JCI - Human intestinal macrophages display profound inflammatory anergy despite avid phagocytic and bacteriocidal activity
Macrophage function and cytokine production assays. Intestinal macrophages and blood monocytes (2 × 106 cells/ml) were cultured ... Phagocytic and bacteriocidal activity of blood monocytes and intestinal macrophages. (A) Blood monocyte and intestinal ... Along with phagocytic activity, intestinal macrophages show strong and rapid bacteriocidal activity for S. typhimurium and E. ... Bacteriocidal assay. Intestinal macrophages, blood monocytes in the presence of S-CM (500 μg/ml), and blood monocytes in the ...https://www.jci.org/articles/view/19229
Metformin and other glucose-lowering drug initiation and rates of community-based antibiotic use and hospital-treated...
... via its negative influence on polymorphonuclear neutrophil function and intracellular bactericidal and opsonic activity.31 ... Obesity and risk of infection: results from the danish blood donor study. Epidemiology 2015;26:580-9. doi:10.1097/EDE. ... Effectiveness and safety of metformin in 51 675 patients with type 2 diabetes and different levels of renal function: a cohort ... 32 and insulin has been suggested to enhance innate and cell-mediated immunity33 and promote macrophage function.31 ,34 This ...http://bmjopen.bmj.com/content/6/8/e011523
Impaired tuftsin activity in cirrhosis: relationship with splenic function and clinical outcome | Gut
Fierer J, Finley F. Deficient serum bactericidal activity against Escherichia coli in patients with cirrhosis of the liver. J ... prothrombin activity, and whole blood examination were assessed using standard methods. Functional liver mass was estimated in ... Methods: Tuftsin activity and splenic function were assessed in 31 patients with liver cirrhosis and 31 healthy subjects. The ... Splenic autotransplantation after splenectomy: tuftsin activity correlates with residual splenic function. Br J Surg1994;81:716 ...http://gut.bmj.com/content/50/5/707
Method For Measuring Complement-Dependent Bactericidal Function With Respect To Pneumococci - The Research Foundation For...
The present invention relates to a measurement method for complement-dependent bactericidal activity against ,i,Streptococcus ... Complement-dependent bactericidal activity against Streptococcus pneumoniae is measured using capsule-deficient Streptococcus ... Herein, the blood sample only needs to be a blood-derived sample, and may be serum or plasma. For example, the sample may be a ... 3. A measurement method for complement-dependent bactericidal activity according to Item 1 or 2, in which a usage amount of the ...http://www.freepatentsonline.com/y2018/0223326.html
Vitamin A - Poultry - Compendium - DSM
1991a, b) reported that beta-carotene enhanced the bactericidal activity of blood and milk PMN, against S. auereus but did not ... Thus, retinoic acid is now recognized to function as a hormone to regulate the transcription activity of a large number of ... Control of free radicals is important for bactericidal activity but not for phagocytosis. The antioxidant activity of vitamin A ... Vitamin A either had no effect or supressed bactericidal activity and phagocytosis. ...https://www.dsm.com/markets/anh/en_US/Compendium/poultry/vitamin_A.html
Vitamin C - Ruminants - Compendium - DSM
Supplementation with both vitamin C and E potentiates white blood cell function in healthy adults (Jeng et al., 1996). ... Vitamin C deficiency impairs the bactericidal activity of neutrophils (Goldschmidt, 1991). Chronic, low-grade skin infections ... Martynjuk (1952) reported the incidence of scurvy and reduced blood ascorbic acid content in weaned calves. Studies of blood ... in detoxification functions and in the normal functioning of the adrenal glands, lungs, brain, eye and immune system. ...https://www.dsm.com/markets/anh/en_US/Compendium/ruminants/vitamin_C.html
Recovery, Structure and Function of Dog Granulocytes After Freeze Preservation with Dimethylsulfoxide.
... bactericidal activity, and ultrastructure before and after freezing. Granulocytes were frozen in DMSO (7.5%) and autologous ... Leucocytes were isolated from defibrinated or anticoagulated whole blood and subsequent erythrocyte sedimentation on a column ... and bactericidal functions and ultrastructure are impaired to different degrees, according to the method of isolation and ... structure and function of dog granulocytes were determined before and after freeze preservation. ...http://www.dtic.mil/docs/citations/ADA033508
BIBR-1048 | Small molecule inhibitors of HCV replication
Opsonophagocytic activity (OPA) and serum bactericidal activity (SBA), aswell as the function of antimeningococcal antibodies, ... Whole blood and serum from a completely C2-deficient and a completely C5-deficient patient were used. The C2-deficient ... Serum bactericidal activity was dependent on C2, C5, and immune sera. MBL did not influence any of the parameters observed. ... Serum bactericidal activity was reliant on C2 firmly, C5, and high antibody titers. MBL didn't influence the variables observed ...http://lecollege.org/tag/bibr-1048/
Effects of Kurozu concentrated liquid on adipocyte size in rats | Lipids in Health and Disease | Full Text
Furthermore, KCL significantly inhibited pancreatic lipase activity in vitro, and also significantly inhibited fat accumulation ... Effects of KCL on pancreatic lipase activity and 3T3-L1 preadipocyte differentiation were investigated in vitro. In the KCL ... and have orexigenic and bactericidal functions . It has been shown to prevent hypertension, improve blood fluidity, and ... The blood glucose area under the plasma concentration time curve (blood glucose AUC) was calculated from the blood glucose ...https://lipidworld.biomedcentral.com/articles/10.1186/1476-511X-9-134
From prevention of pin-tract infection to treatment of osteomyelitis during paediatric external fixation | SpringerLink
Forster H, Marotta JS, Heseltine K, Milner R, Jani S (2004) Bactericidal activity of antimicrobial coated polyurethane sleeves ... the blood serum may act as a Trojan horse by entering cells and then releasing silver ions that damage intracellular function [ ... nano-TiO2 shows strong bactericidal activity [65, 67]. One new, attractive perspective for combating PTI is the covalent ... New pins with bactericidal effects. A number of technical advances have been made to reduce the risk of PTI while maintaining ...https://link.springer.com/article/10.1007%2Fs11832-016-0787-8
Tropical birds have a slow pace of life | PNAS
Tieleman et al. (74) found that, in tropical birds, bactericidal activity of whole blood was negatively correlated with mass- ... A) PMR (filled circles) and BMR (open circles) as a function of body mass for 19 species of tropical birds. Solid line, ... BMR (W) as a function of body mass (g) in tropical and temperate birds. Open circles, temperate species; filled circles, ... Residual basal metabolic rate of temperate birds plotted as a function of residual basal metabolic rate of tropical birds. The ...http://www.pnas.org/content/104/22/9340?ijkey=4bb5d8e897fae396fedf3f4e094d50101039ff04&keytype2=tf_ipsecsha
4-Hydroxy-17-methylincisterol from Agaricus blazei Decreased Cytokine Production and Cell Proliferation in Human Peripheral...
Our observation correlated with A. blazei putative pharmacological activities [54, 55].. Abbreviations. PBMC:. Peripheral blood ... Therefore, the inhibitory function of 4-HM was not related to DMSO. Results of cell viability tests indicated that there was no ... Y. Osaki, T. Kato, K. Yamamoto, J. Okubo, and T. Miyazaki, "Antimutagenic and bactericidal substances in the fruit body of a ... The inhibitory activity of 4-HM on PBMC proliferation was calculated by the following formula: ...https://www.hindawi.com/journals/ecam/2013/435916/
Heterogeneous vancomycin-intermediate susceptibility in a community-associated methicillin-resistant Staphylococcus aureus...
TMP-SMX has bactericidal activity in-vitro and it may be considered to be an alternative therapy to vancomycin for MRSA ... Sma I restriction patterns were indistinguishable for SaU (urine isolate), SaB1 (initial blood isolate) and SaB2 (later blood ... including changes in renal function, TMP-SMX apparently contributed to bacteraemia clearance. Only few cases of patients with ... The blood (SaB1 and SaB2) and urine (SaU) MRSA isolates were sent to the CIBICI ("Centro de Investigaciones en Bioquimica ...https://rd.springer.com/article/10.1186/1476-0711-10-15
NOS1 - Wikipedia
NO is also responsible for endothelium-derived relaxing factor activity regulating blood pressure. In macrophages, NO mediates ... NO is a chemical messenger[disambiguation needed] with diverse functions throughout the body. In the brain and peripheral ... tumoricidal and bactericidal actions, as indicated by the fact that inhibitors of NO synthase (NOS) block these effects. ... haplotype associated with schizophrenia modifies prefrontal cortex function". Mol. Psychiatry. 11 (3): 286-300. doi:10.1038/sj. ...https://en.wikipedia.org/wiki/NOS1
Amoxicillin Suspension - FDA prescribing information, side effects and uses
High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of ... Amoxicillin, USP is a semisynthetic antibiotic, an analog of ampicillin, with a broad spectrum of bactericidal activity against ... In blood serum, amoxicillin is approximately 20% protein-bound. Following a 1 gram dose and utilizing a special skin window ... Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may ...https://www.drugs.com/pro/amoxicillin-suspension.html
Leptin Indirectly Activates Human Neutrophils via Induction of TNF-α | The Journal of Immunology
Neutrophil function in whole blood and after purification: changes in receptor expression, oxidase activity and responsiveness ... Leptin: a potential regulator of polymorphonuclear neutrophil bactericidal action?. J. Leukocyte Biol. 69:414. ... Blood samples. Peripheral blood (20 ml) was collected into sterile tubes containing EDTA or heparin from healthy adult male ... Leptin augments the response of PMN in whole blood to PMA and TNF-α. Whole blood was preincubated with leptin (250 ng/ml) for 1 ...http://www.jimmunol.org/content/172/3/1809.long
... demonstrated improvements in bactericidal activity of monocytes and neutrophils, but 'had no changes in blood chemistry').. ... Recombinant human interferon-gamma reconstitutes defective phagocyte function in patients with chronic granulomatous disease of ... While also known as type II interferon, interferon gamma has only modest direct antiviral activity and is unrelated in ... liver fibrosis and histologic activity scores did not change; one patient had a 2 fold increase in serum ALT levels on therapy ...https://livertox.nlm.nih.gov/InterferonGamma.htm
To Evaluate Antimicrobial Properties of Platelet Rich Plasma and Source of Colonization in Pressure Ulcers in Spinal Injury...
... blood). After a ten-minute centrifugation at 2000 rpm, the blood was layered in three basic components: red blood cells, ... T. Burnouf, M. L. Chou, Y. W. Wu, C. Y. Su, and L. W. Lee, "Antimicrobial activity of platelet (PLT)-poor plasma, PLT-rich ... Platelets participate in antibody-dependent cell cytotoxicity functions to kill protozoal pathogens. Finally, platelets release ... the oxidation of chloride to generate hypochlorous acid and other reactive oxygen derivatives that act as potent bactericidal ...https://www.hindawi.com/journals/ulcers/2015/749585/
Studies On Phytochemical Screening And Antioxidant Activity Of Chromolaena Odorata And Annona squamosa | Open Access Journals
The aim of this study was to investigate the phytochemical composition and antioxidant activity of Chromolaena odorata and ... antispasmodic and bactericidal activities (Stary et al., 1998). Saponins have properties of precipitating and coagulating red ... blood cells and they also have cholesterol binding properties, formation of foams in aqueous solutions and haemolytic activity ... The biological function of alkaloids and their derivatives are very important and are used in analgesic, ...http://www.rroij.com/open-access/studies-on-phytochemical-screening-and-antioxidant-activity-of-chromolaena-odorata-and-annona-squamosa-.php?aid=48439
Substrate recognition by complement convertases revealed in the C5-cobra venom factor complex | The EMBO Journal
... mediated haemolytic and bactericidal activity by binding to C5 through its C‐terminal β‐grasp domain (Laursen et al, 2010). ... Pangburn MK, Rawal N (2002) Structure and function of complement C5 convertase enzymes. Biochem Soc Trans 30: 1006-1010. ... The release of C3a and C5a increases vascular permeability and blood flow, thereby promoting further transport of other snake ... Adcock SA, McCammon JA (2006) Molecular dynamics: survey of methods for simulating the activity of proteins. Chem Rev 106: 1589 ...http://emboj.embopress.org/content/30/3/606
Genome-wide association study for T lymphocyte subpopulations in swine | BMC Genomics | Full Text
... and maximizing bactericidal activity of phagocytes such as macrophages. Shedlock and Shen showed that CD4+ cells are ... The blood cells were incubated with 10 μl of mouse anti porcine CD4-FITC (Serotec UK) and 10 μl of mouse anti porcine CD8-RPE ( ... In addition to the individual functions of CD4 and CD8, different combinations of them, i.e., CD4+CD8+, CD4+CD8−, CD4−CD8+ and ... Swine has a substantial number of CD4-CD8-T lymphocytes in peripheral blood[10, 18-20]. Swine is also the only species so far ...https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-13-488
Neutrophil Functional Disorders
2013) Defects in neutrophil granule mobilization and bactericidal activity in familial hemophagocytic lymphohistiocytosis type ... Blood 122: 109-111.. van Zwieten R, Verhoeven AJ and Roos D (2014) Inborn defects in the antioxidant systems of human red blood ... 1999) Neutrophil‐specific granule deficiency results from a novel mutation with loss of function of the transcription factor ... Blood 121: 2385-2392.. Flynn R, Grundmann A, Renz P, et al. (2015) CRISPR‐mediated genotypic and phenotypic correction of a ...http://www.els.net/WileyCDA/ElsArticle/refId-a0002182.html
Infections in Patients with Cancer - Holland-Frei Cancer Medicine - NCBI Bookshelf
... thereby providing greater bactericidal activity in blood and tissues and, on occasion, rendering organisms that are resistant ... T lymphocytes mediate specific immune functions and also modulate the activity of other cells in the immune system. Activation ... Toxoplasmosis may also be transmitted by blood transfusion, including transfusion of whole blood, platelets, or white blood ... A number of studies have demonstrated that serum bactericidal activity is of great importance when treating infections in ...https://www.ncbi.nlm.nih.gov/books/NBK20904/
Cathelicidin-2 peptide showed potent bactericidal and fungicidal activity against all tested microorganisms, including chicken- ... The biological functions of avian cathelicidins are poorly defined. In mammals, cathelicidins have shown to possess potent ... head-kidney leukocytes - hydrogen-peroxide production - trout oncorhynchus-mykiss - diluted whole-blood - rainbow-trout - ... The real-time chemiluminescence assay was used to measure respiratory burst activity in macrophage and neutrophilic granulocyte ...http://library.wur.nl/WebQuery/wurpubs?A320==polymorphonuclear%20leukocytes
Glucagon‐like Peptide‐2 and the Regulation of Intestinal Growth and Function - Comprehensive Physiology
... barrier function, and blood flow in healthy animals as well as preventing damage and improving repair in preclinical models of ... and enhanced activity of the Paneth cells that secrete bactericidal agents.. ... GLP-2 improves intestinal function, by increasing nutrient digestion and absorption, transit time, and blood flow as well as by ... and improved function as a barrier between toxic agents in the lumen (i.e., bacteria) and the blood supply, through increased ...http://www.comprehensivephysiology.com/WileyCDA/CompPhysArticle/refId-c170055.html