Treena Arinzeh | Biomedical Engineering
... tissue-engineering scaffolds and biomaterials for the repair of bone and other related musculoskeletal tissue, nerve tissue ... cartilage and other related musculoskeletal tissues. Her research interests also include nerve tissue regeneration, ... with a focus in the development of functional biomaterials that can accelerate repair utilizing stem cells and other cell types ... Lecture on Tissue Engineering (Fall 2001-2003). Mechanical Foundations of Biomedical Engineering, Undergraduate Level. Lectures ...http://biomedical.njit.edu/people/arinzeh.php
Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering
... Stefano Focaroli,1 Gabriella Teti,1 ... "Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering," Stem Cells International, vol. 2016, ...https://www.hindawi.com/journals/sci/2016/2030478/cta/
Calcium/Cobalt Alginate Beads as Functional Scaffolds for Cartilage Tissue Engineering
... Stefano Focaroli,1 Gabriella Teti,1 ... The field of tissue engineering currently offers some of the most promising strategies for cartilage restoration, in which ... Articular cartilage is a highly organized tissue with complex biomechanical properties. However, injuries to the cartilage ... These novel chondrogenesis-promoting scaffolds take advantage of the synergy between the alginate matrix and Co+2 ions, without ...https://www.hindawi.com/journals/sci/2016/2030478/abs/
Table of Contents - March 04, 2014, 111 (9) | PNAS
Engineering. *. You have access. Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage ... Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage Jonathan M. Brunger, Nguyen P. T. ... Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations Nathalie Magnus, Delphine Garnier ... State transitions in Chlamydomonas reinhardtii strongly modulate the functional size of photosystem II but not of photosystem I ...https://www.pnas.org/content/111/9
Engineering Cartilage | National Institutes of Health (NIH)
The approach could lead to orthopedic implants to replace cartilage and other tissues. ... Researchers developed a 3-D scaffold that guides the development of stem cells into cartilage-producing cells. ... References: Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage. Brunger JM, Huynh NP, ... Engineering Cartilage. Artistic rendering of human stem cells on the polymer scaffold.Charles Gersbach and Farshid Guilak, Duke ...https://www.nih.gov/news-events/nih-research-matters/engineering-cartilage
Modulating the oxidative environment during mesenchymal stem cells chondrogenesis with serum increases collagen accumulation in...
Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage.. *Jonathan M Brunger, Nguyen P T ... Transforming growth factor Beta-releasing scaffolds for cartilage tissue engineering.. *Henning Madry, Ana Rey-Rico, Jagadeesh ... Large, stratified, and mechanically functional human cartilage grown in vitro by mesenchymal condensation.. *Sarindr ... Effects of Mesenchymal Stem Cell and Growth Factor Delivery on Cartilage Repair in a Mini-Pig Model. *Matthew B. Fisher, Nicole ...https://www.semanticscholar.org/paper/Modulating-the-oxidative-environment-during-mesenc-Tangtrongsup-Kisiday/6168db2b7fe3131d1c3037d50753fd3dc7a9d401
Anti-Collagen I antibody [COL-1] (ab90395) References | Abcam
Brunger JM et al. Scaffold-mediated lentiviral transduction for functional tissue engineering of cartilage. Proc Natl Acad Sci ... Chen T et al. Engineering superficial zone features in tissue engineered cartilage. Biotechnol Bioeng 110:1476-86 (2013). ... Rowland CR et al. The effects of crosslinking of scaffolds engineered from cartilage ECM on the chondrogenic differentiation of ... Glass KA et al. Tissue-engineered cartilage with inducible and tunable immunomodulatory properties. Biomaterials 35:5921-31 ( ...https://www.abcam.com/collagen-i-antibody-col-1-ab90395-references.html
A cartilage ECM-derived 3-D porous acellular matrix scaffold for in vivo cartilage tissue engineering with PKH26-labeled...
In conclusion, the cartilage ECM-derived porous scaffold shows potential as biomaterial for cartilage tissue engineering, and ... Four weeks later, cartilage-like tissue formed, with positive staining for Safranin O, tuoluidine blue and collagen II. Cells ... The scaffold was fabricated by simple freeze-drying and cross-linking techniques. On histology, scaffolds showed most of the ... In vitro study showed that the novel scaffold could provide a suitable 3-D environment to support the adheration, proliferation ...https://www.semanticscholar.org/paper/A-cartilage-ECM-derived-3-D-porous-acellular-matrix-Yang-Peng/475874697bc633d7e48f2c588c8682b4fdafb573
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Beyond cartilage repair, this functional biphasic scaffold may provide a biomaterial framework for one-step tissue engineering ... Electrospinning is a promising technology for the fabrication of scaffolds in cartilage tissue engineering. Two other important ... the CBrhTE scaffold could synchronously improve all three of the basic components required for cartilage tissue engineering in ... which paves the road for designing and building more efficient tissue scaffolds for cartilage repair. ...https://www.jove.com/visualize?author=Yuan-Long+Lan
British Library EThOS: Biofunctionalised electrospun scaffolds for cartilage tissue engineering
... more importantly the proof of concept of cell-mediated activation of growth factors as a novel approach for functional tissue ... The thesis first focused on the development and characterisation of the tissue scaffold. A non-woven fibrous scaffold was ... the scaffold architecture closely resembled that of the native cartilage extracellular matrix; (2) the scaffold surface was ... The field of tissue engineering has advanced and evolved to focus on biomimetic strategies to meet the rise in demands of ...http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.538200
Gallery: The Art in Biomedical Research
This work to use tissue engineering to generate replacement cartilage is supported by NIH funding from the National Institutes ... Scaffold for Cartilage Regeneration. Credit: FASEB 2012 Bio-Art Winner - Frank Moutos and Farshid Guilak Due to a lack of blood ... or the artificially-stimulated production of functional replacement tissue. The image shows a three-dimensionally woven ... This work to use tissue engineering to generate replacement cartilage is supported by NIH funding from the National Institutes ...https://www.livescience.com/20501-gallery-art-biomedical-research.html
Department of Orthopaedic Surgery, National University of Singapore, Singapore - Postdoctoral Staff - Dr. Yang Zheng
... future design of functional scaffold and pre-implantation culturing conditions for stem cell-based cartilage tissue engineering ... The use of elastomeric scaffold to study the effect of mechanical stimulation on cartilage tissue engineering ... My research focuses on cartilage tissue engineering using adult and embryonic stem cells, with the emphasis on the ... scaffold.. Tissue engineering. Part A (2011). Zheng Yang , Yingnan Wu , Chao Li , Tianting Zhang , Yu Zou , Hui Hoi Po James , ...http://medicine.nus.edu.sg/os/staff/yang_zheng.html
Cartilage Tissue Engineering using a Elastic Poly (L-Lactide-co-ε-Caprolactone) Scaffold
Consequently, the elastic PLCL scaffolds could be used to engineer cartilage in mechanically dynamic environments ... As a control group for elastic properties of polymer scaffolds, rigid poly L-lactide scaffolds were fabricated. The scaffolds ... Histological analysis showed that implants of PLCL constructs formed mature and well-developed cartilaginous tissue, as ... The scaffolds with 80 % porosity and 300~500 μm pore size were prepared by a gel-pressing method. ...https://www.scientific.net/KEM.342-343.405
Label-free Raman monitoring of extracellular matrix formation in three-dimensional polymeric scaffolds | Journal of The Royal...
... of scaffolds could enhance ECM formation and therefore could potentially lead to more functional cartilage tissue-engineered ... 2007 Design of biphasic polymeric 3-dimensional fiber deposited scaffolds for cartilage tissue engineering applications. Tissue ... 1998 Dynamic cell seeding of polymer scaffolds for cartilage tissue engineering. Biotechnol. Progr. 14, 193-202. doi:10.1021/ ... 2004 Tissue engineering of autologous cartilage grafts in three-dimensional in vitro macroaggregate culture system. Tissue Eng. ...http://rsif.royalsocietypublishing.org/content/10/86/20130464
Influence of Physical Properties of Biomaterials on Cellular Behavior | SpringerLink
... cryogels as a cell scaffold for cartilage tissue engineering. Tissue Eng Part A. 2010;16:3033-41.PubMedCrossRefGoogle Scholar ... Both scaffolds and cells have been shown to play a crucial role in regenerating tissues that emulate structural and functional ... Bryant SJ, Anseth K. The effects of scaffold thickness on tissue engineered cartilage in photocrosslinked poly(ethylene oxide) ... Hydrogels are considered as a preferred scaffold for cartilage tissue engineering due to their structural similarities and ...https://link.springer.com/article/10.1007%2Fs11095-011-0378-9
Most British Surgeons Would Consider Using a Tissue-Engineered Anterior Cruciate Ligament: A Questionnaire Study
J. Cooper, H. H. Lu, F. K. Ko, J. W. Freeman, and C. T. Laurencin, "Fiber-based tissue-engineered scaffold for ligament ... D. Nesic, R. Whiteside, M. Brittberg, D. Wendt, I. Martin, and P. Mainil-Varlet, "Cartilage tissue engineering for degenerative ... where a chemical or mechanical stimulus may also be applied to promote the formation of a functional tissue. This concept was ... S. Rathbone and S. Cartmell, "Tissue engineering of a ligament," in Regenerative Medicine and Tissue Engineering; From Cells to ...https://www.hindawi.com/journals/sci/2012/303724/
Using Stem Cells to Cure Arthritis and Cartilage Damage
Researchers are starting to learn how to use stem cells to repair cartilage and ease arthritis symptoms, but widespread use is ... There are investigations on types of 3-dimensional tissue scaffolds engineered to have a cartilage-like structure. The stem ... On a positive note, these studies have often shown improvement in symptoms, with less pain and improved functional scores. On ... In order to regenerate cartilage, the complex tissue structure of cartilage must also be reconstructed. Cartilage is often ...https://www.verywell.com/can-stem-cells-treat-arthritis-and-cartilage-damage-4126778
Materials | Special Issue : Smart Hydrogels for (Bio)printing Applications
... scaffold with the RAD16-I self-assembling nanofibers to obtain multi-scale functional and biomimetic tissue-engineered ... Tissue engineering aims to produce cartilage-like tissues that recreate the complex mechanical and biological properties found ... Tissue engineering aims to produce cartilage-like tissues that recreate the complex mechanical and biological properties found ... The development of cohesive biphasic systems is highly relevant for current and future cartilage tissue engineering. Full ...http://www.mdpi.com/journal/materials/special_issues/bioprinting_applications
Chondrogenic induction of mesenchymal stromal/stem cells from Wharton's jelly embedded in alginate hydrogel and without added...
Today, WJ-MSC represent a real alternative source of stem cells for cartilage tissue engineering. ... After 28 days of scaffold culture, our results showed strong upregulation of cartilage-specific transcript expression. WJ-MSC ... have long been the most used stem cell source in cartilage tissue engineering, they have certain limits. Thanks to their ... promise to be an interesting source of MSC for cartilage tissue engineering. In this study, we propose to evaluate chondrogenic ...https://stemcellres.biomedcentral.com/articles/10.1186/s13287-015-0263-2
TGF-β1 conjugated chitosan collagen hydrogels induce chondrogenic differentiation of human synovium-derived stem cells |...
In this study, we demonstrate a biofunctional hydrogel for specific use in cartilage regeneration by conjugating transforming ... This study demonstrates successful engineering of a biofunctional hydrogel with a specific microenvironment tailored to promote ... This hydrogel system can provide promising efficacious therapeutics in the treatment of cartilage defects. ... articular cartilage regeneration has not been very successful and has many challenges ahead. We have previously developed ...https://jbioleng.biomedcentral.com/articles/10.1186/1754-1611-9-1
Polymers | Free Full-Text | Polymers in Cartilage Defect Repair of the Knee: Current Status and Future Prospects | Notes
Within the last two decades, tissue engineering based techniques using a wide variety of polymers, cell sources, and signaling ... further optimization of degradable scaffolds towards more biomimetic grafts and improved joint environment. Second, we predict ... We start this review with basic background information on cartilage structure, its intrinsic repair, and an overview of the ... There is a need for effective joint preserving treatments in patients suffering from cartilage defects, as untreated defects ...http://www.mdpi.com/2073-4360/8/6/219/notes
Combining regenerative medicine strategies to provide durable reconstructive options: auricular cartilage tissue engineering |...
Creating functional and durable tissue has the potential to shift the paradigm in reconstructive surgery by obviating the need ... Combining biomimetic regenerative medicine strategies will allow us to improve tissue-engineered auricular cartilage with ... We use auricular cartilage as an exemplar to illustrate how the use of tissue-specific adult stem cells, assembly through ... Current tissue-engineered auricular constructs implanted into immune-competent animal models have been observed to undergo ...https://stemcellres.biomedcentral.com/articles/10.1186/s13287-015-0273-0
Bioengineering | Free Full-Text | Fed-Batch Synthesis of Poly(3-Hydroxybutyrate) and Poly(3-Hydroxybutyrate-co-4...
Blend Scaffolds for Tissue Engineering ... Bio-Inspired Multi-Functional Drug Transport Design Concept and ... An Approach to In Vitro Manufacturing of Hypertrophic Cartilage Matrix for Bone Repair ...http://www.mdpi.com/2306-5354/4/2/36
Remodelling in engineered cartilage | Journal of The Royal Society Interface
The aim of functional tissue engineering is to create viable substitutes to repair damaged tissues. Many tissue-engineering ... 2011 High amplitude direct compressive strain enhances mechanical properties of scaffold-free tissue-engineered cartilage. ... 2000 Functional tissue engineering of articular cartilage through dynamic loading of chondrocyte-seeded agarose gels. J. ... 2004 The local matrix distribution and the functional development of tissue engineered cartilage, a finite element study. Ann. ...http://rsif.royalsocietypublishing.org/content/early/2011/09/07/rsif.2011.0449
Endogenous and exogenous stem cells: a role in lung repair and use in airway tissue engineering and transplantation | Journal...
Hyaluronan-based scaffolds in tissue-engineered cartilage. Cells Tissues Organs. 2007, 186: 97-103. 10.1159/000102539.View ... Tissue engineering presents a promising technique to create a functional tracheal substitute that may overcome many ... Most cartilage tissue engineering approaches use biodegradable three-dimensional (3D) scaffolds, which are important for ... Raghunath J, Rollo J, Sales KM, Butler PE, Seifalian AM: Biomaterials and scaffold design: key to tissue-engineering cartilage ...https://jbiomedsci.biomedcentral.com/articles/10.1186/1423-0127-17-92