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*  Assessment of novel oral lipid-based formulations of amphotericin B using an in vitro lipolysis model. | Sigma-Aldrich
Amphotericin B (AmB) was formulated in three lipid-based formulations consisting of different lipid components: iCo-009, iCo- ... Assessment of novel oral lipid-based formulations of amphotericin B using an in vitro lipolysis model.. [Fady Ibrahim, Pavel ... The purpose of this study was to investigate the intraluminal processing of novel oral lipid-based formulations of amphotericin ... The lipid components of iCo-009 experienced lower extent of lipolysis as compared to other formulations. Amphotericin B ...
  https://www.sigmaaldrich.com/catalog/papers/22369857
*  A cell impedance-based real-time in vitro assay to assess the toxicity of amphotericin B formulations
A cell impedance-based real-timein vitroassay to assess the toxicity of amphotericin B formulations. ... Aerosolized liposomal amphotericin B (L-AmB) has been investigated as prophylaxis against invasive aspergillosis. However, the ... or amphotericin B deoxycholate (D-AmB; 50 to 200 μg/ml) by monitoring real-time A549 cell viability using an impedance-based ...
  https://insights.ovid.com/pubmed?PMID=28865757
*  METHODS AND FORMULATIONS FOR REDUCING AMPHOTERICIN B TREATMENT SIDE EFFECTS - Patent application
... formulation that comprises a polyene active ingredient that includes amphotericin B, wherein the amphotericin B compound is ... providing a formulation that comprises a polyene active ingredient that includes amphotericin B, wherein the amphotericin B ... Samples of each amphotericin formulation are diluted in about 1.0 mL DMSO, then further diluted with about 5 mL methanol. A 400 ... Amphotericin B Amphotericin B (generic) 1958 deoxycholate (AmBD) Amphotericin B lipid ABELCET ® The Liposome 1995 complex (ABLC ...
  http://www.patentsencyclopedia.com/app/20110152211
*  Coccidioidomycosis
Data regarding lipid formulations of amphotericin B are limited, but these formulations are likely as effective. ... Certain specialists add triazole to amphotericin B therapy and continue triazole once amphotericin B is stopped (BIII). ... Clin Infect Dis 2005;41:1217-23.). Most experience has been with the deoxycholate formulation using 0.7-1.0 mg/kg daily as an ... Therapy with amphotericin B should continue until clinical improvement is observed. Certain specialists would use a triazole ...
  http://hivinsite.ucsf.edu/hiv?page=md-agl-cocc
*  Amphotericin B Treatment for Indian Visceral Leishmaniasis: Conventional versus Lipid Formulations : Clinical Infectious...
To test the efficacy of amphotericin B deoxycholate versus that of its lipid formulations, Indian patients were randomized to ... To test the efficacy of amphotericin B deoxycholate versus that of its lipid formulations, Indian patients were randomized to ... Estimated total treatment costs for a 25-kg patient-$417 for amphotericin B deoxycholate, $872 for liposomal amphotericin B, ... Substantial reductions (∼60%) in the price of liposomal amphotericin B and amphotericin B lipid complex would make treatment ...
  http://oxfordindex.oup.com/view/10.1086/380971
*  Cocci | Invasive Mycoses | Adult and Adolescent Opportunistic Infection | AIDSinfo
There are no reported studies that have used lipid formulations of amphotericin B for the treatment of coccidioidomycosis, but ... Lipid formulation amphotericin B 3-5 mg/kg IV daily (AIII), or ... Amphotericin B deoxycholate 0.7-1.0 mg/kg IV daily (AII). *Use ... to amphotericin B therapy and continue the triazole once amphotericin B is stopped (BIII) ... A dose of 400 mg twice daily of the older liquid formulation of posaconazole has been used (BII),22 but the current extended- ...
  https://aidsinfo.nih.gov/guidelines/html/4/adult-and-adolescent-oi-prevention-and-treatment-guidelines/335/cocci
*  Abelcet (amphotericin B lipid complex) dose, indications, adverse effects, interactions... from PDR.net
In general, amphotericin B deoxycholate is preferred in neonates; lipid formulation amphotericin B should be used with caution ... In general, amphotericin B deoxycholate is preferred in neonates; lipid formulation amphotericin B should be used with caution ... In general, amphotericin B deoxycholate is preferred in neonates; lipid formulation amphotericin B should be used with caution ... In general, amphotericin B deoxycholate is preferred in neonates; lipid formulation amphotericin B should be used with caution ...
  https://www.pdr.net/drug-summary/Abelcet-amphotericin-B-lipid-complex-539
*  Infections in Recipients of Hematopoietic Cell Transplantation
Lipid formulation amphotericin B 3-5 mg/kg/day. PCP pneumonia. sulfamethoxazole-trimethoprim. 15-20 mg/kg/d in 3-4 divided ... posaconazole, liposomal amphotericin or ABLC. PCP pneumonia. sulfamethoxazole-trimethoprim. 1 DS tablet PO 3-4 doses per week. ... Acetaminophen and diphenhydramine are frequently given prior to administration of amphotericin B infusions to reduce rigors ... Normal saline is generally given to reduce renal toxicity of amphotericin products ...
  https://www.endocrinologyadvisor.com/infectious-diseases/infections-in-recipients-of-hematopoietic-cell-transplantation/article/609951/
*  Antifungals Flashcards by Sean Osborne | Brainscape
what is the purpose of creating lipid formulations of amphotericin? created to improve tolerability. helps deliver amphotericin ... Amphotericin. what class does it belong to?. when was it first made?. how is it administered?. how long is its half-life?. what ...
  https://www.brainscape.com/flashcards/antifungals-2211883/packs/3950087
*  Search of: aspergillosis - List Results - ClinicalTrials.gov
Drug: Comparator: amphotericin B. *Drug: Comparator: lipid formulation of amphotericin B and/or azole ... Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis. *Aspergillosis. *Drug: nebulised liposomal ... Nebulized Amphotericin B Lipid Complex in Invasive Pulmonary Aspergillosis in Paediatric Patients With Acute Leukaemia. * ... Value of Amphotericin B Inhalation for Prophylaxis of Invasive Pulmonary Aspergillosis After Renal Transplantation. *Invasive ...
  https://clinicaltrials.gov/ct2/results?term=aspergillosis&Search=Search
*  Cryptococcus laurentii Diarrhea in a Neoplastic Patient
At this point, lipid formulation of amphotericin B (AmBisome) 3 mg/Kg was started and continued for ten days. Anamnesis ... During treatment with lipid formulation of amphotericin B (AmBisome) we noticed a gradual improvement in leukoneutropenia up to ... Figure 2: Chest X-ray after lipid formulation of amphotericin B therapy. ... R. A. Colmers, W. Irniger, and D. H. Steinberg, "Cryptococcus neoformans endocarditis cured by amphotericin B," The Journal of ...
  https://www.hindawi.com/journals/crionm/2015/216458/
*  Search of: 'Aspergillosis' - List Results - ClinicalTrials.gov
Drug: Comparator: amphotericin B. *Drug: Comparator: lipid formulation of amphotericin B and/or azole ... Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis. *Aspergillosis. *Drug: nebulised liposomal ... Trial of Micafungin (FK463) in Combination With Liposomal Amphotericin B (AmBisome) for Aspergillosis. *Aspergillosis ... Evaluation of a Therapeutic Strategy Including Nebulised Liposomal Amphotericin B (Ambisome®) in Maintenance Treatment of ...
  https://clinicaltrials.gov/ct2/results?cond=%22Aspergillosis%22&show_rss=Y
*  Amphotericin B Cholesteryl Sulfate Complex Injection Drug Shortage Notice - Drugs.com
Current drugs shortage notification for Amphotericin B Cholesteryl Sulfate Complex Injection including reason for shortage, ... The shortage of amphotericin b cholesteryl sulfate lipid complex is not affecting other amphotericin formulations. ... Alkopharma was the sole supplier of amphotericin b cholesteryl sulfate lipid complex. The company's phone is no longer in ... Amphotericin B Cholesteryl Sulfate Complex Injection. Last Updated: October 20, 2014. Status: Discontinued ...
  https://www.drugs.com/drug-shortages/amphotericin-b-cholesteryl-sulfate-complex-injection-894
*  ISMP Quarterly Action Agenda
Problem: Mix-ups have occurred between liposomal and conventional formulations of IV amphotericin B. Conventional amphotericin ... Mix-ups between various formulations of amphotericin B (21) ... Restrict the preparation and dispensing of amphotericin B to ... Reccomendation:Communicate orders using both the proprietary and complete generic name (e.g., AMBISOME [amphotericin B ... Dose checking alerts should be utilized in computer systems for both liposomal and conventional formulations. Consider adding a ...
  https://www.ismp.org/Newsletters/acutecare/articles/A1Q13Action.asp
*  Invasive Candidiasis/Candidemia
FluconazoleORlipid formulation amphotericin B (AmBisome, Abelcet). Urinary tract infection. Fluconazole. 200mg oral daily for ... Lipid formulation amphotericin B (AmBisome, Abelcet). Hepatosplenic candidiasis. Fluconazole for stable patientsLipid ... Echinocandins (Micafungin, anidulafungin, caspofungin)ORlipid formulation amphotericin B (AmBisome, Abelcet). Candidemia. ... Amphotericin B deoxycholate. Abdominal abscess. Fluconazole in a setting in which C. glabrata is not commonly seen and in a ...
  https://www.endocrinologyadvisor.com/infectious-diseases/invasive-candidiasiscandidemia/article/609346/
*  Single-dose AmBisome (Liposomal amphotericin B) as prophylaxis for murine systemic candidiasis and histoplasmosis. - Semantic...
In this study, amphotericin B deoxycholate (Fungizone) (1 mg/kg) and AmBisome (1 to 20 mg/kg) were tested as single-dose ... AmBisome is a liposomal formulation of amphotericin B that has broad-spectrum antifungal activity and greatly reduced toxicity ... Distribution of lipid formulations of amphotericin B into bone marrow and fat tissue in rabbits.. *Andreas H Groll, Diana ... AmBisome is a liposomal formulation of amphotericin B that has broad-spectrum antifungal activity and greatly reduced toxicity ...
  https://www.semanticscholar.org/paper/Single-dose-AmBisome-%28Liposomal-amphotericin-B%29-as-Garc%C3%ADa-Adler-Moore/75a7d9b3f78debc4ebda58b9c46d317ade09d64a
*  Candida | Adult and Adolescent Opportunistic Infection | AIDSinfo
Lipid formulation of amphotericin B 3-4 mg/kg IV daily (BIII) ... amphotericin B (either deoxycholate or lipid formulations) and ... Both amphotericin B deoxycholate and the lipid preparations of amphotericin B have been used successfully (BII). Amphotericin B ... On the basis of these data, substitution of amphotericin B for high-dose fluconazole in the first trimester is recommended for ... Krishna G, Ma L, Martinho M, Preston RA, O'Mara E. A new solid oral tablet formulation of posaconazole: a randomized clinical ...
  https://aidsinfo.nih.gov/guidelines/html/4/adult-and-adolescent-opportunistic-infection/331/
*  Biotech's Vibrant Merry Go-Round: Part II | Princeton Info
The firm has the leading lipid-based formulation of amphotericin B in the United States and one marketed product, Abelcet, to ...
  https://princetoninfo.com/biotechs-vibrant-merry-go-round-part-ii/
*  Bioactivity, Safety, and Efficacy of Amphotericin B Nanomicellar Aerosols Using Sodium Deoxycholate Sulfate as the Lipid...
We report nanomicelles of amphotericin B (AmB) using various molar ratios of AmB and sodium deoxycholate sulfate (SDCS) for ... Amphotericin B formulations: a comparative review of efficacy and toxicity. Drugs. 2013;73:919-34.CrossRefPubMedGoogle Scholar ... Dupont B. Overview of the lipid formulations of amphotericin B. J Antimicrob Chemoth. 2002;49:31-6.CrossRefGoogle Scholar ... Torrado J, Espada R, Ballesteros M, Torrado-Santiago S. Amphotericin B formulations and drug targeting. J Pharm Sci. 2008;97: ...
  https://link.springer.com/article/10.1208%2Fs12249-018-1013-4
*  Candidiasis
Amphotericin B has decreased activity against biofilms; liposomal Amphotericin formulations are more active. ... Amphotericin B has decreased activity against biofilms; liposomal Amphotericin formulations are more active. ... Lipid formulations of Amphotericin B (LFAmBs) (IV). (3-5 in guidelines) 5 mg/kg/day. Increased daily dose tolerated & less ... The lipid formulations of Amphotericin B (LFAmBs) are less nephrotoxic; however, as a result they do not penetrate the kidneys ...
  http://www.endocrinologyadvisor.com/pediatrics/candidiasis/article/623590/
*  Fungemia - Wikipedia
The lipid formulation amphotericin B is a reasonable alternative if there is limited antifungal availability, antifungal ...
  https://en.wikipedia.org/wiki/Fungemia
*  Amphotericin B - Wikipedia
As the original formulation of amphotericin, it is often referred to as "conventional" amphotericin. In order to improve the ... They are more expensive than amphotericin B deoxycholate. AmBisome (LAMB) is a liposomal formulation of amphotericin B for ... Two amphotericins, amphotericin A and amphotericin B, are known, but only B is used clinically, because it is significantly ... Amphotericin B alone is insoluble in normal saline at a pH of 7. Therefore, several formulations have been devised to improve ...
  https://en.wikipedia.org/wiki/Amphotericin_B
*  Blastomycosis - Wikipedia
Patients who cannot tolerate deoxycholate formulation of Amphotericin B can be given lipid formulations. Fluconazole has ... Amphotericin B is considerably more toxic, and is usually reserved for immunocompromised patients who are critically ill and ... excellent CNS penetration and is useful where there is CNS involvement after initial treatment with Amphotericin B. Mortality ...
  https://en.wikipedia.org/wiki/Blastomycosis
*  Goliath heron - Wikipedia
Bonar, Christopher J.; Lewandowski, Albert H. (2004). "Use of a Liposomal Formulation of Amphotericin B for Treating Wound ... "Use of a Liposomal Formulation of Amphotericin B for Treating Wound Aspergillosis in a Goliath heron (Ardea goliath)". Journal ...
  https://en.wikipedia.org/wiki/Goliath_heron