Frontiers | Structure, function, and plasticity of GABA transporters | Frontiers in Cellular Neuroscience
There is also evidence that the expression of GABA transporters on the cell membrane and their lateral mobility can be ... There is also evidence that the expression of GABA transporters on the cell membrane and their lateral mobility can be ... distribution and diffusion rate of GABA transporters within the cell membrane. These findings are intriguing because they ... distribution and diffusion rate of GABA transporters within the cell membrane. These findings are intriguing because they ...https://www.frontiersin.org/articles/10.3389/fncel.2014.00161/full
Norepinephrine transporter - Wikipedia
They are found closer to the plasma membrane of the cell. This requires norepinephrine to diffuse from the site it is released ... The genetic defect in the NET protein results in decreased NET activity that could account for abnormally high NE plasma levels ... The transport of norepinephrine back into presynaptic cell is made possible by the cotransport with Na+ and Cl−. The sequential ... serotonin and GABA transporters. A single-nucleotide polymorphism (SNP) is a genetic variation in which a genome sequence is ...https://en.wikipedia.org/wiki/Norepinephrine_transporter
Discovery of Novel Biomarkers for Alzheimer's Disease from Blood.
GABA Plasma Membrane Transport Proteins. Homeodomain Proteins. Humans. Knowledge Bases. Proteome. RNA, Messenger. ... In this study we used a knowledge-based protein feature pool and two novel support vector machine embedded feature selection ... Our panels included the proteins ECH1, NHLRC2, HOXB7, FN1, ERBB2, and SLC6A13 and demonstrated promising sensitivity (,87%), ...https://pearl.plymouth.ac.uk/handle/10026.1/5119
Impairment of GABA release due to reduction of VGAT in | Open-i
A and B) Measurement of glutamate (A) and GABA (B) release was performed as descr ... Impairment of GABA release due to reduction of VGAT in μ3B−/−ΔNeo mice. ( ... Adaptor Protein Complex 3. *Adaptor Proteins, Vesicular Transport. *Animals. *Electrophysiology. *GABA Plasma Membrane ... AP-3 is a member of the adaptor protein (AP) complex family that regulates the vesicular transport of cargo proteins in the ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2172536_200405032f4&req=4
Activated GABAergic neurons in the vlPAG/DpMe region af | Open-i
GABA Plasma Membrane Transport Proteins/metabolism*. *Glutamate Decarboxylase/biosynthesis*. *Neurons/metabolism*. *Sleep, REM/ ... GABA synthesis enzyme) in control rats, rats deprived of PS for 72 h and rats allowed to recover after such deprivation. Here ... GABA synthesis enzyme) in control rats, rats deprived of PS for 72 h and rats allowed to recover after such deprivation. Here ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2629845_pone.0004272.g002&req=4
Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1...
Beckman ML, Bernstein EM, and Quick MW. Multiple G protein-coupled receptors initiate protein kinase C redistribution of GABA ... Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 ... Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 ... Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 ...http://ajpcell.physiology.org/content/290/4/C1230
GABA Uptake Inhibitors | CTD
... that suppress or block the plasma membrane transport of GAMMA-AMINOBUTYRIC ACID by GABA PLASMA MEMBRANE TRANSPORT PROTEINS.. ... GABA Uptake Inhibitors Equivalent Terms GABA Reuptake Inhibitors , Gamma Aminobutyric Acid Plasma Membrane Transport Inhibitors ... Gamma-Aminobutyric Acid Plasma Membrane Transport Inhibitors , Inhibitors, GABA Reuptake , Inhibitors, GABA Uptake , Reuptake ... Membrane Transport Modulators ← Neurotransmitter Uptake Inhibitors ← GABA Uptake Inhibitors 2.. Chemicals ← Chemical Actions ...http://ctdbase.org/detail.go?type=chem&acc=D058805
Frontiers | The Amino Acid Transporters of the Glutamate/GABA-Glutamine Cycle and Their Impact on Insulin and Glucagon...
Moreover, high levels of glutamate, GABA and glutamine and their respective vesicular and plasma membrane transporters have ... Interestingly, proteins involved in the CNS in secretion of the neurotransmitters and emitting their responses as well as the ... Moreover, high levels of glutamate, GABA and glutamine and their respective vesicular and plasma membrane transporters have ... Interestingly, proteins involved in the CNS in secretion of the neurotransmitters and emitting their responses as well as the ...https://www.frontiersin.org/articles/10.3389/fendo.2013.00199/full
GABA-T - What does GABA-T stand for? The Free Dictionary
GABA-T is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms ... Looking for online definition of GABA-T or what GABA-T stands for? ... Gaba plasma membrane transport proteins. *Gaba plasma membrane transport proteins. *Gaba plasma membrane transport proteins ... EFFECT OF UNLABELED GABA AND [beta]ALA ON GABA-T ACTIVITY. To investigate the difference in affinity of GABA-T for both ...https://acronyms.thefreedictionary.com/GABA-T
GABA transporters and GABAC-like receptors on catfish cone- but not rod-driven horizontal cells. - PubMed - NCBI
GABA Plasma Membrane Transport Proteins. *GABA-C receptor. *Membrane Proteins. *Membrane Transport Proteins ... two potent GABA transporter blockers. The GABA transporter current could also be eliminated when sodium was replaced by either ... GABA transporters and GABAC-like receptors on catfish cone- but not rod-driven horizontal cells.. Dong CJ1, Picaud SA, Werblin ... The effects of GABA and related agents were studied in solitary rod- and cone-driven horizontal cells, acutely isolated from ...https://www.ncbi.nlm.nih.gov/pubmed/8182433
Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo | Genome Biology | Full Text
... proteins have key roles in the transport of small molecules including neurotransmitters across vesicular and plasma membranes [ ... 33]. It is tempting to speculate that the specific downregulation of the GABA transporter SCL6 member 1 by VA (see Table 5) may ... Strikingly, a general response to oxidative stress or protein damage does not seem to exist in the zebrafish embryo. A number ... The latter compound also triggered genes involved in G-protein-coupled signaling and phototransduction. Induction of genes with ...https://genomebiology.biomedcentral.com/articles/10.1186/gb-2007-8-10-r227
... the level of intracellular immunoreactivity may not be well correlated with levels of immunoreactivity on the plasma membrane ( ... 1992) Characterization of the oligosaccharide side chains on kainate binding proteins and AMPA receptors. Brain Res 590:187-192 ... 1989) Synaptic organization of GABAergic neurons and GABAA receptors in the lateral geniculate nucleus and visual cortex. in ... transport, assembly, and degradation of receptor subunits, but not to the number or location of actually expressed receptor ...http://www.jneurosci.org/content/17/9/3352
Sodium:neurotransmitter symporter, serotonin, N-terminal (IPR013086) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible ... GABA), noradrenaline/adrenaline, dopamine, serotonin, proline, glycine, choline, betaine and taurine. They are structurally ...http://www.ebi.ac.uk/interpro/entry/IPR013086
SLM4 protein (Saccharomyces cerevisiae) - STRING interaction network
General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane ... Permease for various amino acids as well as for GABA. Can also transport L-cysteine and beta-alanine ... Edges represent protein-protein associations. associations are meant to be specific and meaningful, i.e. proteins jointly ... Can also transport L-cysteine and beta-alanine. PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex ...https://string-db.org/network/4932.YBR077C
Mediation of Highly Concentrative Uptake of Pregabalin by L-Type Amino Acid Transport in Chinese Hamster Ovary and Caco-2 Cells...
... stable cell lines could result from overexpression of GAT protein in or lack of regulated translocation to the plasma membranes ... Since PGB and GBP are GABA analogs, we first examined if PGB interacts with GABA transport by using different subtypes of GABA ... Although both PGB and GBP are chemically derived from GABA, consistent with our previous GABA transport study with GBP in ... PGB seemed not to interact with GABA transport in GAT1, GAT2, and GAT3 cell lines, system y+, b0,+, B0,+, and B0 transport ...http://jpet.aspetjournals.org/content/313/3/1406.long
Inhibition of Activity of GABA Transporter GAT1 by -Opioid Receptor
A novel family of integral plasma membrane proteins," FEBS Letters, vol. 307, no. 1, pp. 76-80, 1992. View at Publisher · View ... Also other transport proteins, channels, G-protein-coupled receptors, and cytoplasmic proteins [65-68] seem to be affected by ... Altered GABA transport as a consequence of activation of G-protein-coupled receptor has been discussed on the basis of indirect ... This became apparent from the observation that GABA uptake was hardly affected by coexpression of another membrane protein (Na+ ...https://www.hindawi.com/journals/ecam/2012/818451/
Brenda Porter, MD | Stanford Medicine Profiles
... although some of the mutant transporter proteins were present on the plasma membrane. The structural model of NaCT suggests ... The effects of the mutations on NaCT transport function and protein expression were examined by transient transfections of COS- ... Heterogeneous GABA(A) receptor subunit expression in pediatric epilepsy patients NEUROBIOLOGY OF DISEASE Porter, B. E., Zhang, ... hypothesize that deformation of the membrane by osmotic stress results in conversion of a membrane component of the transport ...https://med.stanford.edu/profiles/brenda-porter
Human Metabolome Database: Showing metabocard for Chloride ion (HMDB0000492)
Chloride-transporting proteins (CLC) play fundamental roles in many tissues in the plasma membrane as well as in intracellular ... GABA(A) receptors are pentameric complexes that function as ligand-gated chloride ion channels. WNK kinases are a family of ... Isoform 2 exhibited a greater effect on cell plasma membrane expression of ENaC and Na(+) transport than isoform 1. Gene Name: ... Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the ...http://www.hmdb.ca/metabolites/HMDB0000492
Expression of GABRA1 in cancer - Summary - The Human Protein Atlas
The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... plasma membrane]. GO:0005887 [integral component of plasma membrane]. GO:0006810 [transport]. GO:0006811 [ion transport]. GO: ... GO:0016020 [membrane]. GO:0016021 [integral component of membrane]. GO:0016917 [GABA receptor activity]. GO:0022851 [GABA-gated ... Predicted membrane proteins. Prediction method-based. Membrane proteins predicted by MDM. MEMSAT3 predicted membrane proteins. ...http://www.proteinatlas.org/ENSG00000022355-GABRA1/pathology
Anti-GABA B Receptor 2 antibody [EP2411Y] Recombinant (ab75838)
Rabbit recombinant monoclonal GABA B Receptor 2 antibody [EP2411Y] validated for WB, IHC, Flow Cyt, ICC/IF and tested in Human ... of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. ... Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates ... Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. ...https://www.abcam.com/gaba-b-receptor-2-antibody-ep2411y-ab75838.html
Anti-GABA B Receptor 1 antibody (ab55051) | Abcam
Mouse monoclonal GABA B Receptor 1 antibody validated for WB, IHC, Flow Cyt, ICC/IF and tested in Human, Mouse and Rat. ... of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. ... Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates ... Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B ...http://www.abcam.com/gaba-b-receptor-1-antibody-ab55051.html
Effects of surface functionalization of hydrophilic NaYF4 nanocrystals doped with Eu3+ on glutamate and GABA transport in brain...
"Effects of surface functionalization of hydrophilic NaYF4 nanocrystals doped with Eu3+ on glutamate and GABA transport in brain ... decreased the potential of the plasma membrane of synaptosomes. In comparison with other nanoparticles studied with similar ... detonation nanodiamonds and an iron storage protein ferritin, whose activity can be registered at 0.08, 0.5 and 0.08 mg/ml, ... Effects of surface functionalization of hydrophilic NaYF4 nanocrystals doped with Eu3+ on glutamate and GABA transport in brain ...https://www.deepdyve.com/lp/springer_journal/effects-of-surface-functionalization-of-hydrophilic-nayf4-nanocrystals-SOZATiky0P
Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in...
GABA Plasma Membrane Transport Proteins * Glutamate Decarboxylase * Green Fluorescent Proteins * Interneurons * Locomotion ... and GABA transporter 1. Interneuron cell density was unaltered in the transgenic mice. Affected subpopulations of interneurons ... basket interneurons evident in NCAM-EC transgenic mice intercrossed with a reporter line expressing green fluorescent protein ...https://scholars.duke.edu/display/pub744580
Frontiers | Gephyrin phosphorylation in the functional organization and plasticity of GABAergic synapses | Frontiers in...
... the prolyl-isomerase activity of Pin1 has been shown to regulate protein synthesis necessary to sustain the late phase of long- ... the prolyl-isomerase activity of Pin1 has been shown to regulate protein synthesis necessary to sustain the late phase of long- ... Gephyrin is a multifunctional scaffold protein essential for the postsynaptic accumulation of inhibitory glycine and GABAA ... Gephyrin is a multifunctional scaffold protein essential for the postsynaptic accumulation of inhibitory glycine and GABAA ...https://www.frontiersin.org/articles/10.3389/fncel.2014.00103/full