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*  Frontiers | A Novel Retinal Oscillation Mechanism in an Autosomal Dominant Photoreceptor Degeneration Mouse Model | Frontiers...
More importantly, weakening the AII-AC gap junction network by activating retinal dopamine receptors abolished oscillations in ... More importantly, weakening the AII-AC gap junction network by activating retinal dopamine receptors abolished oscillations in ... C) Representative IPSCs seen in an OFF-SAC were inhibited by GABA antagonists but not by glycine receptor antagonist. ... were used simultaneously to inhibit both of GABAA and GABAC receptors. Strychnine (1 μM) was used to block glycinergic ...
  https://www.frontiersin.org/articles/10.3389/fncel.2015.00513/full
*  Characteristics and Interaction of GABAergic and Glycinergic Processes in Frog Spinal Cord Neurons | Springer for Research &...
... spinal cord neurons from the frog Rana temporariawere made to study the interaction of processes induced by application of GABA ... P. Li and M. Slaughter, "Glycine receptor subunit composition alters the action of GABA antagonists," Vis. Neurosci., 24, 513- ... "Comparison of glycine and GABA actions on the zebrafish homomeric glycine receptor," J. Physiol., 517, No. 2, 369-383 (1999). ... P. Q. Trombley, B. J. Hill, and M. S. Horning, "Interactions between GABA and glycine at inhibitory amino acid receptors on rat ...
  https://rd.springer.com/article/10.1007/s11055-010-9297-1
*  Convulsants Acting at the Inhibitory Glycine Receptor | Springer for Research & Development
GABA) and glycine. Whereas GABAergic synapses are abundant in the cortex and cerebellum, glycine predominates... ... Inhibition of glycine and GABA receptor binding by several opiate agonists and antagonists. Gen Pharmacol 12: 477-479PubMed ... Interactions between three pyridazinyl-GABA derivatives and central GABA and glycine receptors in the rat, an in vivo ... The glycine receptor deficiency of the mutant mouse spastic: evidence for normal glycine receptor structure and localization. J ...
  https://rd.springer.com/chapter/10.1007/978-3-642-85117-9_15
*  Novel Systemically Active Antagonists of the Glycine Site of the N-Methyl-d-aspartate Receptor: Electrophysiological,...
GABA. γ-aminobutyric acid. GlycineB. strychnine-insensitive, co-agonistic glycine site of the NMDA receptor. MES. maximal ... activation of glycineB receptors. Experiments to test the glycine dependence of the Merz glycineBantagonists were performed in ... The NMDA receptor antagonism observed was typical for glycineB antagonists,i.e., showed competition with glycine, revealed ... 1992) Glycine antagonists: regulation of the NMDA receptor-channel complex by the strychnine-insensitive glycine site. Drugs ...
  http://jpet.aspetjournals.org/content/283/3/1264
*  Plus it
... but not the glycine receptor antagonist strychnine (Stry) or the GABAB receptor antagonist CGP55458A (D). ... Strychnine is considered as a selective glycine receptor antagonist; however, it may cross-react on GABA-A receptors when ... Metabotropic GABAB receptors are also expressed in SPNs (Whyment et al., 2004); therefore, the effect of the GABAB antagonist ... 1B). A noncompetitive GABAA receptor antagonist picrotoxin (100 μm) also induced a membrane depolarization in all 4 neurons ...
  http://www.jneurosci.org/content/28/47/12445
*  Luis de Lecea | Stanford Medicine Profiles
GABA, and glycine receptors. Collectively, these results suggest that UII plays a role in the regulation of REM sleep ... whereas peripheral administration of the NPS receptor antagonist SHA 68 reduced it. Manipulation of the NPS receptor system did ... The effects of Hcrt-1 were blocked by SB334867, but not by the CRF1 receptor antagonist antalarmin. Moreover, SB334867 did not ... This model may prove useful to predict the effects of orexin receptor antagonists in sleep disorders and other conditions. ...
  https://med.stanford.edu/profiles/luis-de-lecea
*  Plus it
... a glycine receptor antagonist), bicuculline (a GABAA receptor antagonist), and atropine (a muscarinic acetylcholine receptor ... Specific competition binding was also observed with the glycine receptor convulsant strychnine, the GABA receptor antagonist ... glycine receptors, and γ-aminobutyric acid receptors (Rothlin et al., 1999; Verbitsky et al., 2000; Elgoyhen et al., 2001). The ... Binding studies were performed with [3H]MLA, a nicotinic receptor antagonist that has been reported to bind with high apparent ...
  http://molpharm.aspetjournals.org/content/65/2/453
*  Levorphanol - Wikipedia
... also acts as a glycine receptor antagonist and GABA receptor antagonist at very high concentrations. Levorphanol is 6 to 8 ... κ-opioid receptor (KOR), and the nociceptin receptor (NOP), as well as an NMDA receptor antagonist and a serotonin- ... Levorphanol acts predominantly as an agonist of the μ-opioid receptor (MOR), but is also an agonist of the δ-opioid receptor ( ... NMDA receptor antagonist), and weakly active opioid. DXO is an active metabolite of the pharmaceutical drug dextromethorphan ( ...
  https://en.wikipedia.org/wiki/Levorphanol
*  Halothane Suppression of Spinal Sensory Neuronal Responses to Noxious Peripheral Stimuli Is Mediated, in Part, by Both GABAAand...
The primary purpose of this study was to examine the effects of GABAAor glycine receptor antagonists on halothane depression of ... The spinal cord contains GABAAand glycine receptors, 15,16 and volatile anesthetic agents enhance currents at GABAAand glycine ... Gamma-aminobutyric acid receptor type A (GABAA) and glycine receptor systems are thought to be the major inhibitory systems in ... GABAAantagonist) and strychnine (glycine antagonist) (Research Biochemicals, Inc., Natick, MA) administered in the absence of ...
  http://anesthesiology.pubs.asahq.org/article.aspx?articleid=1943841
*  Direct Measurement of AMPA Receptor Desensitization Induced by Glutamatergic Synaptic Transmission | Journal of Neuroscience
Slices were bathed in antagonists of NMDA, GABAA, and glycine receptors (100 μm d,l2-amino-5-phosphonovalerate, 5 μm SR-95531, ... AMPA receptor agonists kainate and glutamate activate the AMPA receptor by binding to the same site, but only glutamate ... Because of the rapid kinetics of AMPA receptors, a direct measurement of receptor sensitivity of the postsynaptic cell after ... transiently desensitizing subsynaptic receptors. An alternative is that synaptic glutamate might inhibit AMPA/kainate receptors ...
  http://www.jneurosci.org/content/16/23/7496
*  Plus it
... a glycine receptor antagonist (strychnine, 20 μm), a GABAA receptor antagonist (bicuculline, 10 μm), and the nonspecific P2 ... glycine receptor antagonist (strychnine, 20 μm), GABAA receptor antagonist (bicuculline, 10 μm), and the nonspecific P2 ... GABA (bicuculline 10 μm), glycine (strychnine 20 μm), and purinergic (RB2 50 μm) ionotropic receptor antagonists. The asterisk ... glycine, GABA, and purinergic receptors. B2, Effect of SP on the discharge of RTN neurons in the absence of synaptic ...
  http://www.jneurosci.org/content/27/51/14128
*  Glycine blocks long-term potentiation of GABAergic synapses in the ventral tegmental area
... a GABAA receptor (GABAAR) antagonist (not illustrated), indicating that they were IPSCs mediated by GABAARs. The amplitude of ... Both GABAA and GABAB receptor subtypes have been identified within the VTA. Activation of GABAA receptor (GABAAR) on GABAergic ... GABA. (gamma - aminobutyric acid). GABAAR. GABAA receptor. GlyR. glycine receptor. HFS. high frequency stimulation. IPSC. ... Glycine blocks LTPGABA in VTA-dopamine neurons in brain slices via the activation of strychnine-sensitive glycine receptors. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4753108/
*  Pharmacological Characterization of Glycine-Activated Currents in HEK 293 Cells Expressing N-Methyl-D-aspartate NR1 and NR3...
... neither the glycine receptor antagonist, strychnine (Fig. 3B; n = 7 cells), or the antagonist at the GABAA antagonist, ... these receptors were not affected by antagonists of inhibitory glycine receptors or glycine transporters. The NMDA receptor ... The NMDA glycine site antagonists, 7-CK and 5,7-DCK, inhibited glycine-activated currents of NR1/NR3A/NR3B receptors. However, ... Unlike results obtained with glycine site antagonists, the NMDA receptor partial agonist, HA-966, only potentiated glycine- ...
  http://jpet.aspetjournals.org/content/322/2/739.long
*  Glycine Inhibitory Dysfunction Induces a Selectively Dynamic, Morphine-Resistant, and Neurokinin 1 Receptor- Independent...
The micropipettes and tubing were filled with GABAA antagonist bicuculline methiodide (50 μmol in 0.5 μl aCSF) or aCSF with ... In line with such idea, we found that blockade of GABAA or glycine receptors induced selective static or dynamic mechanical ... 2002) Spinal GABA(A) and GABA(B) receptor pharmacology in a rat model of neuropathic pain. Anesthesiology 96:1161-1167. ... used a mixture of bicuculline and strychnine to block both GABAA and glycine receptors, which implies that activation of ...
  http://www.jneurosci.org/content/29/8/2519
*  Convulsant - Wikipedia
Thujone GABA synthesis inhibitors 3-Mercaptopropionic acid Allylglycine Glycine receptor antagonists Bicuculline Brucine ... Most convulsants are antagonists (or inverse agonists) at either the GABAA or glycine receptors, or ionotropic glutamate ... Advantages of an antagonist: bicuculline and other GABA antagonists. British Journal of Pharmacology. 2013 May;169(2):328-36. ... also GABA antagonist) Sinomenine Strychnine Thebaine Tutin Ionotropic glutamate receptor agonists AMPA Domoic acid Kainic acid ...
  https://en.wikipedia.org/wiki/Convulsant
*  Shilajit - Scientific Review on Usage, Dosage, Side Effects | Examine.com
... glycine receptor antagonist) and partially reduced by a GABAA antagonist.[13] ... Yin H, et al. Glycine- and GABA-mimetic Actions of Shilajit on the Substantia Gelatinosa Neurons of the Trigeminal Subnucleus ... Shilajit was found to not interact with either glutamate receptors nor acetylcholine (nAchR) receptors in vitro.[13] ...
  https://examine.com/supplements/Shilajit/
*  Emeritus Professor Graham Johnston - The University of Sydney
GABA and glycine receptors; Johnston G; DVC Research/Bridging Support Grant. * Synthesis, testing and development of GABA-C ... Johnston, G. (2013). Advantages of an antagonist: bicuculline and other GABA antagonists. British Journal of Pharmacology, 169( ... Cage compounds as blockers of GABA and glycine receptor channels; Moorhouse A, Johnston G, Duke R; National Health and Medical ... Cage compounds GABA and glycine receptors; Johnston G; University of Sydney/Medicine Bridging. ...
  http://sydney.edu.au/medicine/people/academics/profiles/graham.johnston.php
*  Post‐phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function | The EMBO...
Recordings were routinely performed in the presence of the GABAA antagonist picrotoxin (50 μM), the GABAB receptor antagonist ... Glycine‐mediated currents were readily blocked by the selective glycine receptor antagonist strychnine (0.5 μM; n=5), ... Feng G, Tintrup H, Kirsch J, Nichol MC, Kuhse J, Betz H, Sanes JR (1998) Dual requirement for gephyrin in glycine receptor ... Kneussel M, Brandstatter JH, Laube B, Stahl S, Muller U, Betz H (1999a) Loss of postsynaptic GABA(A) receptor clustering in ...
  http://emboj.embopress.org/content/26/7/1761
*  Plus it
... experiments demonstrated modulation of SON response properties with application of both glycine and GABAA receptor antagonists ... Kinetic analysis of sIPSCs was consistent with a corelease model of GABA and glycine. First, if GABA and glycine were released ... so data for GABAA receptor block were pooled for population analysis. GABAA antagonist application increased acoustically ... Spontaneous postsynaptic currents are modulated by blockade of both GABA and glycine receptors. A: representative 5-s epochs of ...
  http://jn.physiology.org/content/105/5/2405
*  SR 95531 hydrobromide Supplier | CAS 104104-50-9 | Gabazine | SR95531 | Tocris Bioscience
Competitive and selective GABAA antagonist. Cited in 143 publications. ... GABAA and GABAA-ρ Receptors / GABAA Receptors / GABAA Receptor Antagonists / SR 95531 hydrobromide ... The kinetics of inhibition of rat recombinant heterotrimeric α1β glycine receptors by the low affinity antagonist SR-95531. J. ... Selective, competitive GABAA receptor antagonist. Displaces [3H]-GABA from rat brain membranes with a Ki of 150 nM. Unlike ...
  https://www.tocris.com/products/sr-95531-hydrobromide_1262
*  General anaesthesia - Wikipedia
... and glycine and serotonin receptors. Halothane has been found to be a GABA agonist, and ketamine is an NMDA receptor antagonist ... Potential pharmacologic targets of general anaesthetics are GABA, glutamate receptors, voltage-gated ion channels, ... "Effects of halothane on GABA(A) receptor kinetics: evidence for slowed agonist unbinding". J. Neurosci. 20 (3): 899-907. PMID ... Harrison, N.; Simmonds, M. (1985). "Quantitative studies on some antagonists of N-methyl D-aspartate in slices of rat cerebral ...
  https://en.wikipedia.org/wiki/General_anaesthesia
*  "Urotensin II Modulates Rapid Eye Movement Sleep Through Activation of " by Salvador Huitron-Resendiz, Morten P. Kristensen et...
GABA, and glycine receptors. Collectively, these results suggest that UII plays a role in the regulation of REM sleep ... depend on action potential generation or fast synaptic transmission because it persisted in the presence of TTX and antagonists ... UII receptor mRNA is also expressed in the CNS, in particular in cholinergic neurons located in the mesopontine tegmental area ... GABA, and glycine receptors. Collectively, these results suggest that UII plays a role in the regulation of REM sleep ...
  https://touroscholar.touro.edu/nymc_fac_pubs/160/
*  Plus it
... thus no antagonists were added to the bath to isolate mPSCs (unless specified in the results). Glycine receptor antagonists ... A, Summary of the effect on mPSCs of 2 d blockade of CB1 receptors in ovo with AM 251. AMPA and GABA mPSC amplitude is ... 4E, left), but did significantly reduce the amplitude of both AMPA and GABA mPSCs (Fig. 4C,E; p = 0.01 AMPA mPSC, p = 0.01 GABA ... In ovo blockade of CB1 receptors increased SNA and caused homeostatic increases in AMPA and GABA mPSC amplitude. We tested ...
  http://www.jneurosci.org/content/32/39/13597
*  CNS targets for pain treatment 14/4 Flashcards by Shay Ford | Brainscape
Therefore, GABA activation of GABA-A receptor results in chloride ions efflux and neuronal depolarization ... PGE2 phosphorylates glycine receptor (inhibitory), to antagonise it. This prevents Cl- entry into the cell. PGE2 therefore ... NMDA receptor antagonists such as ketamine are effective in treating pain, however the widespread distribution of NMDA ... Due to binding of VGCC, GBP inhibits glutamate release and interacts with the glycine site of NMDA receptor. This blocks pain ...
  https://www.brainscape.com/flashcards/cns-targets-for-pain-treatment-14-4-6725216/packs/10375701
*  Simultaneous Quantification of Flavonol Glycosides, Terpene Lactones, Biflavones, Proanthocyanidins, and Ginkgolic Acids in...
"Terpene trilactones from Ginkgo biloba are antagonists of cortical glycine and GABA(A) receptors," The Journal of Biological ... S. Jaracz, K. Nakanishi, A. A. Jensen, and K. Stromgaard, "Ginkgolides and glycine receptors: a structure-activity relationship ... "Structure-activity analysis of ginkgolide binding in the glycine receptor pore," Journal of Neurochemistry, vol. 105, no. 4, pp ... and recently there has been considerable interest concerning the antagonistic effect of ginkgolides on the glycine receptor [8- ...
  https://www.hindawi.com/journals/bmri/2013/582591/