HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer+ Gag-Specific CD4+ T Cells...
Human Immunodeficiency Virus / immunology* Substances * Histocompatibility Antigens Class II * gag Gene Products, Human ... Keywords: CD4 T helper cells; MHC class II tetramers; human immunodeficiency virus, HIV. ... Here, we defined the MHC class II alleles for immunodominant Gag CD4+ T cell epitopes in clade C virus infection, constructed ... Here, we employed MHC class II tetramers designed to immunodominant Gag epitopes and used them to characterize CD4+ T cell ...
Human T cells expressing two additional receptors (TETARs) specific for HIV-1 recognize both epitopes
An HLA-A2-restricted gag-specific TCR and an HLA-B13- … ... gag Gene Products, Human Immunodeficiency Virus / genetics * ... Human T cells expressing two additional receptors (TETARs) specific for HIV-1 recognize both epitopes Blood. 2011 Nov 10;118(19 ... An HLA-A2-restricted gag-specific TCR and an HLA-B13-restricted nef-specific TCR were chosen. When both TCRs were transfected ... simultaneously, strong competitive effects occurred that were overcome by replacing the human constant domains of one TCR with ...
Pol (HIV) - Wikipedia
Gene+Products,+Human+Immunodeficiency+Virus at the U.S. National Library of Medicine Medical Subject Headings (MeSH) v t e ( ... Gag/pol translational readthrough site Gene+Products,+pol at the U.S. National Library of Medicine Medical Subject Headings ( ... Pol (DNA polymerase) refers to a gene in retroviruses, or the protein produced by that gene. Products of pol include: Common to ... HIVs gag and pol genes do not produce their proteins in their final form, but as larger combination proteins; the specific ...
Mucosal Immunization with Newcastle Disease Virus Vector Coexpressing HIV-1 Env and Gag Proteins Elicits Potent Serum, Mucosal,...
gag Gene Products, Human Immunodeficiency Virus. *env Gene Products, Human Immunodeficiency Virus ... gag Gene Products, Human Immunodeficiency Virus. *env Gene Products, Human Immunodeficiency Virus ... Env-Gag (gp160 located between the P and M genes and Gag between the HN and L genes), rNDV-Gag-Env (Gag located between the P ... The Gag and Env proteins expressed by all the recombinants except rNDV-Env-Gag self-assembled into human immunodeficiency virus ...
Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective...
... env Gene Products, Human Immunodeficiency Virus; Enzyme-Linked Immunosorbent Assay; Female; Flow cytometry; Fusion Proteins, ... gag-pol; Gene Products, env; Genetic Vectors; HIV Infections; HIV-1; Humans; Injections, Intramuscular; Male; Nausea; ... BACKGROUND: The development of an effective human immunodeficiency virus (HIV) vaccine is a high global priority. Here, we ... METHODS: The vaccine is a mixture of 4 rAd5 vectors that express HIV-1 subtype B Gag-Pol fusion protein and envelope (Env) from ...
"3D visualization of HIV virions by cryoelectron tomography." by Jun Liu, Elizabeth R Wright et al.
... have provided a new approach for determining the 3D structures of the intact virus, the HIV capsid, and the envelope ... The structure of the human immunodeficiency virus (HIV) and some of its components have been difficult to study in three- ... gag Gene Products, Human Immunodeficiency Virus ... The structure of the human immunodeficiency virus (HIV) and ... have provided a new approach for determining the 3D structures of the intact virus, the HIV capsid, and the envelope ...
Inhibition of HIV type 1 replication by simultaneous infection of peripheral blood lymphocytes with human immunodeficiency...
Human Immunodeficiency Virus Proteins Medicine & Life Sciences 8% * gag Gene Products Medicine & Life Sciences 8% ... of HIV type 1 replication by simultaneous infection of peripheral blood lymphocytes with human immunodeficiency virus types 1 ... of HIV type 1 replication by simultaneous infection of peripheral blood lymphocytes with human immunodeficiency virus types 1 ... of HIV type 1 replication by simultaneous infection of peripheral blood lymphocytes with human immunodeficiency virus types 1 ...
Preexisting compensatory amino acids compromise fitness costs of a HIV-1 T cell escape mutation. - Nuffield Department of...
... viruses. RESULTS: The T242N mutation resulted in various levels of fitness loss in four different T/F viruses. However, the ... escape mutation T242N in Gag in HIV-1-infected individuals carrying HLA-B*57/5801 alleles. However, the impact of different ... Virus Replication, gag Gene Products, Human Immunodeficiency Virus ... viruses. RESULTS: The T242N mutation resulted in various levels of fitness loss in four different T/F viruses. However, the ...
Protease cleavage leads to formation of mature trimer interface in HIV-1 capsid. - Immunology
Results from crosslinking analyses of mature and immature HIV-1 particles containing the same Cys substitutions in the Gag ... Collectively, our results indicate that the proteolytic cleavage of Gag leads to a structural reorganization of the polypeptide ... the assembled Gag polyprotein is cleaved by the viral protease into matrix (MA), capsid (CA), and nucleocapsid (NC) proteins. ... gag Gene Products, Human Immunodeficiency Virus ... our results indicate that the proteolytic cleavage of Gag leads ...
Molecular investigation of human immunodeficiency virus (HIV) infection in a patient of an HIV-infected surgeon. - Peter...
Nucleotide sequencing of the gag gene and maximum likelihood phylogenetic analysis were used to investigate the relationships ... among sequences from the surgeon, the patient, and an anonymous blood donor from whom the patient had received blood products. ... Recall of patients who had been treated by a human immunodeficiency virus (HIV)-infected surgeon uncovered 1 previously unknown ... Base Sequence, Blood Transfusion, DNA, Viral, Gene Products, gag, General Surgery, HIV, HIV Infections, Humans, Molecular ...
Expansion and diversification of virus-specific T cells following immunization of human immunodeficiency virus type 1 (HIV-1)...
Gag-specific CD8(+) and CD4(+) T-cell proliferation also increased postvaccination. These data suggest that immunization with ... In this study, we performed a comprehensive analysis of the changes in virus-specific CD8(+) and CD4(+) T-cell responses ... individuals with a recombinant modified vaccinia virus Ankara-vectored vaccine expressing the consensus HIV-1 clade A Gag p24/ ... Affordable therapeutic strategies that induce sustained control of human immunodeficiency virus type 1 (HIV-1) replication and ...
HLA-mediated control of HIV and HIV adaptation to HLA. - Immunology
The genes encoding the human leukocyte antigen (HLA) class I molecules have a critical influence in the success or failure of ... response that is made against the virus. This chapter describes the role of HLA class I and the CTL response in controlling HIV ... indicating the dynamic and shifting nature of the evolutionary interplay between HIV and human populations. ... The human immunodeficiency virus (HIV) epidemic provides a rare opportunity to examine in detail the initial stages of a host- ...
HLA-specific intracellular epitope processing shapes an immunodominance pattern for HLA-B*57 that is distinct from HLA-B*58:01....
T cells targeting the KF11-Gag epitope, which has been linked to low viremia. Here we show that HLA-B*58:01 binds and presents ... gag Gene Products, Human Immunodeficiency Virus ... Humans, Peptide Fragments, T-Lymphocytes, Cytotoxic, Viral Load ... T cells targeting the KF11-Gag epitope, which has been linked to low viremia. Here we show that HLA-B*58:01 binds and presents ...
The molecular epidemiology of human immunodeficiency virus type 1 in Edinburgh. - Experimental Medicine Division
... that 12 of 14 hemophiliac patients who had been exposed to a single common batch of factor VIII had closely related gag gene ... However, epidemiologic relationships inferred from analysis of the V3 region of the env gene were less conclusive, especially ... in different risk groups in Edinburgh were studied to determine the number and origin of virus variants and patterns of virus ... Human immunodeficiency virus (HIV) type 1 sequences obtained from HIV-infected persons ...
HLA-B*57 Micropolymorphism shapes HLA allele-specific epitope immunogenicity, selection pressure, and HIV immune control. -...
These findings are consistent with HLA class I alleles mediating effective immune control of HIV through the number of p24 Gag- ... T-cell specificities and by clear-cut differences in selection pressure imposed on the virus by those responses. These studies ... specific CD8(+) T-cell responses generated that can drive significant selection pressure on the virus. ... The genetic polymorphism that has the greatest impact on immune control of human immunodeficiency virus (HIV) infection is ...
Safety and immunogenicity of recombinant low-dosage HIV-1 A vaccine candidates vectored by plasmid pTHr DNA or modified...
... human immunodeficiency virus type 1 (HIV-1) vaccine candidates were evaluated in four Phase I clinical trials in Kenya and ... Both vaccines, expressing HIV-1 subtype A gag p24/p17 and a string of CD8 T-cell epitopes (HIVA), were generally safe and well- ... Vaccinia virus, gag Gene Products, Human Immunodeficiency Virus ... human immunodeficiency virus type 1 (HIV-1) vaccine candidates ... Both vaccines, expressing HIV-1 subtype A gag p24/p17 and a string of CD8 T-cell epitopes (HIVA), were generally safe and well- ...
A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class...
... we have compared the effector functions and fate of a number of human CTL clones in vitro or ex vivo following contact with ... gag Gene Products, Human Immunodeficiency Virus ... Gene Products, gag, HIV Antigens, HLA-A2 Antigen, HLA-B ... In this study, we have compared the effector functions and fate of a number of human CTL clones in vitro or ex vivo following ... Antigens, HLA-B44 Antigen, Humans, Influenza A virus, Lymphocyte Activation, Membrane Glycoproteins, Membrane Proteins, ...
The presence of prolines in the flanking region of an immunodominant HIV-2 gag epitope influences the quality and quantity of...
PPP-gag sequence and both strong gag-specific CTL responses as well as lower viral load. ... Previously, we showed that the magnitude of the HIV-2 gag-specific T-cell response is inversely correlated with plasma viral ... We also showed that the presence of three proline residues, at positions 119, 159 and 178 of gag-p26, was significantly ... Since this proline motif was also associated with stronger gag-specific CTL responses, we investigated the impact of these ...
Sequential broadening of CTL responses in early HIV-1 infection is associated with viral escape. - The Jenner Institute
A subset of patients developed broad responses, which selected for consensus B epitope variants in Gag, Pol, and Nef, ... gag Gene Products, Human Immunodeficiency Virus, pol Gene Products, Human Immunodeficiency Virus, nef Gene Products, Human ... T-Lymphocytes, Cytotoxic, Humans, HIV-1, HIV Infections, Disease Progression, Tumor Necrosis Factor-alpha, HLA-A2 Antigen, HIV ... A subset of patients developed broad responses, which selected for consensus B epitope variants in Gag, Pol, and Nef, ...
NEW (2008) DeCS DESCRIPTORS WITH SCOPE NOTES (UNIT RECORD FORMAT; 21/02/2008
Proteins encoded by the GAG GENE of the HUMAN IMMUNODEFICIENCY VIRUS. HN - 2008 MH - pol Gene Products, Human Immunodeficiency ... HN - 2008 for HIV VIF GENE PRODUCT use GENE PRODUCTS, VIF 1991-2007 BX - HIV vif Gene Product MH - Human Immunodeficiency Virus ... HN - 2008 BX - nef Protein, Human Immunodeficiency Virus MH - vif Gene Products, Human Immunodeficiency Virus UI - D054320 MN ... Proteins encoded by the ENV GENE of the HUMAN IMMUNODEFICIENCY VIRUS. HN - 2008 FX - Genes, env MH - nef Gene Products, Human ...
NEW (2008) DeCS DESCRIPTORS WITH SCOPE NOTES (UNIT RECORD FORMAT; 21/02/2008
Proteins encoded by the GAG GENE of the HUMAN IMMUNODEFICIENCY VIRUS. HN - 2008 MH - pol Gene Products, Human Immunodeficiency ... HN - 2008 for HIV VIF GENE PRODUCT use GENE PRODUCTS, VIF 1991-2007 BX - HIV vif Gene Product MH - Human Immunodeficiency Virus ... HN - 2008 BX - nef Protein, Human Immunodeficiency Virus MH - vif Gene Products, Human Immunodeficiency Virus UI - D054320 MN ... Proteins encoded by the ENV GENE of the HUMAN IMMUNODEFICIENCY VIRUS. HN - 2008 FX - Genes, env MH - nef Gene Products, Human ...
NEW (2008) DeCS DESCRIPTORS WITH SCOPE NOTES (UNIT RECORD FORMAT; 21/02/2008
Proteins encoded by the GAG GENE of the HUMAN IMMUNODEFICIENCY VIRUS. HN - 2008 MH - pol Gene Products, Human Immunodeficiency ... HN - 2008 for HIV VIF GENE PRODUCT use GENE PRODUCTS, VIF 1991-2007 BX - HIV vif Gene Product MH - Human Immunodeficiency Virus ... HN - 2008 BX - nef Protein, Human Immunodeficiency Virus MH - vif Gene Products, Human Immunodeficiency Virus UI - D054320 MN ... Proteins encoded by the ENV GENE of the HUMAN IMMUNODEFICIENCY VIRUS. HN - 2008 FX - Genes, env MH - nef Gene Products, Human ...
NEW (2008) DeCS DESCRIPTORS WITH SCOPE NOTES (UNIT RECORD FORMAT; 21/02/2008
Proteins encoded by the GAG GENE of the HUMAN IMMUNODEFICIENCY VIRUS. HN - 2008 MH - pol Gene Products, Human Immunodeficiency ... HN - 2008 for HIV VIF GENE PRODUCT use GENE PRODUCTS, VIF 1991-2007 BX - HIV vif Gene Product MH - Human Immunodeficiency Virus ... HN - 2008 BX - nef Protein, Human Immunodeficiency Virus MH - vif Gene Products, Human Immunodeficiency Virus UI - D054320 MN ... Proteins encoded by the ENV GENE of the HUMAN IMMUNODEFICIENCY VIRUS. HN - 2008 FX - Genes, env MH - nef Gene Products, Human ...
Simian Immunodeficiency Virus (SIV) p27 Antigen ELISA (96 Determinations)
Microwells are coated with a monoclonal antibody specific for the p27 gag gene product of SIV. Viral antigen in the specimen is ... Human source material used in the manufacture of the SIV Detector Antibody has been tested and found negative for Hepatitis B ... The RETRO-TEK SIV p27 Antigen ELISA is an enzyme linked immunoassay used to detect Simian Immunodeficiency Virus (SIV) p27 ... Simian Immunodeficiency Virus (SIV) p27 Antigen ELISA (96 Determinations). https://www.gentaur.be/shop/0002-0801169-simian- ...
Gene Products, gag | Profiles RNS
Gene Products, gag. *Fusion Proteins, gag-pol. *gag Gene Products, Human Immunodeficiency Virus ... "Gene Products, gag" by people in UAMS Profiles by year, and whether "Gene Products, gag" was a major or minor topic of these ... "Gene Products, gag" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Gene Products, gag" by people in Profiles over the past ten years. ...
US Patent for Directed evolution and in vivo panning of virus vectors Patent (Patent # 8,632,764 issued January 21, 2014) -...
The present invention provides methods of achieving directed evolution of viruses by in vivo screening or ... immunogens from human immunodeficiency virus, influenza virus, gag proteins, tumor antigens, cancer antigens, bacterial ... and the HIV or SIV gag, pol and env genes products). The immunogen may also be an arenavirus immunogen (e.g., Lassa fever virus ... an equine infectious anemia virus immunogen, a Simian Immunodeficiency Virus (SIV) immunogen, or a Human Immunodeficiency Virus ...
Gene Products, env | Colorado PROFILES
Critical role for Env as well as Gag-Pol in control of a simian-human immunodeficiency virus 89.6P challenge by a DNA prime/ ... "Gene Products, env" by people in this website by year, and whether "Gene Products, env" was a major or minor topic of these ... "Gene Products, env" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Gene Products, env" by people in Profiles. ...
HIV-1 GAG Protein | HIV1 Recombinant GAG Antigen| ProSpec
HIV-1 GAG Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain, encoded by the HIV gag gene, HXB2 ( ... Human immunodeficiency virus (HIV) is a retrovirus which may lead to a immune systembegins failure and to opportunistic ... HIV-1 GAG Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain, encoded by the HIV gag gene, HXB2 ( ... ProSpecs products are furnished for LABORATORY RESEARCH USE ONLY. They may not be used as drugs, agricultural or pesticidal ...
Biology | September 2012 - Browse Articles
Gene expression of the human immunodeficiency virus type 1 (HIV-1) is a highly regulated process. Basal transcription of the ... Basal transcription of the integrated provirus generates early transcripts that encode for the viral products Tat and Rev. Tat ... These RNAs are exported from the nucleus to allow expression of Gag-Pol and Env proteins and for the production of full-length ... Gene expression of the human immunodeficiency virus type 1 (HIV-1) is a highly regulated process. ...
DeCS 2017 - December 21, 2017 version
gag Proteins, Human Immunodeficiency Virus use gag Gene Products, Human Immunodeficiency Virus ... gag Gene Products use Gene Products, gag gag Gene Products, HIV use gag Gene Products, Human Immunodeficiency Virus ... gag Gene Products, Human Immunodeficiency Virus gag Gene Related Protein use Gene Products, gag ... gag Antigens use Gene Products, gag gag Gene use Genes, gag gag Gene Product use Gene Products, gag ...