*  Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of...
GLP-1 receptor, PDX-1, and insulin expression in exocrine ducts.. As previously reported (32), GLP-1 receptors were expressed ... Structure of CD26 (dipeptidyl peptidase IV) and function in human T cell activation. Adv Exp Med Biol 1997; 421: 109- 116. ... deficit in β-cells and islet amyloid derived from islet amyloid polypeptide (IAPP), a 37-amino acid peptide cosecreted with ... Diabetes due to a progressive defectin beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP rat): a new ...
  http://diabetes.diabetesjournals.org/content/58/7/1604.full
*  Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology
"An amylin receptor is revealed following co-transfection of a calcitonin receptor with receptor activity modifying proteins-1 ... of islet amyloid polypeptide and the 8-37 fragment of islet amyloid polypeptide on insulin release from perifused rat islets," ... P. Westermark, A. Andersson, and G. T. Westermark, "Islet amyloid polypeptide, islet amyloid, and diabetes mellitus," ... mediates islet amyloid-induced beta cell apoptosis in cultured human islet amyloid polypeptide transgenic mouse islets," ...
  https://www.hindawi.com/journals/jdr/2016/2798269/ref/
*  Beta cell - Wikipedia
Amylin, also known as islet amyloid polypeptide (IAPP). The function of amylin is to slow the rate of glucose entering the ... Gastric inhibitory polypeptide receptor List of terms associated with diabetes Guangxitoxin Alpha cell Pancreatic development ... They make up 65-80% of the cells in the islets. The primary function of a beta cell is to store and release insulin. Insulin is ... It is believed to be due to the decline of specific receptors on the surface of the liver and muscle cells which lose their ...
  https://en.wikipedia.org/wiki/Beta_cell
*  Plus it
... in particular islet amyloid polypeptide (IAPP), which encodes amylin and was transcriptionally regulated by TAp63 and TAp73. ... and receptor activity modifying protein 3 (RAMP3), as depletion or inhibition of either receptor ablated the antitumor effects ... Restoration of wild-type p53 function has been shown to effectively suppress tumor growth in mice, but has proven difficult to ... Mechanistically, secreted amylin suppressed p53-deficient tumor growth via interaction with the calcitonin receptor (CALCR) ...
  http://cancerdiscovery.aacrjournals.org/content/5/1/11.2
*  JCI - Role of innate and adaptive immunity in obesity-associated metabolic disease
... islet amyloid polypeptide (60), serum amyloid A (61), cholesterol crystals (62), and oxidized LDL cholesterol (63). Other ... Serum amyloid A activates the NLRP3 inflammasome via P2X7 receptor and a cathepsin B-sensitive pathway. J Immunol. 2011;186(11 ... The primary function of CD8+ T cells is to kill infected or foreign cells by releasing perforin and granzyme B and secreting ... Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. ...
  https://www.jci.org/articles/view/88876
*  Upregulated NLRP3 Inflammasome Activation in Patients With Type 2 Diabetes | Diabetes
... islet amyloid polypeptide (IAPP), and monosodium uric acid crystals (MSU). The diabetic subjects also had higher mitochondrial ... including improvement of vascular function, regulation of vaspin levels and ovary function in polycystic ovary syndrome, ... Interleukin-1-receptor antagonist in type 2 diabetes mellitus. N Engl J Med 2007;356:1517-1526pmid:17429083. ... islet amyloid polypeptide, and monosodium uric acid crystals). Mitochondrial reactive oxygen species and NLRP3 were required ...
  http://diabetes.diabetesjournals.org/content/62/1/194?with-ds=yes
*  Pancreatic Beta Cell Death: Novel Potential Mechanisms in Diabetes Therapy
P. Westermark, A. Andersson, and G. T. Westermark, "Islet amyloid polypeptide, islet amyloid, and diabetes mellitus," ... Insulin is a polypeptide hormone formed by 51 amino acids [5] which once bound with its receptor, mainly expressed in the liver ... "Sustained NF-κB activation and inhibition in β-cells have minimal effects on function and islet transplant outcomes," PLoS ONE ... "Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide," Diabetologia, vol. 55, no ...
  https://www.hindawi.com/journals/jdr/2018/9601801/
*  Forum Scientium Former Members: Publications
Drosophila Melanogaster as a Model System for Studies of Islet Amyloid Polypeptide Aggregation. PLoS ONE, 2011, 6( 6). Fulltext ... Differential effects of IGF-I, IGF-II and insulin in human preadipocytes and adipocytes - Role of insulin and IGF-I receptors. ... Determination of right ventricular volume and function using multiple axially rotated MRI slices. Clinical Physiology and ... Studies on Islet Amyloid Polypeptide Aggregation: From Model Organism to Molecular Mechanisms. 2011. ...
  http://www.ep.liu.se/Forum_Scientum/FormerMembers/ForumScientumFormerMembers.asp?Volume=2011
*  Forum Scientium Former Members: Publications
Intracellular amyloid-like deposits contain unprocessed pro-islet amyloid polypeptide (proIAPP) in beta cells of transgenic ... Insulin and IGF-I action on insulin receptors, IGF-I receptors, and hybrid insulin/IGF-I receptors in vascular smooth muscle ... Induction of structure and function in a designed peptide upon adsorption on a silica nanoparticle. Angewandte Chemie ... Proislet Amyloid Polypeptide (proIAPP): Impaired Processing is an Important Factor in Early Amyloidogenesis in Type 2 Diabetes ...
  http://www.ep.liu.se/Forum_Scientum/FormerMembers/ForumScientumFormerMembers.asp?Volume=2006
*  A Category Names List - Drug Information Portal - U.S. National Library of Medicine
Included under this heading is the endogenous form of ISLET AMYLOID POLYPEPTIDE and synthetic compounds that mimic its effect. ... Adenosine A2A Receptor Agonists (0) see Adenosine A2 Receptor Agonists. Adenosine A2A Receptor Antagonists (0) see Adenosine A2 ... chemicals that introduce alkyl radicals into biologically active molecules and thereby prevent their proper functioning. Many ... Adenosine A2B Receptor Agonists (0) see Adenosine A2 Receptor Agonists. Adenosine A2B Receptor Antagonists (0) see Adenosine A2 ...
  https://druginfo.nlm.nih.gov/drugportal/drug/categories
*  L. Marzban | Department of Surgery
... peptide-1 receptor agonist exenatide restores impaired pro-islet amyloid polypeptide processing in cultured human islets: ... Three-dimensional scaffolds reduce islet amyloid formation and enhance survival and function of cultured human islets. Am J ... Suppression of Pro-Islet Amyloid Polypeptide Expression Inhibits Islet Amyloid Formation and Enhances Survival of Human Islets ... Deletion of Fas protects islet beta cells from cytotoxic effects of human islet amyloid polypeptide. Diabetologia 55(4): 1035- ...
  http://surgery.med.ubc.ca/people/lmarzban/
*  Proprotein convertase 2 - Wikipedia
2001). "The prohormone convertase enzyme 2 (PC2) is essential for processing pro-islet amyloid polypeptide at the NH2-terminal ... Mbikay M, Seidah NG, Chrétien M (2001). "Neuroendocrine secretory protein 7B2: structure, expression and functions". Biochem. J ... 2000). "Interactions between the prohormone convertase 2 promoter and the thyroid hormone receptor". Endocrinology. 141 (9): ...
  https://en.wikipedia.org/wiki/Proprotein_convertase_2
*  The role of SDF-1/CXCR4 in the vasculogenesis and remodeling of cerebr | TCRM
... are believed to exert multiple physiological functions including angiogenesis. Thus, we investigated the role of SDF-1/CXCR4 in ... Stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, ... factors for formation of toxic islet amyloid polypeptide ... Stromal cell-derived factor-1 (SDF-1) and its receptor, CXCR4, are believed to exert multiple physiological functions including ... Several features of this site will not function whilst javascript is disabled. ...
  https://www.dovepress.com/the-role-of-sdf-1cxcr4-in-the-vasculogenesis-and-remodeling-of-cerebra-peer-reviewed-article-TCRM
*  j.imbio.2017.10.038
Abbreviations: FAP, familial amyloidotic polyneuropathy; SAA, serum amyloid A; IAPP, islet amyloid polypeptide; Aβ, amyloid β; ... amyloid can also influence the immunosuppressive function, resulting in immune function-specific outcomes of its related diseases ... Innate immunity receptor CD36 promotes cerebral amyloid angiopathy. Proc. Natl. Acad. Sci. U. S. A. 110, 3089-3094. Patton, R.L ... Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes ...
  https://www.docme.ru/doc/2192837/j.imbio.2017.10.038
*  Plus it
Matrix metalloproteinase-9 reduces islet amyloid formation by degrading islet amyloid polypeptide. J Biol Chem 2013;288:3553- ... Glucagon receptor knockout mice display increased insulin sensitivity and impaired beta-cell function. Diabetes 2006;55:3463- ... Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function. Diabetes 2009;58 ... protease that limits islet amyloid deposition and its concomitant toxic effects via degradation of the amyloid polypeptide (18 ...
  http://diabetes.diabetesjournals.org/content/66/1/45
*  Cell responses without receptors and ligands, using nanosecond pulsed | IJN
... streptolysin O both create pores that allow unsolicited molecular transfer across membranes that disrupts vital functions. ... Cell responses without receptors and ligands, using nanosecond pulsed electric fields (nsPEFs) Stephen J Beebe Frank Reidy ... Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus Jeong HR, An SSA ... Cell responses without receptors and ligands, using nanosecond pulsed electric fields (nsPEFs). ...
  https://www.dovepress.com/cell-responses-without-receptors-and-ligands-using-nanosecond-pulsed-e-peer-reviewed-article-IJN
*  Recent advances in neutralizing the IL-6 pathway in arthritis | OARRR
... a fully humanized monoclonal antibody that neutralizes the biological activity of the IL-6-receptor (IL-6R). Significant ... interleukin-6/interleukin-6 receptor/glycoprotein 130, JAK/STAT pathway, SAP/MAPK pathway, osteoarthritis, rheumatoid arthritis ... of how IL-6 trans-signaling regulates immune cell function and promotes inflammation in autoimmune arthritis are critically ... Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus Jeong HR, An SSA ...
  https://www.dovepress.com/recent-advances-in-neutralizing-the-il-6-pathway-in-arthritis-peer-reviewed-article-OARRR-recommendation1
*  Asna1/TRC40 Controls β-Cell Function and Endoplasmic Reticulum Homeostasis by Ensuring Retrograde Transport | Diabetes
In contrast, pancreatic content of the hormone islet amyloid polypeptide, which is stored and cosecreted with insulin, was ... Steneberg P, Rubins N, Bartoov-Shifman R, Walker MD, Edlund H. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis ... Moreover, vesicular proinsulin localization appears unaltered in Asna1β−/− β-cells, pancreatic islet amyloid polypeptide ... 6A and B). Islet proinsulin and insulin content, however, was reduced by ∼70% in Asna1β−/− islets compared with Asna1β+/− ...
  http://diabetes.diabetesjournals.org/content/65/1/110
*  Calcitonin Gene Products: Molecular Biology, Chemistry, and Actions | Springer for Research & Development
Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets. Biochem Biophys ... function and relationship to islet amyloid and to diabetes mellitus. Biochim Biophys Acta 1014:247-258PubMedCrossRefGoogle ... Marx SJ, Woodard CJ, Aurbach GD (1972) Calcitonin receptors of kidney and bone. Science 178:999-1001PubMedCrossRefGoogle ... Nishi M, Sanke T, Seino S, Eddy RL, Fan Y-S, Byers MG, Shows TB, Bell GI, Steiner DF (1989) Human islet amyloid polypeptide ...
  https://rd.springer.com/chapter/10.1007/978-3-642-77991-6_16
*  Full text] Optogenetics: illuminating the neural bases of rodent behavior | OAAP
Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus Jeong HR, An SSA ... Motor function. Motor function was one the first behavioral outputs explored using in vivo optogenetics. Aravanis et al75 ... A subsequent study from this same group used a vertebrate melanopsin coupled with a 5-HT2C receptor, a Gq linked receptor, in ... In vivo optogenetics has provided insight into the function of specific neural circuits underlying motor function and movement, ...
  https://www.dovepress.com/optogenetics-illuminating-the-neural-bases-of-rodent-behavior-peer-reviewed-fulltext-article-OAAP
*  Forum Scientium Transformers: Publications
Drosophila Melanogaster as a Model System for Studies of Islet Amyloid Polypeptide Aggregation. PLoS ONE, 2011, 6( 6). Fulltext ... PAR1, PAR4 and GPIB form functional interdependent units in a receptor complex mediating platelet activation by thrombin in ... Studies on Islet Amyloid Polypeptide Aggregation: From Model Organism to Molecular Mechanisms. 2011. ... Angiotensin-converting enzyme in cardiovascular function and dysfunction. 2011. Fulltext Cecilia Andrésen. Protein Structure ...
  http://www.ep.liu.se/Forum_Scientum/Transformers/ForumScientumTransformers.asp?Volume=2011
*  Table of Contents | Diabetes
Lack of Effect of Islet Amyloid Polypeptide in Causing Insulin Resistance in Conscious Dogs During Euglycemic Clamp Studies A A ... Abnormalities of Cognitive Functions in IDDM Revealed by P300 Event-Related Potential Analysis: Comparison With Short-Latency ... Inducement of Antibody That Mimics Insulin Action on Insulin Receptor by Insulin Autoantibody Directed at Determinant at ... on Regional Hemodynamic Actions of Rat Islet Amyloid Polypeptide in Conscious Long-Evans Rats Sheila M Gardiner, Alix M Compton ...
  http://diabetes.diabetesjournals.org/content/40/8
*  The transcriptional landscape of mouse beta cells compared to human beta cells reveals notable species differences in long non...
... lncRNARNA-seqProlactin receptorPrlrGrowth hormone receptorGhrCiliary neurotrophic factor receptorCntfrIslet amyloid polypeptide ... The unique cytoarchitecture of human pancreatic islets has implications for islet cell function. Proc Natl Acad Sci U S A. 2006 ... Westermark P, Andersson A, Westermark GT: Islet amyloid polypeptide, islet amyloid, and diabetes mellitus. Physiol Rev. 2011, ... including pancreatic polypeptide (Ppy), somatostatin (Sst), peptide YY (Pyy) and islet amyloid polypeptide (Iapp), is between ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-15-620
*  Browse by Ulster Authors and Editors - Ulster Institutional Repository
Evaluation of the inhibitory action of islet amyloid polypeptide on insulin secretion from clonal rat pancreatic beta-cells. ... Effects of glucose-dependent insulinotropic polypeptide receptor knockout and a high-fat diet on cognitive function and ... Influence of neuropeptide Y and pancreatic polypeptide on islet function and beta-cell survival. Biochimica et Biophysica Acta ... Proceedings of the EASD Islet Study Group, Meeting on Molecular Aspects of Pancreatic Islet Function, 1 . p. 26. [Journal ...
  http://uir.ulster.ac.uk/view/author_or_editor/228.html
*  Publications - Mayo Clinic
Islet amyloid polypeptide is not a satisfactory marker for detecting pancreatic cancer. Gastroenterology. 2001 Sep; 121(3):640- ... Receptor activity-modifying protein-dependent impairment of calcitonin receptor splice variant Delta(1-47)hCT((a)) function. Br ... Silencing of secretin receptor function by dimerization with a misspliced variant secretin receptor in ductal pancreatic ... Transmembrane segment peptides can disrupt cholecystokinin receptor oligomerization without affecting receptor function. ...
  http://www.mayo.edu/research/searchpublications/publications?authid=10223401