Molecules | Free Full-Text | Pharmacokinetics, Tissue Distribution and Excretion of Isoalantolactone and Alantolactone in Rats...
Here, an UPLC-MS/MS method was developed and applied to study the pharmacokinetics, distribution and excretion of ... tissue distribution; excretion Radix Inulae; isoalantolactone; alantolactone; pharmacokinetics; tissue distribution; excretion ... Pharmacokinetics, Tissue Distribution and Excretion of Isoalantolactone and Alantolactone in Rats after Oral Administration of ... "Pharmacokinetics, Tissue Distribution and Excretion of Isoalantolactone and Alantolactone in Rats after Oral Administration of ...http://www.mdpi.com/1420-3049/20/5/7719
Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following...
The relationship of exposure and tissue concentration of parent chemical and metabolites over prolonged exposure is a critical ... Tissue distribution and urinary excretion of inorganic arsenic and its methylated metabolites in C57BL6 mice following ... In this study, dose-dependency in tissue distribution and urinary excretion for inorganic arsenic and its methylated ... excretion was non-linear with respect to dose. Total tissue arsenic accumulation was greatest in kidney , lung , urinary ...http://www.biomedsearch.com/nih/Tissue-distribution-urinary-excretion-inorganic/18706920.html
Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats. -...
However, information regarding absorption, metabolism, and especially, tissue distribution are only beginning to accumulate. In ... and we aimed at providing initial information with regard to tissue distribution. Based on HPLC and LC-MS analyses we ... with levels reaching 0.5 and 0.15 nmol pelargonidin equivalents/g tissue, respectively. Brain and lung tissues contained ... Other tissues, including spleen and heart, did not contain detectable levels of pelargonidin or ensuing metabolites. At 18 h ...https://www.semanticscholar.org/paper/Absorption%2C-tissue-distribution-and-excretion-of-to-Mohsen-Marks/7742be4a0933b32ddf009049d12c9bff377030c3
Ultraviolet light and laser irradiation enhances the antibacterial act | IJN
Tissue distribution and excretion kinetics of orally administered silica nanoparticles in rats Lee JA, Kim MK, Paek HJ, Kim YR ... Optical imaging of absorption and distribution of RITC-SiO2 nanoparticles after oral administration Lee CM, Lee TK, Kim DI, Kim ...https://www.dovepress.com/ultraviolet-light-and-laser-irradiation-enhances-the-antibacterial-act-peer-reviewed-article-IJN-recommendation1
Core-shell nanostructured hybrid composites for volatile organic compo | IJN
Tissue distribution and excretion kinetics of orally administered silica nanoparticles in rats Lee JA, Kim MK, Paek HJ, Kim YR ... Optical imaging of absorption and distribution of RITC-SiO2 nanoparticles after oral administration Lee CM, Lee TK, Kim DI, Kim ...https://www.dovepress.com/core-shell-nanostructured-hybrid-composites-for-volatile-organic-compo-peer-reviewed-article-IJN
The characteristic AgcoreAushell nanoparticles as SERS substrates in d | IJN
Tissue distribution and excretion kinetics of orally administered silica nanoparticles in rats Lee JA, Kim MK, Paek HJ, Kim YR ... Optical imaging of absorption and distribution of RITC-SiO2 nanoparticles after oral administration Lee CM, Lee TK, Kim DI, Kim ...https://www.dovepress.com/the-characteristic-agcoreaushell-nanoparticles-as-sers-substrates-in-d-peer-reviewed-article-IJN
Real-time monitoring of cisplatin cytotoxicity on three-dimensional sp | DDDT
... tissue engineering, and drug development. 3D systems could relate better to in vivo models than two-dimensional (2D) cultures. ... Tissue distribution and excretion kinetics of orally administered silica nanoparticles in rats Lee JA, Kim MK, Paek HJ, Kim YR ... Optical imaging of absorption and distribution of RITC-SiO2 nanoparticles after oral administration Lee CM, Lee TK, Kim DI, Kim ... tissue engineering, and drug development. 3D systems could relate better to in vivo models than two-dimensional (2D) cultures. ...https://www.dovepress.com/real-time-monitoring-of-cisplatin-cytotoxicity-on-three-dimensional-sp-peer-reviewed-article-DDDT
Ultrafast sonochemical synthesis of protein-inorganic nanoflowers | IJN
Differences in the Brain Penetration of the Anticholinergic Drugs Trospium Chloride and Oxybutynin
Biliary Excretion and Tissue Distribution. Wild-type mice and mdr1-/- knockout mice were anesthetized with a combination of ... compare tissue distribution of trospium chloride versus oxybutynin, and (2) analyze brain penetration and drug excretion of ... Tissue Distribution and Brain Penetration of Trospium Chloride and Oxybutynin in Mice ... Tissue distribution of the drugs was analyzed after 12 hours. Additionally, oxybutynin was applied intravenously to gall ...https://www.urotoday.com/volume-3-2010/vol-3-issue-1/34099-differences-in-the-brain-penetration-of-the-anticholinergic-drugs-trospium-chloride-and-oxybutynin-2227015.html
838. Bifenthrin (Pesticide residues in food: 1992 evaluations Part II Toxicology)
El Naggar, S.F., Dow, K.D., Robinson, R.A., & Stenzel, J.I. (1983). Excretion/tissue distribution of alcohol-14C FMC 54800 in ... excretion and biotransformation Absorption, distribution, excretion and biotransformation of bifenthrin was investigated in ... Selim, S., El Naggar, S.F., Isbell, D., Mazur, P., & Patterson, R. (1986a). Absorption, distribution and excretion studies of ... Total absorption of bifenthrin using the sum of average biliary and urinary excretion and tissue concentrations determined in ...http://www.inchem.org/documents/jmpr/jmpmono/v92pr04.htm
Bioactive metabolites from chaetomium globosum L18, an endophytic fungus in the medicinal plant curcuma wenyujin. - Free Online...
Pharmacokinetic, tissue distribution and excretion of ginsenoside-Rd in rodents.. Topics:. Antifungal agents ... 2003). However, little is known about secondary metabolites produced by endophytes harbored inside the healthy tissues of C. ... Fungal endophytes are microorganisms that colonize living, internal tissues of plants without causing any immediate, overtly ... Natural products from plant-associated microorganisms:distribution, structural diversity, bioactivity, and implications of ...https://www.thefreelibrary.com/Bioactive+metabolites+from+chaetomium+globosum+L18%2C+an+endophytic+...-a0289724694
NIH Guide: PRECLINICAL PHARMACOLOGICAL STUDIES OF ANTITUMOR AND ANTI-HIV AGENTS
... tissue distribution and urinary excretion studies; structural determination of metabolites and/or degradation products of ... test agents and/or metabolites in animal body fluids and tissues; stability studies of test agents in biological fluids; plasma ... effective concentrations in body fluids and tissues; bioavailability studies following administration of an agent by various ...https://grants.nih.gov/grants/guide/notice-files/not94-035.html
Frontiers | Prediction of a Therapeutic Dose for Buagafuran, a Potent Anxiolytic Agent by Physiologically Based Pharmacokinetic...
Buagafuran concentrations in human plasma were fitted and brain tissue concentrations were predicted by using a human PBPK ... Buagafuran concentrations in human plasma were fitted and brain tissue concentrations were predicted by using a human PBPK ... The software GastroPlusTM was used to build the PBPK/PD model for buagafuran in rat which related the brain tissue ... The software GastroPlusTM was used to build the PBPK/PD model for buagafuran in rat which related the brain tissue ...https://www.frontiersin.org/articles/10.3389/fphar.2017.00683/full
Table of Contents - August 01, 1990, 254 (2) | Journal of Pharmacology and Experimental Therapeutics
Single-dose kinetics of tissue distribution, excretion and metabolism of amiodarone in rats. P A Wyss, M J Moor and M H Bickel ... Effect of UDP-glucuronic acid depletion by salicylamide on biliary bilirubin excretion in the rat. T Kamisako, Y Adachi and T ... Norepinephrine and BRL 37344 stimulate adenylate cyclase by different receptors in rat brown adipose tissue. J G Granneman ... inhibition of drug metabolism and distribution of covalent adducts. D C Mays, J B Hilliard, D D Wong, M A Chambers, S S Park, H ...http://jpet.aspetjournals.org/content/254/2
Tissue Distribution of Cardiac Glycosides | SpringerLink
Fischer, C.S., Sjoerdsma, A., Johnson, R.: The tissue distribution and excretion of radioactive digitoxin. Circulation 5, 496- ... Kuhlmann J., Rietbrock N., Schnieders B. (1978) Tissue Distribution of Cardiac Glycosides. In: Bodem G., Dengler H.J. (eds) ... Doherty, J.E., Perkins, W.H.: Tissue concentration and turnover of tritiated digoxin in dogs. Am. J. Cardiol. 17, 47-52 (1966) ... Bine, R., Friedman, M., Byers, S.O., Bland, C.: The deposition of digitoxin in the tissues of the rat after parenteral ...https://link.springer.com/chapter/10.1007/978-3-642-66904-0_10
Frontiers | Management of Benign Prostatic Hyperplasia: Could Dietary Polyphenols Be an Alternative to Existing Therapies? |...
2006). Absorption, tissue distribution and excretion of pelargonidin and its metabolites following oral administration to rats ... these polyphenols were found in the conjugated and free forms in the prostate tissue in addition to other tissues. These ... The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited ... 2006) indicated that polyphenols were detected by HPLC technique in a number of tissues in mice and rats, one of which is the ...https://www.frontiersin.org/articles/10.3389/fphar.2017.00234/full
Pharmacokinetics of paclitaxel-containing liposomes in rats
Tissue distribution, metabolism and excretion of paclitaxel in mice. Anticancer Drugs. 1996;7:78-86. doi: 10.1097/00001813- ... Animals were killed at various times, and pharmacokinetic parameters were determined from the blood and tissue distribution of ... Apparent tissue partition coefficients (Kp) also were calculated. For bone marrow, a tissue in which paclitaxel exerts ... Gabizon A, Shiota R, Papahadjopoulos D. Pharmacokinetics and tissue distribution of doxorubicin encapsulated in stable ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2750994/
Ginsenoside Rg1 Attenuates Cigarette Smoke-Induced Pulmonary Epithelial-Mesenchymal Transition via Inhibition of the TGF-β1...
D. Sun, B. Wang, M. Shi et al., "Pharmacokinetic, tissue distribution and excretion of ginsenoside-Rd in rodents," ... EMT is a vital process during wound healing and tissue repair but it can also induce complete tissue fibrosis if the damage or ... b) The mRNA level of TGF-β1 in lung tissue was determined by real-time PCR. (c) Protein levels of TGF-β1, TGF-βR1, p-Smad2, ... The lung tissues were embedded in paraffin and cut into 4 μm thick sections, which were then rehydrated and stained with ...https://www.hindawi.com/journals/bmri/2017/7171404/
Recent patents for sodium reduction in foods.
1184809 - Iodine absorption, excretion, recycling, and tissue distribution in the dairy cow.. 20422559 - Creation of the food ...http://www.biomedsearch.com/nih/Recent-patents-sodium-reduction-in/20653529.html
Development of Magnetic Nanoparticles for Cancer Gene Therapy: A Comprehensive Review
M. Baek, H. E. Chung, J. Yu et al., "Pharmacokinetics, tissue distribution, and excretion of zinc oxide nanoparticles," ... M. Kong, X. Li, C. Wang et al., "Tissue distribution and cancer growth inhibition of magnetic lipoplex-delivered type 1 insulin ... and cellular distribution," International Journal of Nanomedicine, vol. 7, pp. 1127-1138, 2012. View at Google Scholar ... distribution, and reproduction in any medium, provided the original work is properly cited. ...https://www.hindawi.com/journals/isrn/2013/646284/ref/
Table of Contents - April 01, 2000, 28 (4) | Drug Metabolism & Disposition
Pharmacokinetics, Biliary Excretion, and Tissue Distribution of Novel Anti-HIV Agents, Cosalane and Dihydrocosalane, in Sprague ... Pharmacokinetics, Metabolism, and Excretion of Irinotecan (CPT-11) Following I.V. Infusion of [14C]CPT-11 in Cancer Patients ...http://dmd.aspetjournals.org/content/28/4
In conclusion, the plasma kinetics, tissue distribution and excretion profile of XMT-1522 are acceptable for clinical ... Exposure to free AF-HPA or AF in other tissues was at least an order of magnitude lower than in tumor; in tissues with ... and in vivo in plasma and tissue disposition and excretion studies. Sample analysis for total AF-HPA drug payload and released ... XMT-1522 tissue disposition was studied in NCI-N87 HER2-positive gastric cancer xenograft tumor bearing mice. After a single 3 ...http://cancerres.aacrjournals.org/content/77/13_Supplement/48
Protocols and Video Articles Authored by Lihua Zhang
Pharmacokinetics, Tissue Distribution and Excretion of Peimisine in Rats Assessed by Liquid Chromatography-tandem Mass ... The aim of this study was to investigate the pharmacokinetics, tissue distribution and excretion of peimisine in male and ... A total of 60 ovarian cancer patients and 15 normal ovarian tissues were enrolled. Tissue array was conducted by using a tissue ... and maternal tissues, respectively; SD12 and SD1-2 acted additively on germination velocity in the offspring tissues; and SD12 ...https://www.jove.com/author/Lihua_Zhang
Prodrugs for Liver-targeted Drug Delivery | Springer for Research & Development
... and other important metabolic substrates to peripheral tissues (Kahl, 1999). The liver... ... Ferrara E, Oishi J, Wannemacher R, and Stephens E. Plasma Disappearance, Urine Excretion and Tissue Distribution of Ribavirin ... I. Enzyme distribution and species specificity. Biochem Pharmacol 1965; 14:1405-1416.PubMedCrossRefGoogle Scholar ... Expression of Cytochrome P450 1A1/2 and 3A4 in Liver Tissues of Hepatocellular Carcinoma Cases and Controls from Taiwan and ...https://rd.springer.com/chapter/10.1007/978-0-387-49785-3_16
Physiologically-based modeling and interspecies prediction of paclitaxel pharmacokinetics | SpringerLink
Sparreboom A, van Tellingen O, Nooijen WJ, Beijnen JH (1996) Tissue distribution, metabolism and excretion of paclitaxel in ... Where Inf is the infusion rate (in simulation for humans), Qti is tissue plasma flow, and Vti is tissue volume (Vrm,vas and Vrm ... Allometric scaling Taxol Tissue distribution Modeling and simulation This is a preview of subscription content, log in to check ... Wei Y, Xue Z, Ye Y, Wang P, Huang Y, Zhao L (2014) Pharmacokinetic and tissue distribution of paclitaxel in rabbits assayed by ...https://link.springer.com/article/10.1007%2Fs10928-018-9586-9