*  Metformin and other glucose-lowering drug initiation and rates of community-based antibiotic use and hospital-treated...
... via its negative influence on polymorphonuclear neutrophil function and intracellular bactericidal and opsonic activity.31 ... Obesity and risk of infection: results from the danish blood donor study. Epidemiology 2015;26:580-9. doi:10.1097/EDE. ... Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort ... 32 and insulin has been suggested to enhance innate and cell-mediated immunity33 and promote macrophage function.31 ,34 This ...
  http://bmjopen.bmj.com/content/6/8/e011523
*  Impaired tuftsin activity in cirrhosis: relationship with splenic function and clinical outcome | Gut
Fierer J, Finley F. Deficient serum bactericidal activity against Escherichia coli in patients with cirrhosis of the liver. J ... prothrombin activity, and whole blood examination were assessed using standard methods. Functional liver mass was estimated in ... Methods: Tuftsin activity and splenic function were assessed in 31 patients with liver cirrhosis and 31 healthy subjects. The ... Splenic autotransplantation after splenectomy: tuftsin activity correlates with residual splenic function. Br J Surg1994;81:716 ...
  http://gut.bmj.com/content/50/5/707
*  Recovery, Structure and Function of Dog Granulocytes After Freeze Preservation with Dimethylsulfoxide.
... bactericidal activity, and ultrastructure before and after freezing. Granulocytes were frozen in DMSO (7.5%) and autologous ... Leucocytes were isolated from defibrinated or anticoagulated whole blood and subsequent erythrocyte sedimentation on a column ... and bactericidal functions and ultrastructure are impaired to different degrees, according to the method of isolation and ... structure and function of dog granulocytes were determined before and after freeze preservation. ...
  http://www.dtic.mil/docs/citations/ADA033508
*  Heterogeneous vancomycin-intermediate susceptibility in a community-associated methicillin-resistant Staphylococcus aureus...
TMP-SMX has bactericidal activity in-vitro and it may be considered to be an alternative therapy to vancomycin for MRSA ... Sma I restriction patterns were indistinguishable for SaU (urine isolate), SaB1 (initial blood isolate) and SaB2 (later blood ... including changes in renal function, TMP-SMX apparently contributed to bacteraemia clearance. Only few cases of patients with ... The blood (SaB1 and SaB2) and urine (SaU) MRSA isolates were sent to the CIBICI ("Centro de Investigaciones en Bioquimica ...
  https://rd.springer.com/article/10.1186/1476-0711-10-15
*  Leptin Indirectly Activates Human Neutrophils via Induction of TNF-α | The Journal of Immunology
Neutrophil function in whole blood and after purification: changes in receptor expression, oxidase activity and responsiveness ... Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?. J. Leukocyte Biol. 69:414. ... Blood samples. Peripheral blood (20 ml) was collected into sterile tubes containing EDTA or heparin from healthy adult male ... Leptin augments the response of PMN in whole blood to PMA and TNF-α. Whole blood was preincubated with leptin (250 ng/ml) for 1 ...
  http://www.jimmunol.org/content/172/3/1809.long
*  Aldesleukin: Interleukin-2
... demonstrated improvements in bactericidal activity of monocytes and neutrophils, but 'had no changes in blood chemistry').. ... Recombinant human interferon-gamma reconstitutes defective phagocyte function in patients with chronic granulomatous disease of ... While also known as type II interferon, interferon gamma has only modest direct antiviral activity and is unrelated in ... liver fibrosis and histologic activity scores did not change; one patient had a 2 fold increase in serum ALT levels on therapy ...
  https://livertox.nlm.nih.gov/InterferonGamma.htm
*  Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex | The EMBO Journal
... mediated haemolytic and bactericidal activity by binding to C5 through its C‐terminal β‐grasp domain (Laursen et al, 2010). ... Pangburn MK, Rawal N (2002) Structure and function of complement C5 convertase enzymes. Biochem Soc Trans 30: 1006-1010. ... The release of C3a and C5a increases vascular permeability and blood flow, thereby promoting further transport of other snake ... Adcock SA, McCammon JA (2006) Molecular dynamics: survey of methods for simulating the activity of proteins. Chem Rev 106: 1589 ...
  http://emboj.embopress.org/content/30/3/606
*  Genome-wide association study for T lymphocyte subpopulations in swine | BMC Genomics | Full Text
... and maximizing bactericidal activity of phagocytes such as macrophages. Shedlock and Shen[7] showed that CD4+ cells are ... The blood cells were incubated with 10 μl of mouse anti porcine CD4-FITC (Serotec UK) and 10 μl of mouse anti porcine CD8-RPE ( ... In addition to the individual functions of CD4 and CD8, different combinations of them, i.e., CD4+CD8+, CD4+CD8−, CD4−CD8+ and ... Swine has a substantial number of CD4-CD8-T lymphocytes in peripheral blood[10, 18-20]. Swine is also the only species so far ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-488
*  Neutrophil Functional Disorders
2013) Defects in neutrophil granule mobilization and bactericidal activity in familial hemophagocytic lymphohistiocytosis type ... Blood 122: 109-111.. van Zwieten R, Verhoeven AJ and Roos D (2014) Inborn defects in the antioxidant systems of human red blood ... 1999) Neutrophil‐specific granule deficiency results from a novel mutation with loss of function of the transcription factor ... Blood 121: 2385-2392.. Flynn R, Grundmann A, Renz P, et al. (2015) CRISPR‐mediated genotypic and phenotypic correction of a ...
  http://www.els.net/WileyCDA/ElsArticle/refId-a0002182.html
*  NOS1 - Wikipedia
NO is also responsible for endothelium-derived relaxing factor activity regulating blood pressure. In macrophages, NO mediates ... NO is a chemical messenger[disambiguation needed] with diverse functions throughout the body. In the brain and peripheral ... tumoricidal and bactericidal actions, as indicated by the fact that inhibitors of NO synthase (NOS) block these effects. ... haplotype associated with schizophrenia modifies prefrontal cortex function". Mol. Psychiatry. 11 (3): 286-300. doi:10.1038/sj. ...
  https://en.wikipedia.org/wiki/NOS1
*  Infections in Patients with Cancer - Holland-Frei Cancer Medicine - NCBI Bookshelf
... thereby providing greater bactericidal activity in blood and tissues and, on occasion, rendering organisms that are resistant ... T lymphocytes mediate specific immune functions and also modulate the activity of other cells in the immune system. Activation ... Toxoplasmosis may also be transmitted by blood transfusion, including transfusion of whole blood, platelets, or white blood ... A number of studies have demonstrated that serum bactericidal activity is of great importance when treating infections in ...
  https://www.ncbi.nlm.nih.gov/books/NBK20904/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Institutions: Blood Research Institute, Mount Sinai School of Medicine , Blood Research Institute, City of Milwaukee Health ... This is conventionally expressed as serum bactericidal titers. Studies of serum bactericidal titers in response to childhood ... Recombinase activity and virus production were monitored. All assays demonstrated the efficient deletion of the provirus from ... Reduction of bacterial load in various organs functions as the main read-out of immunogenicity. However, no such assays have ...
  https://www.jove.com/visualize/abstract/21292881/characterization-plasmodium-vivax-transmission-blocking-activity-low
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The blood brain barrier (BBB) specifically regulates molecular and cellular flux between the blood and the nervous tissue. Our ... This is conventionally expressed as serum bactericidal titers. Studies of serum bactericidal titers in response to childhood ... Mast cell function has been dissected in detail with the use of rat basophilic leukemia mast cells (RBL-2H3), a widely accepted ... Functional activity is then evaluated using clonogenic assays in methylcellulose or soft agar cultures. Experimental compounds ...
  https://www.jove.com/visualize/abstract/24505329/pentacyclic-nitrofurans-with-vivo-efficacy-activity-against
*  Primary immunodeficiency - Wikipedia
... bactericidal activity. Due to the rarity of many primary immunodeficiencies, many of the above tests are highly specialised and ... Primary immunodeficiencies are disorders in which part of the body's immune system is missing or does not function normally. To ... The basic tests performed when an immunodeficiency is suspected should include a full blood count (including accurate ... Quantification of the different types of mononuclear cells in the blood (i.e. lymphocytes and monocytes): different groups of T ...
  https://en.wikipedia.org/wiki/Primary_immunodeficiency
*  Phase 2a EBA Trial of AZD5847 - Full Text View - ClinicalTrials.gov
Early Bactericidal Activity: Rate of change in sputum colony forming unit (CFU) counts (bactericidal activity) during the ... Adverse event collection: Complete blood count, coagulation panels, liver function tests, Creatine phosphokinase, urinalysis ... The duration of therapy will be 14 days in order to support an assessment of early bactericidal activity (days 0-2) and ... Early Bactericidal Activity of AZD5847 in Patients with Pulmonary Tuberculosis. Antimicrob Agents Chemother. 2016 Oct 21;60(11 ...
  https://clinicaltrials.gov/ct2/show/NCT01516203?term=NIAID&recr=Open&no_unk=Y&cond=tuberculosis&rank=9
*  Platelet-neutrophil interactions under thromboinflammatory conditions
Blood. 2010;116(23):4978-4989. [PubMed]. 174. Lassegue B, Griendling KK. NADPH oxidases: functions and pathologies in the ... In vitro bactericidal capacity of human polymorphonuclear leukocytes: diminished activity in chronic granulomatous disease of ... Blood Rev. 2007;21(2):99-111. [PubMed]. 17. Wagner DD, Frenette PS. The vessel wall and its interactions. Blood. 2008;111(11): ... Hypoxia-inducible factor 2alpha regulates key neutrophil functions in humans, mice, and zebrafish. Blood. 2014;123(3):366-376. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC4480154/
*  Hepcidin - Wikipedia
Optimal function of hepcidin may be predicated upon the adequate presence of vitamin D in the blood. The peptide was initially ... Hepcidin has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker antimicrobial activity against S. ... and appeared to have bactericidal properties ("-cide" for "killing"). Although it is primarily synthesized in the liver, ... Moura IC, Hermine O (2015). "Erythroferrone: the missing link in β-thalassemia?". Blood. 126 (17): 1974-5. doi:10.1182/blood- ...
  https://en.wikipedia.org/wiki/Hepcidin
*  Difloxacin - Wikipedia
Difloxacin is a bactericidal, broad-spectrum antibiotic that has activity against Gram-negative bacteria and Gram-positive ... This allows reentry into the blood stream and recirculation, a mechanism that can extend the half-life. The longer half-life ... which makes it an attractive choice for dogs with compromised renal function. aTotal body clearance/F = Dose/AUC bSteady state ... It has broad-spectrum, concentration dependent, bactericidal activity; however, its efficacy is not as good as enrofloxacin or ...
  https://en.wikipedia.org/wiki/Difloxacin
*  Judo Research Abstracts - Judo Info
There were no significant changes in net chemotaxis, bactericidal activity, and superoxide anion release after anaerobic ... Neutrophil function response to aerobic and anaerobic exercise in female judoka and untrained subjects. Author: Wolach B , Falk ... Abstract: Regional cerebral blood flow (rCBF) was measured by 133-xenon inhalation in 24 amateur and 20 professional boxers, ... bactericidal activity, and superoxide anion release between the judoka and the untrained women. There was a significant ...
  http://judoinfo.com/research24/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
To ensure its proper function, the levels and activity of p53 are under a tight regulation in cells. MicroRNAs are short non- ... Furthermore, Pt5e displayed no cytotoxicity to murine RAW264.7 macrophages and no hemolytic activity toward human red blood ... showed the strongest bactericidal activities against Escherichia coli and Staphylococcus aureus. We then demonstrated that Pt5e ... which are defined as mutant p53 gain-of-function. The frequent loss of wild-type p53 function and the gain-of-function of ...
  https://www.jove.com/visualize?author=Feng+Fu
*  The Application of Dextran Sedimentation as an Initial Step in Neutrophil Purification Promotes Their Stimulation, due to the...
"Neutrophil function in whole blood and after purification: changes in receptor expression, oxidase activity and responsiveness ... and bactericidal activity against S. aureus. The results revealed that bactericidal activity were not different between the ... Blood Reconstitution. For the reconstitution of blood with reconfiguration of various components, blood was subjected to high- ... and then compared the adherence activity of neutrophils from each blood configuration. "Reconstituted blood" was generated by ...
  https://www.hindawi.com/journals/jir/2017/1254792/
*  Thrombosis, Neuroinflammation, and Poststroke Infection: The Multifaceted Role of Neutrophils in Stroke
Their primary function is to trap bacteria and exert bactericidal effects [20]. Platelets can bind to released NETs and get ... Blood-borne neutrophils immediately migrate, even against blood flow, and then transmigrate out of blood vessels to reach the ... An additional neutrophil contribution to thrombus formation results from the prothrombotic activity of NETs [19]. NETs have a ... We discuss the function of neutrophils in bacterial defense, after stroke, and the associated therapeutic targets in Section 4 ...
  https://www.hindawi.com/journals/jir/2017/5140679/
*  Medical Xpress - cd4 t cells
... and in maximizing bactericidal activity of phagocytes such as macrophages. It is this diversity in function and their role in ... T helper cells (also known as effector T cells or Th cells) are a sub-group of lymphocytes (a type of white blood cell or ... These cells are unusual in that they have no cytotoxic or phagocytic activity; they cannot kill infected host (also known as ...
  https://medicalxpress.com/tags/cd4+t+cells/sort/date/6h/
*  Alveolar macrophage - Wikipedia
PGE2 functions in amplifiying peripheral blood lymphocyte IL-10 transcription and protein production; as well as in ... Activity of the alveolar macrophage is relatively high, because they are located at one of the major boundaries between the ... ROI generation by NADPH oxidase is an important bactericidal mechanism after FcR-mediated phagocytosis. PGE2 activates both Gs- ... endocytic PRRs that function in pathogen binding and phagocytosis, and secreted PRRs that usually function as opsonins or ...
  https://en.wikipedia.org/wiki/Alveolar_macrophage
*  Kidney & Bladder
... and supplements we can give support to our kidneys and bladder and their proper function. ... Bio Boost markedly increases the bactericidal activity of blood cells and has a beneficial effect on the complement properdin ... Chelidonium Plex 1 fl oz Unda supports kidney and liver functions,especially when there is an overindulgence of alcohol and ... Our kidneys and liver are constantly working to process and detoxify the blood. Toxins from the liver and kidneys are partially ...
  http://www.naturalhealinghouse.com/health-topic-kidneys-bladder-s/1996.htm