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*  FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein
Amyloid precursor protein (APP) facilitates synapse formation in the developing brain, while beta-amyloid (Aβ) accumulation, ... The plaques are predominantly composed of beta-amyloid (Aβ), a 39-42 amino acid peptide cleaved from the amyloid precursor ... amyloid precursor protein. Aβ. beta-amyloid. ELISA. enzyme-linked immunosorbent assay. FMRP. fragile X mental retardation ... Extracellular-regulated kinase controls beta-amyloid precursor protein mRNA decay. Brain Res Mol Brain Res. 2001;90:193-201. [ ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC1808499/?lang=en-ca
*  Amyloid precursor protein - Wikipedia
Ohsawa I, Takamura C, Kohsaka S (Mar 2001). "Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and ... "Synapse formation and function is modulated by the amyloid precursor protein". The Journal of Neuroscience. 26 (27): 7212-21. ... "Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production". Nature. 360 ... a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition". The ...
  https://en.wikipedia.org/wiki/Amyloid_precursor_protein
*  Amyloid beta (A4) precursor protein degradation products - Biology-Online
... resulting in excess of A beta 40 and A beta 42, the formation of A beta deposition as the core of senile plaques and disease. ... including a relatively long extracellular amino terminal peptide fragment, the smaller the A beta protein (the main component ... Amyloid beta (A4) precursor protein degradation products. Debate and discussion of any biological questions not pertaining to a ... Amyloid beta (A4) precursor protein degradation products of the pathogenic role of Alzheimer's disease research progress. APP ...
  https://www.biology-online.org/biology-forum/viewtopic.php?t=25181&p=143084&hilit=fraumeni+syndrome
*  Frontiers | Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1 |...
In Alzheimer's disease (AD), a prevalent protein folding disorder in the brain, the heat shock response of some critical ... In Alzheimer's disease (AD), a prevalent protein folding disorder in the brain, the heat shock response of some critical ... leading to increased synthesis of a class of inducible chaperones known as heat shock proteins (HSP). Although HSP synthesis is ... leading to increased synthesis of a class of inducible chaperones known as heat shock proteins (HSP). Although HSP synthesis is ...
  https://www.frontiersin.org/articles/10.3389/fnins.2017.00192/full
*  Method of use of serum amyloid a protein - Patent # 6004936 - PatentGenius
... native serum amyloid A (SAA) and a ligand having SAA properties thereby increasing the affinity of high density lipoprotein ( ... Narindrasorasak et al., 1991, "High Affinity Interactions Between the Alzheimer's beta-Amyloid Precursor Proteins and the ... As discussed above, preferred ligands will not significantly increase amyloid formation in vivo. Amyloid formation in vivo can ... 1982), "Amino Acid Sequence of Amyloid-Related Apoprotein (apoSAA.sub.1) from Human High-Density Lipoprotein", J. Biochem. 21( ...
  http://www.patentgenius.com/patent/6004936.html
*  Produktübersicht anti-MAPK8IP1 Antikörper
... knockdown of JIP1 did not affect either amyloid precursor protein (zeige APP Antikörper) transport or amyloid-beta peptide ... mitogen-activated protein kinase 8 interacting protein 1 , c-Jun-amino-terminal kinase-interacting protein 1-like , C-Jun-amino ... Data show that small GTPase (zeige RACGAP1 Antikörper) RALA (zeige rala Antikörper) regulates formation of a JIP1 (C-Jun (zeige ... mitogen activated protein kinase 8 interacting protein 1 , mitogen-activated protein kinase 8-interacting protein 1 , protein ...
  https://www.antikoerper-online.de/abstract/Mitogen-Activated+Protein+Kinase+8+Interacting+Protein+1+
*  TCDB » SEARCH
... of type I membrane proteins, including amyloid-beta precursor protein and Notch receptor. A hydrophilic pore is formed by TMS6 ... are critical for the catalytic activity and the formation of the γ-secretase complex. The amino acid residues around the PAL ... Contribution of the gamma-secretase subunits to the formation of catalytic pore of presenilin 1 protein. J Biol Chem. 287(31): ... View Proteins belonging to: The γ-Secretase (γ-Secretase) Family. References associated with 9.B.47 family:. Bolduc, D.M., D.R ...
  http://tcdb.org/search/result.php?tc=9.B.47
*  anti-APP Antikörper (Amyloid beta (A4) Precursor Protein) (AA 18-32)</span...
... to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of ... Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and ... Amyloid beta A4 protein antibody,Amyloid Beta A4 Protein Precursor Isoform A antibody,Amyloid beta A4 protein precursor isoform ... Amyloid beta A4 protein precursor isoform c antibody,Amyloid Beta Peptide antibody,Amyloid beta protein antibody,Amyloid ...
  https://www.antikoerper-online.de/antibody/3044384/anti-Amyloid+beta+A4+Precursor+Protein+APP+AA+18-32,+N-Term+antibody/
*  Alzheimerâ s Disease | Neurofibrillary Tangles | Amyloid-β-protein | Tau Protein
The alluvium of toxic amyloid-β-protein in th.. ... emblems of Alzheimer's disease are the accumulation of amyloid- ... Formation of Aβ-peptides. Amyloid β-precursor protein (AβPP) derives Aβ- peptides [23,28] that is an integral type I ... The adult tau protein isoforms are of 441, 412, 410, 383, 381 amino acids and fetal tau-protein isoform is of 352 amino acids [ ... Role of Amyloid-beta and Hyperphosphorylated Tau Protein. Rabia Sajjad, Rawaba Arif, A. A. Shah1, I. Manzoor1 and G. Mustafa2* ...
  http://www.ijpsonline.com/articles/pathogenesis-of-alzheimers-disease-role-of-amyloidbeta-and-hyperphosphorylated-tau-protein-3505.html?view=mobile
*  Frontiers | Involvement of BDNF in Age-Dependent Alterations in the Hippocampus | Frontiers in Aging Neuroscience
Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein ... The hippocampal formation is innervated by cortical and subcortical areas; however, within the aged forebrain, cell losses in ... The plaques are mainly composed of amyloid beta-peptide (Aß), a 40-42 amino acid fragment of the beta-amyloid precursor (APP), ... Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature 387, 500- ...
  https://www.frontiersin.org/articles/10.3389/fnagi.2010.00036/full
*  Patent US5221607 - Assays and reagents for amyloid deposition - Google Patents
The present invention provides an in vitro tissue culture-based assay for amyloid deposition specific for Alzheimer's disease ... The term "beta-amyloid precursor protein" refers to either the amyloid precursor protein of 695 amino acids (Kang et al., (1987 ... expression of the respective amyloid protein and analysis for preamyloid formation, and (2) production of amyloid antibodies. ... The major protein component of amyloid is an .sup.˜ 4 kilodalton (kd) protein, designated the beta-protein or A4 protein due to ...
  http://www.google.com/patents/US5221607?dq=oakley+D523,461&ei=qiI4T-CjGqXf0QHz_PSUCA
*  Secretases related to alzheimer's dementia - Patent # 6245884 - PatentGenius
... secretase that produce the A.beta. peptides found in the plaques of Alzheimer Dementia (AD) patients. The invention also ... "Evidence that the 42-and 40-amino acid forms of amyloid .beta. protein are generated from the .beta.-amyloid precursor protein ... Agents that effectively reduce or inhibit A.beta. peptide production or amyloid plaque formation or increase memory in any of ... The A.beta. peptides are derived from larger amyloid precursor proteins (APP proteins), which consist of four proteins, ...
  http://www.patentgenius.com/patent/6245884.html
*  The Functions of the Amyloid Precursor Protein Gene and Its Derivative Peptides: II Experimental Evidence and Clinical Studies
In vitro observations indicate Aβ has a role in amyloid formation, excitotoxic neuronal injury, tachykinin interaction, ... and interaction with GTP binding proteins. In vivo experiments show a role in embryonic development, response to cerebral ... In vitro studies suggest Amyloid Precursor Protein Gene (APP) is involved in interaction with the extracellular matrix, neurite ... X. D. Cai, T. E. Golde and S. G. Younkin, "Excess Amyloid Beta-Protein is Released from a Mutant Amyloid Beta Protein Precursor ...
  https://www.scirp.org/journal/PaperInformation.aspx?PaperID=7413
*  Can Micronutrient Intake Alter the Trajectory of Alzheimer's Disease? - News - en US
Amyloid beta monomers are produced when two enzymes (beta-secretase and gamma-secretase) cleave amyloid precursor protein (APP ... The resulting amyloid beta is then released into brain tissue. It is thought that a specific amyloid beta 42 (AB42)(an amino ... One of the hallmarks of the pathology of Alzheimer's disease is the formation of neurotoxic beta amyloid plaques. ... In the healthy brain, amyloid protein acts to help any injury to the brain. However, in Alzheimer's disease the beta-amyloid ...
  http://www.nutri-facts.org/en_US/news/can-micronutrient-intake-alter-the-trajectory-of-alzheimers-disease.html
*  Emile Gervin, Author at LifeDocLifetime
... called amyloid precursor protein. By disrupting neuronal network interaction, formation of these beta-amyloid proteins and ... Beta-amyloid is an important peptide, an amino acid chain from a host protein.. It does leave fragments between neurons that ... Beta-amyloid comes from a larger protein found in the fatty membrane surrounding nerve cells. Beta-amyloid is chemically " ... beta-amyloid, beta-amyloid plaque, dementia, scientists erase Alzheimer-causing gene in human brain , Leave a reply Post ...
  http://lifedoclifetime.com/author/gizny11/
*  NLRP3 Inflammasome: Activation and Regulation in Age-Related Macular Degeneration
D. M. Walsh, I. Klyubin, J. V. Fadeeva et al., "Naturally secreted oligomers of amyloid beta protein potently inhibit ... N. Murphy, B. Grehan, and M. A. Lynch, "Glial uptake of amyloid beta induces NLRP3 inflammasome formation via cathepsin- ... β is generated through the amyloidogenic pathway by cleaving the amyloid precursor protein (APP) into the intramembrane Aβ ... domain of 36-43 amino acids in length [61]. The accumulation of Aβ in tissue results from its disturbed balance between ...
  https://www.hindawi.com/journals/mi/2015/690243/
*  Alzheimer's disease - Wikipedia
... called amyloid beta (Aβ). Aβ is a fragment from the larger amyloid precursor protein (APP). APP is a transmembrane protein that ... Synapse Formation and Function is Modulated by the Amyloid Precursor Protein. The Journal of Neuroscience. 2006;26(27):7212-21 ... and tau protein in the brain. Plaques are made up of small peptides, 39-43 amino acids in length, ... In early 2017, a trial of verubecestat, which inhibits the beta-secretase protein responsible for creating beta-amyloid protein ...
  https://en.wikipedia.org/wiki/Alzheimer's_disease
*  Inclusion Body Myositis: Background, Pathophysiology, Epidemiology
Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein- ... Greenberg SA, Pinkus JL, Amato AA. Nuclear membrane proteins are present within rimmed vacuoles in inclusion-body myositis. ... overexpression of alphaB-crystallin is associated with amyloid precursor protein and accumulation of beta-amyloid. J Neurol ... Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal ...
  https://emedicine.medscape.com/article/1172746-overview
*  IJMS | Free Full-Text | Oxidative Stress and Neurodegenerative Disorders | HTML
Synapse formation and function is modulated by the amyloid precursor protein. J. Neurosci 2006, 26, 7212-7221. [Google Scholar] ... Protein misfolding occurs in AD, manifested by accumulation of abnormally folded beta-amyloid (Aβ) and tau proteins in the ... HPLC is also utilized for determination of protein oxidation products generated by direct oxidation of amino acid residues or ... Hooper, N.M. Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein. Biochem ...
  http://www.mdpi.com/1422-0067/14/12/24438/htm
*  Protocols and Video Articles Authored by Taisuke Tomita
Both secretases are transmembrane proteases: beta-site amyloid-beta precursor protein cleaving enzyme 1, the main neuronal beta ... both being critical for the catalytic activity and the formation of the gamma-secretase complex. We found that the amino acid ... Proteolytic processing of amyloid precursor protein (APP) by beta- and gamma-secretases generates beta-amyloid (Abeta) peptides ... Abeta is generated from amyloid-beta precursor protein by beta- and gamma-secretases, which are plausible molecular targets for ...
  https://www.jove.com/author/Taisuke_Tomita
*  Development of molecular recognition by rational and combinatorial engineering
2. Stabilization of a beta-hairpin in monomeric Alzheimer´s amyloid beta-peptide inhibits amyloid formation. Open this ... which fortunately would indicate that the Affibody molecules should not bind the amyloid precursor protein (APP). In addition, ... Affibody (Affibody) ligands specific for human amyloid beta (Abeta) peptides (40 or 42 amino acid residues in size), involved ... s amyloid beta-peptide inhibits amyloid formation. Hoyer, Wolfgang. Department of Medical Biochemistry, Swedish Nuclear ...
  http://kth.diva-portal.org/smash/record.jsf?pid=diva2:201734
*  Beta-secretase 1 - Wikipedia
Beta-secretase 1 (BACE1), also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 ... Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two ... BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. The transmembrane ... "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE". Science. 286 ( ...
  https://en.wikipedia.org/wiki/Beta-secretase_1
*  bace1, beta-site APP-cleaving enzyme 1 - Creative Biogene
... beta-site amyloid beta A4 precursor protein-cleaving enzyme; BACE, beta site APP cleaving enzyme; FLJ90568; KIAA1149; C76936; ... The production of 40 or 42 amino acids long amyloid-β peptide accumulated in the brain is the central pathological feature of ... reduction in the formation of amyloidogenic peptides in vitro. The A673T substitution is located at position 2 in the amyloid-β ... Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is ...
  https://www.creative-biogene.com/symbolsearch_bace1.html
*  Angus Clark Nairn, PhD > Psychiatry | Yale School of...
Protein phosphorylation regulates relative utilization of processing pathways for Alzheimer beta/A4 amyloid precursor protein. ... Amyloid beta peptide formation in cell-free preparations. Regulation by protein kinase C, calmodulin, and calcineurin. J Biol ... Huang HB, Horiuchi A, Goldberg J, Greengard P, Nairn AC: Site-directed mutagenesis of amino acid residues of protein ... Phosphorylation of the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein at Ser655 by a novel protein kinase. ...
  http://medicine.yale.edu/psychiatry/people/angus_nairn-2.profile
*  Alzheimer's disease - OurMed
... amyloid precursor protein) and cut it into fragments. The beta-amyloid fragment is crucial in the formation of senile plaques ... Plaques are made up of small peptides, 39-43 amino acids in length, called beta-amyloid (also written as A-beta or Aβ). Beta- ... amyloid is a fragment from a larger protein called amyloid precursor protein (APP), a transmembrane protein that penetrates ... It is a compelling theory because the gene for the amyloid beta precursor (APP) is located on chromosome 21, and people with ...
  http://ourmed.org/wiki/Alzheimer%27s_disease