*  Dehydroepiandrosterone sulfate - Wikipedia
DHEA is synthesized from cholesterol via the enzymes cholesterol side-chain cleavage enzyme (CYP11A1; P450scc) and 17α- ... originating from the adrenal cortex in women. Approximately 10 to 15 mg of DHEA-S is secreted by the adrenal cortex per day in ... Rainey WE, Nakamura Y (February 2008). "Regulation of the adrenal androgen biosynthesis". J. Steroid Biochem. Mol. Biol. 108 (3 ... However, a 2005 study found that DHEA could be converted into DHEA-S but found no evidence of conversion of DHEA-S into DHEA. ...
  https://en.wikipedia.org/wiki/Dehydroepiandrosterone_sulfate
*  Midterm 2 Review Flashcards by Kiana Hagerty | Brainscape
Cholesterol --> pregnenolone by StAR (uptake in mito) and P450scc (side chain cleavage) ... PNMT enzyme converts nor into epinephrine and is enhanced by cortisol. PNMT is found in tissues such as lung, kidney, and ... Adrenal cortex (mainly zona reticularis) contributes to the production of DHEAS and androstenedione -regulated by ACTH and ... i.e. zona glomerulosa lacks 17alpha-hydroxylase = can't synthesize either cortisol or androgens, only aldosterone. This enzyme ...
  https://www.brainscape.com/flashcards/midterm-2-review-6819563/packs/10832084
*  Lipoid congenital adrenal hyperplasia - Wikipedia
"Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc ... of the adrenal cells and increases LDL receptors to amplify transport of cholesterol into the cells of the adrenal cortex which ... All other cases of lipoid adrenal hyperplasia that have been studied have been found to be due to mutations of the gene for the ... Ovarian and adrenal androgen production is minimal and produces little pubic or other body hair. However insufficient estradiol ...
  https://en.wikipedia.org/wiki/Lipoid_congenital_adrenal_hyperplasia
*  Dehydroepiandrosterone - Wikipedia
DHEA is synthesized from cholesterol via the enzymes cholesterol side-chain cleavage enzyme (CYP11A1; P450scc) and 17α- ... DHEA has been found to competitively inhibit TRPV1. DHEA is produced in the zona reticularis of the adrenal cortex under the ... DHEA and other adrenal androgens such as androstenedione, although relatively weak androgens, are responsible for the ... DHEA-S itself originates almost exclusively from the adrenal cortex, with 95 to 100% being secreted from the adrenal cortex in ...
  https://en.wikipedia.org/wiki/Dehydroepiandrosterone
*  Cholesterol side-chain cleavage enzyme - Wikipedia
The highest level of the cholesterol side-chain cleavage system is found in the adrenal cortex and the corpus luteum. The ... but not for the mineralocorticoid aldosterone or androgen DHEAS that are secreted from other zones of the adrenal cortex. ... Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage. ... "Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc ...
  https://en.wikipedia.org/wiki/Cholesterol_side-chain_cleavage_enzyme
*  China Injectable Polypeptide Hormones Corticotropin Muscle Building and Collagen Diseases - China Muscle Building, Injectable...
Find details about China Muscle Building, Injectable Homone from Injectable Polypeptide Hormones Corticotropin Muscle Building ... ACTH Stimulates cholesterol side-chain cleavage enzyme, which makes the rate-limiting step in steroidogenesis. ... This increases the bio-availability of cholesterol in the cells of the adrenal cortex. ACTH increases the transport of ... Find Similar Products By Category. * Chemicals  Organic Chemicals  Organic Intermediate (16114) * Health & Medicine  ...
  http://wuhanycg.en.made-in-china.com/product/TSbxHAKwHrVU/China-Injectable-Polypeptide-Hormones-Corticotropin-Muscle-Building-and-Collagen-Diseases.html
*  Adrenal gland - Wikipedia
The first enzymatic step in the production of all steroid hormones is cleavage of the cholesterol side chain, a reaction that ... Therefore, ACTH stimulation of the adrenal cortex induces the release of excessive amounts of adrenal androgens, which can lead ... Adrenal tumors are commonly found as incidentalomas, unexpected asymptomatic tumors found during medical imaging. They are seen ... The adrenal gland secretes a number of different hormones which are metabolised by enzymes either within the gland or in other ...
  https://en.wikipedia.org/wiki/Adrenal_gland
*  Adrenal gland - Wikipedia
The first enzymatic step in the production of all steroid hormones is cleavage of the cholesterol side chain, a reaction that ... Therefore, ACTH stimulation of the adrenal cortex induces the release of excessive amounts of adrenal androgens, which can lead ... Adrenal tumorsEdit. Main article: Adrenal tumor. Adrenal tumors are commonly found as incidentalomas, unexpected asymptomatic ... Congenital adrenal hyperplasiaEdit. Congenital adrenal hyperplasia is a congenital disease in which mutations of enzymes that ...
  https://en.m.wikipedia.org/wiki/Adrenal_gland
*  Adrenal Physiology Flashcards by Shane Hagen | Brainscape
conversion of cholesterol to pregnenolone using cytochrome P450 side-chain cleavage via cholesterol desmolase (requires ... this is a fetal adrenal cortex and soon after birth it involutes, and is replaced by the three-layered adult adrenal cortex ... all from cholesterol delivered via blood or made de novo which then use layer-specific enzymes to produce specific hormones ... non-enzymatic conversion to androsterone (which then makes androgens testosterone and estradiol) NOTE: in males, adrenal ...
  https://www.brainscape.com/flashcards/adrenal-physiology-5449468/packs/8217453
*  Chapter 342. Disorders of the Adrenal Cortex | Harrison's Principles of Internal Medicine, 18e | AccessMedicine | McGraw-Hill...
cholesterol side chain cleavage enzyme CYP11A1 generates pregnenolone. Glucocorticoid synthesis requires conversion of ... Adrenal androgen secretion is disrupted in both primary and secondary adrenal insufficiency (Table 342-9). Hypothalamic- ... Metastases are found with similar frequency in adrenal masses of all sizes. Tumor density on unenhanced CT is of additional ... Adrenal steroidogenesis. CYP11A1, side chain cleavage enzyme; CYP17A1, 17α-hydroxylase/17,20 lyase; POR, P450 oxidoreductase; ...
  http://accessmedicine.mhmedical.com/content.aspx?bookid=331§ionid=40727147
*  Estradiol - Wikipedia
Estradiol, like other steroids, is derived from cholesterol. After side chain cleavage and using the Δ5 or the Δ4- pathway, Δ4- ... Smaller amounts of estradiol are also produced by the adrenal cortex, and, in men, by the testes.[citation needed] Estradiol is ... women were found to change and approximate typical female brain structures when exposed to estrogen concomitantly with androgen ... enzymes and metabolic transformations also being involved. Estradiol is additionally conjugated with an ester into lipoidal ...
  https://en.wikipedia.org/wiki/Estradiol
*  JCI Insight - PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal
Product of side-chain cleavage of cholesterol, isocaproaldehyde, is an endogenous specific substrate of mouse vas deferens ... Model describing the role of PKA signaling in adrenal zonation, cortex replenishment, and interplay with testicular androgen. ... Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies. Clin Endocrinol ... In the region in which the zR is found in primates, mouse adrenals are characterized by the presence of a transient X-zone, ...
  https://insight.jci.org/articles/view/98394
*  C-17 Hydroxylase Deficiency Medication: Glucocorticoids, Estrogens, Progestogens, Androgens, Antihypertensive agents,...
The rare variant of congenital adrenal hyperplasia (CAH) known as 17-hydroxylase deficiency was first described in the 1960s in ... 17-hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites. ... The synthesis of DHEA occurs exclusively in the adrenal cortex in women, while in men, 10-25% of DHEA is synthesized by the ... Early steps in androgen biosynthesis: from cholesterol to DHEA. Baillieres Clin Endocrinol Metab. 1998 Apr. 12(1):67-81. [ ...
  https://emedicine.medscape.com/article/117140-medication
*  Frontiers | Neurosteroid Influences on Sensitivity to Ethanol | Endocrinology
... physiological states associated with activity of the hypothalamic-pituitary adrenal (HPA) and hypothalamic-pituitary-gonadal ( ... the enzyme P450 side-chain cleavage transforms cholesterol to pregnenolone. Neuroactive steroids with activity at GABAA ... As a result, ACTH promotes the production of pregnenolone from cholesterol in the adrenal cortex (Lavoie and King, 2009). As ... 1973) are confirmed, lower levels of androgens in alcoholics could indicate that the role of androgens in alcoholism is ...
  https://www.frontiersin.org/articles/10.3389/fendo.2012.00010/full
*  Frontiers | Neurosteroid biosynthesis in the brain of amphibians | Endocrinology
... brains express the major steroidogenic enzymes and are able to synthesize de novo a number of neurosteroids from cholesterol/ ... brains express the major steroidogenic enzymes and are able to synthesize de novo a number of neurosteroids from cholesterol/ ... to summarize the current knowledge regarding the neuroanatomical distribution and biochemical activity of steroidogenic enzymes ... to summarize the current knowledge regarding the neuroanatomical distribution and biochemical activity of steroidogenic enzymes ...
  https://www.frontiersin.org/articles/10.3389/fendo.2011.00079/full
*  Adrenodoxin reductase - Wikipedia
"Comparison of the immunochemical properties of human placental and bovine adrenal cholesterol side-chain cleavage enzyme ... The highest levels of the enzyme are found in the adrenal cortex, granulosa cells of the ovary and leydig cells of the testis ... Gonzalez MI, Robins DM (Mar 2001). "Oct-1 preferentially interacts with androgen receptor in a DNA-dependent manner that ... was first isolated from bovine adrenal cortex where it functions as the first enzyme in the mitochondrial P450 systems that ...
  https://en.wikipedia.org/wiki/Adrenodoxin_reductase
*  MCAT - Biology Flashcards by Caitlin Rodeghier | Brainscape
Secretes enzyme Renin which initiates a regulatory cascade producing angiotensin (stimulates adrenal cortex to secrete ... A series of disaccharide polymer chains with amino acids, three of which are not found in proteins. The chains are connected by ... 5. Hydrophobic side chains pushed away from water and towards the center of the peptide (denatured by organic solvents). All ... Derived from and often chemically similar to cholesterol. Formed mainly in smooth ER and mitochondria.. Come only from adrenal ...
  https://www.brainscape.com/flashcards/mcat-biology-422004/packs/486133
*  Pregnenolone - Wikipedia
... with cleavage of the side chain.[14] The enzyme performing this task is cytochrome P450scc, located in the mitochondria, and ... most circulating pregnenolone is derived from the adrenal cortex.[15] To assay conversion of cholesterol to pregnenolone, ... "Inhibition of basal and adrenocorticotropin-stimulated plasma levels of adrenal androgens after treatment with an antiandrogen ... Pregnenolone has been found to bind with high, nanomolar affinity to microtubule-associated protein 2 (MAP2) in the brain.[7][8 ...
  https://en.wikipedia.org/wiki/Pregnenolone
*  Steroidogenic acute regulatory protein : Wikis (The Full Wiki)
Cholesterol side-chain cleavage enzyme * 3-beta-HSD * Cholesterol 7 alpha-hydroxylase ... StAR has thus far been found in all tissues that can produce steroids, including the adrenal cortex, the gonads, the brain and ... To androgens. 17α-hydroxylase/17,20 lyase · 3β dehydrogenase · 17β dehydrogenase · 5α reductase (1,2) ... mitochondrial membrane to the inner membrane where cytochrome P450scc enzyme is located to split off the cholesterol side chain ...
  http://www.thefullwiki.org/Steroidogenic_acute_regulatory_protein
*  Steroid - Wikipedia
"Optimization of steroid side chain cleavage by Mycobacterium sp. in the presence of cyclodextrins". Enzyme and Microbial ... and testosterone are produced in the adrenal cortex.[citation needed] Estradiol, estrone and progesterone are made primarily in ... When the two methyl groups and eight carbon side chains (at C-17, as shown for cholesterol) are present, the steroid is said to ... a potent androgen) through among others 17,20 Lyase (a member of the cytochrome P450 family of enzymes), 5α-Reductase and 3α- ...
  https://en.wikipedia.org/wiki/Steroid
*  Steroid Hormones Flashcards - Cram.com
Desmolase - what kind of enzyme?. Another name? Monooxygenase enzyme. 'Cytochrome P450scc'. scc = side chain cleavage ... Cholesterol = steroids What are the major steroid hormone producing organs? -Adrenal cortex. -Ovaries. -Testes ... Add to folder[?] Introducing Cram Folders! Find out how you can intelligently organize your Flashcards.. ... Primary target tissue & Effects of Androgens: Target: Reproductive organs and muscle.. -Spermatogenesis. -2ndary male ...
  http://www.cram.com/flashcards/steroid-hormones-396466
*  Insulin - New World Encyclopedia
Thyroid: T3 and T4 - calcitonin , Parathyroid: PTH , Adrenal medulla: epinephrine - norepinephrine , Adrenal cortex: ... A monomer unit is highlighted with the A chain in blue and the B chain in cyan. Yellow denotes disulfide bonds, and magenta ... glycation, proteolytic cleavage. Pathway(s):. Insulin signaling pathway (KEGG); Type II diabetes mellitus (KEGG); Type I ... The structure of insulin. The left side is a space-filling model of the insulin monomer, believed to be biologically active. ...
  http://www.newworldencyclopedia.org/entry/Insulin
*  Metabolomics/Hormones/Corticosteroids - Wikibooks, open books for an open world
... cholesterol is first converted into Pregnenolone by way of a side chain cleavage. Pregnenolone is then converted into ... Corticosteroids, or Corticoids are hormones that are produced in the adrenal cortex. This family can be broken down into two ... The activities of these enzymes were also able to be inhibited by glycyrrhetinic acid (GE), because of their similar enzyme ... Long acting beta agonists have been found to make the medications more effective and have been suggested for patients to use in ...
  https://en.m.wikibooks.org/wiki/Metabolomics/Hormones/Corticosteroids
*  PPT - Pharmacology Part 2 for Medical Students and Nurse PowerPoint presentation | free to download - id: 7ec142-NzU2N
cholesterol levels. Dyspepsia, abdominal pain and flatulence, the most common side effects, are usually mild, transient and ... The Adrenal Gland can synthesize estrogens, whereas fat cells, muscle cells can convert circulating androgens (androstredione) ... It is also synthesized in the adrenal cortex in bothe sexes *Progesterone helps in the development of a secretory endometrium ... dephosphorylating of the myosin light chain and smooth muscle relaxation. *AT Low doses Veins dilate and this reduces PRELOAD. ...
  http://www.powershow.com/view0/7ec142-NzU2N/Pharmacology_Part_2_for_Medical_Students_and_Nurse_powerpoint_ppt_presentation
*  EMC/Paradigm: College Resource Center: Health Careers: Readings in Subject Area: Complete Glossary
... any of the steroids elaborated by the adrenal cortex except the sex hormones; also their synthetic equivalents. cotinine. a ... lipoproteins containing 6% triglycerides and 65% cholesterol; bad cholesterol lymphatic system. a network of vessels that carry ... sweat glands found in the axillary, perineal, and genital regions apothecaries early pharmacists and/or their shops. aqueous ... an enzyme that metabolizes levodopa in the body; inhibited by certain anti-Parkinson s agents. ceiling effect a point at which ...
  http://www.emcp.com/college_resource_centers/resourcelist.php?GroupID=7238