*  Treena Arinzeh | Biomedical Engineering
... tissue-engineering scaffolds and biomaterials for the repair of bone and other related musculoskeletal tissue, nerve tissue ... cartilage and other related musculoskeletal tissues. Her research interests also include nerve tissue regeneration, ... with a focus in the development of functional biomaterials that can accelerate repair utilizing stem cells and other cell types ... Lecture on Tissue Engineering (Fall 2001-2003). Mechanical Foundations of Biomedical Engineering, Undergraduate Level. Lectures ...
  http://biomedical.njit.edu/people/arinzeh.php
*  Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering
... Stefano Focaroli,1 Gabriella Teti,1 ... "Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering," Stem Cells International, vol. 2016, ...
  https://www.hindawi.com/journals/sci/2016/2030478/cta/
*  Modulating the oxidative environment during mesenchymal stem cells chondrogenesis with serum increases collagen accumulation in...
Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage.. *Jonathan M Brunger, Nguyen P T ... Transforming growth factor Beta-releasing scaffolds for cartilage tissue engineering.. *Henning Madry, Ana Rey-Rico, Jagadeesh ... Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation.. *Sarindr ... Effects of Mesenchymal Stem Cell and Growth Factor Delivery on Cartilage Repair in a Mini-Pig Model. *Matthew B. Fisher, Nicole ...
  https://www.semanticscholar.org/paper/Modulating-the-oxidative-environment-during-mesenc-Tangtrongsup-Kisiday/6168db2b7fe3131d1c3037d50753fd3dc7a9d401
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Beyond cartilage repair, this functional biphasic scaffold may provide a biomaterial framework for one-step tissue engineering ... Electrospinning is a promising technology for the fabrication of scaffolds in cartilage tissue engineering. Two other important ... the CBrhTE scaffold could synchronously improve all three of the basic components required for cartilage tissue engineering in ... which paves the road for designing and building more efficient tissue scaffolds for cartilage repair. ...
  https://www.jove.com/visualize?author=Yuan-Long+Lan
*  British Library EThOS: Biofunctionalised electrospun scaffolds for cartilage tissue engineering
... more importantly the proof of concept of cell-mediated activation of growth factors as a novel approach for functional tissue ... The thesis first focused on the development and characterisation of the tissue scaffold. A non-woven fibrous scaffold was ... the scaffold architecture closely resembled that of the native cartilage extracellular matrix; (2) the scaffold surface was ... The field of tissue engineering has advanced and evolved to focus on biomimetic strategies to meet the rise in demands of ...
  http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538200
*  Gallery: The Art in Biomedical Research
This work to use tissue engineering to generate replacement cartilage is supported by NIH funding from the National Institutes ... Scaffold for Cartilage Regeneration. Credit: FASEB 2012 Bio-Art Winner - Frank Moutos and Farshid Guilak Due to a lack of blood ... or the artificially-stimulated production of functional replacement tissue. The image shows a three-dimensionally woven ... This work to use tissue engineering to generate replacement cartilage is supported by NIH funding from the National Institutes ...
  https://www.livescience.com/20501-gallery-art-biomedical-research.html
*  Label-free Raman monitoring of extracellular matrix formation in three-dimensional polymeric scaffolds | Journal of The Royal...
... of scaffolds could enhance ECM formation and therefore could potentially lead to more functional cartilage tissue-engineered ... 2007 Design of biphasic polymeric 3-dimensional fiber deposited scaffolds for cartilage tissue engineering applications. Tissue ... 1998 Dynamic cell seeding of polymer scaffolds for cartilage tissue engineering. Biotechnol. Progr. 14, 193-202. doi:10.1021/ ... 2004 Tissue engineering of autologous cartilage grafts in three-dimensional in vitro macroaggregate culture system. Tissue Eng. ...
  http://rsif.royalsocietypublishing.org/content/10/86/20130464
*  Materials | Special Issue : Smart Hydrogels for (Bio)printing Applications
... scaffold with the RAD16-I self-assembling nanofibers to obtain multi-scale functional and biomimetic tissue-engineered ... Tissue engineering aims to produce cartilage-like tissues that recreate the complex mechanical and biological properties found ... Tissue engineering aims to produce cartilage-like tissues that recreate the complex mechanical and biological properties found ... The development of cohesive biphasic systems is highly relevant for current and future cartilage tissue engineering. Full ...
  http://www.mdpi.com/journal/materials/special_issues/bioprinting_applications
*  Using Stem Cells to Cure Arthritis and Cartilage Damage
Researchers are starting to learn how to use stem cells to repair cartilage and ease arthritis symptoms, but widespread use is ... There are investigations on types of 3-dimensional tissue scaffolds engineered to have a cartilage-like structure. The stem ... On a positive note, these studies have often shown improvement in symptoms, with less pain and improved functional scores. On ... In order to regenerate cartilage, the complex tissue structure of cartilage must also be reconstructed. Cartilage is often ...
  https://www.verywell.com/can-stem-cells-treat-arthritis-and-cartilage-damage-4126778
*  Bioengineering | Free Full-Text | Fed-Batch Synthesis of Poly(3-Hydroxybutyrate) and Poly(3-Hydroxybutyrate-co-4...
Blend Scaffolds for Tissue Engineering ... Bio-Inspired Multi-Functional Drug Transport Design Concept and ... An Approach to In Vitro Manufacturing of Hypertrophic Cartilage Matrix for Bone Repair ...
  http://www.mdpi.com/2306-5354/4/2/36
*  Polymers | Free Full-Text | Polymers in Cartilage Defect Repair of the Knee: Current Status and Future Prospects | Notes
Within the last two decades, tissue engineering based techniques using a wide variety of polymers, cell sources, and signaling ... further optimization of degradable scaffolds towards more biomimetic grafts and improved joint environment. Second, we predict ... We start this review with basic background information on cartilage structure, its intrinsic repair, and an overview of the ... There is a need for effective joint preserving treatments in patients suffering from cartilage defects, as untreated defects ...
  http://www.mdpi.com/2073-4360/8/6/219/notes
*  Remodelling in engineered cartilage | Journal of The Royal Society Interface
The aim of functional tissue engineering is to create viable substitutes to repair damaged tissues. Many tissue-engineering ... 2011 High amplitude direct compressive strain enhances mechanical properties of scaffold-free tissue-engineered cartilage. ... 2000 Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J. ... 2004 The local matrix distribution and the functional development of tissue engineered cartilage, a finite element study. Ann. ...
  http://rsif.royalsocietypublishing.org/content/early/2011/09/07/rsif.2011.0449
*  Nanopatterned natural biological scaffold for stem cells may allow for softer engineered tissues | KurzweilAI
Highly aligned nanofibers created by fibroblasts form a biological scaffold that could prove an ideal foundation for engineered ... Abstract of Advanced Functional Materials paper. Native tissues are endowed with a highly organized nanofibrous extracellular ... combining a synthetic scaffolding material with gene delivery techniques to direct stem cells into becoming new cartilage, as ... Nanopatterned natural biological scaffold for stem cells may allow for softer engineered tissues. February 26, 2014. ...
  http://www.kurzweilai.net/nanopatterned-natural-biological-scaffold-for-stem-cells-may-allow-for-softer-engineered-tissues
*  Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and transplantation | Journal...
Hyaluronan-based scaffolds in tissue-engineered cartilage. Cells Tissues Organs. 2007, 186: 97-103. 10.1159/000102539.View ... Tissue engineering presents a promising technique to create a functional tracheal substitute that may overcome many ... Most cartilage tissue engineering approaches use biodegradable three-dimensional (3D) scaffolds, which are important for ... Raghunath J, Rollo J, Sales KM, Butler PE, Seifalian AM: Biomaterials and scaffold design: key to tissue-engineering cartilage ...
  https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-17-92
*  Regenerative Medicine - Daniel J. Kelly, B.A., B.A.I., M.Sc., Ph.D., F.T.C.D.
... to tissue engineer functional cartilage grafts. They have recently demonstrated that it is possible to engineer zonally ... Porous decellularized tissue engineered hypertrophic cartilage as a scaffold for large bone defect healing. Acta Biomaterilia ( ... TGF-β3 and hydrostatic pressure stimulation enhances the functional development of cartilage tissues engineered using human ... Articular cartilage tissue engineering: Dr. Kelly s lab is pioneering the use of adult stem cells isolated from synovial joints ...
  http://www.mee.tcd.ie/regenerative/People/DKelly
*  Engineered cartilage template to heal broken bones | EurekAlert! Science News
... cartilage, and bone-cartilage interface tissue engineering. Other UConn authors include graduate students Paiyz E. Mikael and ... The researchers next plan to integrate the hybrid extracellular matrix with a load-bearing scaffold to develop cartilage ... and ultimately the establishment of functional bone marrow to repair long bone defects through EO. ... Engineered cartilage template to heal broken bones. University of Connecticut. Journal. Journal of Biomedical Materials ...
  https://www.eurekalert.org/pub_releases/2018-03/uoc-ect030818.php
*  Home | Mauck Laboratory | McKay Orthopaedic Research Laboratory | Perelman School of Medicine at the University of Pennsylvania
... will better direct our efforts to generate functional tissue replacements with a particular focus on articular cartilage and ... The goals of our research program in soft tissue mechanobiology and tissue engineering are to understand the physiologic and ... Our program utilizes various mechanical and biological testing modalities, scaffold fabrication techniques, and bioreactor ... patho-physiologic processes that regulate the formation, maturation, and adult function of soft connective tissues. We believe ...
  http://www.med.upenn.edu/orl/maucklab/index.shtml
*  Scientists develop tissue-engineered model of human lung and trachea | EurekAlert! Science News
... was published this week in the online version of the journal Tissue Engineering. ... Scientists at Children's Hospital Los Angeles have developed a tissue-engineered model of lung and trachea which contains the ... Grikscheit's lab developed tissue-engineered small intestine (TESI) and showed that this regenerated tissue was functional and ... transplanting stem and progenitor cells on biodegradable polymer scaffolds. The tissue that grows from this strategy is termed ...
  https://www.eurekalert.org/pub_releases/2016-11/chla-sdt111116.php
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
... focuses particularly on the importance of scaffold design and its role in the success of osteochondral tissue engineering. ... The use of functional scaffolds with a controllable delivery strategy of multiple signaling molecules is also considered a ... The biphasic constructs also showed the development of a possible formation of cartilage and bone tissue in vivo. Results ... Among the possible therapies, tissue engineering of osteochondral tissues has shown considerable promise where multiple ...
  https://www.jove.com/visualize?author=Jin-A%20Seo%20
*  Surgeons Implant Synthetic Trachea in Baltimore Man - The New York Times
"Then we replaced the trachea with this tissue-engineered scaffold." The Y-shaped scaffold, fashioned from nano-size fibers of a ... said that once the cells were inside the scaffold, they began to grow and divide and produce cartilage. "After two or three ... "It looks very functional at this stage," Dr. Trounson said. "But there's going to be a reaction of some kind." More work will ... Macchiarini is a leader in the field of tissue engineering, in which the goal is to produce replacement tissues and organs ...
  http://www.nytimes.com/2012/01/13/health/research/surgeons-transplant-synthetic-trachea-in-baltimore-man.html?_r=2
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Cellular Biology, Issue 38, Stem cells, cartilage defect, agarose, scaffold, tissue engineering, implantation, MASI ... cell biology and medicine towards the regeneration of specific cells and functional tissue. Matrix associated stem cell ... Therefore, articular cartilage injuries remain a prime target for regenerative techniques such as Tissue Engineering. In ... When preparing a tissue-engineered implant, proliferation rate and differentiation capacity are crucial for a successful tissue ...
  https://www.jove.com/visualize/abstract/24098678/long-term-evaluation-impact-autologous-peripheral-blood-stem-cell
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Cellular Biology, Issue 38, Stem cells, cartilage defect, agarose, scaffold, tissue engineering, implantation, MASI ... However, to date results regarding functional outcome and/or tissue regeneration following stem cell transplantation are quite ... The field of tissue engineering integrates the principles of engineering, cell biology and medicine towards the regeneration of ... specific cells and functional tissue. Matrix associated stem cell implants (MASI) aim to regenerate cartilage defects due to ...
  https://www.jove.com/visualize/abstract/25250622/superparamagnetic-iron-oxide-nanoparticles-function-as-long-term
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Cellular Biology, Issue 38, Stem cells, cartilage defect, agarose, scaffold, tissue engineering, implantation, MASI ... cell biology and medicine towards the regeneration of specific cells and functional tissue. Matrix associated stem cell ... The field of tissue engineering integrates the principles of engineering, ... In order to provide local retention and viability of transplanted MSCs in cartilage defects, a scaffold is needed, which also ...
  https://www.jove.com/visualize/abstract/24647802/isolated-insular-strokes-plasma-mr-proanp-levels-are-associated-with
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Cellular Biology, Issue 38, Stem cells, cartilage defect, agarose, scaffold, tissue engineering, implantation, MASI ... ultimately affecting the functional properties of the developed tissue4-8. In this paper, we illustrate the method to ... One such method is to resurface the damaged area with tissue-engineered cartilage; however, the engineered tissue typically ... Cartilage tissue engineering offers promising potential to regenerate and restore tissue function. This technology typically ...
  https://www.jove.com/visualize/abstract/25369528/quantitative-assessment-murine-articular-cartilage-bone-using-x-ray
*  NIH Research Festival 2004
Functional Properties of MSC-laden Hydrogels for Articular Cartilage Tissue Engineering CB-15 McLeod, Christopher John (NHLBI) ... Engineering Anisotropy in Electrospun Biodegradable Nanofibrous Scaffolds for Musculoskeletal Tissue Engineering CB-14 Mauck, ...
  https://researchfestival.nih.gov/festival04/sessions/CategoryCB.html