Metformin and other glucose-lowering drug initiation and rates of community-based antibiotic use and hospital-treated...
... via its negative influence on polymorphonuclear neutrophil function and intracellular bactericidal and opsonic activity.31 ... Obesity and risk of infection: results from the danish blood donor study. Epidemiology 2015;26:580-9. doi:10.1097/EDE. ... Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort ... 32 and insulin has been suggested to enhance innate and cell-mediated immunity33 and promote macrophage function.31 ,34 This ...http://bmjopen.bmj.com/content/6/8/e011523
Recovery, Structure and Function of Dog Granulocytes After Freeze Preservation with Dimethylsulfoxide.
... bactericidal activity, and ultrastructure before and after freezing. Granulocytes were frozen in DMSO (7.5%) and autologous ... Leucocytes were isolated from defibrinated or anticoagulated whole blood and subsequent erythrocyte sedimentation on a column ... and bactericidal functions and ultrastructure are impaired to different degrees, according to the method of isolation and ... structure and function of dog granulocytes were determined before and after freeze preservation. ...http://www.dtic.mil/docs/citations/ADA033508
NOS1 - Wikipedia
NO is also responsible for endothelium-derived relaxing factor activity regulating blood pressure. In macrophages, NO mediates ... NO is a chemical messenger[disambiguation needed] with diverse functions throughout the body. In the brain and peripheral ... tumoricidal and bactericidal actions, as indicated by the fact that inhibitors of NO synthase (NOS) block these effects. ... haplotype associated with schizophrenia modifies prefrontal cortex function". Mol. Psychiatry. 11 (3): 286-300. doi:10.1038/sj. ...https://en.wikipedia.org/wiki/NOS1
Heterogeneous vancomycin-intermediate susceptibility in a community-associated methicillin-resistant Staphylococcus aureus...
TMP-SMX has bactericidal activity in-vitro and it may be considered to be an alternative therapy to vancomycin for MRSA ... Sma I restriction patterns were indistinguishable for SaU (urine isolate), SaB1 (initial blood isolate) and SaB2 (later blood ... including changes in renal function, TMP-SMX apparently contributed to bacteraemia clearance. Only few cases of patients with ... The blood (SaB1 and SaB2) and urine (SaU) MRSA isolates were sent to the CIBICI ("Centro de Investigaciones en Bioquimica ...https://rd.springer.com/article/10.1186/1476-0711-10-15
... demonstrated improvements in bactericidal activity of monocytes and neutrophils, but 'had no changes in blood chemistry').. ... Recombinant human interferon-gamma reconstitutes defective phagocyte function in patients with chronic granulomatous disease of ... While also known as type II interferon, interferon gamma has only modest direct antiviral activity and is unrelated in ... liver fibrosis and histologic activity scores did not change; one patient had a 2 fold increase in serum ALT levels on therapy ...https://livertox.nlm.nih.gov/InterferonGamma.htm
Amoxicillin Suspension - FDA prescribing information, side effects and uses
High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of ... Amoxicillin, USP is a semisynthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against ... In blood serum, amoxicillin is approximately 20% protein-bound. Following a 1 gram dose and utilizing a special skin window ... Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may ...https://www.drugs.com/pro/amoxicillin-suspension.html
Leptin Indirectly Activates Human Neutrophils via Induction of TNF-α | The Journal of Immunology
Neutrophil function in whole blood and after purification: changes in receptor expression, oxidase activity and responsiveness ... Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?. J. Leukocyte Biol. 69:414. ... Blood samples. Peripheral blood (20 ml) was collected into sterile tubes containing EDTA or heparin from healthy adult male ... Leptin augments the response of PMN in whole blood to PMA and TNF-α. Whole blood was preincubated with leptin (250 ng/ml) for 1 ...http://www.jimmunol.org/content/172/3/1809.long
To Evaluate Antimicrobial Properties of Platelet Rich Plasma and Source of Colonization in Pressure Ulcers in Spinal Injury...
... blood). After a ten-minute centrifugation at 2000 rpm, the blood was layered in three basic components: red blood cells, ... T. Burnouf, M. L. Chou, Y. W. Wu, C. Y. Su, and L. W. Lee, "Antimicrobial activity of platelet (PLT)-poor plasma, PLT-rich ... Platelets participate in antibody-dependent cell cytotoxicity functions to kill protozoal pathogens. Finally, platelets release ... the oxidation of chloride to generate hypochlorous acid and other reactive oxygen derivatives that act as potent bactericidal ...https://www.hindawi.com/journals/ulcers/2015/749585/
Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex | The EMBO Journal
... mediated haemolytic and bactericidal activity by binding to C5 through its C‐terminal β‐grasp domain (Laursen et al, 2010). ... Pangburn MK, Rawal N (2002) Structure and function of complement C5 convertase enzymes. Biochem Soc Trans 30: 1006-1010. ... The release of C3a and C5a increases vascular permeability and blood flow, thereby promoting further transport of other snake ... Adcock SA, McCammon JA (2006) Molecular dynamics: survey of methods for simulating the activity of proteins. Chem Rev 106: 1589 ...http://emboj.embopress.org/content/30/3/606
Genome-wide association study for T lymphocyte subpopulations in swine | BMC Genomics | Full Text
... and maximizing bactericidal activity of phagocytes such as macrophages. Shedlock and Shen showed that CD4+ cells are ... The blood cells were incubated with 10 μl of mouse anti porcine CD4-FITC (Serotec UK) and 10 μl of mouse anti porcine CD8-RPE ( ... In addition to the individual functions of CD4 and CD8, different combinations of them, i.e., CD4+CD8+, CD4+CD8−, CD4−CD8+ and ... Swine has a substantial number of CD4-CD8-T lymphocytes in peripheral blood[10, 18-20]. Swine is also the only species so far ...https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-488
The role of miR-21 and its predicted target gene, PTEN, in the development of ventilator associated pneumonia
Blood monocytes exert the function of phagocytosis and give rise to lung macrophages through multiple steps [6,7]. Activated ... Myeloid PTEN promotes inflammation but impairs bactericidal activities during murine pneumococcal pneumonia. J Immunol 2010; ... Peripheral blood monocytes were also isolated from peripheral blood. Anticoagulant-treated blood was dilute with an equal ... Serum was collected from sterile peripheral blood from subjects. In general, 10-15 ml of peripheral blood were placed in 4°C ...http://www.alliedacademies.org/articles/the-role-of-mir21-and-its-predicted-target-gene-pten-in-the-development-of-ventilator-associated-pneumonia.html
Neutrophil Functional Disorders
2013) Defects in neutrophil granule mobilization and bactericidal activity in familial hemophagocytic lymphohistiocytosis type ... Blood 122: 109-111.. van Zwieten R, Verhoeven AJ and Roos D (2014) Inborn defects in the antioxidant systems of human red blood ... 1999) Neutrophil‐specific granule deficiency results from a novel mutation with loss of function of the transcription factor ... Blood 121: 2385-2392.. Flynn R, Grundmann A, Renz P, et al. (2015) CRISPR‐mediated genotypic and phenotypic correction of a ...http://www.els.net/WileyCDA/ElsArticle/refId-a0002182.html
Infections in Patients with Cancer - Holland-Frei Cancer Medicine - NCBI Bookshelf
... thereby providing greater bactericidal activity in blood and tissues and, on occasion, rendering organisms that are resistant ... T lymphocytes mediate specific immune functions and also modulate the activity of other cells in the immune system. Activation ... Toxoplasmosis may also be transmitted by blood transfusion, including transfusion of whole blood, platelets, or white blood ... A number of studies have demonstrated that serum bactericidal activity is of great importance when treating infections in ...https://www.ncbi.nlm.nih.gov/books/NBK20904/
Complement Receptors | Springer for Research & Development
Complement was first described as a heat-labile component in serum with bactericidal activity. It was subsequently found to ... Complement was first described as a heat-labile component in serum with bactericidal activity. It was subsequently found to ... Burton, D. R., and Woof, J. M., 1992, Human antibody effector function, Adv. Immunol. 51: 1-84.PubMedCrossRefGoogle Scholar ... Medof, M. E., and Oger, J. J. F., 1982, Competition for immune complexes by red cells in human blood, J. Lab. Clin. Immunol. 7 ...https://rd.springer.com/chapter/10.1007/978-1-4757-9534-9_9
Induction of Granulysin and Perforin Cytolytic Mediator Expression in 10-Week-Old Infants Vaccinated with BCG at Birth
"Cord blood T lymphocytes lack constitutive perforin expression in contrast to adult peripheral blood T lymphocytes," Blood, vol ... These include IL-4 and the Th1 cytokine balance [49, 50] and induction of cytolytic activity in memory T-cells [40, 51]. ... By contrast, PPD antigenic stimulation could only induce cytolytic effector functions in memory CD4+ and CD8+ T-cells. While no ... is bactericidal to intracellular organisms . In addition, granulysin and perforin were significantly increased in lymphoid ...https://www.hindawi.com/journals/jir/2011/438463/
Hepcidin - Wikipedia
Optimal function of hepcidin may be predicated upon the adequate presence of vitamin D in the blood. The peptide was initially ... Hepcidin has strong antimicrobial activity against E.coli ML35P N.cinerea and weaker antimicrobial activity against S. ... and appeared to have bactericidal properties ("-cide" for "killing"). Although it is primarily synthesized in the liver, ... Moura IC, Hermine O (2015). "Erythroferrone: the missing link in β-thalassemia?". Blood. 126 (17): 1974-5. doi:10.1182/blood- ...https://en.wikipedia.org/wiki/Hepcidin
NAVER Academic > Search...
Anticoagulants, Blood Bactericidal Activity, Blood Banks, Blood Preservation, Graft vs Host Reaction, Humans, Lectins, ... Effect of blood-bank storage on leucocyte function.. 1969 J McCullough et al. The Lancet cited 13 times ... Angina Pectoris, epidemiology, Aorta, Arteriosclerosis, blood, mortality, Blood Glucose, analysis, Cholesterol, Fatty Acids, ... Drug-Induced Liver Injury, etiology, Female, Humans, Liver Function Tests, Middle Aged, Nitrofurantoin, adverse effects, ...https://academic.naver.com/search.naver?field=3&query=The+Lancet+2%EA%B6%8C+7634%ED%98%B8
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
Institutions: Blood Research Institute, Mount Sinai School of Medicine , Blood Research Institute, City of Milwaukee Health ... This is conventionally expressed as serum bactericidal titers. Studies of serum bactericidal titers in response to childhood ... Recombinase activity and virus production were monitored. All assays demonstrated the efficient deletion of the provirus from ... Reduction of bacterial load in various organs functions as the main read-out of immunogenicity. However, no such assays have ...https://www.jove.com/visualize/abstract/21292881/characterization-plasmodium-vivax-transmission-blocking-activity-low
JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
The blood brain barrier (BBB) specifically regulates molecular and cellular flux between the blood and the nervous tissue. Our ... This is conventionally expressed as serum bactericidal titers. Studies of serum bactericidal titers in response to childhood ... Mast cell function has been dissected in detail with the use of rat basophilic leukemia mast cells (RBL-2H3), a widely accepted ... Functional activity is then evaluated using clonogenic assays in methylcellulose or soft agar cultures. Experimental compounds ...https://www.jove.com/visualize/abstract/24505329/pentacyclic-nitrofurans-with-vivo-efficacy-activity-against
... macrophages subsequently acquire strong cytotoxic activity and have a strong bactericidal effect against pathogens become ... That function of the immune system is performed by the T-cells that acquire the ability to execute it in the thymus after three ... They can migrate into the blood and lymph. They are activated by irritation of those who fell in the human pathogenic ... Their main function is to synthesize mediators and cytokines.. Basophil cells and mast cells contain receptors for ...http://www.gentaur-worldwide.com/index.php?option=com_k2&view=itemlist&layout=category&task=category&id=7&Itemid=629
Impaired tuftsin activity in cirrhosis: relationship with splenic function and clinical outcome | Gut
Fierer J, Finley F. Deficient serum bactericidal activity against Escherichia coli in patients with cirrhosis of the liver. J ... prothrombin activity, and whole blood examination were assessed using standard methods. Functional liver mass was estimated in ... Methods: Tuftsin activity and splenic function were assessed in 31 patients with liver cirrhosis and 31 healthy subjects. The ... Splenic autotransplantation after splenectomy: tuftsin activity correlates with residual splenic function. Br J Surg1994;81:716 ...http://gut.bmj.com/content/50/5/707
NAVER Academic > Search...
Adolescent, Adult, Aged, Blood Bactericidal Activity, Cell Adhesion, Cell Aggregation, Chemotaxis, Female, Humans, In Vitro ... Blood neutrophil function in primary myelodysplastic syndromes.. M A Boogaerts et al. British Journal of Haematology cited 29 ... Blood neutrophil function in primary myelodysplastic syndromes. 1983 M. A. Boogaerts et al. British Journal of Haematology ... Anemia, Dyserythropoietic, Congenital, blood, Anemia, Hemolytic, Congenital, Anion Transport Proteins, Carbohydrates, Carrier ...https://academic.naver.com/search.naver?field=3&query=British+Journal+of+Haematology+55%EA%B6%8C+2%ED%98%B8
Difloxacin - Wikipedia
Difloxacin is a bactericidal, broad-spectrum antibiotic that has activity against Gram-negative bacteria and Gram-positive ... This allows reentry into the blood stream and recirculation, a mechanism that can extend the half-life. The longer half-life ... which makes it an attractive choice for dogs with compromised renal function. aTotal body clearance/F = Dose/AUC bSteady state ... It has broad-spectrum, concentration dependent, bactericidal activity; however, its efficacy is not as good as enrofloxacin or ...https://en.wikipedia.org/wiki/Difloxacin
Primary immunodeficiency - Wikipedia
... bactericidal activity. Due to the rarity of many primary immunodeficiencies, many of the above tests are highly specialised and ... Primary immunodeficiencies are disorders in which part of the body's immune system is missing or does not function normally. To ... The basic tests performed when an immunodeficiency is suspected should include a full blood count (including accurate ... Quantification of the different types of mononuclear cells in the blood (i.e. lymphocytes and monocytes): different groups of T ...https://en.wikipedia.org/wiki/Primary_immunodeficiency
Alveolar macrophage - Wikipedia
PGE2 functions in amplifiying peripheral blood lymphocyte IL-10 transcription and protein production; as well as in ... Activity of the alveolar macrophage is relatively high, because they are located at one of the major boundaries between the ... ROI generation by NADPH oxidase is an important bactericidal mechanism after FcR-mediated phagocytosis. PGE2 activates both Gs- ... endocytic PRRs that function in pathogen binding and phagocytosis, and secreted PRRs that usually function as opsonins or ...https://en.wikipedia.org/wiki/Alveolar_macrophage