Frontiers | Structure, function, and plasticity of GABA transporters | Frontiers in Cellular Neuroscience
There is also evidence that the expression of GABA transporters on the cell membrane and their lateral mobility can be ... There is also evidence that the expression of GABA transporters on the cell membrane and their lateral mobility can be ... distribution and diffusion rate of GABA transporters within the cell membrane. These findings are intriguing because they ... distribution and diffusion rate of GABA transporters within the cell membrane. These findings are intriguing because they ...https://www.frontiersin.org/articles/10.3389/fncel.2014.00161/full
Norepinephrine transporter - Wikipedia
They are found closer to the plasma membrane of the cell. This requires norepinephrine to diffuse from the site it is released ... The genetic defect in the NET protein results in decreased NET activity that could account for abnormally high NE plasma levels ... The transport of norepinephrine back into presynaptic cell is made possible by the cotransport with Na+ and Cl−. The sequential ... serotonin and GABA transporters. A single-nucleotide polymorphism (SNP) is a genetic variation in which a genome sequence is ...https://en.wikipedia.org/wiki/Norepinephrine_transporter
Discovery of Novel Biomarkers for Alzheimer's Disease from Blood.
GABA Plasma Membrane Transport Proteins. Homeodomain Proteins. Humans. Knowledge Bases. Proteome. RNA, Messenger. ... In this study we used a knowledge-based protein feature pool and two novel support vector machine embedded feature selection ... Our panels included the proteins ECH1, NHLRC2, HOXB7, FN1, ERBB2, and SLC6A13 and demonstrated promising sensitivity (,87%), ...https://pearl.plymouth.ac.uk/handle/10026.1/5119
Impairment of GABA release due to reduction of VGAT in | Open-i
A and B) Measurement of glutamate (A) and GABA (B) release was performed as descr ... Impairment of GABA release due to reduction of VGAT in μ3B−/−ΔNeo mice. ( ... Adaptor Protein Complex 3. *Adaptor Proteins, Vesicular Transport. *Animals. *Electrophysiology. *GABA Plasma Membrane ... AP-3 is a member of the adaptor protein (AP) complex family that regulates the vesicular transport of cargo proteins in the ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2172536_200405032f4&req=4
Activated GABAergic neurons in the vlPAG/DpMe region af | Open-i
GABA Plasma Membrane Transport Proteins/metabolism*. *Glutamate Decarboxylase/biosynthesis*. *Neurons/metabolism*. *Sleep, REM/ ... GABA synthesis enzyme) in control rats, rats deprived of PS for 72 h and rats allowed to recover after such deprivation. Here ... GABA synthesis enzyme) in control rats, rats deprived of PS for 72 h and rats allowed to recover after such deprivation. Here ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2629845_pone.0004272.g002&req=4
Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1...
Beckman ML, Bernstein EM, and Quick MW. Multiple G protein-coupled receptors initiate protein kinase C redistribution of GABA ... Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 ... Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 ... Impaired trafficking of choline transporter-like protein-1 at plasma membrane and inhibition of choline transport in THP-1 ...http://ajpcell.physiology.org/content/290/4/C1230
GABA Uptake Inhibitors | CTD
... that suppress or block the plasma membrane transport of GAMMA-AMINOBUTYRIC ACID by GABA PLASMA MEMBRANE TRANSPORT PROTEINS.. ... GABA Uptake Inhibitors Equivalent Terms GABA Reuptake Inhibitors , Gamma Aminobutyric Acid Plasma Membrane Transport Inhibitors ... Gamma-Aminobutyric Acid Plasma Membrane Transport Inhibitors , Inhibitors, GABA Reuptake , Inhibitors, GABA Uptake , Reuptake ... Membrane Transport Modulators ← Neurotransmitter Uptake Inhibitors ← GABA Uptake Inhibitors 2.. Chemicals ← Chemical Actions ...http://ctdbase.org/detail.go?type=chem&acc=D058805
Frontiers | The Amino Acid Transporters of the Glutamate/GABA-Glutamine Cycle and Their Impact on Insulin and Glucagon...
Moreover, high levels of glutamate, GABA and glutamine and their respective vesicular and plasma membrane transporters have ... Interestingly, proteins involved in the CNS in secretion of the neurotransmitters and emitting their responses as well as the ... Moreover, high levels of glutamate, GABA and glutamine and their respective vesicular and plasma membrane transporters have ... Interestingly, proteins involved in the CNS in secretion of the neurotransmitters and emitting their responses as well as the ...https://www.frontiersin.org/articles/10.3389/fendo.2013.00199/full
GABA-T - What does GABA-T stand for? The Free Dictionary
GABA-T is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms ... Looking for online definition of GABA-T or what GABA-T stands for? ... Gaba plasma membrane transport proteins. *Gaba plasma membrane transport proteins. *Gaba plasma membrane transport proteins ... EFFECT OF UNLABELED GABA AND [beta]ALA ON GABA-T ACTIVITY. To investigate the difference in affinity of GABA-T for both ...https://acronyms.thefreedictionary.com/GABA-T
Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo | Genome Biology | Full Text
... proteins have key roles in the transport of small molecules including neurotransmitters across vesicular and plasma membranes [ ... 33]. It is tempting to speculate that the specific downregulation of the GABA transporter SCL6 member 1 by VA (see Table 5) may ... Strikingly, a general response to oxidative stress or protein damage does not seem to exist in the zebrafish embryo. A number ... The latter compound also triggered genes involved in G-protein-coupled signaling and phototransduction. Induction of genes with ...https://genomebiology.biomedcentral.com/articles/10.1186/gb-2007-8-10-r227
... the level of intracellular immunoreactivity may not be well correlated with levels of immunoreactivity on the plasma membrane ( ... 1992) Characterization of the oligosaccharide side chains on kainate binding proteins and AMPA receptors. Brain Res 590:187-192 ... 1989) Synaptic organization of GABAergic neurons and GABAA receptors in the lateral geniculate nucleus and visual cortex. in ... transport, assembly, and degradation of receptor subunits, but not to the number or location of actually expressed receptor ...http://www.jneurosci.org/content/17/9/3352
Sodium:neurotransmitter symporter, serotonin, N-terminal (IPR013086) | InterPro | EMBL-EBI
We combine protein signatures from a number of member databases into a single searchable resource, capitalising on their ... InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites ... High affinity transport proteins found in the plasma membrane of presynaptic nerve terminals and glial cells are responsible ... GABA), noradrenaline/adrenaline, dopamine, serotonin, proline, glycine, choline, betaine and taurine. They are structurally ...http://www.ebi.ac.uk/interpro/entry/IPR013086
Mediation of Highly Concentrative Uptake of Pregabalin by L-Type Amino Acid Transport in Chinese Hamster Ovary and Caco-2 Cells...
... stable cell lines could result from overexpression of GAT protein in or lack of regulated translocation to the plasma membranes ... Since PGB and GBP are GABA analogs, we first examined if PGB interacts with GABA transport by using different subtypes of GABA ... Although both PGB and GBP are chemically derived from GABA, consistent with our previous GABA transport study with GBP in ... PGB seemed not to interact with GABA transport in GAT1, GAT2, and GAT3 cell lines, system y+, b0,+, B0,+, and B0 transport ...http://jpet.aspetjournals.org/content/313/3/1406.long
Brenda Porter, MD | Stanford Medicine Profiles
... although some of the mutant transporter proteins were present on the plasma membrane. The structural model of NaCT suggests ... The effects of the mutations on NaCT transport function and protein expression were examined by transient transfections of COS- ... Heterogeneous GABA(A) receptor subunit expression in pediatric epilepsy patients NEUROBIOLOGY OF DISEASE Porter, B. E., Zhang, ... hypothesize that deformation of the membrane by osmotic stress results in conversion of a membrane component of the transport ...https://med.stanford.edu/profiles/brenda-porter
Expression of GABRA1 in cancer - Summary - The Human Protein Atlas
The cancer tissue page shows antibody staining of the protein in 20 different cancers. ... plasma membrane]. GO:0005887 [integral component of plasma membrane]. GO:0006810 [transport]. GO:0006811 [ion transport]. GO: ... GO:0016020 [membrane]. GO:0016021 [integral component of membrane]. GO:0016917 [GABA receptor activity]. GO:0022851 [GABA-gated ... Predicted membrane proteins. Prediction method-based. Membrane proteins predicted by MDM. MEMSAT3 predicted membrane proteins. ...http://www.proteinatlas.org/ENSG00000022355-GABRA1/pathology
Anti-GABA B Receptor 2 antibody [EP2411Y] Recombinant (ab75838)
Rabbit recombinant monoclonal GABA B Receptor 2 antibody [EP2411Y] validated for WB, IHC, Flow Cyt, ICC/IF and tested in Human ... of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. ... Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates ... Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily. ...https://www.abcam.com/gaba-b-receptor-2-antibody-ep2411y-ab75838.html
Anti-GABA B Receptor 1 antibody (ab55051) | Abcam
Mouse monoclonal GABA B Receptor 1 antibody validated for WB, IHC, Flow Cyt, ICC/IF and tested in Human, Mouse and Rat. ... of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. ... Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates ... Isoform 1E function may be to regulate the availability of functional GABA-B-R1A/GABA-B-R2 heterodimers by competing for GABA-B ...http://www.abcam.com/gaba-b-receptor-1-antibody-ab55051.html
Effects of surface functionalization of hydrophilic NaYF4 nanocrystals doped with Eu3+ on glutamate and GABA transport in brain...
"Effects of surface functionalization of hydrophilic NaYF4 nanocrystals doped with Eu3+ on glutamate and GABA transport in brain ... decreased the potential of the plasma membrane of synaptosomes. In comparison with other nanoparticles studied with similar ... detonation nanodiamonds and an iron storage protein ferritin, whose activity can be registered at 0.08, 0.5 and 0.08 mg/ml, ... Effects of surface functionalization of hydrophilic NaYF4 nanocrystals doped with Eu3+ on glutamate and GABA transport in brain ...https://www.deepdyve.com/lp/springer_journal/effects-of-surface-functionalization-of-hydrophilic-nayf4-nanocrystals-SOZATiky0P
Neural cell adhesion molecule-secreting transgenic mice display abnormalities in GABAergic interneurons and alterations in...
GABA Plasma Membrane Transport Proteins * Glutamate Decarboxylase * Green Fluorescent Proteins * Interneurons * Locomotion ... and GABA transporter 1. Interneuron cell density was unaltered in the transgenic mice. Affected subpopulations of interneurons ... basket interneurons evident in NCAM-EC transgenic mice intercrossed with a reporter line expressing green fluorescent protein ...https://scholars.duke.edu/display/pub744580
Frontiers | Gephyrin phosphorylation in the functional organization and plasticity of GABAergic synapses | Frontiers in...
... the prolyl-isomerase activity of Pin1 has been shown to regulate protein synthesis necessary to sustain the late phase of long- ... the prolyl-isomerase activity of Pin1 has been shown to regulate protein synthesis necessary to sustain the late phase of long- ... Gephyrin is a multifunctional scaffold protein essential for the postsynaptic accumulation of inhibitory glycine and GABAA ... Gephyrin is a multifunctional scaffold protein essential for the postsynaptic accumulation of inhibitory glycine and GABAA ...https://www.frontiersin.org/articles/10.3389/fncel.2014.00103/full
Anion Transport Systems: Continuous Monitoring of Transport by Fluorescence (CMTF) in Cells and Vesicles | Springer for...
Anion transport mechanisms are found in mammalian cell membranes in the form of exchangers or antiporters (Passow, 1987; ... Hoffman, E. K., 1986: Anion transport systems in the plasma membrane of vertebrate cells, Biochim. Biophys. Acta, 864: 1-32. ... Passow, H., 1987: Molecular aspects of band 3 protein-mediated anion transport across the red blood cell membrane,Rev. Phvsiol ... Activation of multiple conductance state chloride channels in spinal neurones by glycine and GABA, Nature, 305: 805-808. ...https://rd.springer.com/chapter/10.1007/978-1-4757-9601-8_18
Research Interests for Edward D. Levin
Serotonin Plasma Membrane Transport Proteins, Serotonin Uptake Inhibitors, Sertraline, Severity of Illness Index, Sex ... GABA Agonists, GABA Antagonists, GABA Modulators, Galantamine, Galvanic Skin Response, gamma-Aminobutyric Acid, Ganglionic ... Membrane Glycoproteins, Membrane Proteins, Membrane Transport Proteins, Membranes, Memory, Memory Disorders, Memory, Short-Term ... Dopamine Plasma Membrane Transport Proteins, Dopamine Uptake Inhibitors, Dopaminergic Neurons, Dose-Response Relationship, Drug ...http://fds.duke.edu/db/aas/pn/faculty/edlevin/research.html
Transport along the dendritic endoplasmic reticulum mediates the trafficking of GABAB receptors | Journal of Cell Science
GABABRs insert throughout the somatodendritic plasma membrane but dendritic post-ER carriers containing GABABRs do not fuse ... This mutant protein lacks the ER retention domain, does not need GABAB2 for ER export and is efficiently transported to the ... Myc-GABAB1, FLAG-GABAB2, HA-GABAB2, Myc-GABAB1-ΔC, GABAB1a-EGFP, GABAB2-EGFP, GABAB1a-mRFP and Bgtx-Myc-GABAB1 were as ... the colocalization of GABAB1 with the ER decreased significantly in the presence of GABAB2 (GABAB1, 54±2%; GABAB1+GABAB2, 45±3 ...http://jcs.biologists.org/content/127/15/3382
Presynaptic proteins can be delivered from intracellular pools via synaptic vesicle protein transport vesicles (STVs), piccolo- ... A, B, Sample images of spontaneous plasma membrane fusion of pHluorin(SEP)_Nrxn1α in two different regions (R1, R2) on an axon ... 10A). The Nxph1/αNrxn complex was able to accumulate GABAARγ2 subunits about twofold at inhibitory synapses (Fig. 10B). Nxph1/ ... αNrxn and βNrxn transport depends on the microtubule motor protein KIF1A. A, B, Average velocities of Nrxn1α+ and Nrxn1β+ STVs ...http://www.jneurosci.org/content/35/40/13629