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*  Shank3 Deficiency Induces NMDA Receptor Hypofunction via an Actin-Dependent Mechanism | Journal of Neuroscience
GABAA receptor antagonist bicuculline (10 μm) was added. The patch pipette was filled with an internal solution containing the ... exemplified by the fact that administration of NMDAR antagonists exacerbates schizophrenia-like symptoms (Luby et al., 1959; ... 2012) Regulation of NMDA receptors by metabotropic glutamate receptor 7. J Biol Chem 287:10265-10275, doi:10.1074/jbc. ... Shank3 Deficiency Induces NMDA Receptor Hypofunction via an Actin-Dependent Mechanism. Lara J. Duffney, Jing Wei, Jia Cheng, ...
  http://www.jneurosci.org/content/33/40/15767
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For instance, it has been demonstrated that certain GABAA receptor antagonists, including bicuculline, inhibit 5-HT3 receptors ... effects of the GABAA receptor antagonist bicuculline were tested on responses of five dorsal horn interneurons (in nine test ... and a GABAA receptor antagonist (bicuculline) (Alexander et al., 2004) were applied locally to differentiate between effects ... and a 5-HT1A receptor antagonist (WAY 100635) (Alexander et al., 2004), a 5-HT3 receptor antagonist [N-(1-azabicyclo[2.2.2]oct- ...
  http://www.jneurosci.org/content/25/3/584
*  Effects of Halothane and Sevoflurane on Inhibitory Neurotransmission to Medullary Expiratory Neurons in a Decerebrate Dog Model...
... and the GABAAreceptor antagonist bicuculline methochloride (BIC, 200 μm; Research Biochemicals), which were dissolved in an ... these neurons receive tonic inhibitory drive that can be antagonized with GABAAantagonists. 4 Thus, the neuronal GABAAreceptors ... 5 The tonic inhibition can be completely and specifically blocked with the GABAAantagonist bicuculline, 6 and this will reveal ... After complete recovery from muscimol, the GABAAantagonist BIC was picoejected until complete block of GABAAergic inhibition ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1944726
*  Robert Fisher, MD, PhD | Stanford Medicine Profiles
GABA)A-receptor antagonist. Cooling from 34 to 21 degrees C reversibly abolished gamma oscillations in all slices tested. Short ... MK-801 and ZNS (in part) are excitatory amino acid antagonists, and FNR is a calcium-channel antagonist. OCBZ is a keto ... receptor blocker, bicuculline (5-20 microM). Bath-apply kynurenic acid (7 mM) blocks synaptic transmission, but fails to ... The selective GABA(B) antagonist CGP-35348 blocks spike-wave bursts in the cholesterol synthesis rat absence epilepsy model ...
  https://med.stanford.edu/profiles/robert-fisher
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For GABAA receptors, the GABAA receptor antagonist bicuculline and GABA were separately applied, and their effects on SWD- ... as typically occurs upon blockade of GABAA receptors in vitro or widespread infusion of GABAA antagonists in vivo, has not been ... Effects of the GABAA receptor antagonist bicuculline (BICU) and GABA on burst firing of a VB neuron (top trace) related to SWDs ... termination of GABA, and, finally, termination of bicuculline application (Fig. 1B). Similarly, for GABAB receptors, the GABAB ...
  http://www.jneurosci.org/content/21/4/1378
*  Frontiers | Epilepsy Mechanisms in Neurocutaneous Disorders: Tuberous Sclerosis Complex, Neurofibromatosis Type 1, and Sturge...
Rapamycin also reduces the duration of epileptiform bursts induced by the GABAA receptor antagonist, bicuculline (71). ... the LTP deficit is partially reversed by NMDA receptor antagonists, and it has been suggested that LTP impairment is due to ... the vesicular GABA transporter VGAT, and GABAA receptor subunits α1 and α2 (56). In cortical specimens from patients with TSC, ... Selective alterations in glutamate and GABA receptor subunit mRNA expression in dysplastic neurons and giant cells of cortical ...
  https://www.frontiersin.org/articles/10.3389/fneur.2017.00087/full
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3C). As expected, bicuculline (10 μm), an antagonist of GABAA receptors, suppressed all sPSCs (Fig. 3C). To test whether the ... These were not affected by nicotinic or muscarinic receptor antagonists. Cell-attached recordings of single GABAA and NMDA ... Therefore, when iGABAA = 0 pA, Vm = Vp − Vrest = EGABAA (i.e., EGABAA − Vrest = −Vp). By definition, EGABAA − Vrest = DFGABAA, ... when iGABAA = 0 pA, DFGABAA = −Vp. Knowing Vrest and DFGABAA, it is easy to calculate EGABAA = DFGABAA + Vrest. In addition, ...
  http://www.jneurosci.org/content/29/24/7776
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... in some rats the GABAA receptor antagonist, bicuculline (0.4 mm), was microinjected into the vlPAG (n = 25). Injection of ... However, the inhibitory actions of 5-HT1B/1D receptor antagonists on the CB1 responses in the vlPAG provide interesting ... changes in dural-evoked neuronal firing in the TCC in response to microinjection of the GABAA receptor antagonist bicuculline ... When a specific CB1 receptor antagonist, SR141716, was given 5 min before treatment with the cannabinoid receptor agonist and ...
  http://www.jneurosci.org/content/33/37/14869
*  Presynaptic α1 Adrenergic Receptors Differentially Regulate Synaptic Glutamate and GABA Release to Hypothalamic Presympathetic...
... the GABAA receptor antagonist (20 μM bicuculline methiodide) and the glutamate non-NMDA antagonist (20 μM CNQX) and the NMDA ... failed to increase the firing of labeled PVN neurons in the presence of GABAA and ionotropic glutamate receptor antagonists in ... In addition to blocking GABAA receptors, bicuculline methiodide may increase the firing activity of PVN neurons through its ... to increase the firing of most labeled PVN neurons in the presence of GABAA and ionotropic glutamate receptor antagonists. Thus ...
  http://jpet.aspetjournals.org/content/316/2/733
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Gabazine is a specific GABAA receptor antagonist, whereas bicuculline may also block calcium-activated potassium channels ( ... cortical points were locally disinhibited by iontophoretic ejection of the GABAA receptor antagonists bicuculline or gabazine. ... summation of outputs was also found when inhibition at one of the cortical points was reduced by GABAA receptor antagonists. A ... Capaday C, Rasmusson DD (2003) Expansion of receptive fields in motor cortex by local blockade of GABAA receptors. Exp Brain ...
  http://www.jneurosci.org/content/26/20/5574
*  GABAergic Control of Arteriolar Diameter in the Rat Retina | IOVS | ARVO Journals
6). Following 1 minute's incubation of the whole-mount preparations with the GABAA receptor antagonist bicuculline (100 μM), 70 ... we performed a set of experiments using GABA receptor antagonists. As no responses were observed with the GABAC receptor ... GABAA receptor antagonist; n = 20) and 2-hydroxysaclofen (GABAB receptor antagonist; n = 31) failed to elicit significant ... GABAA receptor antagonist; n = 20) and 2-hydroxysaclofen (GABAB receptor antagonist; n = 31) failed to elicit significant ...
  https://iovs.arvojournals.org/article.aspx?articleid=2202995
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In mouse thalamocortical slices in vitro, the potassium channel blocker 4-AP and GABAA receptor antagonist bicuculline together ... The induction of synchronized activity by 4-AP and/or GABAAreceptor antagonists has been studied extensively in the hippocampus ... A recent study demonstrated that the GABAAreceptor antagonist used in this study, bicuculline methchloride, also directly ... The NMDA receptor antagonist APV and the non-NMDA glutamate receptor antagonist CNQX were applied together in the bath (n = 4 ...
  http://www.jneurosci.org/content/19/8/2865
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... were abolished by perfusion of slices with 10 μm bicuculline methiodide, a GABAAreceptor antagonist (Fig. 4 C), but they ... Glutamate receptor antagonists and the adenosine receptor antagonist 8-cyclopentyl-1,3-dipropylxanthin (DCPCX) were obtained ... Fourth, the frequency of the slow oscillations can be manipulated by partial blockade of GABAA receptors with 10 nmbicuculline ... a GABAB receptor antagonist (n = 5, CA1 neurons). In CA1 neurons recorded in the current-clamp mode, the Cs+-induced rhythmic ...
  http://www.jneurosci.org/content/18/22/9256
*  US20050119712A1 - Device and method to promote neurogenesis - Google Patents
... and GABA receptor antagonists, such as CGP56433Aor bicuculline. ... receptor antagonist is a GABA receptor antagonist an alpha 1- ... a glutamate receptor agonist, a GABA receptor antagonist, and an anti-Nogo-A antiboby. ... a glutamate receptor agonist, a GABA receptor antagonist, and an anti-Nogo-A antibody. ... adrenergic antagonist, an alpha 2-adrenergic antagonist, a serotonergic antagonist, a dopaminergic antagonist, or a GABAergic ...
  https://patents.google.com/patent/US20050119712A1/en
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... shows recordings at 0 mV 15 min after superfusion of the slice with ACSF containing the GABAA receptor antagonist bicuculline ( ... and during superfusion of slices with ACSF containing glutamate receptor antagonists APV (50 μM) and CNQX (10 μM) (bottom trace ... For instance, microinfusion of the GABAA receptor antagonist picrotoxin in the ventral hippocampus of rats impairs prepulse ... and disrupted prepulse inhibition following disinhibition of the rat ventral hippocampus by the GABAA receptor antagonist ...
  http://jpet.aspetjournals.org/content/341/2/500
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Bilateral microinfusion of the GABA receptor antagonist bicuculline and GABA-depleting agent isoniazid into the substantia ... 1989) Effects of dopamine D1 and D2 receptor antagonists on oral activity in rats. Pharmacol. Biochem. Behav. 34:43-48. ... 1993) Chronic treatment with the D1 receptor antagonist, SCH 23390, and the D2 receptor antagonist, raclopride, in cebus ... not by the 5-HT1A/1B receptor antagonist pindolol or 5-HT2/3 receptor antagonist MDL-72222 (3-tropanyl-3,5,-dichlorobenzoate) ( ...
  http://jpet.aspetjournals.org/content/280/1/268
*  GABA receptor antagonist - Wikipedia
GABA receptor antagonists are drugs that inhibit the action of GABA. In general these drugs produce stimulant and convulsant ... Examples include bicuculline, securinine and metrazol, and the benzodiazepine GABAA receptor antagonist flumazenil. Also ... GABA antagonists at the US National Library of Medicine Medical Subject Headings (MeSH). ... thujone, ginkgo biloba, kudzu and muira puama[citation needed] may have properties of GABAA receptor antagonism. ...
  https://en.wikipedia.org/wiki/GABA_receptor_antagonist
*  Gabazine - Wikipedia
Behrens, CJ; Van Den Boom, LP; Heinemann, U (2007). "Effects of the GABA(A) receptor antagonists bicuculline and gabazine on ... Gabazine (SR-95531) is a drug that acts as an antagonist at GABAA receptors. It is used in scientific research and has no role ... Gabazine binds to the GABA recognition site of the receptor-channel complex and acts as an allosteric inhibitor of channel ... Gabazine has been found to bind to and antagonize α4βδ subunit-containing GABAA receptors, which may represent the GHB receptor ...
  https://en.wikipedia.org/wiki/Gabazine
*  Pitrazepin - Wikipedia
Murphy VF, Wann KT (November 1988). "The action of GABA receptor agonists and antagonists on muscle membrane conductance in ... Bicuculline Strychnine Gähwiler BH, Maurer R, Wüthrich HJ (April 1984). "Pitrazepin, a novel GABAA antagonist". Neuroscience ... "Interaction of pitrazepin with the GABA/benzodiazepine receptor complex and with glycine receptors". European Journal of ... Pitrazepin is a competitive GABAA and glycine receptor antagonist. It has been used to study insect and snail nervous systems ...
  https://en.wikipedia.org/wiki/Pitrazepin
*  Convulsant - Wikipedia
Advantages of an antagonist: bicuculline and other GABA antagonists. British Journal of Pharmacology. 2013 May;169(2):328-36. ... GABAA receptor antagonists, inverse agonists or negative allosteric modulators Bemegride Bicuculline Cicutoxin Cyclothiazide ... Thujone GABA synthesis inhibitors 3-Mercaptopropionic acid Allylglycine Glycine receptor antagonists Bicuculline Brucine ... also GABA antagonist) Sinomenine Strychnine Thebaine Tutin Ionotropic glutamate receptor agonists AMPA Domoic acid Kainic acid ...
  https://en.wikipedia.org/wiki/Convulsant
*  GABA receptor - Wikipedia
Additional information on GABAB receptors has been reviewed elsewhere. GABA agonist GABA antagonist Kuffler SW, Edwards C ( ... Takeuchi A, Onodera K (March 1972). "Effect of bicuculline on the GABA receptor of the crayfish neuromuscular junction". Nature ... Enna SJ (October 1997). "GABAB receptor agonists and antagonists: pharmacological properties and therapeutic possibilities". ... Although the term "GABAС receptor" is frequently used, GABAС may be viewed as a variant within the GABAA receptor family. ...
  https://en.wikipedia.org/wiki/GABA_receptor
*  GABAA-rho receptor - Wikipedia
... not sensitive to the GABAB agonist baclofen nor the GABAA receptor antagonist bicuculline; not modulated by many GABAA receptor ... Although the term "GABAС receptor" is frequently used, GABAС may be viewed as a variant within the GABAA receptor family. ... CACA CAMP GABOB Mixed GABAA-ρ / GABAB antagonists ZAPA ((Z)-3-[(Aminoiminomethyl)thio]prop-2-enoic acid) SKF-97541 (3- ... Drew CA, Johnston GA, Weatherby RP (December 1984). "Bicuculline-insensitive GABA receptors: studies on the binding of (−)- ...
  https://en.wikipedia.org/wiki/GABAA-rho_receptor
*  Quisqualamine - Wikipedia
... that its actions are inhibited in vitro by GABAA antagonists like bicuculline and picrotoxin and by the glycine antagonist ... an antagonist of both the AMPA and kainate receptors, and 2-hydroxysaclofen, a GABAB receptor antagonist, do not affect ... GABA) related depressant amino acid". The Journal of Pharmacy and Pharmacology. 30 (6): 364-7. doi:10.1111/j.2042-7158.1978. ... suggesting that it does not directly affect the ionotropic glutamate receptors or the GABAB receptor in any way. Whether it ...
  https://en.wikipedia.org/wiki/Quisqualamine