*  Clostridium difficile toxin A - Wikipedia
Earlier research established TcdA strictly as an enterotoxin, and TcdB as a cytotoxin, but later both toxins were found to have ... It was also found that a double tcdAtcdB knockout was completely attenuated in virulence. Overall, this research has ... The tcdA and tcdB genes are situated on the Clostridium difficile chromosome in a 19.6-kb pathogenicity locus (PaLoc) found ... Over 90% of patients infected with C. difficile were found to have cytotoxic activity in their stool. Glucosylation of Rho ...
  https://en.wikipedia.org/wiki/Clostridium_difficile_toxin_A
*  Clostridium difficile infection - Wikipedia
Fidaxomicin has been found to be as effective as vancomycin in those with mild to moderate disease and may be better in those ... Toxin B (cytotoxin) induces actin depolymerization by a mechanism correlated with a decrease in the ADP-ribosylation of the low ... Healthcare watchdog finds significant failings in infection control at Maidstone and Tunbridge Wells NHS Trust (press release ... In adults, a clinical prediction rule found the best signs to be significant diarrhea ("new onset of more than three partially ...
  https://en.wikipedia.org/wiki/Clostridium_difficile_infection
*  Clostridial Cytotoxin family - Wikipedia
2007). A novel toxin homologous to large clostridial cytotoxins found in culture supernatant of Clostridium perfringens type C ... Cytotoxins of the CCT family are large (e.g., toxin B of C. difficile is 2366 aas long) and tripartite with the N-terminal ... The Clostridial Cytotoxin (CCT) Family (TC# 1.C.57) is a member of the RTX-toxin superfamily. There are currently 13 classified ... Proteolytically processed clostridial cytotoxins A (306 kDa; TC# 1.C.57.1.2) and B (269 kDa; TC# 1.C.57.1.1) are O- ...
  https://en.wikipedia.org/wiki/Clostridial_Cytotoxin_family
*  Staphylococcus Aureus: Structure and Functions
Genes encoding cytotoxins were found to be up-regulated shortly following phagocytosis. One of the toxins, Hla, was shown to be ... Ehp was found to contain two C3d binding sites and showed higher levels of inhibition compared to Efb, though the mechanism of ... It was found that SSL14 was able to interact with endothelial cells and, most interestingly, T cells and B cells, though the ... 1.4). C1q was found to be the complement component targeted by SSL14, as evidenced by both affinity pull down and direct ...
  https://www.ukessays.com/essays/biology/a-review-of-staphylococcus-aureus-biology-essay.php
*  Anticancer Drugs from the Coral Reef: Prospects and Promise by Ken S. Feldman and Lauren F. Vernese - Reefkeeping.com
Consequently, some of the most potent cytotoxins known have been found in extracts from marine organisms. Through 2004, ... found in drug molecules). So, the question arises, how can these infinitesimal odds for finding a drug be improved? If ... Eleutherobin, a New Cytotoxin that Mimics Paclitaxel (Taxol) by Stabilizing Microtubles. J. Am. Chem. Soc. 119, 8744-8745. ... If an organism has evolved an effective cytotoxin, presumably to use against another organism in its environment, could that ...
  http://www.reefkeeping.com/issues/2006-11/kf/index.php
*  ASMscience | |span class='jp-italic'|Clostridium perfringens|/span| Sporulation and Sporulation-Associated Toxin Production
A novel toxin homologous to large clostridial cytotoxins found in culture supernatant of Clostridium perfringens type C. ... A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins. J Biol ... Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases. J ...
  http://www.asmscience.org/content/journal/microbiolspec/10.1128/microbiolspec.TBS-0022-2015
*  Genetic diversity in the plasticity zone and the presence of the chlamydial plasmid differentiates Chlamydia pecorum strains...
We also identified a third copy of the chlamydial cytotoxin gene, found only in porcine C. pecorum isolates. Phylogenetic ... In terms of cytotoxin genes, almost all of the analysed strains had two copies of the cytotoxin gene, with observed toxA ... No plasmids were reported in any of the C. pecorum genomes published prior to this study [1-3]. The unexpected finding of a C. ... To see if toxC could be found in strains from other hosts, we designed a toxC-specific PCR (amplifying a 644 bp toxC specific ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-015-2053-8
*  High prevalence of cytotoxin positive Helicobacter pylori in patients unrelated to the presence of peptic ulcers in Japan | Gut
13-18 Tee et al 18 reported that the highest percentages of the strains producing cytotoxin were found in subjects with peptic ... The size of the native cytotoxin, which reacted with the antibody against the recombinant cytotoxin, was the same as that which ... Methods-A Western blot assay was conducted to detect serum antibodies against the cytotoxin using recombinant cytotoxin (VacA ... In order to assess the serum antivacuolating cytotoxin antibody which is thought to indicate infection with cytotoxin positive ...
  http://gut.bmj.com/content/41/4/463
*  Apratoxin A - Wikipedia
In particular, Apartoxin A has been found to be a potent cancer cell cytotoxin. It has been found to be remarkably cytotoxic in ... Apartoxin A has been found to induce G1-phase cell cycle arrest and apoptosis. Although much work has been done to understand ... It is a derivative of the Apratoxin family of cytotoxins. The mixed peptide-polyketide natural product comes from a polyketide ... Cyanobacterial metabolites are commonly found to be useful in cancer treatment. ...
  https://en.wikipedia.org/wiki/Apratoxin_A
*  List of dangerous snakes - Wikipedia
Two forms of "cytotoxin II" (cardiotoxin) were found in the venom of this species. The crude venom of this species produced the ... The water cobras found in central and western Africa are an extremely venomous cobra species (Naja). These species were ... The venom of this species has the most potent composition of toxins found among any cobra species known. It is made up of ... The venom of the Egyptian cobra consists mainly of neurotoxins and cytotoxins. The average venom yield is 175 to 300 mg in a ...
  https://en.wikipedia.org/wiki/List_of_dangerous_snakes
*  Лаборатория биомолекулярной ЯМР-спектроскопии - ИБХ РАН
... luteus was found most susceptible to cytotoxins. A correlation was revealed between this activity and hydrophobicity of the ... Case study of cytotoxin I from cobra N. oxiana. Protein Expr. Purif. 130, 13-20 [+]. Cytotoxins or cardiotoxins is a group of ... Dubovskii V., Vorontsova V., Utkin N., Arseniev S., Efremov G., Feofanov V. (2014). Cobra cytotoxins: determinants of ... Cytotoxins (or cardiotoxins; CTs) are toxins from cobra venom characterized by the three-finger (TF) fold. CTs are on average ...
  http://www.ibch.ru/structure/groups/nmr/
*  Lethal Cytotoxins Used By Bacteria To Evade Antibiotic Treatment - Redorbit
Bacteria that cause infectious diseases produce a number of cytotoxins, and an international research team has now found the ... On the molecular level, this process is controlled by a number of advanced cytotoxins produced by the bacteria themselves in ... which are found in plants such as castor beans and are twice as venomous as cobra snake poison. ... that the location in the ribosome that is cleaved by VapC20 is the same place that is destroyed by the strong cytotoxins α- ...
  http://www.redorbit.com/news/science/1113005966/lethal-cytotoxins-used-by-bacteria-to-evade-antibiotic-treatment/
*  Toxins | Free Full-Text | Escherichia coli Subtilase Cytotoxin
Subtilase cytotoxin (SubAB) is the prototype of a new AB5 toxin family produced by a subset of Shiga toxigenic Escherichia coli ... "Escherichia coli Subtilase Cytotoxin." Toxins 2, no. 2: 215-228. Find Other Styles. ... Subtilase cytotoxin (SubAB) is the prototype of a new AB5 toxin family produced by a subset of Shiga toxigenic Escherichia coli ... Escherichia coli Subtilase Cytotoxin. Toxins. 2010; 2(2):215-228. Chicago/Turabian Style. Paton, Adrienne W.; Paton, James C. ...
  http://www.mdpi.com/2072-6651/2/2/215
*  SMART: Secondary literature for TNF domain
The cytotoxin was not cytostatic. Survival was found to be inversely proportional to cell death. The change in survival was ... Muscle tissues were found to accumulate TNF over the entire experimental period, whereas the visceral organs were found to have ... and this property was also found in the present study for HeLa cells. In addition to this, Mab 32 was found to enhance the ... We found that a protein of approximately 52 kDa (pp52) bound to GST-p60CD delta 1 from [35S]methionine- and 32P-labeled cells. ...
  http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=TNF
*  Toxins | Free Full-Text | DXD Motif-Dependent and -Independent Effects of the Chlamydia trachomatis Cytotoxin CT166
The only partially characterized cytotoxin CT166 of serovar D exhibits a DXD motif, which is important for the enzymatic ... Find out the new papers from selected authors. *Updated daily for 49'000+ journals and 6000+ publishers ... Bothe M, Dutow P, Pich A, Genth H, Klos A. DXD Motif-Dependent and -Independent Effects of the Chlamydia trachomatis Cytotoxin ... DXD Motif-Dependent and -Independent Effects of the Chlamydia trachomatis Cytotoxin CT166. Miriam Bothe 1. ...
  http://www.mdpi.com/2072-6651/7/2/621
*  Biology | Free Full-Text | Expression of a Synthetic Gene for the Major Cytotoxin (Cyt1Aa) of Bacillus thuringiensis subsp....
Expression of a Synthetic Gene for the Major Cytotoxin (Cyt1Aa) of Bacillus thuringiensis subsp. israelensis in the Chloroplast ... Kang, S.; Odom, O.W.; Malone, C.L.; Thangamani, S.; Herrin, D.L. Expression of a Synthetic Gene for the Major Cytotoxin (Cyt1Aa ... Expression of a Synthetic Gene for the Major Cytotoxin (Cyt1Aa) of Bacillus thuringiensis subsp. israelensis in the Chloroplast ... "Expression of a Synthetic Gene for the Major Cytotoxin (Cyt1Aa) of Bacillus thuringiensis subsp. israelensis in the Chloroplast ...
  http://www.mdpi.com/2079-7737/7/2/29
*  Tracheal cytotoxin - Wikipedia
... found in the cell wall of all gram-negative bacteria. Like all PGNs, TCT is composed of a disaccharide and a peptide chain. The ... Tracheal cytotoxin (TCT) is a 921 dalton glycopeptide released by Bordetella pertussis and Neisseria gonorrhoeae. In 1980, it ... Cundell, DR; Kanthakumar, K; Taylor, GW; Goldman, WE; Flak, T; Cole, PJ; Wilson, R (1994). "Effect of tracheal cytotoxin from ... Subsequently, they named the newly sequestered molecule tracheal cytotoxin (TCT). TCT is a soluble piece of peptidoglycan (PGN ...
  https://en.wikipedia.org/wiki/Tracheal_cytotoxin
*  SMART: Secondary literature for Aerolysin domain
All of the A. hydrophila isolates produced haemolysin and Vero active cytotoxin. The aerolysin gene was found in all tested ... Some strains were found to be positive in reacting with Ae and C1, but negative with C2. The findings led to the conclusion ... Proaerolysin was found to unfold in two steps corresponding to the unfolding of the large COOH-terminal lobe followed by the ... We found that Chinese hamster ovary cells were able to convert the protoxin to aerolysin in the absence of exogenous proteases ...
  http://smart.embl-heidelberg.de/smart/show_secondary.cgi?domain=Aerolysin
*  Nanocomputational Observation of Interaction of Two Cytotoxins and Nanobio Membrane: Molecular Dynamics Simulation Study
It has been found that the toxin interacts with zwitterionic bilayer formed by POPC. At the beginning of simulation the ... Experimental observations have shown that cardio toxins (cobra cytotoxins), small proteins of three-fingered cytotoxin group, ... The A4 cytotoxin molecule has been finally oriented toward surface of nanobiomembrane with base and one of loop's tip including ... The obtained data suggest that cytotoxin A3 meets the nanobiomembrane with sides of loops near tips and A4 meets POPC ...
  https://www.scientific.net/AMM.110-116.3888
*  Discovering Novel Antibiotics | The Scientist Magazine®
... the antibiotic trimethoprim was found to activate the silent gene cluster that produces the cytotoxin malleilactone B.FEMS ... to find antibiotics we may never find otherwise," he says.. Limitations: The main drawback of the method is that it can be slow ... "There may be a limit to what we're able to find in single culture, and we may only be able to cross that by going to co-culture ... This suggests that old antibiotics could be used to find new antibiotics.. Advantages: "One of the advantages of our method is ...
  https://www.the-scientist.com/lab-tools/discovering-novel-antibiotics-32100/amp
*  Patente US5213970 - Method for obtaining soluble antitumor factor - Google Patentes
... to release cytotoxins; the principal species from the ML-2 line was found to be 40 kilodaltons. Armstrong et al. ((1985), J. ... Moreover, other activators have been found to exhibit the same tendency. In general, it has been found that the presence of a ... It has been found that in isolating the present HMT factor, care must be taken to ensure that a proper dose range of activator ... Beta-HMT is found to have a pI of 5.8 as determined by chromatofocusing, whereas recombinant HuTNF has a pI of about 5.3. ...
  http://www.google.es/patents/US5213970
*  Cytotoxins Contribute to Virulence of Deadly Bacterial Infections
They found that mutant strains lacking either SPN or SLO or both do not cause the most severe forms of necrotizing fasciitis, ... Cytotoxins Contribute to Virulence of Deadly Bacterial Infections. by Bidita Debnath on February 2, 2017 at 11:58 PM Research ... Bacteria produce cytotoxins that can cause cell death and result in infections of the deep fascia and other tissues, including ... Bacteria produce cytotoxins that can cause cell death and result in infections of the deep fascia and other tissues, including ...
  https://www.medindia.net/news/cytotoxins-contribute-to-virulence-of-deadly-bacterial-infections-167480-1.htm
*  Plus it
Recombinant Cytokine, Cytotoxin, and Cell Cultures. Recombinant human IL-13 and IL-13 cytotoxin (IL13-PE38QQR) were produced ... 8G). These two markers were found to co-localize in the same cells, as assessed by image merger (Fig. 8H). Because iNOS is an ... IL-13 cytotoxin did not show antitumor activity in MCF-7 tumors injected with IL-13Rα1 cDNA in vivo. Tumors implanted in nude ... IL-4 cytotoxin did not mediate protein synthesis inhibition in SK-BR-3 cells transfected with IL-13Rα2 cDNA. SK-BR-3 cells were ...
  http://mct.aacrjournals.org/content/3/2/137
*  Plus it
We previously have found that 2-chloroethyl-3-sarcosinamide-1-nitrosourea (SarCNU) is a selective cytotoxin that enters cells ... In the present in vivo study, we did not find a correlation between SarCNU antitumor effect and EMTh expression alone, but ... However, a significant correlation was found between MGMT expression and BCNU antitumor efficacy. Interestingly, multiple ... was found to have interesting characteristics (Panasci et al., 1985, 1996). ...
  http://jpet.aspetjournals.org/content/296/3/712
*  PrimeGene: High Quality Protein Manufacturer
IL-21 elicits its effect through binding to IL-21R, which also contains the gamma chain found in other cytokine receptors such ... for instance cytotoxin T cells and natural killer cells. Additionally, it can induce target cells division or proliferation. ...
  http://primegene.com/Product/info_49.aspx?Number=101-21&ProductName=Recombinant%20Human%20Interleukin-21