*  FMRP Mediates mGluR5-Dependent Translation of Amyloid Precursor Protein
Amyloid precursor protein (APP) facilitates synapse formation in the developing brain, while beta-amyloid (Aβ) accumulation, ... The plaques are predominantly composed of beta-amyloid (Aβ), a 39-42 amino acid peptide cleaved from the amyloid precursor ... amyloid precursor protein. Aβ. beta-amyloid. ELISA. enzyme-linked immunosorbent assay. FMRP. fragile X mental retardation ... Extracellular-regulated kinase controls beta-amyloid precursor protein mRNA decay. Brain Res Mol Brain Res. 2001;90:193-201. [ ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC1808499/?lang=en-ca
*  Amyloid beta (A4) precursor protein degradation products - Biology-Online
... resulting in excess of A beta 40 and A beta 42, the formation of A beta deposition as the core of senile plaques and disease. ... including a relatively long extracellular amino terminal peptide fragment, the smaller the A beta protein (the main component ... Amyloid beta (A4) precursor protein degradation products. Debate and discussion of any biological questions not pertaining to a ... Amyloid beta (A4) precursor protein degradation products of the pathogenic role of Alzheimer's disease research progress. APP ...
  https://www.biology-online.org/biology-forum/viewtopic.php?t=25181&p=143084&hilit=fraumeni+syndrome
*  Amyloid precursor protein - Wikipedia
Ohsawa I, Takamura C, Kohsaka S (Mar 2001). "Fibulin-1 binds the amino-terminal head of beta-amyloid precursor protein and ... "Synapse formation and function is modulated by the amyloid precursor protein". The Journal of Neuroscience. 26 (27): 7212-21. ... "Mutation of the beta-amyloid precursor protein in familial Alzheimer's disease increases beta-protein production". Nature. 360 ... a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition". The ...
  https://en.wikipedia.org/wiki/Amyloid_precursor_protein
*  Frontiers | Molecular Chaperone Accumulation in Cancer and Decrease in Alzheimer's Disease: The Potential Roles of HSF1 |...
In Alzheimer's disease (AD), a prevalent protein folding disorder in the brain, the heat shock response of some critical ... In Alzheimer's disease (AD), a prevalent protein folding disorder in the brain, the heat shock response of some critical ... leading to increased synthesis of a class of inducible chaperones known as heat shock proteins (HSP). Although HSP synthesis is ... leading to increased synthesis of a class of inducible chaperones known as heat shock proteins (HSP). Although HSP synthesis is ...
  https://www.frontiersin.org/articles/10.3389/fnins.2017.00192/full
*  Method of use of serum amyloid a protein - Patent # 6004936 - PatentGenius
... native serum amyloid A (SAA) and a ligand having SAA properties thereby increasing the affinity of high density lipoprotein ( ... Narindrasorasak et al., 1991, "High Affinity Interactions Between the Alzheimer's beta-Amyloid Precursor Proteins and the ... As discussed above, preferred ligands will not significantly increase amyloid formation in vivo. Amyloid formation in vivo can ... 1982), "Amino Acid Sequence of Amyloid-Related Apoprotein (apoSAA.sub.1) from Human High-Density Lipoprotein", J. Biochem. 21( ...
  http://www.patentgenius.com/patent/6004936.html
*  TCDB » SEARCH
... of type I membrane proteins, including amyloid-beta precursor protein and Notch receptor. A hydrophilic pore is formed by TMS6 ... are critical for the catalytic activity and the formation of the γ-secretase complex. The amino acid residues around the PAL ... Contribution of the gamma-secretase subunits to the formation of catalytic pore of presenilin 1 protein. J Biol Chem. 287(31): ... View Proteins belonging to: The γ-Secretase (γ-Secretase) Family. References associated with 9.B.47 family:. Bolduc, D.M., D.R ...
  http://tcdb.org/search/result.php?tc=9.B.47
*  anti-APP Antikörper (Amyloid beta (A4) Precursor Protein) (AA 18-32)</span...
... to 42-amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of ... Its primary function is not known, though it has been implicated as a regulator of synapse formation, neural plasticity and ... Amyloid beta A4 protein antibody,Amyloid Beta A4 Protein Precursor Isoform A antibody,Amyloid beta A4 protein precursor isoform ... Amyloid beta A4 protein precursor isoform c antibody,Amyloid Beta Peptide antibody,Amyloid beta protein antibody,Amyloid ...
  https://www.antikoerper-online.de/antibody/3044384/anti-Amyloid+beta+A4+Precursor+Protein+APP+AA+18-32,+N-Term+antibody/
*  Frontiers | Involvement of BDNF in Age-Dependent Alterations in the Hippocampus | Frontiers in Aging Neuroscience
Age-related learning deficits in transgenic mice expressing the 751-amino acid isoform of human beta-amyloid precursor protein ... The hippocampal formation is innervated by cortical and subcortical areas; however, within the aged forebrain, cell losses in ... The plaques are mainly composed of amyloid beta-peptide (Aß), a 40-42 amino acid fragment of the beta-amyloid precursor (APP), ... Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature 387, 500- ...
  https://www.frontiersin.org/articles/10.3389/fnagi.2010.00036/full
*  Patent US5221607 - Assays and reagents for amyloid deposition - Google Patents
The present invention provides an in vitro tissue culture-based assay for amyloid deposition specific for Alzheimer's disease ... The term "beta-amyloid precursor protein" refers to either the amyloid precursor protein of 695 amino acids (Kang et al., (1987 ... expression of the respective amyloid protein and analysis for preamyloid formation, and (2) production of amyloid antibodies. ... The major protein component of amyloid is an .sup.˜ 4 kilodalton (kd) protein, designated the beta-protein or A4 protein due to ...
  http://www.google.com/patents/US5221607?dq=oakley+D523,461&ei=qiI4T-CjGqXf0QHz_PSUCA
*  Secretases related to alzheimer's dementia - Patent # 6245884 - PatentGenius
... secretase that produce the A.beta. peptides found in the plaques of Alzheimer Dementia (AD) patients. The invention also ... "Evidence that the 42-and 40-amino acid forms of amyloid .beta. protein are generated from the .beta.-amyloid precursor protein ... Agents that effectively reduce or inhibit A.beta. peptide production or amyloid plaque formation or increase memory in any of ... The A.beta. peptides are derived from larger amyloid precursor proteins (APP proteins), which consist of four proteins, ...
  http://www.patentgenius.com/patent/6245884.html
*  Can Micronutrient Intake Alter the Trajectory of Alzheimer's Disease? - News - en US
Amyloid beta monomers are produced when two enzymes (beta-secretase and gamma-secretase) cleave amyloid precursor protein (APP ... The resulting amyloid beta is then released into brain tissue. It is thought that a specific amyloid beta 42 (AB42)(an amino ... One of the hallmarks of the pathology of Alzheimer's disease is the formation of neurotoxic beta amyloid plaques. ... In the healthy brain, amyloid protein acts to help any injury to the brain. However, in Alzheimer's disease the beta-amyloid ...
  http://www.nutri-facts.org/en_US/news/can-micronutrient-intake-alter-the-trajectory-of-alzheimers-disease.html
*  Inclusion Body Myositis: Background, Pathophysiology, Epidemiology
Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein- ... Greenberg SA, Pinkus JL, Amato AA. Nuclear membrane proteins are present within rimmed vacuoles in inclusion-body myositis. ... overexpression of alphaB-crystallin is associated with amyloid precursor protein and accumulation of beta-amyloid. J Neurol ... Transfer of beta-amyloid precursor protein gene using adenovirus vector causes mitochondrial abnormalities in cultured normal ...
  https://emedicine.medscape.com/article/1172746-overview
*  IJMS | Free Full-Text | Oxidative Stress and Neurodegenerative Disorders | HTML
Synapse formation and function is modulated by the amyloid precursor protein. J. Neurosci 2006, 26, 7212-7221. [Google Scholar] ... Protein misfolding occurs in AD, manifested by accumulation of abnormally folded beta-amyloid (Aβ) and tau proteins in the ... HPLC is also utilized for determination of protein oxidation products generated by direct oxidation of amino acid residues or ... Hooper, N.M. Roles of proteolysis and lipid rafts in the processing of the amyloid precursor protein and prion protein. Biochem ...
  http://www.mdpi.com/1422-0067/14/12/24438/htm
*  Alzheimer's disease - Wikipedia
... called amyloid beta (Aβ). Aβ is a fragment from the larger amyloid precursor protein (APP). APP is a transmembrane protein that ... Synapse Formation and Function is Modulated by the Amyloid Precursor Protein. The Journal of Neuroscience. 2006;26(27):7212-21 ... and tau protein in the brain. Plaques are made up of small peptides, 39-43 amino acids in length, ... In early 2017, a trial of verubecestat, which inhibits the beta-secretase protein responsible for creating beta-amyloid protein ...
  https://en.wikipedia.org/wiki/Alzheimer's_disease
*  Development of molecular recognition by rational and combinatorial engineering
2. Stabilization of a beta-hairpin in monomeric Alzheimer´s amyloid beta-peptide inhibits amyloid formation. Open this ... which fortunately would indicate that the Affibody molecules should not bind the amyloid precursor protein (APP). In addition, ... Affibody (Affibody) ligands specific for human amyloid beta (Abeta) peptides (40 or 42 amino acid residues in size), involved ... s amyloid beta-peptide inhibits amyloid formation. Hoyer, Wolfgang. Department of Medical Biochemistry, Swedish Nuclear ...
  http://kth.diva-portal.org/smash/record.jsf?pid=diva2:201734
*  Beta-secretase 1 - Wikipedia
Beta-secretase 1 (BACE1), also known as beta-site amyloid precursor protein cleaving enzyme 1, beta-site APP cleaving enzyme 1 ... Generation of the 40 or 42 amino acid-long amyloid-β peptides that aggregate in the brain of Alzheimer's patients requires two ... BACE1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells. The transmembrane ... "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE". Science. 286 ( ...
  https://en.wikipedia.org/wiki/Beta-secretase_1
*  Angus Clark Nairn, PhD > Psychiatry | Yale School of...
Protein phosphorylation regulates relative utilization of processing pathways for Alzheimer beta/A4 amyloid precursor protein. ... Amyloid beta peptide formation in cell-free preparations. Regulation by protein kinase C, calmodulin, and calcineurin. J Biol ... Huang HB, Horiuchi A, Goldberg J, Greengard P, Nairn AC: Site-directed mutagenesis of amino acid residues of protein ... Phosphorylation of the cytoplasmic domain of Alzheimer's beta-amyloid precursor protein at Ser655 by a novel protein kinase. ...
  http://medicine.yale.edu/psychiatry/people/angus_nairn-2.profile
*  Alzheimer's disease - OurMed
... amyloid precursor protein) and cut it into fragments. The beta-amyloid fragment is crucial in the formation of senile plaques ... Plaques are made up of small peptides, 39-43 amino acids in length, called beta-amyloid (also written as A-beta or Aβ). Beta- ... amyloid is a fragment from a larger protein called amyloid precursor protein (APP), a transmembrane protein that penetrates ... It is a compelling theory because the gene for the amyloid beta precursor (APP) is located on chromosome 21, and people with ...
  http://ourmed.org/wiki/Alzheimer%27s_disease
*  A Window into the Heterogeneity of Human Cerebrospinal Fluid Aβ Peptides
... in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation," Journal of ... "Amino-terminal modification and tyrosine phosphorylation of carboxy-terminal fragments of the amyloid precursor protein in ... A. Garcia-Osta and C. M. Alberini, "Amyloid beta mediates memory formation," Neurobiology of Learning and Memory, vol. 16, no. ... C. Hock, S. Golombowski, F. Müller-Spahn et al., "Cerebrospinal fluid levels of amyloid precursor protein and amyloid β-peptide ...
  https://www.hindawi.com/journals/bmri/2011/697036/
*  Fight Aging! Newsletter, August 7th 2017 - Fight Aging!
Scientists have identified a couple of crucial steps in the formation of a protein called amyloid beta, which accumulates in ... They found that the amino acid substitution affected where the precursor protein was cleaved. The Icelandic mutation resulted ... Those discoveries inspired efforts at disrupting the biochemical carving of amyloid beta's precursor protein into its final, ... According to the study, the APP A673T gene variant, which is a variant in the amyloid precursor protein gene protecting against ...
  https://www.fightaging.org/archives/2017/08/fight-aging-newsletter-august-7th-2017/
*  Insulin-degrading enzyme - Wikipedia
... amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo". Proceedings of the National Academy ... 45.2 kDa in size and composed of 464 amino acids (missing 1-555 amino acids). The calculated theoretical pI of this protein ... though the primary neuropathology observed is the formation of amyloid plaques and neurofibrillary tangles. One hypothesized ... Kerr ML, Small DH (Apr 2005). "Cytoplasmic domain of the beta-amyloid protein precursor of Alzheimer's disease: function, ...
  https://en.wikipedia.org/wiki/Insulin-degrading_enzyme
*  Search results | ALZFORUM
... mutations in the amyloidprotein (Aβ) precursor, APP, result in single amino acid substitutions in Aβ. These substitutions, ... David Teplow on Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering.. COMMENT Less Is More... ... COMMENT The Enron Collapse and Amyloid Formation What, you might ask, could the Enron collapse have to do with amyloid ... David Teplow on Functional amyloid formation within mammalian tissue.. COMMENT Functional amyloid and nonfunctional ...
  https://www.alzforum.org/search?fq%5B%5D=entity_type:comment&fq%5B%5D=tm_comment_authors_full_name:Teplow,%20David
*  A new kid on the Alzheimer's block | Chemiotics II
The APP (for amyloid precursor protein) contains anywhere from 563 to 770 amino acids in 5 distinct transcripts made by… ... and it may explain why the huge sums thrown at beta-secretase inhibitors by big pharma has been such an abject failure. First, ... to find out just at what amino acids of the amyloid precursor protein(s) the 3 secretases (alpha, beta, gamma) cleave. ... Another set of carboxy terminal fragments (CTFs) called CTFneta is formed from the amyloid precurosr protein (APP). Formation ...
  https://luysii.wordpress.com/2015/10/21/a-new-kid-on-the-alzheimers-block/
*  Frontiers | Metals and cholesterol: two sides of the same coin in Alzheimer's disease pathology | Frontiers in Aging...
Pathological hallmarks of AD include the accumulation of β-amyloid in plaques and hyperphosphorylated tau in neurofibrillary ... Pathological hallmarks of AD include the accumulation of β-amyloid in plaques and hyperphosphorylated tau in neurofibrillary ... beta-amyloid (Abeta) and apoE/Abeta complexes on protein kinase C-alpha (PKC-alpha) translocation and amyloid precursor protein ... 2009). Restored degradation of the Alzheimer's amyloid-beta peptide by targeting amyloid formation. J. Neurochem. 108, 1198- ...
  https://www.frontiersin.org/articles/10.3389/fnagi.2014.00091/full
*  Lipid Metabolism sub-cluster 51
Amyloid deposits consist of accumulations of beta-amyloid (Abeta), which is a 39-43 amino-acid peptide cleaved from the Abeta- ... protein precursor (APP). Another cleavage product of APP is the P3-peptide, which consists of the amino acids 17-42 of ... ... Effects of N-methacryloyl amino acid applications on hybrid layer formation at the ... ... Identification of amino acids is extremely important for the evaluation of protein structure. Thin layer chromatography is an ...
  http://www.biomedsearch.com/cluster/14/Lipid-Metabolism/sub-51-p9.html