*  FANCG - Wikipedia
Fanconi anemia group G protein is a protein that in humans is encoded by the FANCG gene. FANCG, involved in Fanconi anemia, confers resistance to both hygromycin B and mitomycin C. FANCG contains a 5-prime GC-rich untranslated region characteristic of housekeeping genes. The putative 622-amino acid protein has a leucine-zipper motif at its N-terminus. Fanconi anemia is an autosomal recessive disorder with diverse clinical symptoms, including developmental anomalies, bone marrow failure, and early occurrence of malignancies. A minimum of 8 FA genes have been identified. The FANCG gene is responsible for complementation group G. The clinical phenotype of all Fanconi anemia (FA) complementation groups is similar. This phenotype is characterized ...
  https://en.wikipedia.org/wiki/FANCG
*  OriGene - FANCG (NM 004629) cDNA Clone
FANCG - FANCG (untagged)-Human Fanconi anemia, complementation group G (FANCG) available for purchase from OriGene - Your Gene Company.
  http://www.origene.com/human_cdna/NM_004629/SC117235.aspx
*  HES1 is a novel interactor of the Fanconi anemia core complex | Blood Journal
Although the FA pathway has been linked to DNA-damage responses, the specific biochemical function of each FA protein (separately or in the context of the FA complex/pathway) remains unclear. In particular, functions that would explain the disease phenotype, stem cell defects leading to bone marrow failure, and developmental abnormalities have been elusive. Our data presented here provide the first evidence linking FA proteins to HES1, a protein involved in stem cell function and developmental processes. We found that FA core complex components (FANCA, FANCG, FANCF, and FANCL) interact directly with HES1 and are present in HES1 immunocomplexes, implying that HES1 is a novel FA core complex interacting protein. We also found that HES1 is detected in immunocomplexes using antibodies directed against multiple FA core complex proteins (FANCA, FANCG, and FANCC), whereas reciprocal immunoprecipitation using anti-HES1 antibodies ...
  http://www.bloodjournal.org/content/112/5/2062.long?sso-checked=true
*  Fanconi Anemia Therapeutics Market - Technology & Market Analysis - 2016 to 2020 | Healthcare
Before It's News). Fanconi Anemia Therapeutics market report covers research informatics related to Fanconi Anemia Therapeutics clinical trials, such as a listing of industry and sponsored clinical trials as well as new drug therapies.. Designed to be a resource both for patients interested in participating in Fanconi Anemia Therapeutics clinical trials and for research professionals.. The report, "Fanconi Anemia Therapeutics Global Clinical Trials Review, H2, 2016″ provides an overview of Fanconi Anemia Therapeutics clinical trials scenario. This report provides top line data relating to the clinical trials on Fanconi Anemia Therapeutics. Report includes an overview of trial numbers and their average enrolment in top countries conducted across the globe. The report also offers coverage of disease clinical ...
  http://beforeitsnews.com/healthcare/2016/11/fanconi-anemia-therapeutics-market-technology-market-analysis-2016-to-2020-2487142.html
*  DNA repair protein complementing XP-G cells
This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011 ...
  https://pharos.nih.gov/idg/targets/P28715
*  FANCG | definition of FANCG by Medical dictionary
Looking for online definition of FANCG in the Medical Dictionary? FANCG explanation free. What is FANCG? Meaning of FANCG medical term. What does FANCG mean?
  http://medical-dictionary.thefreedictionary.com/FANCG
*  Crystallizing Fanconi Anemia Proteins | Science Signaling
Fanconi anemia (FA) is characterized by hypersensitivity to DNA interstrand cross-linking agents. The resulting genomic instability is thought to underlie early-onset cancer, bone marrow failure, and other problems seen in the disease. Central to the FA DNA repair pathway is the Fanconi anemia I-Fanconi anemia D2 (ID) complex formed by the FANCD2 and FANCI proteins, which localize to sites of DNA repair. Joo et al. determined the crystal structure of the mouse ID complex and the isolated FANCI protein. The complex has a trough-like shape, with the monoubiquitination sites within the ID interface, at the bottom of the electropositive trough, in two solvent-accessible tunnels that could each accommodate a ubiquitin tail. The trough forms a series of grooves that, in FANCI, are able to bind to a Y-shaped fragment of DNA, suggesting how the complex might bind to a replication ...
  http://stke.sciencemag.org/content/4/182/ec202
*  Fanconi Anemia Research Community - OpenWetWare
Welcome to the Fanconi Anemia Research Community ,wikionly,wiki,/wikionly,,nonwikionly,website.,/nonwikionly,. We are researchers interested in understanding how the Fanconi anemia proteins contribute to the maintenance of genomic stability with the goal of developing better treatments for Fanconi patients. Because this is a wiki, you can add a website for your lab, find out about other labs doing Fanconi research, start or participate in discussions, find out about research materials, post results for other researchers to see, and more. To begin, you'll need an OpenWetWare account. See this page to sign up. Need help? Consult the getting started tutorial. ...
  https://openwetware.org/wiki/?title=Fanconi_Anemia_Research_Community&oldid=76624
*  Plus it
We then examined the levels of mRNA of five FA genes (FANCA, FANCC, FANCE, FANCF, and FANCG) in nine CC cell lines. The FANCA, FANCC, FANCE, and FANCG genes showed no evidence of decreased expression (data not shown). However, the FANCF gene showed a down-regulated expression in all three cell lines (SiHa, SW756, and ME-180) that exhibited promoter hypermethylation (Fig. 2A) ⇓ . In addition, three other cell lines (C-4I, MS751, and HeLa), which did not show promoter methylation, also showed down-regulated FANCF mRNA compared with normal cervix (Fig. 2A ⇓ ; Table 1 ⇓ ). Overall, six of nine (66.6%) cell lines exhibited FANCF gene down-regulation. Thus, the present results suggest that FANCF is inactivated by mechanisms other than complete methylation of its promoter such as partial methylation or mutation. To evaluate the latter possibility, we examined mutations in the coding region in a panel of 16 methylated and 16 unmethylated CC. No nonsense or frameship mutations could be found. ...
  http://cancerres.aacrjournals.org/content/64/9/2994
*  Fanconi Anemia 101: A Primer for Scientists | Fanconi Anemia Research Fund
This video presentation of fundamental Fanconi anemia information, or "FA 101", was recorded at the Fanconi Anemia Research Fund's 21st Annual Scientific Symposium, held in Baltimore, Maryland in 2009. The presentation runs about one hour and 25 minutes in length.. ...
  http://fanconi.org/index.php/research/fanconi_anemia_101
*  Home | Fanconi Anemia Research Fund
Fanconi anemia is an inherited disease that can lead to bone marrow failure and cancer. Though considered primarily a blood disease, FA may affect all systems of the body. It is a complex and chronic disorder that is psychologically demanding. FA is also a cancer-prone disease, affecting patients decades earlier than the general population.. Lynn and Dave Frohnmayer started the Fanconi Anemia Research Fund, in 1989 to find effective treatments and a cure for Fanconi anemia and to provide education and support services to affected families worldwide.. Learn more about Fanconi anemia and the Fanconi Anemia Research Fund here.. resources for familiesresearchers/cliniciansdonate. ...
  http://fanconi.org
*  FANCG polyclonal antibody - (PAB6485) - Products - Abnova
Goat polyclonal antibody raised against synthetic peptide of FANCG. A synthetic peptide corresponding to human FANCG. (PAB6485) - Products - Abnova
  http://www.abnova.com/products/products_detail.asp?catalog_id=PAB6485
*  FANCA Gene - GeneCards | FANCA Protein | FANCA Antibody
Complete information for FANCA gene (Protein Coding), Fanconi Anemia Complementation Group A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=FANCA
*  FAAP24 Gene - GeneCards | FAP24 Protein | FAP24 Antibody
Complete information for FAAP24 gene (Protein Coding), Fanconi Anemia Core Complex Associated Protein 24, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
  http://www.genecards.org/cgi-bin/carddisp.pl?gene=FAAP24
*  current treatment for Fanconi anemia | From Doctor
Fanconi anemia is an inherited disease, classified as a rare disease, and is caused, due to problems in DNA repair that cause a deficit in ...
  https://fromdoctor.com/tag/current-treatment-for-fanconi-anemia
*  Use of Antioxidants to Stabilize Fanconi Anemia
Combination of lipoic acid and N-acetylcysteine can stabilize the DNA of blood cells from Fanconi anemia (FA) patients, says study.
  http://www.medindia.net/news/use-of-antioxidants-to-stabilize-fanconi-anemia-101348-1.htm
*  Difference between revisions of "Stacie Stone" - OpenWetWare
Caretaker' type gene diseases, such as Fanconi Anemia (FA), provide an opportunity to understand the fundamental mechanisms of host susceptibility to cancer. Unlike many caretaker gene diseases, where the defects have been associated with specific molecular processes, the precise underlying molecular defect in FA is unknown. Although recent developments in the FA field have furthered our understanding of the FA pathway and its role in genomic stability, there are still unidentified FA patient groups, which means there are still unidentified FA genes. Until all the FA proteins, their complexes, and other important functional cofactors that impact the FA pathway are identified we are missing necessary pieces to complete the FA pathway puzzle. ...
  https://openwetware.org/wiki/?title=Stacie_Stone&diff=175494&oldid=175493
*  Difference between revisions of "Stacie Stone" - OpenWetWare
Caretaker' type gene diseases, such as Fanconi Anemia (FA), provide an opportunity to understand the fundamental mechanisms of host susceptibility to cancer. Unlike many caretaker gene diseases, where the defects have been associated with specific molecular processes, the precise underlying molecular defect in FA is unknown. Although recent developments in the FA field have furthered our understanding of the FA pathway and its role in genomic stability, there are still unidentified FA patient groups, which means there are still unidentified FA genes. Until all the FA proteins, their complexes, and other important functional cofactors that impact the FA pathway are identified we are missing necessary pieces to complete the FA pathway puzzle. ...
  https://openwetware.org/wiki/?title=Stacie_Stone&diff=248437&oldid=248435
*  Stacie Stone - OpenWetWare
Caretaker' type gene diseases, such as Fanconi Anemia (FA), provide an opportunity to understand the fundamental mechanisms of host susceptibility to cancer. Unlike many caretaker gene diseases, where the defects have been associated with specific molecular processes, the precise underlying molecular defect in FA is unknown. Although recent developments in the FA field have furthered our understanding of the FA pathway and its role in genomic stability, there are still unidentified FA patient groups, which means there are still unidentified FA genes. Until all the FA proteins, their complexes, and other important functional cofactors that impact the FA pathway are identified we are missing necessary pieces to complete the FA pathway puzzle. ...
  https://openwetware.org/wiki/?title=Stacie_Stone&oldid=285940
*  Eisele, David W.
Downregulation of Fanconi anemia genes in sporadic head and neck squamous cell carcinoma. ORL; journal for oto-rhino-laryngology and its related specialties. 2007 ...
  http://vivo.med.cornell.edu/display/person946960906
*  Difference between revisions of "Hoatlin:Publications" - OpenWetWare
Sobeck, A., Stone, S. Costanzo, V., de Graaf, B., Reuter, T. de Winter, J., Wallisch, M., Akkari, Y., Olson, S., Wang, W., Joenje, H., Christian, J., Lupardus, P. L., Cimprich, K.A., Gautier, J., and Hoatlin, M. E. Fanconi Anemia Proteins are Required to Prevent Accumulation of Replication-Associated DNA Double Strand Breaks. Mol Cell Biol. 2006 Jan;26(2):425-37. [http://mcb.asm.org/content/vol26/issue24/index.dtl Cover] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16382135 abstract] [[Media:Sobecketal.pdf,PDF reprint]],font color ...
  https://openwetware.org/wiki/?title=Hoatlin:Publications&diff=492078&oldid=106365
*  Difference between revisions of "Hoatlin:Publications" - OpenWetWare
Sobeck, A., Stone, S. Costanzo, V., de Graaf, B., Reuter, T. de Winter, J., Wallisch, M., Akkari, Y., Olson, S., Wang, W., Joenje, H., Christian, J., Lupardus, P. L., Cimprich, K.A., Gautier, J., and Hoatlin, M. E. Fanconi Anemia Proteins are Required to Prevent Accumulation of Replication-Associated DNA Double Strand Breaks. Mol Cell Biol. 2006 Jan;26(2):425-37. [http://mcb.asm.org/content/vol26/issue24/index.dtl Cover] [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=16382135 abstract] [[Media:Sobecketal.pdf,PDF reprint]],font color ...
  https://openwetware.org/wiki/?title=Hoatlin:Publications&diff=492078&oldid=106367
*  FANCA Gene mutation; responsible for early onset of Cancer - AgriHunt
Safa Khalid. BS (hons) Bioinformatics. University of Agriculture, Faisalabad. ABSTRACT:. FANCA gene is responsible for the activation of DNA repair pathway. Due to genetic mutations, this gene could not work properly thus leading to the uncontrolled production of abnormal cells i.e. Cancer. This article presents how FANCA gene is involved in the early onset of Cancer.. ARTICLE:. Cancer is not a single, rather a group of diseases that involve abnormal growth of body cells. These abnormal cells are capable of invading or spreading to other parts as well. About 14.1 million people suffer from cancer each year. This deadly disease causes nearly 8.8 million deaths annually. In 2012, about 165,000 children under the age of 15 years were diagnosed with cancer. People in old age are more likely to suffer from cancer and the risk of this disease is increasing due to the changed lifestyle of developing countries. 90-95% of cancer types are caused by genetic mutations from the environmental factors ...
  https://agrihunt.com/articles/breeding-and-genetics/fanca-gene-mutation-responsible-for-early-onset-of-cancer/
*  FANCC MaxPab mouse polyclonal antibody (B01) - (H00002176-B01) - Products - Abnova
Mouse polyclonal antibody raised against a full-length human FANCC protein. FANCC (NP_000127.2, 1 a.a. ~ 558 a.a) full-length human protein. (H00002176-B01) - Products - Abnova
  http://www.abnova.com/products/products_detail.asp?catalog_id=H00002176-B01
*  OriGene - FANCC (NM 000136) shRNA
FANCC - FANCC - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector shRNA available for purchase from OriGene - Your Gene Company.
  http://www.origene.com/shrna/TG313069.aspx