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*  The compact genome of the plant pathogen Plasmodiophora brassicae is adapted to intracellular interactions with host Brassica...
After filtering (on allele frequency, SNP positions with heterozygous genotypes and indels) 132,429 SNPs remained and were ... The VCF file was filtered to remove positions where the variant allele frequency was 100 %. Additionally, if a single pathotype ... 21]). Pathotypes alleles are coded in green or red for the reference (Pb3) or alternate alleles, respectively. Clustering was ... Pathotype alleles are coded in green or red for the reference (Pb3) or alternate alleles, respectively. Clustering was ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-016-2597-2
*  cnvlib package - CNVkit 0.9.5 documentation
with heterozygous genotype, or allele frequency between the specified thresholds.. Return type:. VariantArray. ... To create the b-allele frequencies column, alterate allele frequencies from the VCF are aligned to the .cnr file bins. Bins ... tumor_boost (bool) - Normalize tumor-sample allele frequencies to the matched normal sample's allele frequencies. ... Set zygosity (genotype) according to allele frequencies.. Creates or replaces 'zygosity' column if 'alt_freq' column is present ...
  http://cnvkit.readthedocs.io/en/latest/cnvlib.html
*  Plus it
... in the regression models and because heterozygous genotype frequencies rather than minor allele homozygous genotype frequencies ... The rs17353856 C allele frequencies (white bars) and genotype CGG/CGG frequencies (black line) in the complication score groups ... The CGG genotype consists of rs17353856 C allele (major), rs7900814 G allele (major), and rs12572872 G allele (major). The ... Genotype and allele frequencies in case and control subjects were compared with χ2 test or with the Fisher exact test where ...
  http://diabetes.diabetesjournals.org/content/60/11/3073
*  Simultaneous Detection of Linkage Disequilibrium and Genetic Differentiation of Subdivided Populations | Genetics
Under H-W equilibrium, probabilities for heterozygous genotypes are obtained by duplicating the product of allele frequencies. ... Let allele frequencies for two loci be pA0, pA1 and pB0, pB1, and let the haplotype frequencies be h00, h01, h10, h11 in a ... are mean allele frequencies over subpopulations, which are estimated from sample allele frequencies. Here, DTOTAL is the ... The mean population allele frequencies of the two loci over subpopulations were assumed as and hence haplotype frequencies were ...
  http://www.genetics.org/content/167/4/2003
*  Association of the Innate Immunity and Inflammation Pathway with Advanced Prostate Cancer Risk
Rarer homozygous genotype; A1A2: Heterozygous genotype; A2A2: Frequent homozygous genotype; MAF: Minor allele frequency; PHardy ... Variant genotypes Is the Subject Area "Variant genotypes" applicable to this article? Yes. No. ... A1: Minor (rarer) allele; A2: Other (frequent) allele; A1A1: ... minor allele frequency, MAF ,0.05) with an r2≥0.8 across each ... For a case-control sample with n individuals sampled and p variants genotyped, G is the n×p matrix of genotypes, and K = GGT is ...
  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051680
*  1846G|A polymorphism of CYP2D6 gene and extrapyramidal side effects during antipsychotic therapy among Russians and Tatars: a...
... significant association between EPD development and heterozygous 1846GA genotype and 1846A allele carrier frequency was ... Heterozygous 1846GA genotype frequency among Tatars was lower (23.8% vs. 32.4% in Russians), but the differences did not reach ... The 1846A allele frequency among Tatars was also lower (11.9% vs. 24.3% in Russians), but the difference was not quite ... Debrisoquine/sparteine hydroxylation genotype and phenotype: analysis of common mutations and alleles of CYP2D6 in a European ...
  https://www.degruyter.com/view/j/dmdi.2016.31.issue-4/dmpt-2016-0027/dmpt-2016-0027.xml?format=INT
*  00207454.2017.1398158
Allele and genotype frequencies and any of assumed genetic models were not significantly differences between patients and ... except heterozygous TC) was observed between cases and controls. Allele C showed a positive association with MS and its ... According to the demonstrated results, no significant differences either in allele or genotype frequencies were found between ... T allele frequency in patients and controls was approximately 34% and 22%, respectively, which means that allele T has a ...
  https://www.docme.ru/doc/2199080/00207454.2017.1398158
*  CERA Resources | Grinnell College
... determined allele/genotype frequencies, inbreeding coefficients, genetic identity, and genetic diversity (expected ... heterozygosity); populations significantly inbred and significantly less heterozygous than expected; populations were also ... number of alleles, proportion of polymorphic alleles, inbreeding coefficient, and genetic structure; observed and expected ... frequency and density of species in their locations, variety of species, and a map detailing sampling locations] ...
  http://www.grinnell.edu/academics/areas/biology/cera/resources?group=15936&qt-search_block=0
*  Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic...
... which requires the frequency of the risk allele, the relative risk of the heterozygous genotype, the relative risk of the ... Imputed variants with imputation quality scores (r2 , 0.9) or low minor allele frequency (, 0.01) were filtered, and genotypes ... Imputed variants with an imputation genotype probability , 0.9, missingness , 0.05, or minor allele frequency , 0.01 were ... The allele frequencies were calculated from the control population of the joint genotyping cohort. Relative risks were ...
  https://link.springer.com/article/10.1186%2Fs13024-018-0270-8
*  Non-homogeneous combination of two porous genomes induces complex body shape trajectories in cyprinid hybrids | Frontiers in...
... maximum-likelihood hybrid estimate of the h index for heterozygous genotypes is thus sensitive to parental allele frequencies [ ... Estimates of the frequency of null alleles for each population and marker. With k visible alleles per locus (frequencies ,0.01 ... As indicated by Nolte et al.[16], an underdominance signal may be an artefact due to a high frequency of null alleles in ... However, in our study the high frequency of null alleles can be an artefact only at the Lid8 locus (See Additional file 2). ...
  https://frontiersinzoology.biomedcentral.com/articles/10.1186/1742-9994-10-22
*  Body Mass Index and Obesity- and Diabetes-Associated Genotypes and Risk for Pancreatic Cancer | Cancer Epidemiology, Biomarkers...
... the homozygous and heterozygous genotypes containing the variant allele were combined if (i) the frequency of the homozygote ... The homozygous and heterozygous genotypes containing the common allele were combined if the genotype was in recessive ... Because of the low minor allele frequency, the interaction of the GG genotype with BMI or diabetes could not be examined in ... The G allele is associated with a reduced protein activity (40). Most studies have linked the G allele or the GG genotype with ...
  http://cebp.aacrjournals.org/content/20/5/779
*  Relation of a Common Methylenetetrahydrofolate Reductase Mutation and Plasma Homocysteine With Intimal Hyperplasia After...
The allele frequency of the T mutation in the 62 patients was 0.48. The distribution of the 3 genotypes was as follows: ... homozygous normal (CC) genotype, 30.7%; heterozygous (CT) genotype, 41.9%; and homozygous mutant (TT) genotype, 27.4%. These ... and heterozygous genotype (CT), we established 2 genotype groups: the mutant homozygote (TT) and the others (non-TT: CC+CT). ... However, the late lumen loss in those with the TT genotype was significantly greater than that in those with non-TT genotypes ...
  http://circ.ahajournals.org/content/103/16/2048
*  One-Locus Two-Allele Models With Maternal (Parental) Selection | Genetics
at the former, genotype AA has zero frequency, whereas at the latter, genotype aa has zero frequency. ... These conditions simplify if β = δ = 0, that is, if offspring of heterozygous mothers are inviable. In this case, the genotype ... Note that neither genotype AA can have a mother with genotype aa, nor can genotype aa have a mother with genotype AA. This ... j be the fitness of an individual with genotype i raised by a mother with genotype j. Genotype frequencies are equal in both ...
  http://www.genetics.org/content/149/2/1147
*  Allele and genotype frequencies of the two single nucleotide polymorphisms in the VKORC1 gene that are most important for...
Allele and genotype frequencies of the two single nucleotide polymorphisms in the VKORC1 gene that are most important for ... while the frequency of the heterozygous genotype, GA, is 0.496. The frequency of the G allele is 0.504 and of the A allele is ... The alleles frequencies for this SNP were 0.660 for the G allele and 0.340 for the A allele. Genotypes and allele frequencies ... genotype (0.393). Allele frequencies are shown in Figure 3B: the frequency of the G allele is 0.660 and of the A allele is ...
  http://hamdanjournal.org/journal/index.php?journal=HAMDAN&page=article&op=view&path%5B%5D=463&path%5B%5D=937
*  Genetic Testing - The Key to Truly Personalized Medicine - Integrative Medicine for Mental Health
This mutation has mutant allele frequency of 39% for the heterozygous genotype and a 17% frequency for the homozygous mutant. ... One set of probes is complementary to the wild-type allele and another set is complementary to the variant allele. These probes ... genotype (what is the change in nucleotide), phenotype (whether the patient is heterozygous or homozygous [one of two mutated ... The DNA is then genotyped by determining the signal intensity ratio of the dyes bonded to the wild-type probe and the mutant ...
  http://www.immh.org/article-source/2016/6/29/genetic-testing-the-key-to-truly-personalized-medicine
*  CYP2C19 | Cancer Genetics Web
The frequencies of the mutant alleles and genotypes were then compared with each other. The frequencies of the homozygous and ... we conclude that people which were not infected with HV but with the homozygous or heterozygous variant genotypes (*2/*2, *2/*3 ... and the allele frequency was 35.0% for allele (*)1, 21.0% for *2, and 18.9% for *4. All poor metabolizers in this series were * ... Patients with ESR1 PvuII wt/wt genotype and at least one UGT2B15 wt allele had a worse DFS (P=0.03) and showed a trend towards ...
  http://www.cancerindex.org/geneweb/CYP2C19.htm
*  An omnibus permutation test on ensembles of two-locus analyses can detect pure epistasis and genetic heterogeneity in genome...
Aa, Bb, Cc and Dd denote heterozygous genotypes. aa, bb, cc and dd denote homozygous variant genotypes. All allele frequencies ... Aa and Bb denote heterozygous genotypes. aa and bb denote homozygous variant genotypes. All allele frequencies are equal (p A ... Aa, Bb and Cc denote heterozygous genotypes. aa, bb and cc denote homozygous variant genotypes. All allele frequencies are ... A population of genotype strings is initialised according to the allele frequency of each SNP in the population-based ...
  https://springerplus.springeropen.com/articles/10.1186/2193-1801-2-230
*  Analysis of variation at transcription factor binding sites in Drosophila and humans | Genome Biology | Full Text
... and the number of genotypes within the mutation in the population (minor allele frequency (MAF)). (b) Relationship between ... Using the human data presented an additional challenge of interpreting heterozygous genotypes. Since the immediate phenotypic ... where w0 is the PWM score of the major allele, and wi and pi are the score and frequency of each allele, respectively. ... Major and minor variants were defined on the basis of the global allele frequency data from [75, 76]. (b) Differences in the ...
  https://genomebiology.biomedcentral.com/articles/10.1186/gb-2012-13-9-r49
*  Genetics
Order of alleles. I have a question from class where we have to write out the genotype of the triply heterozygous mother (given ... can you calculate the allele frequencies? Can you calculate the genotype frequencies? Show your calculations. ... Consider the following two genotypes: AABB , aabb where A and B are dominant and a and b are recessive: 1) What is the genotype ... If the frequency of the dominant phenotypes (AA + Aa) is 0.8 and the population is in Hardy-Weinberg equilibrium, ...
  https://brainmass.com/biology/genetics/pg6
*  Linkage disequilibrium blocks, haplotype structure, and htSNPs of human CYP7A1 gene | BMC Genetics | Full Text
... microarray-based platform on thin-film biosensor chips was then developed for high-throughput genotyping to study ... The LD patterns and haplotype blocks of CYP7A1 gene were defined in Africans, Caucasians, and Asians using genotyping data ... FA2: frequency of allele 2; ObH: observed frequency of heterozygous genotypes; HW-p: Hardy-Weinberg p value. ... By uploading the files into HaploView, frequencies of allele 2, frequencies of observed heterozygous genotypes, and Hardy- ...
  https://bmcgenet.biomedcentral.com/articles/10.1186/1471-2156-7-29
*  Plus it
... heterozygous, and homozygous variant) when the allele frequencies allowed or into two groups (major allele homozygous and minor ... The minimum detectable odds ratio (OR) was calculated for each sequence variant based on its genotype frequency, our study ... Therefore, for some genes, we added selected SNPs from dbSNP, 14 which either (a) had a high frequency of the rare allele (to ... Unfortunately, because of the nature of the method of genotyping where all the SNPs are analyzed on one chip, genotyping that ...
  http://cancerres.aacrjournals.org/content/66/22/11062
*  A Markov Chain Monte Carlo Approach for Joint Inference of Population Structure and Inbreeding Rates From Multilocus Genotype...
5)where pA is the allele frequency of A in its assigned subpopulation. If individual i is heterozygous at locus l (suppose the ... 2000), denote marker allele frequencies by , and such that pklj is the allele frequency of the jth allele type at the lth locus ... xil. , F, zil., p.l.) is the genotype frequency of individual i at locus l. If the two alleles for this genotype are from ... If the two alleles for this genotype are from different subpopulations (i.e., zil1 ≠ zil2), we assume the genotype frequency is ...
  http://www.genetics.org/content/176/3/1635
*  Andrew Fire | Stanford Medicine Profiles
At heterozygous loci, remarkably different rearrangement frequencies were seen for the various IGHV alleles, and these ... frequencies were consistent between individuals. The specific alleles that make up an individual's Ig genotype may therefore be ... new large data sets should allow the rearrangement frequency of different genes and alleles to be seen with clarity. We ... It is likely that in some manner the frequency of an initiation of transcription at nine of these sites is affected by one or ...
  https://med.stanford.edu/profiles/andrew-fire
*  Answer in Other Biology Question for Katelyn Q&A 46586
... of the population and the heterozygous genotype makes up 42% of the population, what is the frequency of the dominant allele in ... Genotype = 2 alleles.. allele frequency = # of allele / all possble alleles at that locus. 9 aa = so two aa per person. 2x 9 = ... allele not genotype.. (genotype % below) out of 100 people. 9% homo reces = 9 people rr. 42% hetero = 42 people w/ Rr. ?% homo ... 1. If the homozygous dominant genotype makes up 36% of the population what is the frequenc… ...
  https://www.assignmentexpert.com/homework-answers/biology/other/question-46586
*  Kompetitive Allele Specific PCR (KASP™) genotyping of 48 polymorphisms at different caprine loci in French Alpine and Saanen...
Using a novel and fast genotyping method called Kompetitive Allele Specific PCR (KASP™), we carried out a pilot study on 48 ... Geno- type. Genotype frequencies. Milk yield (kg). Milk fat (%). Milk protein (%). Milk lactose (%). Genotype frequencies. Milk ... The results of the current study showed that the homozygous genotypes were more frequent than heterozygous in most cases. All ... The different genotype frequencies are shown in Table 2. The results of our study outlined that homozygous genotypes were more ...
  https://peerj.com/articles/4416/