Anticonvulsant effect of fosphenytoin in amygdala-kindled rats: comparison with phenytoin. - Semantic Scholar
... fosphenytoin showed anticonvulsant properties similar to phenytoin in amygdala kindled rats. We conclude that fosphenytoin is ... Recently, fosphenytoin, a prodrug of phenytoin, has been developed by phosphorylating phenytoin which makes the drug water ... The pharmacokinetic parameters of phenytoin and fosphenytoin were compared by determining plasma levels of phenytoin after i.p ... The relative bioavailability of fosphenytoin was 83%. In contrast to phenytoin, failed injections resulting in non-detectable ...https://www.semanticscholar.org/paper/Anticonvulsant-effect-of-fosphenytoin-in-rats%3A-with-Loescher-Reissmueller/591111a43c590a25040333c054d0912c65b68e8e
Fosphenytoin Sodium Injection, USP Rx Only
... fosphenytoin is converted to the anticonvulsant phenytoin. For every mmol of fosphenytoin administered, one mmol of phenytoin ... Fosphenytoin is a prodrug of phenytoin and accordingly, its anticonvulsant effects are attributable to phenytoin. ... Fosphenytoin can also be substituted, short-term, for oral phenytoin. Fosphenytoin should be used only when oral phenytoin ... Phenytoin (after fosphenytoin administration) In general, IM administration of fosphenytoin generates systemic phenytoin ...https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=87ff8a91-5b37-401c-b75c-dc6efd348761&type=display
Tipifarnib in Treating Older Patients With Acute Myeloid Leukemia - Full Text View - ClinicalTrials.gov
Use of enzyme-inducing anticonvulsants (e.g., phenytoin, fosphenytoin, phenobarbital, primidone, carbamazepine, oxcarbazepine) ... If clinically indicated, subjects may use non-enzyme-inducing anticonvulsants during treatment with R115777 ...https://clinicaltrials.gov/ct2/show/NCT01364038?recr=Open&cond=%22Leukemia%2C+Myeloid%2C+Acute%22&rank=18
Hydantoins: (Moderate) Hydantoin anticonvulsants (i.e., phenytoin, fosphenytoin, or ethotoin) may reduce verapamil serum ...http://www.pdr.net/drug-summary/Calan-verapamil-hydrochloride-1693
Oxazepam by Pro Doc Limitee - Pharmasave
anticonvulsants (e.g., fosphenytoin, gabapentin, lamotrigine, lamotrigine, phenytoin). *antihistamines (e.g., cetirizine, ...http://www.pharmasave.com/medications/oxazepam-by-pro-doc-limitee/
Simple Partial Seizures Medication: Anticonvulsants
Fosphenytoin is phosphorylated phenytoin, a prodrug that is highly soluble and converted rapidly to phenytoin; it contains 50 ... Anticonvulsants. Class Summary. These agents prevent seizure recurrence and terminate clinical and electrical seizure activity. ... Phenytoin is a poorly soluble compound that is highly protein bound, metabolized by cytochrome P-450 system, and has nonlinear ... Many anticonvulsants currently are approved by the US Food and Drug Administration (FDA) for partial seizures with and without ...https://emedicine.medscape.com/article/1184384-medication
Preparing for Pediatric Emergencies: Drugs to Consider | FROM THE AMERICAN ACADEMY OF PEDIATRICS | Pediatrics
Diazepam should be followed immediately by a long-acting anticonvulsant, such as phenytoin/fosphenytoin, because it is rapidly ... Lower risk of hypotension or cardiac effects than phenytoin.. Warning. Rate of infusion should not exceed 3 PE/kg per min. ... Phenytoin should be diluted in normal saline to avoid precipitation. Incompatible with glucose-containing solutions. ... If available, fosphenytoin is preferred, because it has a lower risk of adverse cardiac effects. ...http://pediatrics.aappublications.org/content/121/2/433.figures-only
Critical Care of the Neurosurgical Patient; Care and management of neurosurgical patients - Renal and Urology News
... including fosphenytoin/phenytoin, valproic acid, phenobarbital, and newer anticonvulsants such as levetiracetam and lacosamide ... However, anticonvulsants should be discontinued after 1-2 weeks as there is no benefit for preventing late post-operative ... Prophylactic anticonvulsant administration is expected to reduce the incidence of early post-operative seizures by 30-50%. ... Seizures should be treated promptly with anticonvulsant agents as seizure activity is a major physiologic stressor that can ...http://www.renalandurologynews.com/critical-care-medicine/critical-care-of-the-neurosurgical-patient-care-and-management-of-neurosurgical-patients/article/585912/
Intravenous Lacosamide Compared With Fosphenytoin in the Treatment of Patients With Frequent Nonconvulsive Seizures - Full Text...
Fosphenytoin. Phenytoin. Anticonvulsants. Voltage-Gated Sodium Channel Blockers. Sodium Channel Blockers. Membrane Transport ... Other Name: Cerebyx, Fosphenytoin. Drug: LCM If after initial treatment with LCM any of the following occurs, the subject will ... Other Name: Cerebyx, Fosphenytoin. Drug: LCM If after initial treatment with LCM any of the following occurs, the subject will ... Intravenous Lacosamide Compared With Fosphenytoin in the Treatment of Patients With Frequent Nonconvulsive Seizures (TRENdS). ...https://clinicaltrials.gov/ct2/show/NCT01458522
Gefitinib in Treating Patients With Metastatic or Unresectable Head and Neck Cancer or Non-Small Cell Lung Cancer - Full Text...
... the anticonvulsants carbamazepine, phenobarbital, phenytoin, oxcarbazepine, fosphenytoin and primidone as well as St. John's ...https://clinicaltrials.gov/ct2/show/NCT00068497?cond=%22Thyroid+cancer+anaplastic%22&rank=16
Cerebyx® - ERFA Canada 2012 Inc.ERFA Canada 2012 Inc.
... fosphenytoin is converted to the anticonvulsant phenytoin. For every mmol of fosphenytoin administered, one mmol of phenytoin ... Fosphenytoin is a prodrug of phenytoin and accordingly, its anticonvulsant effects are attributable to phenytoin. ... fosphenytoin and phenytoin are equipotent anticonvulsants on a molar basis.. *The time course of anticonvulsant actions for ... Fosphenytoin is not excreted in urine. Each mmol of fosphenytoin is metabolized to 1 mmol of phenytoin, phosphate, and formate ...http://eci2012.net/product/cerebyx/?lang=en
"Glossary of Pharmacology Stubs" related terms, short phrases and...
Fosphenytoin is a new phenytoin prodrug that fulfills many of the properties of an ideal anticonvulsant drug.. ... Fosphenytoin. *Fosphenytoin is for parenteral use only.. *Fosphenytoin was developed to eliminate the poor aqueous solubility ... Fosphenytoin is a diphosphate ester of phenytoin that is very water-soluble, making it a convenient intravenous dosage form.. ... FOSPHENYTOIN. LEVETIRACETAM. METRONIDAZOLE. NORTRIPTYLINE. RISEDRONATE. TEICOPLANIN. TINIDAZOLE. TYLENOL PM. VINORELBINE. ...http://keywen.com/en/GLOSSARY_OF_PHARMACOLOGY_STUBS
GRN1005 Alone or in Combination With Trastuzumab in Breast Cancer Patients With Brain Metastases - Full Text View -...
Patients must be neurologically stable: On stable doses of corticosteroids and anticonvulsants (not EIAEDs, including phenytoin ... phenobarbitol, carbamazepine, fosphenytoin, primidone, oxcarbazepine) for ≥ 5 days prior to obtaining the baseline Gd-MRI of ...https://clinicaltrials.gov/ct2/show/study/NCT01480583?term=Breast+Cancer&lup_s=09%2F07%2F2013&lup_d=30&show_locs=Y
Anticonvulsant - Wikipedia
Phenobarbital was the main anticonvulsant from 1912 until the development of phenytoin in 1938. Today, phenobarbital is rarely ... Mephenytoin Fosphenytoin (1996). The following are oxazolidinediones: Paramethadione Trimethadione (1946). Ethadione Beclamide ... Anticonvulsant Screening Program Use of Anticonvulsants in Pharmacotherapy of Bronchial Asthma MDNG: Anticonvulsants and Bone ... Anticonvulsants suppress the excessive rapid firing of neurons during seizures. Anticonvulsants also prevent the spread of the ...https://en.wikipedia.org/wiki/Anticonvulsant
Dilantin-125 (phenytoin) dose, indications, adverse effects, interactions... from PDR.net
Anticonvulsants, such phenytoin and fosphenytoin (which is metabolized to phenytoin), can decrease the activity of vitamin D by ... Calcitriol: (Moderate) Anticonvulsants, such phenytoin and fosphenytoin (which is metabolized to phenytoin), can increase the ... Dilantin/Phenytoin Oral Susp: 5mL, 125mg. Dilantin/Phenytoin Oral Tab Chew: 50mg. Phenytoin/Phenytoin Sodium Intramuscular Inj ... Phenytoin capsules contain phenytoin sodium, which is 92% phenytoin. Chewable tablets and suspensions contain 100% phenytoin. ...http://www.pdr.net/drug-summary/dilantin-125?druglabelid=1843
GRN1005 in Non-Small Cell Lung Cancer (NSCLC) Patients With Brain Metastases (GRABM-L) - Full Text View - ClinicalTrials.gov
... including phenytoin, phenobarbitol, carbamazepine, fosphenytoin, primidone, oxcarbazepine) for ≥ 5 days prior to obtaining the ... Patients must be neurologically stable, defined as being on stable doses of corticosteroids and anticonvulsants (not EIAEDs, ...https://clinicaltrials.gov/ct2/show/study/NCT01497665?view=record
Anticonvulsant medications - hydantoin derivatives | Lima Memorial Health System
Fosphenytoin (Cerebyx). *Ethotoin (Peganone) Depletions. Taking phenytoin may deplete calcium, phosphate, vitamin B9, vitamin D ... Anticonvulsant medications - hydantoin derivatives. Hydantoin derivative medications include:. *Phenytoin (Dilantin and ... Drug Monograph: Fosphenytoin 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-269. Accessed July 14, 2016. ... Drug Monograph: Phenytoin 2016. www.clinicalkey.com/#!/content/drug_monograph/6-s2.0-232. Accessed July 7, 2016. ...http://www.limamemorial.org/health-library/Complementary%20and%20Alternative%20Medicine/33/000187
Newer Anti-Eptileptic Drugs: Gabapentin, Lamotrigine, Felbamate, Topiramate and Fosphenytoin - American Family Physician
Treatment with standard anticonvulsants such as phenytoin, carbamazepine, valproic acid and phenobarbital is often complicated ... Fosphenytoin is a parenteral prodrug of phenytoin that is more tolerable than parenteral phenytoin. ... Effects of Newer Anticonvulsants on Drug Levels of Standard Anticonvulsants. Standard anticonvulsants. Newer anticonvulsants. ... Effects of Newer Anticonvulsants on Drug Levels of Standard Anticonvulsants. Standard anticonvulsants. Newer anticonvulsants. ...https://www.aafp.org/afp/1998/0201/p513.html
Hydantoin - Wikipedia
In pharmaceuticals, hydantoin derivatives form a class of anticonvulsants; phenytoin and fosphenytoin both contain hydantoin ... For example, phenytoin (mentioned below) has two phenyl groups substituted onto the number 5 carbon in a hydantoin molecule. ... "Hydantoin anticonvulsants". drugs.com. Drauz, Karlheinz; Grayson, Ian; Kleemann, Axel; Krimmer, Hans-Peter; Leuchtenberger, ... moieties and are both used as anticonvulsants in the treatment of seizure disorders. The hydantoin derivative dantrolene is ...https://en.wikipedia.org/wiki/Hydantoin
GRN1005 for Brain Metastases From Breast or Lung Cancer - Full Text View - ClinicalTrials.gov
... including phenytoin, phenobarbitol, carbamazepine, fosphenytoin, primidone, oxcarbazepine) for greater than or equal to 5 days ... Treatment with P450 CYP 3A4 or 2C8 enzyme-inducing anticonvulsant drugs less than or equal to 14 days prior to first dose of ... Patients must be neurologically stable, defined as being on stable doses of corticosteroids and anticonvulsants (not enzyme- ...https://clinicaltrials.gov/ct2/show/NCT01679743?recr=Open&cond=%22Lung+Neoplasms%22&rank=18
Traumatic Brain Injury - Injuries; Poisoning - Merck Manuals Professional Edition
Newer anticonvulsants are under study. Fosphenytoin, a form of phenytoin that has better water solubility, is being used in ... a prophylactic anticonvulsant should be considered. If phenytoin is used, a loading dose of 20 mg/kg IV is given (at a maximum ... If no seizures develop within 1 wk, anticonvulsants should be stopped because their value in preventing future seizures is not ... Dosing is the same as for phenytoin. Levetiracetam is used increasingly, particularly in patients with liver disorders. ...http://www.merckmanuals.com/professional/injuries-poisoning/traumatic-brain-injury-tbi/traumatic-brain-injury
Anticonvulsants | Pharmacology Corner
Filed Under: Anticonvulsants, FDA media releases, Internal Medicine, Neurology. Phenytoin and fosphenytoin linked to Stevens ... Filed Under: Anticonvulsants, Neurology, Pharmacology animations. Anticonvulsants MCQS for USMLE. Posted on February 15, 2009. ... Category Archives: Anticonvulsants. Glutamate receptors. Posted on January 9, 2011. by Flavio Guzmán, MD • 0 Comments ... Filed Under: Anticonvulsants, FDA media releases. Barbiturates review: a video lecture. Posted on February 15, 2009. by Flavio ...http://pharmacologycorner.com/category/therapeutic-groups/cns-drugs/anticonvulsants/
Established Status Epilepticus Treatment Trial - Full Text View - ClinicalTrials.gov
Fosphenytoin. Valproic Acid. Phenytoin. Piracetam. Anticonvulsants. Nootropic Agents. Neuroprotective Agents. Protective Agents ... Active Comparator: Fosphenytoin (FOS) Administer 20 mg/Kg fosphenytoin intravenously up to a maximum dose of 1500 mg ( 75 Kg) ... Drug Information available for: Valproic acid Valproate sodium Divalproex sodium Fosphenytoin sodium Fosphenytoin Levetiracetam ... Drug: Fosphenytoin Active Comparator: Valproic acid Administer 40 mg/Kg valproic acid intravenously up to a maximum dose of ...https://clinicaltrials.gov/ct2/show/NCT01960075?term=esett&rank=1
Quillivant XR (methylphenidate hydrochloride) dose, indications, adverse effects, interactions... from PDR.net
Phenytoin: (Moderate) Psychostimulants, such as methylphenidate, may lower the seizure threshold, thereby reducing the efficacy ... Fosphenytoin: (Moderate) Psychostimulants, such as methylphenidate, may lower the seizure threshold, thereby reducing the ... Concomitant use of methylphenidate and anticonvulsants has not been established. If seizures occur, methylphenidate therapy ... Nevertheless, a dose adjustment of phenytoin and more frequent monitoring of plasma concentrations may be required when ...http://www.pdr.net/drug-summary/Quillivant-XR-methylphenidate-hydrochloride-3038
Quinidine Gluconate Extended-Release Tablets (quinidine gluconate) dose, indications, adverse effects, interactions... from PDR...
Inducers of CYP3A4, such as fosphenytoin or phenytoin, may increase hepatic elimination of quinidine and decrease its serum ... Quinidine concentrations should be monitored closely after the anticonvulsant is added to the treatment regimen. No special ...http://www.pdr.net/drug-summary/Quinidine-Gluconate-Extended-Release-Tablets-quinidine-gluconate-789