Top Five Examples of Overdiagnosis and Unnecessary Treatment | Public Citizen
False-positive tests are likely to lead to harm through unnecessary invasive procedures, overtreatment, and misdiagnosis. ... only if generic statins cause clinical reactions or do not achieve LDL cholesterol goals. ... Pharmaceutical Industry Is Biggest Defrauder of the Federal Government under the False Claims Act, New Public Citizen Study ... Only lipid screening [cholesterol, etc.] yielded significant numbers of positive results among asymptomatic patients. ...https://www.citizen.org/our-work/health-and-safety/top-five-examples-overdiagnosis-and-unnecessary-treatment
Validation of a Novel Assay to Distinguish Bacterial and Viral Infections | Articles | Pediatrics
FN, false-negative; FP, false-positive; TN, true-negative; TP, true-positive. ... First, microbiological polymerase chain reaction analysis of nasal swabs to detect common respiratory viral and bacterial ... significantly reducing both false-negatives (potentially reducing missed bacterial infections) and false-positives (potentially ... and 21 false-positive outcomes (patients with viral reference standard and bacterial assay outcomes). The cohort included 6 ...http://pediatrics.aappublications.org/content/140/4/e20163453.long
Journal of Pediatrics Review - Zika Virus, Congenital Infection, and Neurologic Manifestations in Children: A Narrative Review
However, false-positive test results could be detected in patients infected with other flaviviruses; in fact, a negative test ... confirmed by reverse transcription-polymerase chain reaction (RT-PCR) assay (24). These women had manifestations compatible ... A positive RT-PCR of serum or urine samples approves congenital ZIKV infection. Also, positive Zika virus IgM test results, ... Children with positive results for congenital ZIKV infection should undergo ophthalmologic and hearing (by auditory brainstem ...http://jpediatricsreview.com/en/articles/9813.html
False positive reaction of the immunohistochemistry technique using anti-BCG polyclonal antibodies to identify Mycobacterium...
... and Gram positive bacteria cocci, showed false positive reaction by the BCG marker. the authors discuss the use of the ... False positive reaction of the immunohistochemistry technique using anti-BCG polyclonal antibodies to identify Mycobacterium ... False positive reaction of the immunohistochemistry technique using anti-BCG polyclonal antibodies to identify Mycobacterium ...http://repositorio.unifesp.br/handle/11600/27902
Tubersol Dosage Guide - Drugs.com
False Positive Reactions. False positive tuberculin reactions can occur in individuals who have been infected with other ... Negative Reactions. An individual who does not show a positive reaction to 5 TU on the first test, but is suspected of being TB ... False-Negative Reactions. Not all infected persons will have a delayed hypersensitivity reaction to a tuberculin test. ... Persons showing positive tuberculin reactions should be considered positive by current public health guidelines and referred ...https://www.drugs.com/dosage/tubersol.html
RNA Therapeutics - & related info | Mendeley
False Positive Reactions. *Functional genomics. *GSK461364. *Gene Expression. *Gene Expression Regulation. *Genetic ...https://www.mendeley.com/research-papers/rna-therapeutics-1/
Hematologic scoring system in early diagnosis of sepsis in neutropenic newborns.
False Positive Reactions. Hematologic Tests*. Humans. Infant, Newborn. Infant, Premature, Diseases / blood, diagnosis, etiology ... 16.5%; P , 0.001). On the initial test a positive screen (scores , or = 3) identified 26 of 28 infants with sepsis or probable ... infection (sensitivity 93%; specificity 82%; positive and negative predictive values 50 and 98%, respectively). Corresponding ...http://www.biomedsearch.com/nih/Hematologic-scoring-system-in-early/8327296.html
Sentinel lymph node biopsy is unsuitable for routine practice in younger female patients with unilateral low-risk papillary...
False Negative Reactions. False Positive Reactions. Female. Humans. Lymph Nodes / pathology*, radionuclide imaging. Methylene ... true positive)/(true positive + false negative); and specificity = (true negative)/(true negative + false positive). All data ... Of the 28 with positive cervical nodes, 7(25%) had metastases detected only in non-positive SLNs, thus giving a false-negative ... The incidence of positive lymph nodes was 65.5%, successful identification of SLN 93.3%, false-negative rate 25.6%, and ...http://www.biomedsearch.com/nih/Sentinel-lymph-node-biopsy-unsuitable/21888655.html
Reintervention as a clinical trial endpoint after peripheral arterial bypass surgery.
False Positive Reactions. Femoral Artery / surgery*. Follow-Up Studies. Graft Survival. Humans. Ischemia / surgery*. Leg / ...http://www.biomedsearch.com/nih/Reintervention-as-clinical-trial-endpoint/11578295.html
Cardiac enzymes. How to use serial determinations to confirm acute myocardial infarction.
False Positive Reactions. Humans. Immunoassay / standards. Isoenzymes. L-Lactate Dehydrogenase / blood*. Myocardial Infarction ...http://www.biomedsearch.com/nih/Cardiac-enzymes-How-to-use/1437917.html
Reduction of the HIV seroconversion window period and false positive rate by using ADVIA Centaur HIV antigen/antibody combo...
Reduction of the HIV seroconversion window period and false positive rate by using ADVIA Centaur HIV antigen/antibody combo ... False Positive Reactions. *Female. *HIV Antibodies (blood, immunology) *HIV Core Protein p24 (blood, immunology) ... To evaluate false-positivity and specificity, 54 HIV false-positive and HIV-negative serum samples from 100 hospitalized ... Reduction of the HIV seroconversion window period and false positive rate by using ADVIA Centaur HIV antigen/antibody combo ...http://www.curehunter.com/public/pubmed24205491.do
Cytomegalovirus (CMV) Clinical Presentation: History, Physical, Causes
False-positive reactions have resulted from the presence of rheumatoid factors.  ... Saliva polymerase-chain-reaction assay for cytomegalovirus screening in newborns. N Engl J Med. 2011 Jun 2. 364(22):2111-8. [ ... Despite its great sensitivity, the CMV IgM test is limited by a one-way cross-reaction of acute EBV infectious mononucleosis ... Reactivation of the virus is not uncommon, sometimes occurring with viremia and a positive IgM result in the presence of IgG ...https://emedicine.medscape.com/article/215702-clinical
The American Journal of Tropical Medicine and Hygiene | Serodiagnosis of Echinococcus Infection*
Two false positive reactions did occur in the CF test. The results of this study indicate that the IHA test is the most ... The IHA and the LF tests were more specific in that no false positive reactions occurred. ... The IHA and the LF tests were more specific in that no false positive reactions occurred. Two false positive reactions did ... Identification of Single Specimens of the Anopheles Gambiae Complex by the Polymerase Chain Reaction Authors: Julie A. Scott, ...http://www.ajtmh.org/content/journals/10.4269/ajtmh.1968.17.752
rAlt a 1 - Phadia - Setting the Standard - Phadia.com
No false-positive reactions were detected. Analysis showed no IgE-binding differences between nAlt a 1 and rAlt a 1. Specific ... No false-positive results were obtained with control patients, even at the highest concentration (14). Evaluation of ... recombinant Alt a 1 using skin test was positive in 6 of 7 individuals allergic to Alternaria. In contrast, in a study using ...http://www.phadia.com/en/Products/Allergy-testing-products/ImmunoCAP-Allergen-Information/Molds-and-other-Microorganisms/Allergen-Components/rAlt-a-1-Alternaria-alternata/
Clinical Evaluation of T.R.U.E. TEST® Panel 3.2 Allergens: Dose Response
Non-persistent reactions might represent initial false-positive reactions, meaning t.... Evaluation of patch test reactivities ... skin reactions (+1 or +2) in 70-90% of sensitive subjects.. - Frequency of positive, negative, doubtful and irritant reactions ... Studies have shown that not all positive patch test reactions are reproducible upon retesting, that is, persistent. ... dermatitis and a positive patch test to the respective reference allergen. Evaluations will include:. - Determination of the ...https://www.bioportfolio.com/resources/trial/90762/Clinical-Evaluation-of-T-R-U-E-TEST-Panel-3-2-Allergens.html
infiltrating ductal and lobular carcinoma of breast drug therapy 2000:2010[pubdate] *count=100 - BioMedLib™ search engine
False Positive Reactions. Female. Humans. Protons. Reproducibility of Results. Sensitivity and Specificity ... False Negative Reactions. Female. Humans. Lymph Nodes / pathology. Lymphatic Metastasis. Middle Aged. Prognosis. Prospective ... with an overall false positive rate was about 8%.. * Normal breast tissue was almost always negative by (1)H-MRS, whereas, ... Patients with ER-positive tumors received surgery alone; surgery and tamoxifen; or surgery, tamoxifen, and chemotherapy. ...http://www.bmlsearch.com/?kwr=infiltrating+ductal+and+lobular+carcinoma+of+breast+drug+therapy+2000:2010%5Bpubdate%5D&cxts=100&stmp=b1
Pregnancy | Britannica.com
Both of these tests are considered somewhat unsatisfactory because false-positive reactions are not uncommon. ... The possibility not only of false-negative but also of false-positive tests makes the tests, at best, probable rather than ... A high rate of false-positive results is associated with this test, and so it is not recommended routinely. This procedure has ... There are rare ovarian and uterine tumours that produce false-positive pregnancy tests. It may be difficult for the physician ...https://www.britannica.com/science/pregnancy
Performance of Syphilis Sentinel Surveillance in the context of endemic Treponematoses: experience from Ghana | BMC Infectious...
... samples were RPR-positive and TPHA-negative (biological false reactions), 640 (28.9%; c3, c7 and c11 cells) samples were RPR- ... negative for TPHA were retested with DS and classified as active syphilis if the DS was positive and biological false reaction ... Of 2,214 samples that were retested, 203 (9.2%) had active syphilis infection, 21 (0.9%) were biological false reactions, 640 ( ... Of the 18,366 samples, 1,097 (6.0%) were positive for both DS and TPHA and classified as "syphilis positive" After the survey, ...https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-016-2085-y
The influence of concomitant HIV infection on the serological diagnosis of primary syphilis in southern Africa. - Free Online...
... and falsely positive serological responses. (10,11) In the study reported here, no biological false positive RPR reactions were ... No false-positive RPR reactions were detected. Among RPR-seropositive patients, 137 (64.9%) had a titre of 1:8 or higher (see ... Association of biologic false-positive reactions for syphilis with human immunodeficiency virus infection. J Infect Dis 1992; ... When comparing RPR seropositivity rates by HIV serostatus, the RPR test was positive in 27 HIV-positive/M-PCR-TP-positive cases ...https://www.thefreelibrary.com/The+influence+of+concomitant+HIV+infection+on+the+serological+...-a0180102052
In situ hybridization with biotinylated DNA probes: a rapid diagnostic test for adenovirus upper respiratory infections. -...
False Positive Reaction Due to Endogenous Biotin Activity in Glandular Epithelium of Decidua. *Liliana Cruz Spano, Paulo ...https://www.semanticscholar.org/paper/In-situ-hybridization-with-biotinylated-DNA-probes%3A-Gomes-Nascimento/033bbef7a3efbf941cdeec03bffb191b27b7827e
Syphilis Infection during pregnancy: fetal risks and clinical management.
False-positive reactions can occur because of pregnancy, autoimmune disorders, and infections . NTTs are usually positive ... False-positive tests can occur in patients with Lyme disease, leptospirosis, and diseases caused by other pathogenic Treponema ... 2]. TTs usually remain positive for life. Polymerase-chain-reaction- (PCR-) based tests and immunoglobulin M immunoblotting ... Jarisch-Herxheimer reactionJournal of Obstetric, Gynecologic, and Neonatal NursingYear: 1996259p. 7312-s2.0-0030279341. ...http://www.biomedsearch.com/nih/Syphilis-Infection-during-Pregnancy-Fetal/22829747.html
Viruses | Free Full-Text | Factors That Improve RT-QuIC Detection of Prion Seeding Activity
Elongation of shaking periods reduced scrapie-seeded reaction times, but continuous shaking promoted false-positive reactions. ... Furthermore, pH 7.4 provided for more rapid RT-QuIC reactions than more acidic pHs. Additionally, we show that small variations ... N-terminal truncated hamster rPrPSen (residues 90-231) hastened both prion-seeded and prion-independent reactions but ... Raising temperatures or shaking speeds accelerated RT-QuIC reactions without compromising specificity. When applied to nasal ...http://www.mdpi.com/1999-4915/8/5/140
Niacin/Lovastatin (Professional Patient Advice) - Drugs.com
Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions and more. ... niacin may give false-positive reactions with cupric sulfate solution ( Benedicts reagent) in urine glucose tests. ... Adverse Reactions. The incidence stated for the following adverse reactions were reported with Advicor (niacin/lovastatin) ... Advise patient that flushing, which may last for several hours after dosing, is a common adverse reaction of therapy but that ...https://www.drugs.com/ppa/niacin-lovastatin.html
ToxiBan Granules for Animal Use - Drugs.com
TESTS FOR ETHYLENE GLYCOL MUST BE CONDUCTED BEFORE TOXIBAN IS ADMINISTERED TO PREVENT FALSE POSITIVE REACTIONS. ...https://www.drugs.com/vet/toxiban-granules.html
EVERYBODY REACTS POSITIVE ON THE ELISA TEST FOR HIV [Roberto A. Giraldo, MD]
The inevitable conclusion is that all positive reactions for antibodies to HIV are simply false positives. If nobody is ... to try to prevent false positive reactions some serologic tests use diluted serum; for example this is the case with tests that ... Therefore, the positive reactions of all undiluted sera would mean that everybody, or at least all the blood samples that I ... JOHNSON C. Factors Known to Cause False-Positive HIV Antibody Test Results: Zenger s San Diego. California, September 1996a 8-9 ...http://whale.to/w/giraldo.html