*  Allopregnanolone - Wikipedia
... similar to those of other positive allosteric modulators of the GABA action at GABAA receptor such as the benzodiazepines, ... Morris KD, Moorefield CN, Amin J (October 1999). "Differential modulation of the gamma-aminobutyric acid type C receptor by ... It is synthesized from progesterone, and is a potent positive allosteric modulator of the action of γ-amininobutyric acid (GABA ... September 2011). "Paradoxical effects of GABA-A modulators may explain sex steroid induced negative mood symptoms in some ...
  https://en.wikipedia.org/wiki/Allopregnanolone
*  The Etiology of Premenstral Dysphoric Disorder: 5 interwoven pieces. - MGH Center for Women's Mental Health
Much like alcohol or benzodiazepines, ALLO is a potent positive allosteric modulator of GABAA receptors and has sedative, ... Amin Z, Canli T, Epperson CN. Effect of estrogen-serotonin interactions on mood and cognition. Behav Cogn Neurosci Rev. 2005;4( ... Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric ... and GABA receptors, and the complemen-tary fashion in which progesterone and estrogen influence each other. ...
  https://womensmentalhealth.org/specialty-clinics/pms-and-pmdd/the-etiology-of-pmdd/?doing_wp_cron=1524245772.2617599964141845703125
*  Halazepam - DrugBank
Halazepam is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative and skeletal muscle relaxant ... Rho-1 GABA.... Gene Name. GABRR1. Uniprot ID. P24046. Uniprot Name. Gamma-aminobutyric acid receptor subunit rho-1. Molecular ... Benzodiazepines. Sub Class. 1,4-benzodiazepines. Direct Parent. 1,4-benzodiazepines. Alternative Parents. Alpha amino acids and ... AGABA-A receptor (anion channel). positive allosteric modulator. Human. Absorption. Not Available. Volume of distribution. Not ...
  https://www.drugbank.ca/drugs/DB00801
*  Basis of the Gabamimetic Profile of Ethanol
Effect of zolpidem on gamma-aminobutyric acid (GABA)-induced inhibition predicts the interaction of ethanol with GABA on ... are potent allosteric modulators of GABA responsiveness from GABAA receptors, having this action at nanomolar concentrations ( ... Benzodiazepine-induced motor impairment linked to point mutation in cerebellar GABAA receptor. Nature. 1993;361:356-359. [ ... AMA Arch Neurol Psychiatry. 1950;64:1-28. [PubMed]. *Janak PH, Redfern JEM, Samson HH. The reinforcing effects of ethanol are ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2958095/?lang=en-ca
*  Frontiers | Identification of amino acids involved in histamine potentiation of GABAA receptors | Pharmacology
GABA(A)Rs) and, in high concentrations (10 mM), as negative modulator of the strychnine-sensitive glycine receptor. However, ... GABA(A)Rs) and, in high concentrations (10 mM), as negative modulator of the strychnine-sensitive glycine receptor. However, ... We expressed GABA(A)Rs with 12 different point mutations in Xenopus laevis oocytes and characterized the effect of histamine on ... We expressed GABA(A)Rs with 12 different point mutations in Xenopus laevis oocytes and characterized the effect of histamine on ...
  https://www.frontiersin.org/articles/10.3389/fphar.2015.00106/full
*  Tracazolate Reveals a Novel Type of Allosteric Interaction with Recombinant γ-Aminobutyric AcidA Receptors | Molecular...
2000) Allosteric modulators affect the efficacy of partial agonists for recombinant GABAA receptors. Br J Pharmacol 129:1794- ... Amin J, *Brooks-Kayal A, and *Weiss DS. (1997) Two tyrosine residues on the α subunit are crucial for benzodiazepine binding ... 1997) Subunit-dependent interaction of the general anaesthetic etomidate with the gamma-aminobutyric acid type A receptor. Br J ... A, concentration-response curves for GABA (●), GABA + 1 μM tracazolate (▪), GABA + 10 μM tracazolate (▴), and GABA + 30 μM ...
  http://molpharm.aspetjournals.org/content/61/4/861.long
*  Keppra-XR - FDA prescribing information, side effects and uses
... such as those associated with benzodiazepines, GABA (gamma-aminobutyric acid), glycine, NMDA (N-methyl-D-aspartate), re-uptake ... However, in vitro studies have demonstrated that levetiracetam opposes the activity of negative modulators of GABA- and glycine ... Levetiracetam was not mutagenic in the Ames test or in mammalian cells in vitro in the Chinese hamster ovary/HGPRT locus assay ... The hydrolysis product and major human metabolite of levetiracetam (ucb L057) was not mutagenic in the Ames test or the in ...
  https://www.drugs.com/pro/keppra-xr.html
*  Key Amino Acids in the γ Subunit of the γ-Aminobutyric AcidA Receptor that Determine Ligand Binding and Modulation at the...
The effects of GABAA receptor modulators were examined on control GABA responses using a concentration that elicited 20% of a ... Amin J., *Brooks-Kayal A., and *Weiss D. S.. (1997) Two tyrosine residues on the α subunit are crucial for benzodiazepine ... 1996) GABA-A receptor subtypes differentiated by their gamma-subunit variants: prevalence, pharmacology and subunit ... GABA. γ-aminobutyric acid. BZ. benzodiazepine. β-CCM. methyl-β-carboline-3-carboxylate. PCR. polymerase chain reaction. HEPES. ...
  http://molpharm.aspetjournals.org/content/52/5/874
*  Plus it
2005) Benzodiazepines affect channel opening of GABAA receptors induced by either agonist binding site. Mol Pharmacol 67:1005- ... 2004) Structural elements involved in activation of the gamma-aminobutyric acid type A (GABAA) receptor. Biochem Soc Trans 32: ... 1). To eliminate GABA binding, the Y205S mutation (Amin and Weiss, 1993) was introduced to one or both β subunits. To eliminate ... Potentiating neuroactive steroids are potent and efficacious modulators of the GABAA receptor that act by allosterically ...
  http://molpharm.aspetjournals.org/content/80/1/79
*  BUTYLAMMONIUM MODULATORS OF FATTY ACID TRANSPORT - Patent application
0121]The procedure is carried out as described in Ames et al., Annals of the New York Academy of Sciences 2004, 1033(Carnitine ... Ornithine aminotransferase inhibition with gaba analogues for treatment of hepatocellular carcinoma. 2016-05-05. Increase of ... gamma-glutamyl transpeptidase ("GGTP," "γ-GTP," or "GGT"), leucine aminopeptidase ("LAP"), liver biopsy, liver ultrasonography ... benzodiazepines, amphetamine-like stimulants, anticoagulants, thrombolytics, fibrates, bile acid sequestrants, CETP inhibitors ...
  http://www.patentsencyclopedia.com/app/20100120917
*  Plus it
The latter class of medications includes benzodiazepines that reduce norepinephrine release through potentiation of gamma- ... aminobutyric acid (GABA) at GABA-A receptors in the central nervous system (37). While β-blockers predominantly affect ... Neurotransmitter receptor-mediated signaling pathways as modulators of carcinogenesis. Prog Exp Tumor Res 2007;39:45-63. ... Amin S, *Boffetta P, *Lucas AL. . The role of common pharmaceutical agents on the prevention and treatment of pancreatic cancer ...
  http://cancerres.aacrjournals.org/content/77/13/3700
*  KEPPRA (levetiracetam) tablets, for oral use KEPPRA (levetiracetam) oral solution Initial U.S. Approval: PDF
... such as those associated with benzodiazepines, GABA (gamma-aminobutyric acid), glycine, NMDA (Nmethyl-D-aspartate), re-uptake ... However, in vitro studies have demonstrated that levetiracetam opposes the activity of negative modulators of GABA- and glycine ... Mutagenesis Levetiracetam was not mutagenic in the Ames test or in mammalian cells in vitro in the Chinese hamster ovary/hgprt ... The hydrolysis product and major human metabolite of levetiracetam (ucb L057) was not mutagenic in the Ames test or the in ...
  http://docplayer.net/21305023-Keppra-levetiracetam-tablets-for-oral-use-keppra-levetiracetam-oral-solution-initial-u-s-approval-1999.html
*  International Union of Pharmacology. LXX. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit...
They are relatively insensitive to bicuculline and also to GABAA-R modulators such as benzodiazepines, barbiturates, and ... Hadley SH and Amin J (2007) Rat α6β2δ GABAA receptors exhibit two distinct and separable agonist affinities. J Physiol 581: ... Kofuji P, Wang JB, Moss SJ, Huganir RL, and Burt DR (1991) Generation of two forms of the gamma-aminobutyric acidA receptor γ2- ... exerts its action via ionotropic GABAA and metabotropic GABAB receptors. GABAA receptors (GABAA-Rs) are the major inhibitory ...
  http://pharmrev.aspetjournals.org/content/60/3/243.long
*  Malignant Hyperthermia and Related Conditions - Renal and Urology News
... a drug that enhances the effects of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter, in the brain and spinal ... Sedation with benzodiazepines may be useful for controlling agitation and for correcting mild increases in heart rate and blood ... Horstick, EJ, Linsley, JW, Dowling, JJ, Hauser, MA, McDonald, KK, Ashley-Koch, A, Saint-Amant, L, Satish, A, Cui, WW, Zhou, W, ... Liechti, M. "Novel psychoactive substances (designer drugs): overview and pharmacology of modulators of monoamine signaling". ...
  http://www.renalandurologynews.com/critical-care-medicine/malignant-hyperthermia-and-related-conditions/article/586968/
*  chakras
GABA, a neurotransmitter) system. This action is similar to that of benzodiazepines, (e.g. diazepam or "Valium"), which relieve ... Johnson, L.Y (1982). The Pineal as a modulator of the Adrenal and Thyroid Axes. In Reiter, R.J., The Pineal Gland, Vol. III: ... Chakra del Corazón: ¿Tengo mis relaciones sanas? ¿Me Amo a mí mismo, amigos y familiares, y tienen un fuerte sentido de la ... carbolines are central nervous system inhibitors via the gamma-aminobutyric acid ( ...
  https://manuelherrerayoga.wordpress.com/tag/chakras/
*  fat ladys fills pussy asshole with monster cock - forum.central-roleplay.com - Page 16 - Central Roleplay
GABA analogue cis-4-aminocrotonic acid (CACA) selectively activates a third class of GABAA Rs in the mammalian CNS. Inform ... Healing manipulation includes good integument hydration, perseverance of topical corticosteroids or untouched modulators, oral ... Lustfully synaptic inhi- bition promotes synchronized gamma oscillations in hippocampal interneuron networks. ... in the imperfect benzodiazepine-binding site of the protein. Upon histopathological division of alkie neuropathy patients, ...
  http://forum.central-roleplay.com/viewtopic.php?f=19&t=39535&sid=23aff073fd9b4aa84897a756da459d8b&start=150
*  Elevage du domaine de la rocheli re, accessoires canins, malinois et tervueren de travail, pension ch cy
... the Zn2+ as unqualified modulator; (6) the polyamines as forceful or adversative modulator, depending on the heighten and their ... mate or GABA. Viral exanthems of adolescence time after time remaining with a singular rash criterion that assists in the ... but take differential affinity from nonclassical benzodiazepines, such as zolpidem, zaleplon, and abecarnil (Korpi et al. ... In July 2006, the AMA rumored the findings from a set of researchers at the Lincoln of city [url=http://www.culturewars.com/ ...
  http://www.rocheliere.com/livreor.php?page=29
*  PolygenicBlog: 01/02/13
GABA (7) Gamete (1) gamma-secretase (2) Ganglioside (1) Gastrointestinal (1) Gastrointestinal cancer (6) Gene expression (7) ... AMA status) of patients with PBC. We thus tested AMA+and AMA- PBC patients' sera for antibodies (Abs) against multiple ... Benzodiazepine (1) beta agonist (1) Beta amyloid (20) Beta blocker (1) beta-amyloid (55) Beta-secretase 1 (2) Bifidobacterium ( ... Some circular RNA molecules serve as molecular "sponges," binding to and deactivating gene modulators called microRNAs to ...
  https://polygenicpathways.blogspot.com/2013_02_01_archive.html