci.org/posts/289
*  ERG Is a Megakaryocytic Oncogene | Cancer Research
Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Nat Genet 2005; 37: 613-9. ... C, relative level of megakaryocytic mRNA expression (CD41, CD42, and PF4), measured by quantitative reverse transcription-PCR, ... Somatic mutations acquired during fetal hematopoiesis in the GATA1 transcription factor are detected in megakaryoblasts from ... Ets-related gene (ERG) is a member of the ETS transcription factor gene family located on Hsa21. ERG is known to have a crucial ...
  http://cancerres.aacrjournals.org/content/69/11/4665.full
*  JCI - Welcome
RNH1 binds to ribosomes and regulates erythropoiesis by controlling translation of the erythroid transcription factor GATA1. ... In Rnh1-deficient embryos, mRNA levels of Gata1 are normal, but GATA1 protein levels are decreased. At the molecular level, we ... Factor XII does double duty in wound healing In this issue, Stavrou et al. pursue coagulation factor FXII's functions in ... Little is known about the molecular mechanisms of selective mRNA translation and involvement of ribosomal-associated factors in ...
  https://minfengtang.net.insight.mobile.jci.org/
*  JCI - Latest articles
RNH1 binds to ribosomes and regulates erythropoiesis by controlling translation of the erythroid transcription factor GATA1. ... In Rnh1-deficient embryos, mRNA levels of Gata1 are normal, but GATA1 protein levels are decreased. At the molecular level, we ... Little is known about the molecular mechanisms of selective mRNA translation and involvement of ribosomal-associated factors in ... Our results reveal an unsuspected role for RNH1 in the control of GATA1 mRNA translation and erythropoiesis. ...
  https://minfengtang.net.insight.mobile.jci.org/just-published
*  Plus it
Because acetylation has been shown to affect the DNA binding activity of several transcription factors (e.g., p53 and GATA-1; ... GAPDH mRNA expression was used as the loading control. The Her-2/neu/GAPDH mRNA level ratio as a percentage of untreated ... Boyes, J., Byfield, P., Nakatani, Y., and Ogryzko, V. Regulation of activity of the transcription factor GATA-1 by acetylation ... We investigated whether treatment with LAQ824 could induce a transcription factor(s) that represses the transcription of Her-2/ ...
  http://mct.aacrjournals.org/content/2/10/971
*  ZFPM2 - Wikipedia
Svensson, E C; Tufts R L; Polk C E; Leiden J M (Feb 1999). "Molecular cloning of FOG-2: a modulator of transcription factor ... A related mRNA suggests an alternatively spliced product but this information is not yet fully supported by the sequence. ... Mutations in ZFPM2 cause Congenital Diaphragmatic Hernia . ZFPM2 has been shown to interact with GATA4, GATA1 and CTBP2. GRCh38 ... The zinc finger protein encoded by this gene is a widely expressed member of the FOG family of transcription factors. The ...
  https://en.wikipedia.org/wiki/ZFPM2
*  Germ cell expression of the transcriptional co-repressor TIF1β is required for the maintenance of spermatogenesis in the mouse ...
... and spermatogenic cycle-specific expression of transcription factor GATA-1 in mouse Sertoli cells. Development 120, 1759-1766. ... regulation by germ cells of the stage-specific expression of CP-2/cathepsin L mRNA by Sertoli cells. Dev. Genet. 16, 104-113. ... Central players in this elaborate process are sequence-specific transcription factors that activate and/or repress ... a novel AP-2-related transcription factor induced by retinoic acid during differentiation of P19 embryonal carcinoma cells. Exp ...
  http://dev.biologists.org/content/129/10/2329.long
*  MicroRNAs and their roles in mammalian stem cells | Journal of Cell Science
... the miR-144-miR-451 locus is directly activated by a key erythroid transcription factor, Gata-1 (Dore et al., 2008). Loss-of- ... miR-145 directly targets and suppresses the mRNAs encoding the transcription factors Oct4, Sox2 and Klf4, which are required to ... Both miR-1 and miR-133 are muscle-specific miRNAs that are induced by serum response factor (SRF), a transcription factor that ... Because transcription mediated by RNA polymerase II is under extensive regulation by transcription factors and diverse ...
  http://jcs.biologists.org/content/124/11/1775
*  KAKEN - Research Projects | Cloning and functional analysis of molecules for eosinophil differentiation (KAKENHI-PROJECT...
We demonstarted a major positive regulatory role for GATA-1 and a negative regulatory role for GATA-2 in MBP gene transcription ... to identify transcription factors involved in regulating the commitment and terminal differentiation of myeloid progenitors to ... In the eosinophilic cell line, HT93A, C/EBPα mRNA expression decreased significantly concomitant with eosinophilic ... We show that both C/EBPβand GATA-1 can bind simultaneously to the C/EBP- and GATA-1 binding sites in the MBP promoter and that ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670959/
*  JCI - Welcome
RNH1 binds to ribosomes and regulates erythropoiesis by controlling translation of the erythroid transcription factor GATA1. ... In Rnh1-deficient embryos, mRNA levels of Gata1 are normal, but GATA1 protein levels are decreased. At the molecular level, we ... The transcription factor PU.1 is often impaired in patients with acute myeloid leukemia (AML). Here, we used AML cells that ... Little is known about the molecular mechanisms of selective mRNA translation and involvement of ribosomal-associated factors in ...
  https://taoyantao.com.www.mobile.jci.org/tags/23
*  Tmem261 - Wikipedia
2004). "Global regulation of erythroid gene expression by transcription factor GATA-1". Blood. 104 (10): 3136-3147. doi:10.1182 ... TMEM261 has 2 exons and 1 intron, and 6 primary transcript variants; the largest mRNA transcript variant consisting of 742bp ... 2004). "Global regulation of erythroid gene expression by transcription factor GATA-1". Blood. 104 (10): 3136-3147. doi:10.1182 ... regulation particularly in the cardiovascular system and two binding sites for GATA1 which is a globin transcription factor 1 ...
  https://en.wikipedia.org/wiki/Tmem261
*  Plus it
Among the recognized transcription factor-binding sites, which include AhR, NF-κB, AP-2, and GATA-1 motifs, the GC-rich, ... GCS mRNA levels were normalized by expression of 18S ribosomal mRNA. B, cells were labeled with [3H]galactose for the final 3 ... 4 ⇓ , Sp1 transcription factors were increased in the nucleus after treatment with 0.35 μmol/L DOX in HL-60/ADR cells, but not ... 4C) ⇓ . These results suggest that DOX-induced activation of the GCS promoter is regulated via transcription factor(s) binding ...
  http://cancerres.aacrjournals.org/content/64/17/6271
*  SIGLEC8 - Wikipedia
... whereas the transcription factor GATA-1 peaks at day 2 and the secondary granule protein MBP-1 peaks at day 4 in this ... kinetic analysis of GATA-1, MBP1 and IL-5R alpha mRNA expression". Pediatric Allergy and Immunology. 21 (4 Pt 1): 640-8. doi: ... Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Siglec-8 is expressed by human ...
  https://en.wikipedia.org/wiki/SIGLEC8
*  Overlapping and Divergent Actions of Estrogen and the Neurotrophins on Cell Fate and p53-Dependent Signal Transduction in...
1996) Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1. Mol Cell Biol 16:1687-1694. ... 1994b) Estrogen differentially regulates estrogen and nerve growth factor receptor mRNAs in adult sensory neurons. J Neurosci ... The two identified estrogen receptors (ERα and ERβ) are transcription factor members of the steroid hormone/retinoic acid ... The large T antigen promotes mammalian cell cycle by inhibiting checkpoint transcription factors like p53 (for review, see ...
  http://www.jneurosci.org/content/19/16/6994.long
*  LMO2 - Wikipedia
"LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1". Leukemia. 11 Suppl 3: 307-12. PMID ... "Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene ... "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". ... "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1". ...
  https://en.wikipedia.org/wiki/LMO2
*  MicroRNA Fingerprints During Human Megakaryocytopoiesis - Patent application
MAFB Transcription Factor is a Target of miR-130a [0194] By using three target prediction algorithms (TARGETSCAN (www.genes.mit ... mRNA) in a sequence specific manner, inducing translational repression or mRNA degradation depending on the degree of ... down GATA1 [0206] PAM selected microRNAs. The fold change of miRNA expression is shown alongside t test score (SAM) and ... Among the transcription factors with well-known function in megakaryocytopoiesis, RUNX-1 (Elagib, K. E., et al. (2003) Blood, ...
  http://www.patentsencyclopedia.com/app/20120329053
*  SMART: Secondary literature for CXC domain
... a Sertoli cell specific transcription factor, GATA-1 and the male germ cell specific, RNA binding motif (RBM), were used to ... although type B mRNA was more abundant than type A mRNA. RT-PCR analysis revealed that these two mRNAs were also expressed in ... TFIIAalpha/beta-like factor (ALF) is a testis-specific counterpart of the large subunit of human general transcription factor ... like factor is encoded by a germ cell-specific gene whose expression is up-regulated with other general transcription factors ...
  http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=CXC
*  ZFPM1 - Wikipedia
1997). "FOG, a multitype zinc finger protein, acts as a cofactor for transcription factor GATA-1 in erythroid and ... Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315-23. doi: ... It is a cofactor of the GATA1 transcription factor. GRCh38: Ensembl release 89: ENSG00000179588 - Ensembl, May 2017 GRCm38: ... 2003). "Molecular cloning and characterization of the GATA1 cofactor human FOG1 and assessment of its binding to GATA1 proteins ...
  https://en.wikipedia.org/wiki/ZFPM1
*  YB-1 is a downstream component of the PI3K/Akt signaling pathway and regulates EGFR in breast carcinoma : a mechanism for...
2002). Another transcription factor, GATA-1, also binds to the 5'-UTR and activates the YB-1 promoter (Yokoyama et. al. 2003). ... The mRNA-binding protein YB-1 (p50) prevents association of the eukaryotic initiation factor eIF4G with mRNA and inhibits ... 1.3.3.2 YB-1 in Transcription As a transcription factor, YB-1 binds to the inverted CCAAT element in the Y-box (Didier et. al. ... Kageyama R., Merlino G.T., and Pastan I. A transcription factor active on the epidermal growth factor receptor gene. Proc Natl ...
  https://open.library.ubc.ca/cIRcle/collections/ubctheses/831/items/1.0092884