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*  Dehydroepiandrosterone sulfate - Wikipedia
DHEA is synthesized from cholesterol via the enzymes cholesterol side-chain cleavage enzyme (CYP11A1; P450scc) and 17α- ... originating from the adrenal cortex in women. Approximately 10 to 15 mg of DHEA-S is secreted by the adrenal cortex per day in ... Rainey WE, Nakamura Y (February 2008). "Regulation of the adrenal androgen biosynthesis". J. Steroid Biochem. Mol. Biol. 108 (3 ... However, a 2005 study found that DHEA could be converted into DHEA-S but found no evidence of conversion of DHEA-S into DHEA. ...
  https://en.wikipedia.org/wiki/Dehydroepiandrosterone_sulfate
*  Midterm 2 Review Flashcards by Kiana Hagerty | Brainscape
Cholesterol --> pregnenolone by StAR (uptake in mito) and P450scc (side chain cleavage) ... PNMT enzyme converts nor into epinephrine and is enhanced by cortisol. PNMT is found in tissues such as lung, kidney, and ... Adrenal cortex (mainly zona reticularis) contributes to the production of DHEAS and androstenedione -regulated by ACTH and ... i.e. zona glomerulosa lacks 17alpha-hydroxylase = can't synthesize either cortisol or androgens, only aldosterone. This enzyme ...
  https://www.brainscape.com/flashcards/midterm-2-review-6819563/packs/10832084
*  Lipoid congenital adrenal hyperplasia - Wikipedia
"Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc ... of the adrenal cells and increases LDL receptors to amplify transport of cholesterol into the cells of the adrenal cortex which ... All other cases of lipoid adrenal hyperplasia that have been studied have been found to be due to mutations of the gene for the ... Ovarian and adrenal androgen production is minimal and produces little pubic or other body hair. However insufficient estradiol ...
  https://en.wikipedia.org/wiki/Lipoid_congenital_adrenal_hyperplasia
*  Dehydroepiandrosterone - Wikipedia
DHEA is synthesized from cholesterol via the enzymes cholesterol side-chain cleavage enzyme (CYP11A1; P450scc) and 17α- ... DHEA has been found to competitively inhibit TRPV1. DHEA is produced in the zona reticularis of the adrenal cortex under the ... DHEA and other adrenal androgens such as androstenedione, although relatively weak androgens, are responsible for the ... DHEA-S itself originates almost exclusively from the adrenal cortex, with 95 to 100% being secreted from the adrenal cortex in ...
  https://en.wikipedia.org/wiki/Dehydroepiandrosterone
*  Cholesterol side-chain cleavage enzyme - Wikipedia
The highest level of the cholesterol side-chain cleavage system is found in the adrenal cortex and the corpus luteum. The ... but not for the mineralocorticoid aldosterone or androgen DHEAS that are secreted from other zones of the adrenal cortex. ... Cholesterol side-chain cleavage enzyme is commonly referred to as P450scc, where "scc" is an acronym for side-chain cleavage. ... "Severe combined adrenal and gonadal deficiency caused by novel mutations in the cholesterol side chain cleavage enzyme, P450scc ...
  https://en.wikipedia.org/wiki/Cholesterol_side-chain_cleavage_enzyme
*  Adrenal gland - Wikipedia
The first enzymatic step in the production of all steroid hormones is cleavage of the cholesterol side chain, a reaction that ... Therefore, ACTH stimulation of the adrenal cortex induces the release of excessive amounts of adrenal androgens, which can lead ... Adrenal tumors are commonly found as incidentalomas, unexpected asymptomatic tumors found during medical imaging. They are seen ... The adrenal gland secretes a number of different hormones which are metabolised by enzymes either within the gland or in other ...
  https://en.wikipedia.org/wiki/Adrenal_gland
*  China Injectable Polypeptide Hormones Corticotropin Muscle Building and Collagen Diseases - China Muscle Building, Injectable...
Find details about China Muscle Building, Injectable Homone from Injectable Polypeptide Hormones Corticotropin Muscle Building ... ACTH Stimulates cholesterol side-chain cleavage enzyme, which makes the rate-limiting step in steroidogenesis. ... This increases the bio-availability of cholesterol in the cells of the adrenal cortex. ACTH increases the transport of ... Find Similar Products By Category. * Chemicals  Organic Chemicals  Organic Intermediate (16114) * Health & Medicine  ...
  http://wuhanycg.en.made-in-china.com/product/TSbxHAKwHrVU/China-Injectable-Polypeptide-Hormones-Corticotropin-Muscle-Building-and-Collagen-Diseases.html
*  Adrenal gland - Wikipedia
The first enzymatic step in the production of all steroid hormones is cleavage of the cholesterol side chain, a reaction that ... Therefore, ACTH stimulation of the adrenal cortex induces the release of excessive amounts of adrenal androgens, which can lead ... Adrenal tumorsEdit. Main article: Adrenal tumor. Adrenal tumors are commonly found as incidentalomas, unexpected asymptomatic ... Congenital adrenal hyperplasiaEdit. Congenital adrenal hyperplasia is a congenital disease in which mutations of enzymes that ...
  https://en.m.wikipedia.org/wiki/Adrenal_gland
*  Adrenal Physiology Flashcards by Shane Hagen | Brainscape
conversion of cholesterol to pregnenolone using cytochrome P450 side-chain cleavage via cholesterol desmolase (requires ... this is a fetal adrenal cortex and soon after birth it involutes, and is replaced by the three-layered adult adrenal cortex ... all from cholesterol delivered via blood or made de novo which then use layer-specific enzymes to produce specific hormones ... non-enzymatic conversion to androsterone (which then makes androgens testosterone and estradiol) NOTE: in males, adrenal ...
  https://www.brainscape.com/flashcards/adrenal-physiology-5449468/packs/8217453
*  Frontiers | Adrenal Mitochondria and Steroidogenesis: From Individual Proteins to Functional Protein Assemblies | Endocrinology
In this paper, we discuss this functionalization, beginning with the tissue zonation of the adrenal cortex and how this impacts ... In this paper, we discuss this functionalization, beginning with the tissue zonation of the adrenal cortex and how this impacts ... The adrenal cortex is critical for physiological function as the central site of glucocorticoid and mineralocorticoid synthesis ... The adrenal cortex is critical for physiological function as the central site of glucocorticoid and mineralocorticoid synthesis ...
  https://www.frontiersin.org/articles/10.3389/fendo.2016.00106/full
*  Dehydroepiandrosterone - The Full Wiki
Cholesterol is converted to pregnenolone by the enzyme P450 scc (side chain cleavage); then another enzyme, CYP17A1, converts ... DHEA is produced by adrenal glands, but also synthesized de novo in the brain.[citation needed] It acts on the androgen ... No relationship was found between serum DHEA and longevity for women during the study period. The study did not find a ... The effect of DHEA on memory appeared to be related to an early activation of the anterior cingulate cortex (ACC) and it was ...
  http://www.thefullwiki.org/Dehydroepiandrosterone
*  Cortisol
... side-chain cleavage enzyme).[95] Metabolism[edit]. Cortisol is metabolized by the 11-beta hydroxysteroid dehydrogenase system ( ... Cortisol is synthesized from cholesterol. Synthesis takes place in the zona fasciculata of the adrenal cortex. (The name ... This article's lead section may not adequately summarize its contents. Relevant discussion may be found on the talk page. To ... Androgens. (C-19: Androstane). 1. Dehydroepiandrosterone → Androstenedione → 5α-Androstanedione1 → Androsterone1. 2. ...
  https://en.wikipedia.org/wiki/Cortisol
*  Chapter 342. Disorders of the Adrenal Cortex | Harrison's Principles of Internal Medicine, 18e | AccessMedicine | McGraw-Hill...
cholesterol side chain cleavage enzyme CYP11A1 generates pregnenolone. Glucocorticoid synthesis requires conversion of ... Adrenal androgen secretion is disrupted in both primary and secondary adrenal insufficiency (Table 342-9). Hypothalamic- ... Metastases are found with similar frequency in adrenal masses of all sizes. Tumor density on unenhanced CT is of additional ... Adrenal steroidogenesis. CYP11A1, side chain cleavage enzyme; CYP17A1, 17α-hydroxylase/17,20 lyase; POR, P450 oxidoreductase; ...
  http://accessmedicine.mhmedical.com/content.aspx?bookid=331§ionid=40727147
*  Estradiol - Wikipedia
Estradiol, like other steroids, is derived from cholesterol. After side chain cleavage and using the Δ5 or the Δ4- pathway, Δ4- ... Smaller amounts of estradiol are also produced by the adrenal cortex, and, in men, by the testes.[citation needed] Estradiol is ... women were found to change and approximate typical female brain structures when exposed to estrogen concomitantly with androgen ... enzymes and metabolic transformations also being involved. Estradiol is additionally conjugated with an ester into lipoidal ...
  https://en.wikipedia.org/wiki/Estradiol
*  JCI Insight - PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal
Product of side-chain cleavage of cholesterol, isocaproaldehyde, is an endogenous specific substrate of mouse vas deferens ... Model describing the role of PKA signaling in adrenal zonation, cortex replenishment, and interplay with testicular androgen. ... Developmental changes in steroidogenic enzymes in human postnatal adrenal cortex: immunohistochemical studies. Clin Endocrinol ... In the region in which the zR is found in primates, mouse adrenals are characterized by the presence of a transient X-zone, ...
  https://insight.jci.org/articles/view/98394
*  C-17 Hydroxylase Deficiency Medication: Glucocorticoids, Estrogens, Progestogens, Androgens, Antihypertensive agents,...
The rare variant of congenital adrenal hyperplasia (CAH) known as 17-hydroxylase deficiency was first described in the 1960s in ... 17-hydroxylase/C17,20-lyase (CYP17) is not the enzyme responsible for side-chain cleavage of cortisol and its metabolites. ... The synthesis of DHEA occurs exclusively in the adrenal cortex in women, while in men, 10-25% of DHEA is synthesized by the ... Early steps in androgen biosynthesis: from cholesterol to DHEA. Baillieres Clin Endocrinol Metab. 1998 Apr. 12(1):67-81. [ ...
  https://emedicine.medscape.com/article/117140-medication
*  Frontiers | Neurosteroid Influences on Sensitivity to Ethanol | Endocrinology
... physiological states associated with activity of the hypothalamic-pituitary adrenal (HPA) and hypothalamic-pituitary-gonadal ( ... the enzyme P450 side-chain cleavage transforms cholesterol to pregnenolone. Neuroactive steroids with activity at GABAA ... As a result, ACTH promotes the production of pregnenolone from cholesterol in the adrenal cortex (Lavoie and King, 2009). As ... 1973) are confirmed, lower levels of androgens in alcoholics could indicate that the role of androgens in alcoholism is ...
  https://www.frontiersin.org/articles/10.3389/fendo.2012.00010/full
*  Frontiers | Neurosteroid biosynthesis in the brain of amphibians | Endocrinology
... brains express the major steroidogenic enzymes and are able to synthesize de novo a number of neurosteroids from cholesterol/ ... brains express the major steroidogenic enzymes and are able to synthesize de novo a number of neurosteroids from cholesterol/ ... to summarize the current knowledge regarding the neuroanatomical distribution and biochemical activity of steroidogenic enzymes ... to summarize the current knowledge regarding the neuroanatomical distribution and biochemical activity of steroidogenic enzymes ...
  https://www.frontiersin.org/articles/10.3389/fendo.2011.00079/full
*  Adrenodoxin reductase - Wikipedia
"Comparison of the immunochemical properties of human placental and bovine adrenal cholesterol side-chain cleavage enzyme ... The highest levels of the enzyme are found in the adrenal cortex, granulosa cells of the ovary and leydig cells of the testis ... Gonzalez MI, Robins DM (Mar 2001). "Oct-1 preferentially interacts with androgen receptor in a DNA-dependent manner that ... was first isolated from bovine adrenal cortex where it functions as the first enzyme in the mitochondrial P450 systems that ...
  https://en.wikipedia.org/wiki/Adrenodoxin_reductase
*  Hormones by Anthony W. Norman and Helen L. Henry by Anthony W. Norman and Helen L. Henry - Read Online
... the cleavage of the side chain of cholesterol; see Chapter 2) and are released as synthesized, not stored in the gland. Thyroid ... adrenal cortex, and other pituitary hormones. In these systems, the hypothalamus receives input from many different areas of ... This is the form in which DNA is found except when it is being transcribed or replicated, at which times the two strands of the ... The receptors for progesterone (PR), androgens (AR), and estrogens (ER) also form homodimers and may either be in the nucleus ...
  https://www.scribd.com/book/282546276/Hormones
*  Pregnenolone - Wikipedia
... with cleavage of the side chain. The enzyme performing this task is cytochrome P450scc, located in the mitochondria, and ... Pregnenolone has been found to act as an agonist of the pregnane X receptor. Pregnenolone is synthesized from cholesterol. This ... It is described in the context of medical use as an "adrenal cortex hormone" or a glucocorticoid for the treatment of ... androgens, estrogens, glucocorticoids, and mineralocorticoids. In addition, pregnenolone is biologically active in its own ...
  https://en.wikipedia.org/wiki/Pregnenolone
*  The fine structure of sow lutein cells.
Toren, D., K. M. J. Menon, E. Forchielli and R. I. Dorfman 1964 112 nitro enzymatic cleavage of the cholesterol side chain in ... There are none of the large mitochondria noted in rat adrenal cortex (Belt and Pease, '56). Nor were any cup-shaped ... The cellular production of steroid hormones by the ovary, testis, or adrenal gland involves many enzymes located in the ... A few profiles of rough endoplasmic reticulum (r.e.r.) can be found in most sections. They are seen most often as single pairs ...
  https://www.docme.ru/doc/2181507/the-fine-structure-of-sow-lutein-cells
*  MCAT - Biology Flashcards by Caitlin Rodeghier | Brainscape
Secretes enzyme Renin which initiates a regulatory cascade producing angiotensin (stimulates adrenal cortex to secrete ... A series of disaccharide polymer chains with amino acids, three of which are not found in proteins. The chains are connected by ... 5. Hydrophobic side chains pushed away from water and towards the center of the peptide (denatured by organic solvents). All ... Derived from and often chemically similar to cholesterol. Formed mainly in smooth ER and mitochondria.. Come only from adrenal ...
  https://www.brainscape.com/flashcards/mcat-biology-422004/packs/486133
*  НЕКОТОРЫЕ АСПЕКТЫ БИОХИМИИ И ФИЗИОЛОГИИ СТЕРОИДНОЙ РЕГУЛЯЦИИ У КОСТИСТЫХ РЫБ | Рендаков | Серия Экспериментальная биология
Chung B. C., Matteson K. J., Voutilainen R., Mohandas T. K., Miller W. L. Human cholesterol side-chain cleavage enzyme, P450scc ... Müller J. Aldosterone: the minority hormone of the adrenal cortex // Steroids. 1995. Vol. 60. no. 1. P. 2-9. doi: 10.1016/0039- ... Borg B. Androgens in teleost fishes // Comp. Biochem. Physiol. Part C Pharmacol. Toxicol. Endocrinol. 1994. Vol. 109. no. 3. P ... Conant G. C., Wolfe K. H. Turning a hobby into a job: How duplicated genes find new functions // Nat. Rev. Genet. 2008. Vol. 9 ...
  http://journals.krc.karelia.ru/index.php/biology/article/view/777
*  RegenerativeMedicine.net - Article Archives
... tracing identifies endocardial origin of liver vasculature Cholesterol analogs with degradation-resistant alkyl side chains are ... via EP4 receptor activation and repression of AP-1 A novel neural prediction error found in anterior cingulate cortex ensembles ... Association between androgen deprivation therapy and risk of dementia Molecular classification of Crohn's disease reveals two ... into embryonic sertoli-like cells by defined factors An RNA virus hijacks an incognito function of a DNA repair enzyme LIN28 ...
  http://regenerativemedicine.net/NewsletterArchives.asp?qEmpID=13643&qCat=RMJ