*  Anti-venom Antibody Discovery and Development Service - Creative Biolabs
Creative Biolabs can offer the custom anti-venom antibody discovery and development service to meet our clients' specific ... such as single domain antibodies (sdAbs) and single-chain antibodies (scFvs), with better properties in terms of homogeneity, ... At minimal expense or time, antibodies are easier to fit the criteria more readily than traditional hybridoma. ... Biolabs has developed a standard pipeline for the generation of recombinant antibodies and smaller functional unit antibodies, ...
  https://www.creative-biolabs.com/anti-venom-antibody-discovery-and-development-service.html
*  Single-domain antibody - Wikipedia
"A versatile nanotrap for biochemical and functional studies with fluorescent fusion proteins". Molecular & Cellular Proteomics ... Single-domain antibodies allow a broad range of applications in biotechnical as well as therapeutic use due to their small size ... As well, they are easily isolated using the same phage panning procedure used for traditional antibodies, allowing them to be ... Human single-domain VHs can be isolated from engineered antibody domain libraries by phage display. Human single-domain ...
  https://en.wikipedia.org/wiki/Single-domain_antibody
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Single-domain antibodies (sdAbs) derived from human V(H) are considered to be less soluble and prone to aggregate which makes ... Molecular Biology, Issue 59, Affinity chromatography, albumin-binding domain, human serum albumin, Z-domain ... The minimal functional and structural unit of SeqA is a dimer, thereby explaining the requirement of at least two GATC ... Traditional methodologies applied to the study of integral membrane protein function can be hampered by the inherent ...
  https://www.jove.com/visualize/abstract/22253912/crystal-structure-human-single-domain-antibody-dimer-formed-through-v
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, as another opportunity, these interesting and stable single-domain antibodies8 can be easily engineered with different ... VHH are the smallest antigen-binding functional fragments of camelid heavy chain antibodies, also called Nanobodies. The ... Overall, the therapeutic benefit seemed well correlated with the time of brain exposure and the plasma half-life of the used ... Molecular Biology, Issue 63, Virology, Poliovirus, VHH, nanobody, magnetic beads, affinity capture, liquid phase based assay, ...
  https://www.jove.com/visualize/abstract/25347556/protective-effect-different-anti-rabies-virus-vhh-constructs-against
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, as another opportunity, these interesting and stable single-domain antibodies8 can be easily engineered with different ... Molecular Biology, Issue 63, Virology, Poliovirus, VHH, nanobody, magnetic beads, affinity capture, liquid phase based assay, ... The methods described here can be adapted for studies of the structural and functional properties of any mammalian multi- ... Our preliminary work suggested that a large portion of nuclear vRNPs were not extracted during traditional cell lysis, and ...
  https://www.jove.com/visualize/abstract/23226397/self-subunit-swapping-occurs-another-gene-type-cobalt-nitrile
*  Application # 2016/0194410. BINDING AGENT - Patents.com
... an antibody. In certain embodiments, a single-domain antibody is a human single-domain antibody (Domantis, Inc., Waltham, Mass ... 0054] Antibody fragments may be generated by traditional means, such as enzymatic digestion or by recombinant techniques. For a ... 0162] The additional binding pair to which a functional moiety X can be bound may be a leucine zipper domain or a hybridizing ... 0036] Bispecific monoclonal antibodies also represent quite interesting novel therapeutic modalities. A broad spectrum of ...
  http://patents.com/us-20160194410.html
*  State of Research
... caplicizumab is the first therapeutic nano antibody. Nano antibodies are single-domain antibody fragments that bear full ... Because they are encoded by single genes, nano antibodies are easier and more cost-effective than traditional antibodies to ... They then took a candidate approach to identify the molecular pathways affected by the loss of MEF2D in MEF2D-null mice. Among ... into its functional form. Without the function of ADAMTS13, multimeric vWF forms aggregates with platelets in the blood. Low ...
  http://blog.allelebiotech.com/category/state-of-research/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, as another opportunity, these interesting and stable single-domain antibodies8 can be easily engineered with different ... Molecular Biology, Issue 65, Luminex, xMAP, Multiplex, MAGPIX, MagPlex Low Concentration Microspheres, xMAP Antibody Coupling ... Thus, this method to study functional differences of antigen-specific antibodies in clinical samples will facilitate ... There is an urgent need to develop approaches for repairing the damaged heart, discovering new therapeutic drugs that do not ...
  https://www.jove.com/visualize/abstract/24751715/development-vhh-antibodies-against-dengue-virus-type-2-ns1-comparison
*  Most recent papers with the keyword Camelid* | Read by QxMD
BACKGROUND: Nanobodies are single-domain antibodies that contain the unique structural and functional properties of naturally- ... As a novel class of antibody, they show many advantages compared with traditional antibodies such as smaller size, higher ... The development of innovative targeted therapeutic approaches are expected to surpass the efficacy of current forms of ... Capable of effectively binding to molecular targets inaccessible to classical immunotherapeutic agents and easily produced in ...
  https://www.readbyqxmd.com/keyword/173
*  NICBR Forum - Biostabilization - Abstracts
Ellen Goldman and Scott Walper will present a brief introduction to the intrinsically stabile single-domain antibodies (sdAb) ... Although Xoma does not work on biostabilizers per say, they do develop therapeutic antibody formulations that could benefit ... There is a need for standardized markers indicating the molecular integrity of products such as ours. We have begun to explore ... Insights gathered from this and other studies offer an opportunity for ATCC to step out from traditional biological sample ...
  https://ncifrederick.cancer.gov/events/Biostabilization/abstracts.asp
*  Diagnostic and Prognostic Markers for Cancer - Patent application
The term includes polyclonal, monoclonal, chimeric, single domain (Dab) and bispecific antibodies. As used herein, antibody or ... antibodies or functional fragments thereof corresponding to these regions may be used to advantage in the design of therapeutic ... molecular modifications that would not affect the functional and novel characteristics of the sequence. [0059] With regard to ... Further, traditional markers associated with outcome such as LN status and ER status are only marginally different. Genetic ...
  http://www.patentsencyclopedia.com/app/20130012409
*  Most recent papers with the keyword Infectious modification | Read by QxMD
Next-Generation DNA Sequencing of VH/VL Repertoires: A Primer and Guide to Applications in Single-Domain Antibody Discovery. ... to multiple antibody biophysical features induced by vaccines and other therapeutic regimens can significantly alter functional ... BACKGROUND: Traditional paramedian forehead flap reconstruction exploits the aesthetic subunit principle. Refinements and ... 29116520/next-generation-dna-sequencing-of-vh-vl-repertoires-a-primer-and-guide-to-applications-in-single-domain-antibody- ...
  https://www.readbyqxmd.com/keyword/87637
*  Neurodegenerative Diseases | Leaders in Pharmaceutical Business Intelligence (LPBI) Group
Choosing the right antibody platform can speed the discovery of a new therapeutics against these new targets. Single domain ... to the extremely heterogeneous cellular and molecular environment and the complexities of the brain's anatomical and functional ... Therapeutic Clearance of Amyloid by Antibodies to Serum Amyloid P Component. N Engl J Med 2015;373:1106-14. ... Nanotechnology is not in itself a single emerging scientific discipline but rather a meeting of traditional sciences such as ...
  https://pharmaceuticalintelligence.com/category/neurodegenerative-diseases/
*  RECOMBINANT RENEWABLE POLYCLONAL ANTIBODIES - Patent application
... the antibody display library is a single domain VH, VHH, VL, scFv or Fab library. In some examples, the antibody display ... Structurally, the provided antibodies are similar to traditional antibodies, allowing scientists to use them without modifying ... With the advent of molecular biology, in vitro methods to generate monoclonal antibodies have been developed, in which antibody ... For instance, the described antibodies (and polyclonal pools of antibodies) can be used in research, in therapeutic ...
  http://www.patentsencyclopedia.com/app/20130085072
*  Protocols and Video Articles Authored by Peter Nagy (Translated to Norwegian)
... single- and multi-domain cyclophilins, TPR-domain co-chaperones and cellular ion pumps. These restriction factors frequently ... FRET with the capability to monitor changes in a molecular complex in real-time making it possible to establish the functional ... Since the therapeutic effects of the administration of a single type of polyphenol might be limited because of the reduced ... Detection of PKCγ antibodies should be considered in PCD and adenocarcinoma without typical onconeural antibodies. ...
  https://www.jove.com/author/Peter_Nagy?language=Norwegian
*  William Weis | Stanford Medicine Profiles
Here we report stabilization of two distinct β2AR conformations using single domain camelid antibodies (nanobodies)-a ... Molecular Definition to Therapeutic Potential Weis, W. I. PLENUM PRESS DIV PLENUM PUBLISHING CORP. 1994: 55-75 View details for ... Here we show that HMP-1 is a monomer with a functional C-terminal F-actin binding domain. However, neither full-length HMP-1 ... An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity BIOESSAYS Dickinson, D. J ...
  https://med.stanford.edu/profiles/william-weis
*  Drag-and-drop DNA ( Using a simple drag-and-drop compu...)
0] Singh Biotechnology Receives Second FDA Orphan Drug Designation for its Novel Single Domain Antibody for the Treatment of ... Scientists work within inSquio to design molecular pieces with specific, functional components. The software then optimizes the ... "When designing a therapeutic compound, we combine knowledge of the cell receptors we are targeting or biological pathways we ... The process, from conception to production, can be performed in weeks, or even days--much faster than traditional drug ...
  http://www.bio-medicine.org/biology-news-1/Drag-and-drop-DNA-27759-1/
*  Diagnostics and Treatment of Metastatic Cancers with Magnetic Nanoparticles | OMICS International
c) relaxation losses in 'superparamagnetic' single-domain magnetic particles. d) frictional losses in viscous suspensions. ... superparamagnetic character and functional groups for conjugating to multiple diagnostic and therapeutic agents. Magnetic ... The capture antibody-bound magnetic beads can lead to rapid immunoassay as they can be instantaneously bound to the substrate ... Nanomagnetic molecular sensing. Highly sensitive detection and accurate analysis of biomarker molecules in human fluid samples ...
  https://www.omicsonline.org/diagnostics-and-treatment-of-metastatic-cancers-with-magnetic-nanoparticles-2155-983X.1000115.php?aid=17991
*  DiVA - Search result
However, fibers carrying complex ligands such as single-chain antibody fragments did not assemble into functional pentons in ... corresponding to regions of the protein domain not addressed by traditional affibody molecule affinity maturation strategies. ... KTH, School of Biotechnology (BIO), Molecular Biotechnology. Nygren, Per-Åke KTH, School of Biotechnology (BIO), Molecular ... investigated affibody variants could be completely blocked by premixing the target with the therapeutic monoclonal antibody ...
  http://kth.diva-portal.org/smash/resultList.jsf?af=%5B%5D&aq=%5B%5B%7B%22personId%22%3A%22authority-person%3A31099+OR+0000-0003-4214-6991%22%7D%5D%5D&aqe=%5B%5D&aq2=%5B%5B%5D%5D&language=en&query=
*  Methods and Compositions for Generating Bioactive Assemblies of Increased Complexity and Uses - Patent application
... and includes antibody fragments such as Fab', Fab, F(ab')2, single domain antibodies (DABs), Fv, scFv (single chain Fv), and ... protein may additionally comprise an antibody or an antibody fragment and a therapeutic agent. Examples of therapeutic agents ... the mouse antibody genes have been inactivated and replaced by functional human antibody genes, while the remainder of the ... antibody and antigen. A peptide mimetic is expected to permit molecular interactions similar to the natural molecule. [0074] ...
  http://www.patentsencyclopedia.com/app/20090202433
*  Nanotechnology | Britannica.com
At very small sizes (a few nanometres), magnetic nanoclusters have a single magnetic domain, and the strongly coupled magnetic ... In his written works he takes a molecular view of the world and envisions molecular machines doing much of the work of the ... Furthermore, antibodies may be attached to the outer gold surface of the shells to cause them to bind specifically to certain ... While such traditional applications for physical sensing generally rely on microscale sensing devices, the advent of nanoscale ...
  https://www.britannica.com/technology/nanotechnology
*  CONSTRUCTS AND LIBRARIES COMPRISING ANTIBODY SURROGATE LIGHT CHAIN SEQUENCES - Patent application
... single domain, or single chain antibody (scFv), or a full length antibody, for example, an IgG (e.g., an IgG1, IgG2, IgG3, or ... molecular targets of therapeutic intervention. In addition, by the techniques described above, highly diverse libraries of ... selections based on the functional properties of the antibody also result in selection of the gene encoding the antibody ... be reinforced by fusing the constant lambda region from a traditional antibody light chain instead of the λ5 protein fragment. ...
  http://www.patentsencyclopedia.com/app/20100004139
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
However, as another opportunity, these interesting and stable single-domain antibodies8 can be easily engineered with different ... Institutions: The Molecular Foundry.. Structural determination of proteins is rather challenging for proteins with molecular ... However, it is apparent that traditional monoclonal technologies are not alone up to this task. This has led to the development ... Peptide-based Identification of Functional Motifs and their Binding Partners. Authors: Martin N. Shelton, Ming Bo Huang, Syed ...
  https://www.jove.com/visualize/abstract/25811612/inhibition-of-type-vi-secretion-by-an-anti-tssm-llama-nanobody
*  IJMS | Free Full-Text | Novel Strategies for Drug Discovery Based on Intrinsically Disordered Proteins (IDPs) | HTML
Structure and Properties of a Complex of alpha-Synuclein and a Single-Domain Camelid Antibody. J. Mol. Biol 2010, 402, 326-343 ... A possible molecular NK between Parkinson's disease and heavy metal exposure. J. Biol. Chem 2001, 276, 44284-44296. [Google ... Protein misfolding, functional amyloid, and human disease. Annu. Rev. Biochem 2006, 75, 333-366. [Google Scholar] ... According to the traditional sequence-to-structure-to-function paradigm, active proteins have well-defined three-dimensional ...
  http://www.mdpi.com/1422-0067/12/5/3205/htm
*  Antibodies That Bind OV064 and Methods of Use Therefor - Patent application
... which consists of a VH domain; (vii) a single domain functional heavy chain antibody, which consists of a VHH domain (known as ... antibodies or fragments thereof of single molecular composition. [0073]The term "bispecific antibody" or "bifunctional antibody ... Most therapeutic antibodies are human, chimeric, or humanized antibodies of the IgG1 type. [0100]The variable regions of each ... 0215]Mouse monoclonal antibodies mAb 4G10, mAb 8G5, mAb 3A4 and mAb 2F3, were generated by traditional hybridoma technology. ...
  http://www.patentsencyclopedia.com/app/20090208489