Previous reports have indicated that CD163 is highly expressed on human macrophages, but found on less than 50% of peripheral ... Antigens, Differentiation, Myelomonocytic / biosynthesis* * Blotting, Northern * Blotting, Western * Cell Line * Cytokines / ... induces high CD163 expression on cultured human monocytes. Glucocorticoid induced CD163 expression was not inhibited by anti-IL ... Human monocytes express CD163, which is upregulated by IL-10 and identical to p155 Cytokine. 2000 Sep;12(9):1312-21. doi: ...
2011 Expression of NOV and BNIP3 gene in mouse myelomonocytic leukemia and its significance 2011 Relationship between WT1- ... differentiation and cell cycle distribution of mouse thymocytes after acute radiation 2011 "CM-DiI labeled mesenchymal stem ... tumor antigen 1-specific T lymphocyte generation soon after nonmyeloablative allergenic stem-cell transplantation in acute and ... feasibility and safety from monkey to human", published in Stem Cells Dev. 2006 Kinetic study of various cytokine mRNA ...
Synovial mRNA expression of 117 cytokines was quantified using PCR techniques and analysed using standard and novel methods of ... Extravascular CXCL7 expression was significantly higher in patients with very early RA compared with longer duration RA or ... RESULTS: A machine learning approach identified expression of mRNA for CXCL4 and CXCL7 as potentially important in the ... Significantly increased CXCL4 and CXCL7 protein expression was observed in patients with early RA compared with those with ...
Results are expressed semi-quantitatively and graphs produced that show that many of the markers show enhanced expression at ... However, the sharpest increase in expression in relation to axon damage was seen for Calpain I (micro-calpain), inducible ... Antigens, Differentiation, Myelomonocytic, Axons, Biomarkers, Brain, CD3 Complex, Calpain, Humans, Immunohistochemistry, Matrix ... Results are expressed semi-quantitatively and graphs produced that show that many of the markers show enhanced expression at ...
FCI defines AML with minimal differentiation (AML-M0), which requires expression of myelomonocytic markers (ie, CD13, CD33) by ... whereas almost all other human neoplasms consistently show nucleus-restricted NPM expression. [50] NPM1 mutations are ... the diagnosis requires demonstration of megakaryocytic antigen expression (ie, CD41, CD42b, and/or CD61) by the blasts. In ... of any degree of CD64 expression with CD15 expression of 3+ intensity and heterogeneous CD13 expression or CD13 expression of ...
In this study, the finding that a significant proportion of all dendritic cells (DCs) resident in vivo in the human postnatal ... Constitutive expression of the myelomonocytic receptor for GM-CSF on myeloid DC1 precursors resident in the human thymus. Our ... cd33 antigen, cd34 antigens, cd44 antigens, dendritic cells, granulocyte-macrophage colony-stimulating factor, homing- ... Proposed model of DC, NK cell, and T-cell differentiation pathways from early CD34hiCD33lo precursors in the human postnatal ...
Selective expression of heat shock genes during differentiation of human myeloid leukemic cells // Leuk. Res. 1994. - Vol. 18 ... Inter-leukin 18 enhances Fas ligand expression and induces apoptosis in Fas-expressing human myelomonocytic KG-1 cells // ... Wolf D., Rotter V. Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL-60 cells // ... Differential expression of ras protooncogene during in vitro differentiation of human erythroleukemia cells // Cancer Res. 1992 ...
Researchers have discovered the existence of myeloid neoplasms that can undergo plasmacytoid dendritic cell differentiation. ... Groundbreaking Gnocchi map reveals hidden secrets of the human genome. *. DNA methylation: A key player in gene expression ... PDCs are a class of specialized dendritic cells that play a role in immunomodulatory functions and antigen presentation. They ... or acute myelomonocytic leukemia are indistinguishable. In addition, the team found no genetic or molecular markers of AML with ...
SUMMARY OF THE ANIMAL HOMOLOGUE SECTION OF HUMAN LEUKOCYTE DIFFERENTIATION ANTIGENS (HLDA8) WORKSHOP - (Abstract Only) ... Gene expression in tonsils in swine following infection with porcine reproductive and respiratory syndrome virus - (Peer ... SUMMARY OF WORKSHOP FINDINGS FOR PORCINE MYELOMONOCYTIC MARKERS - (Peer Reviewed Journal) WESTERN REGIONAL RESEARCH PROJECT W- ... Summary of the animal homologue section of human leukocyte differentiation antigens (hlda8) workshop [abstract]. International ...
A lymphodepleted non-human primate model for the assessment of acute on-target and off-tumor toxicity of human chimeric antigen ... Myelomonocytic differentiation associated with NPM1-RARA rearrangement. BRITISH JOURNAL OF HAEMATOLOGY,179(2):183-183 2017(Oct ... Enhancement of CAR Expression of piggyBac Transposon-Engineered T Cells by Stimulation with Viral Antigens. MOLECULAR THERAPY, ... Autologous non-human primate model for safety assessment of piggyBac transposon-mediated chimeric antigen receptor T cells on ...
Allogeneic HSCT is used in patients age ,70-75 years with a human leukocyte antigen (HLA)-compatible donor who have high-risk ... occurring noncoding RNAs that have been shown to regulate the expression of proteins involved in hematopoietic differentiation ... Acute myelomonocytic leukemia. Acute monoblastic and monocytic leukemia. Acute erythroid leukemia. Acute megakaryoblastic ... Similarly, acute megakaryoblastic leukemia can often be diagnosed only by expression of the platelet-specific antigens CD41 and ...
A Long Noncoding RNA from the HBS1L-MYB Intergenic Region on Chr6q23 Regulates Human Fetal Hemoglobin Expression ... Integrated Molecular Profiling of Juvenile Myelomonocytic Leukemia. Masahiro Uni, MD, PhD. Department of Transfusion Medicine, ... Antibody-Mediated Immunosuppression Can Result from RBC Antigen Loss Independent of Fcγ Receptors in Mice ... Transcriptome High-Resolution Maps Define the Effects of Epigenetic Modifiers on the Landscape of Hematopoietic Differentiation ...
Myelomonocytic Antigens (CD13, CD14, CD15, CD33, and CD64). The expression of CD13 and CD33 was seen, respectively, in 229 (76 ... The expression of CD2, CD4, CD7, CD10, and CD19 cannot be taken as evidence of lymphoid differentiation because we have seen, ... The expression of lymphoid antigens on myeloid leukemias was more promiscuous than expression of myeloid antigens on lymphoid ... Megakaryocyte and NK Cell-Associated Antigens (CD41, CD61, and CD56). The expression of megakaryocyte-associated antigens, CD41 ...
Immunohistochemistry showed expression of macrophage antigens (CD68; MS-1 high-molecular-weight protein) in epithelioid ... Differentiation of Langerhans cells in Langerhans cell histiocytosis. Geissmann F, Lepelletier Y, Fraitag S, Valladeau J, ... we examined the X-linked polymorphic human androgen receptor assay (HUMARA) locus to assess clonality in female patients with ... or a still less differentiated myelomonocytic precursor cell. Furthermore, gel systems of clonally cultured cells appear to ...
... human leukocyte antigen; HPA: human platelet antigen; OS: overall survival; RFS: relapse free survival; PI: post-transfusion ... Here, we demonstrated that connexin 43 (CX43) expression was downregulated in CRC and that loss of CX43 expression was ... Enrichment analysis showed that the hub genes were associated with T helper type 17 (Th17) cell differentiation as well as the ... chronic myelomonocytic leukemia; MPN: myeloproliferative neoplasm; SI: splenic irradiation; Abs: antibodies; CR: complete ...
Th17 differentiation of human and murine naïve T cells is markedly suppressed in the presence of IFNα. Bioactivity IL-17A ... Antigen References 1. Yu J, et al. Front Biosci 13:170-177 2008.. 2. Toy D, et al. J. Immunol. 177:36-39 2006.. 3. Benghiat FS ... IL-17AR is expressed in epithelial cells, fibroblasts, B and T lymphocytes, myelomonocytic cells, and marrow stromal cells. ... which activates Stat3 and induces the expression of the transcription factor retinoic acid-related orphan receptors (RORγt and ...
... recognizes the human CD11b cell surface glycoprotein, a 165 kDa molecule also known as the alphaM integrin, MAC-1 and CR3. This ... strong,Mouse anti Human CD11b antibody, clone ICRF44,/strong, ... and induce human myeloid leukemia cell differentiation via MAP ... FITC conjugated Mouse anti Human CD11b antibody, clone ICRF44 (MCA551F) used to evaluate CD11b expression levels on human ... Malhotra, V. et al. (1986) Ligand binding by the p150,95 antigen of U937 monocytic cells: properties in common with complement ...
The high level of expression of PECAM-1 on CD34+ cells suggests that this glycoprotein may function as a heterotypic adhesion ... Three-color flow-cytometric analyses also show that normal human bone marrow CD31+ CD34+ subsets coexpress myeloid (CD33) or B- ... enriched precursor cell population from normal human bone marrow. A single molecular weight species was generally observed with ... In this report, we show that enriched CD34+ human hematopoietic progenitor cell populations, containing early myeloid, ...
The expression of RUNX1 mutant in ASXL1-mutated myeloid cells augmented proliferation, blocked differentiation, and increased ... gene expression microarray, quantitative RT-PCR, cell proliferation, differentiation, and clonogenic assays for in vitro ... Co-expression of two mutant genes increased myeloid stem cells in animal model, suggesting that cooperation of RUNX1 and ASXL1 ... Moreover, the RUNX1 mutant protein was more stable than WT and increased HIF1-α and its target ID1 gene expression in ASXL1 ...
... was used to drive expression in cone cell precursors at appropriate levels. Expression of one copy of wild type Gap1 under ... Using antibodies against HRP to mark the membrane of neuronal cells, Gap1 is found to colocalize with the HRP antigen in the ... The regulation of Ras activation by PI 3-kinase has been investigated in the myelomonocytic U937 cell line. These cells exhibit ... 1999). Control of growth and differentiation by Drosophila RasGAP, a homolog of p120 ras-GTPase-activating protein. Mol. Cell. ...
Human leukocyte antigen (HLA) participates in the immune response to block HPV infection and invasion by its target/recognition ... Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. ... Juvenile myelomonocytic leukemia (JMML) is a rare, aggressive clonal myeloproliferative disorder of infancy and early childhood ... OBJECTIVES: This research aims to verify that the long non-coding RNA differentiation antagonizing nonprotein coding RNA ( ...
The human CD20 antigen, a 35 kDa cell surface nonglycosylated hydrophobic phoshpoprotein is expressed consistently on almost ... The expression of bcl-2 mRNA in lymphocytes of established cell line was increased by FIV. The amounts of mRNAs of bax, caspase ... Here, we report on DNA methylomes in TET2 wild-type (TET2-WT) and mutant (TET2-MT) cases of chronic myelomonocytic leukemia ( ... recognized in the past decade as critical factors for physiological phenomena such as embryogenesis and the differentiation of ...
We performed a multi-omics interrogation to define gene expression and chromatin remodeling associated with ASXL1MT in chronic ... Here the authors use a multi-omics approach for chronic myelomonocytic leukemia (CMML) and investigate the transcriptome and ... Chromatin remodeling of promoters and enhancers is strongly associated with gene expression and heterogenous among ... myelomonocytic leukemia (CMML). ASXL1MT are associated with a loss of repressive histone methylation and increase in permissive ...
Surface CD3 expression may sometimes be absent. The neoplastic cells usually show co-expression or co-deletion of CD4 and CD8. ... Noppen M, De Waele M, Li R, Gucht KV, DHaese J, Gerlo E, et al. Volume and cellular content of normal pleural fluid in humans ... Acute myelomonocytic leukemia typically is positive for non-specific esterase (NSE). B-cell and T-cell markers are generally ... Other T-cell/NK antigens such as CD4, CD5, CD8, CD16, and CD57 are usually negative. Most cases are also positive for cytotoxic ...
O Reduced antigen-specific T cell proliferation,O Reduced antithrombin III activity,O Reduced antithrombin antigen,O Reduced ... O Abnormal muscle fiber merosin expression,O Abnormal muscle fiber myotilin,O Abnormal muscle fiber protein expression,O ... O Chronic myelomonocytic leukemia,O Chronic neutropenia,O Chronic neutropenia in myeloid maturation arrest in bone marrow,O ... O Defective B cell differentiation,O Defective DNA repair after ultraviolet radiation damage,O Defective T cell proliferation,O ...
Expression, epitope analysis, and functional role of the LFA-2 antigen detectable on neoplastic mast cells. Schernthaner, G.H ... The alpha form of human tryptase is the predominant type present in blood at baseline in normal subjects and is elevated in ... a known inhibitor of in vitro mast cell differentiation, in a patient with benign, adult-onset systemic mastocytosis [22]. ... 816 to Val in microdissected bone marrow infiltrates in a case of systemic mastocytosis associated with chronic myelomonocytic ...
Gene Expression. The process of using information from a gene to create a genetic product.. Gene Expression Profile. The ... This method uses antigen-antibody interactions to localize particular antigens in FFPE tissues.. Invasive Cancer. Cancer that ... This is one of three known human RAS genes, which together are the most common oncogenes in human cancer. KRAS mutations are ... Chronic Myelomonocytic Leukemia. This cancer affects the bone marrows blood-forming cells, and spreads into the blood stream. ...
Modulation of human leukocyte antigen-C by human cytomegalovirus stimulates KIR2DS1 recognition by natural killer cells. Front ... 2002). Identification and expression of human cytomegalovirus transcription units coding for two distinct Fcgamma receptor ... 1997). A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic ... recipients showed that indeed CMV is a powerful driver of NK cell differentiation favoring the expansion of KIR+NKG2A-LILRB1+ ...
... salivarium is responsible for the expression of intercellular adhesion molecule-1 on the cell surface of normal human gingival ... Association of a major protein antigen of Mycoplasma arthritidis with virulence. Infect. Immun., 73(1):245-249. ... Induction of leukemia cell differentiation and apoptosis by recombinant P48, a modulin derived from Mycoplasma fermentans. ... Effects of Mycoplasma fermentans on the myelomonocytic lineage. Different molecular entities with cytokine-inducing and ...