*  PAX2 - Wikipedia
"The paired-box transcription factor, PAX2, positively modulates expression of the Wilms' tumor suppressor gene (WT1)". Oncogene ... one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene ... The Pax2 gene encodes for the transcription factor which appears to be essential in the organization of the midbrain and ... The transcription factor gene Pax2 is important in the regionalized embryological development of the central nervous system. In ...
  https://en.wikipedia.org/wiki/PAX2
*  Protocols and Video Articles Authored by Adrian W. Moore (Translated to Russian)
Морфологический анализ Drosophila Личинок периферийных сенсорных дендритов нейронов и аксонов с использованием генетических ... Мозаики', 'Immunohistological Маркировка микротрубочек в Сенсорные дендритов нейронов, трахеи, и мышцы в Drosophila Личинка ... Prdm Proto-oncogene Transcription Factor Family Expression and Interaction with the Notch-Hes Pathway in Mouse Neurogenesis ... We show that the neural precursor gene prospero is essential for nerfin-1 expression. Unlike nerfin-1 mRNA, which is expressed ...
  https://www.jove.com/author/Adrian+W._Moore?language=Russian
*  Paired domain (IPR001523) | InterPro | EMBL-EBI
Mammalian protein Pax2, a probable transcription factor that may have a role in kidney cell differentiation. ... Structure of two genes at the gooseberry locus related to the paired gene and their spatial expression during Drosophila ... also known as B-cell specific transcription factor (BSAP). Pax5 is involved in the regulation of the CD19 gene. It plays an ... Conservation of a large protein domain in the segmentation gene paired and in functionally related genes of Drosophila.. Cell ...
  http://www.ebi.ac.uk/interpro/entry/IPR001523
*  OSR1 - Wikipedia
"Odd-skipped related 1 gene expression is regulated by Runx2 and Ikzf1 transcription factors". Gene. 426 (1-2): 81-90. doi: ... Osr1 acts upstream of and causes expression of the transcription factors Lhx1, Pax2 and Wt1 which are involved in early ... OSR1 and OSR2 are homologous to the Odd-skipped class transcription factors in Drosophila, encoded by odd, bowl, sob and arm. ... Protein odd-skipped-related 1 is a transcription factor that in humans is encoded by the OSR1 gene. The OSR1 and OSR2 ...
  https://en.wikipedia.org/wiki/OSR1
*  Distinct developmental programs require different levels of Bmp signaling during mouse retinal development | Development
By contrast, the expression of retinal anterior homeobox gene Rx and LIM domain-containing transcription factor gene Lhx2, both ... Initiation of neurogenesis is associated with the expression of Math5, a mouse homologue of the Drosophila pro-neural gene, ... Vax and Pax2 (Koshiba-Takeuchi et al., 2000). Bmp4 signaling may be subject to negative regulation by the ventrally localized ... Ectopic expression of Bmp4 in the embryonic chick retina leads to the upregulation of the dorsal transcription factor, Tbx5, ...
  http://dev.biologists.org/content/132/5/913
*  Enhancer evolution and animal diversity | Philosophical Transactions of the Royal Society B: Biological Sciences
2012 DNA regions bound at low occupancy by transcription factors do not drive patterned reporter gene expression in Drosophila ... The 362-bp core region of the sparkling (spa) enhancer of Pax2, which drives expression to cone cells in the Drosophila ... 2008 Transcription factors bind thousands of active and inactive regions in the Drosophila blastoderm. PLoS Biol. 6, e27. (doi: ... 101] reported that the neprilysin-1 gene (Nep1) of Drosophila santomea has gained a novel expression pattern in optic lobe ...
  http://rstb.royalsocietypublishing.org/content/368/1632/20130017
*  Pax genes - Wikipedia
A Review of the Highly Conserved PAX6 Gene in Eye Development Regulation Paired domain in PROSITE Pax Transcription Factors at ... including extensive study of the ectopic expression in Drosophila using murine Pax6. PAX1 has been identified in mice with the ... PAX2 has been identified with kidney and optic nerve development. It transcribes a 417 amino acid protein from 11 exons and ... "Homology of the eyeless gene of Drosophila to the small eye gene in mice and Aniridia in humans". Science. 265 (5173): 785-9. ...
  https://en.wikipedia.org/wiki/Pax_genes
*  Identification of Pax2-regulated genes by expression profiling of the mid-hindbrain organizer region | Development
Pax2-dependent regulation of the En2 transcription factor gene. Pax2 also controls the expression of the transcriptional ... two mouse genes with sequence homology to the Drosophila engrailed gene: expression during embryogenesis. Genes Dev. 1,29 -38. ... Pax2-dependent gene expression in the developing mid-hindbrain region. Pax2+/+ or Pax2+/- control embryos (A,C,E,G,I) and Pax2 ... The gene coding for the POU domain transcription factor Brn1 was identified as a direct target of Pax2 by two criteria. First, ...
  http://dev.biologists.org/content/132/11/2633
*  Functional annotation of novel lineage-specific genes using co-expression and promoter analysis
Gene expression is regulated by a complex interaction of transcription factors (TFs) and their binding sites (TFBS) on the gene ... The AsxL1 gene in Drosophila is required to maintain homeotic gene activation and silencing, and its homologs have been ... The composite TFBS pair, STAT*Pax-2, was over-represented in three co-expressed genes; 34FL, PAG2, and PTGS2. The PWM for the ... Transcription factor AP-2 functions as a repressor that contributes to the liver-specific expression of serum amyloid A1 gene. ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2848242/
*  Frontiers | Making sense of Wnt signaling-linking hair cell regeneration to development | Frontiers in Cellular Neuroscience
Figure 2. Wnt expression in developing inner ear in chicken and mice. Overview of Wnt gene expression in the developing inner ... which complexes with transcription factors of the TCF/LEF family to initiate transcription (Figure 1). Several reporter mouse ... The Drosophila homolog of the mouse mammary oncogene int-1 is identical to the segment polarity gene wingless. Cell 50, 649-657 ... Padanad, M. S., and Riley, B. B. (2011). Pax2/8 proteins coordinate sequential induction of otic and epibranchial placodes ...
  https://www.frontiersin.org/articles/10.3389/fncel.2015.00066/full
*  Expression Patterns of Developmental Control Genes in Normal andEngrailed-1 Mutant Mouse Spinal Cord Reveal Early Diversity in...
... and to a third gene expressed in the spinal cord, Lmx-1, a member of the LIM-domain transcription factor family. ... 1985) Expression during embryogenesis of a mouse gene with sequence homology to the Drosophila engrailed gene. Cell 43:29-37. ... 1990) Pax2, a new murine paired-box-containing gene and its expression in the developing excretory system. Development 109:787- ... Role of transcription factors in interneuron development. What function does the differential expression of transcription ...
  http://www.jneurosci.org/content/17/20/7805
*  Distinct domains within Mash1 and Math1 are required for function in neuronal differentiation versus neuronal cell-type...
... and their expression of specific LIM HD transcription factors (Fig. 2M) (Gross et al., 2002; Helms and Johnson, 2003; Müller et ... a homolog of the Drosophila atonal gene (Akazawa et al., 1995), both belong to the early expressed sub-group of bHLH factors ... that over-expression of Mash1 resulted in a moderate decrease in dI4/6 interneurons as defined by Lhx1/5 and Pax2 expression. ... The neural bHLH factors belong to a much larger family of transcription factors that are essential for diverse processes such ...
  http://dev.biologists.org/content/131/6/1319
*  Interactive Fly, Drosophila
This report is one of the first demonstrations of correlation between gene expression, binding of transcription factors and ... PTIP promotes assembly of the ALR complex and H3K4 methylation at a PAX2-binding DNA element. Without PTIP, Pax2 binds to this ... How MLL or MLL fusion proteins regulate gene expression remains obscure. MLL regulates target Hox gene expression through ... MLL, the human homolog of Drosophila trithorax, maintains Hox gene expression H3 lysine 4-specific methylation. MLL, the human ...
  http://www.sdbonline.org/sites/fly/polycomb/histh3-2c.htm
*  Protocols and Video Articles Authored by Bernd Fritzsch
2008 , Pubmed ID: 18956331 The Sox family of transcription factors is thought to regulate gene expression in a wide variety of ... 2010 , Pubmed ID: 20727173 Pax2;5;8 transcription factors play diverse roles in vertebrate and invertebrate organogenesis, ... and in sensilla of Drosophila and C. elegans. Thus, miRNA-183 family member expression is conserved in possibly homologous but ... Sox2 expression is promoted by Notch signaling and Prox1, a homeobox transcription factor, is a downstream target of Sox2. ...
  https://www.jove.com/author/Bernd_Fritzsch
*  Untitled Document
Ohno, S., from Muller, 1998). In Drosophila, ectopic expression of this gene can cause eyes to form on inappropriate body parts ... There are almost 2000 homeodomain transcription factors known from animals, plants, and fungi. Plants and Drosophila possess at ... Pax 3, 7, and 6 expression is involved in the subdivision of neural tube and Pax2, 5, and 8 in midbrain-hindbrain boundary ( ... The sponge homeobox gene EmH-3 is homologous to Hox 11 in higher animals. This gene in mammals and Drosophila is a member of ...
  http://bio.sunyorange.edu/updated2/GENETICS/5%20HOMEODOMAINS.htm
*  Dicyema Pax6 and Zic: tool-kit genes in a highly simplified bilaterian | BMC Evolutionary Biology | Full Text
Homologues of the Drosophila pair-rule gene odd-paired. J Biol Chem. 1996, 271: 1043-1047. 10.1074/jbc.271.2.1043.View Article ... and other developmentally critical transcription factors. Our most important finding may be the presence of both genes in the ... Callaerts P, Munoz-Marmol AM, Glardon S, Castillo E, Sun H, Li WH, Gehring WJ, Salo E: Isolation and expression of a Pax-6 gene ... a cnidarian PaxB gene uniting Pax2 and Pax6 functions. Dev Cell. 2003, 5: 773-785. 10.1016/S1534-5807(03)00325-3.View Article ...
  https://bmcevolbiol.biomedcentral.com/articles/10.1186/1471-2148-7-201
*  Interactive Fly, Drosophila
It has therefore been predicted that the phenotype caused by knockdown of a character identity gene (i.e. transcription factor ... Pax-2 and c-ret expressions in the Wolffian duct and WT-1 and GDNF expressions in the metanephric blastema are initially normal ... The genes Emx1 and Emx2 are mouse cognates of the Drosophila head gap gene empty spiracles. Their expression patterns in the ... Expression of the En-1 gene (Drosophila homolog: Engrailed) at the isthmus is essentially normal, consistent with the presence ...
  http://www.sdbonline.org/sites/fly/segment/emptysp2.htm
*  FLY LABS AND REFERENCES
The transcription factor FoxK participates with Nup98 to regulate antiviral gene expression. MBio 6. PubMed ID: 25852164 Buchon ... Integration of an abdominal Hox complex with Pax2 yields cell-specific EGF secretion from Drosophila sensory precursor cells. ... The Drosophila Transcription Factor Adf-1 (nalyot) Regulates Dendrite Growth by Controlling FasII and Staufen Expression ... The Drosophila transcription factors Tinman and Pannier activate and collaborate with Myocyte enhancer factor-2 to promote ...
  http://www.sdbonline.org/sites/fly/flylabs/c.html
*  Gene Expression Literature Summary - MGI
Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development. Dev Biol. 2016 ... J:69976 Tanaka M, Schinke M, Liao HS, Yamasaki N, Izumo S, Nkx2.5 and Nkx2.6, homologs of Drosophila tinman, are required for ... J:219797 Ranghini EJ, Dressler GR, Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP ... Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc ...
  http://www.informatics.jax.org/gxdlit/marker/MGI:97493
*  Interactive Fly, Drosophila
The Otx2 gene encodes a paired-type homeobox transcription factor that is essential for the induction and the patterning of the ... See Drosophila Apterous). Transcripts encoding these factors can be detected as early as mouse E8.5, with maximal expression ... as Unpg/Gbx and Otd/Otx also negatively regulate one another to form a boundary that positions En and Pax2/5/8 in Drosophila. ... The Otx2 gene, a mammalian orthologue of the Drosophila orthodenticle homeobox gene, is a crucial target of N-myc during inner ...
  http://www.sdbonline.org/sites/fly/segment/orthdn2e.htm
*  Protocols and Video Articles Authored by Edwin S. Monuki (Translated to Portuguese)
We report that Lhx2 is required for the expression of transcription factor paired box gene 6, axon guidance molecule Ephrin A5 ... Expression of two homologues of the Drosophila homeobox Cut gene, Cux-1 and Cux-2, is strikingly specific to the pyramidal ... Lhx2(-/-) optic vesicles and lens ectoderm upregulate Pax2, Fgf15 and Sox2 in response to BMP treatments, and Lhx2 genetic ... Several transcription factors and extracellular signals mediate this transition, but whether a single factor links them into a ...
  https://www.jove.com/author/Edwin+S._Monuki?language=Portuguese
*  Identification and expression of the lamprey Pax6 gene: evolutionary origin of the segmented brain of vertebrates | Development
Among these regulatory genes, the Pax gene family encodes transcription factors that are characterized by paired-type ... and the Pax6 gene, a homolog of the Drosophila gene eyeless, has a recognized role in eye development in various metazoans ( ... Although one of Pax2/5/8 genes has been isolated from the lamprey, the number of this gene family still remains unknown. Pax3/7 ... A) Expression of LjPax6. An arrow indicates the dorsal hindbrain that does not express this gene. (B) Expression pattern of ...
  http://dev.biologists.org/content/128/18/3521
*  Neurogenin 2 is required for the development of ventral midbrain dopaminergic neurons | Development
Lo, L., Tiveron, M. C. and Anderson, D. J. (1998). MASH1 activates expression of the paired homeodomain transcription factor ... Transient and restricted expression during mouse embryogenesis of Dll1 a murine gene closely related to Drosophila Delta. ... Urbanek, P., Fetka, I., Meisler, M. H. and Busslinger, M. (1997). Cooperation of Pax2 and Pax5 in midbrain and cerebellum ... Expression data showed that the VZ of the midbrain can be divided into three distinct zones based on proneural gene expression ...
  http://dev.biologists.org/content/133/3/495
*  Browse by Academic Unit (A-Z) - White Rose Research Online
1 more author) (2018) Differential roles of the Drosophila EMT-inducing transcription factors Snail and Serpent in driving ... 6 more authors) (2009) Expression-independent gene trap vectors for random and targeted mutagenesis in embryonic stem cells. ... The histone demethylase LSD1 regulates inner ear progenitor differentiation through interactions with Pax2 and the NuRD ... 1 more author) (2008) Plasticity of Drosophila Stat DNA binding shows an evolutionary basis for Stat transcription factor ...
  http://eprints.whiterose.ac.uk/view/iau/Sheffield=2EBMS.html
*  bHLH transcription factor Her5 links patterning to regional inhibition of neurogenesis at the midbrain-hindbrain boundary |...
... the loss of organizer-specific gene expression such as Pax2, Wnt1 and Fgf8 precedes neuronal differentiation defects (Hirata et ... In Drosophila, Hairy has a prominent role in inhibiting neurogenesis. Unlike most transcription factors encoded by the E(spl) ... transcription factor that is not driven by Notch activation, rather it acts as a prepattern gene to define domains in the notum ... Her5 expression and function appear more reminiscent of those of Drosophila Hairy than of other vertebrate Hairy/E(Spl) factors ...
  http://dev.biologists.org/content/130/8/1591