*  Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase.
... in Ig genes into uracils (U). This alone produces C:G to T:A transition mutations. Processing of U:G base pairs via U N- ... Di Noia J.M.,Rada C.,Neuberger M.S.. Year: 2006SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation ... Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase ... UNG2 is classically thought to excise U in the vicinity of replication forks (i.e., in S phase; Otterlei et al., 1999; Nilsen ...
  http://www.biomedsearch.com/nih/Ectopic-restriction-DNA-repair-reveals/22529268.html
*  Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase |...
SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair. EMBO J. 25:585-595. doi:10.1038/ ... Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase. ... single-strand selective monofunctional uracil DNA glycosylase. U. uracil. ugi. U glycosylase inhibitor. UNG2. U N-glycosylase 2 ... Ectopic restriction of DNA repair reveals that UNG2 excises AID-induced uracils predominantly or exclusively during G1 phase ...
  http://jem.rupress.org/content/early/2012/04/17/jem.20112379
*  Tomas Lindahl and the Surprising Instability of DNA | The Lindau Nobel Laureate Meetings
Now, an enzyme called glycosylase detects this problem and excises uracil. Next, the enzyme DNA polymerase fills the gap with ... the result is a base called uracil. But uracil cannot bind with guanine, the other half of the GC base pair. ... Also, the remaining DNA bases had changed, "the most important of these is the deamination of cytosine residues to uracil". ... to excise, and finally to replace a damaged nucleotide. Cytosine, one of the four building blocks of DNA, easily loses one ...
  http://www.lindau-nobel.org/tomas-lindahl-and-the-surprising-instability-of-dna/
*  Uracil - Wikipedia
Uracil-DNA glycosylase excises uracil bases from double-stranded DNA. This enzyme would therefore recognize and cut out both ... In DNA, the uracil nucleobase is replaced by thymine. Uracil is a demethylated form of thymine. Uracil is a common and ... Uracil is a weak acid. The first site of ionization of uracil is not known. The negative charge is placed on the oxygen anion ... When uracil reacts with anhydrous hydrazine, a first-order kinetic reaction occurs and the uracil ring opens up. If the pH of ...
  https://en.wikipedia.org/wiki/Uracil
*  DNA polymerase β is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch...
Normally, uracil in DNA is excised by UNG or by single-strand selective monofunctional uracil glycosylase (SMUG1), and less ... SMUG1 is able to excise uracil from immunoglobulin genes: insight into mutation versus repair. EMBO J. 25:585-595. [PubMed] ... enzyme uracil DNA glycosylase (UNG), leaving an abasic site (6, 20). Uracil excision by UNG is critical for CSR, as UNG ... which converts cytosines to uracils in switch (S) regions. Subsequent excision of dU by uracil DNA glycosylase (UNG) of the ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2118644/?lang=en-ca
*  ung - Uracil-DNA glycosylase - Streptococcus pneumoniae (strain Hungary19A-6) - ung gene & protein
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due ... Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due ... Uracil-DNA glycosylaseUniRule annotation. ,p>Manual validated information which has been generated by the UniProtKB automatic ... Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation. ,p>Manual validated information which ...
  http://www.uniprot.org/uniprot/B1IBW9
*  ung - Uracil-DNA glycosylase - Coxiella burnetii (strain RSA 493 / Nine Mile phase I) - ung gene & protein
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due ... Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due ... Uracil-DNA glycosylaseUniRule annotation. ,p>Manual validated information which has been generated by the UniProtKB automatic ... Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation. ,p>Manual validated information which ...
  http://www.uniprot.org/uniprot/Q83CW4
*  ung - Uracil-DNA glycosylase - Lactococcus lactis subsp. cremoris (strain SK11) - ung gene & protein
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due ... Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due ... Uracil-DNA glycosylaseUniRule annotation. ,p>Manual validated information which has been generated by the UniProtKB automatic ... Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.UniRule annotation. ,p>Manual validated information which ...
  http://www.uniprot.org/uniprot/Q032L5
*  Uracil-DNA glycosylase-like domain superfamily (IPR036895) | InterPro | EMBL-EBI
Uracil-DNA glycosylases are DNA repair enzymes that excise uracil residues from DNA by cleaving the N-glycosylic bond, ... Short name: Uracil-DNA_glycosylase-like_sf Description. This entry represents various uracil-DNA glycosylases and related DNA ... These aberrant uracil residues are genotoxic [PMID: 16860315]. The sequence of uracil-DNA glycosylase is extremely well ... Thermostable uracil-DNA glycosylase from Thermotoga maritima a member of a novel class of DNA repair enzymes.. Curr. Biol. 9 ...
  http://www.ebi.ac.uk/interpro/entry/IPR036895
*  DNA glycosylase - Wikipedia
Uracil-DNA glycosylases are DNA repair enzymes that excise uracil residues from DNA by cleaving the N-glycosydic bond, ... Family 2 excise uracil from mismatches with guanine. A variety of glycosylases have evolved to recognize oxidized bases, which ... and single-strand selective monofunctional uracil-DNA glycosylase (SMUG1). Uracil DNA glycosylases remove uracil from DNA, ... In addition to unmodified uracil, SMUG1 can excise 5-hydroxyuracil, 5-hydroxymethyluracil and 5-formyluracil bearing an ...
  https://en.wikipedia.org/wiki/DNA_glycosylase
*  UniProt: C4ZYK3
191:4025-4029(2009). CC -!- FUNCTION: Excises uracil residues from the DNA which can arise as CC a result of misincorporation ... DR InterPro; IPR005122; Uracil-DNA_glycosylase-like. DR InterPro; IPR036895; Uracil-DNA_glycosylase-like_sf. DR PANTHER; ... DE RecName: Full=Uracil-DNA glycosylase {ECO:0000255,HAMAP-Rule:MF_00148}; DE Short=UDG {ECO:0000255,HAMAP-Rule:MF_00148}; DE ... DR GO; GO:0004844; F:uracil DNA N-glycosylase activity; IEA:InterPro. DR GO; GO:0006284; P:base-excision repair; IEA:InterPro. ...
  http://www.genome.jp/dbget-bin/www_bget?uniprot:C4ZYK3
*  SMUG1 - Wikipedia
SMUG1 is able to excise uracil from both single- and doubledstranded DNA. Other DNA glycosylases linked to U removal are UNG, ... Di Noia JM, Rada C, Neuberger MS (February 2006). "SMUG1 is able to excise uracil from immunoglobulin genes: insight into ... SMUG1 is an important uracil-DNA glycosylases that process uracil in DNA. SMUG1 function is to remove U or its derivatives from ... Uracil-DNA repair is essential to protect against mutations. Current evidence suggests that UNG and SMUG1 are the major enzymes ...
  https://en.wikipedia.org/wiki/SMUG1
*  SMART: Secondary literature for Bro-N domain
... displayed the ability to excise uracil residues from double-stranded plasmid DNA substrates, with the subsequent formation of ... This gene has recently been shown to encode a 25-kDa protein with uracil DNA glycosylase activity (D. T. Stuart, C. Upton, M. A ... Infection of cultured mammalian cells with the Leporipoxvirus Shope fibroma virus (SFV) causes the induction of a novel uracil ... The viral enzyme, like all other characterized uracil DNA glycosylases, is active in the presence of high concentrations of ...
  http://smart.embl.de/smart/show_secondary.cgi?domain=Bro-N
*  Plus it
In vitro DNA repair assays. In vitro, the Ung and Smug1 uracil-DNA glycosylases efficiently excise uracil from U:A base pairs ... Our data indicate that whereas both Smug1 and Ung excise uracil incorporated in U:A base pairs in vivo, the Smug1 uracil-DNA ... Furthermore, the Smug1, but not the Ung, uracil-DNA glycosylase excises FU from DNA and protects against cell killing. The data ... SMUG1 is able to excise uracil derivatives with substitutions at the C5 position of the pyrimidine ring, as the aromatic ...
  http://cancerres.aacrjournals.org/content/67/3/940
*  L-methylfolate, Methylcobalamin, and N-acetylcysteine in the Treatment of Alzheimer's Disease-Related Cognitive Decline «...
81 Uracil is excised from DNA, generating transient breaks requiring repair. Poly (ADP-ribose) polymerase (PARP) recognizes ... Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal ... In vivo, decreased thymidylate synthesis with subsequent uracil misincorporation into DNA probably also contributes. ...
  http://primarypsychiatry.com/l-methylfolate-methylcobalamin-and-n-acetylcysteine-in-the-treatment-of-alzheimeras-diseasearelated-cognitive-decline/
*  Uracil-DNA glycosylase - Wikipedia
UDG excises uracil in both AU and GU pairs to prevent propagation of the base mismatch to downstream transcription and ... UDG cleaves the uracil base from the phosphodiester backbone of uracil-containing DNA, but has no effect on natural (i.e., ... The first uracil DNA-glycosylase was isolated from Escherichia coli. The human gene encodes one of several uracil-DNA ... One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by ...
  https://en.wikipedia.org/wiki/Uracil-DNA_glycosylase
*  UDG - Wikipedia
Montenegro Uracil-DNA glycosylase, an enzyme which excises uracils from DNA Double-stranded uracil-DNA glycosylase, an enzyme ...
  https://en.wikipedia.org/wiki/UDG
*  Activation-induced cytidine deaminase - Wikipedia
U is analogous to T in DNA and is treated as such when replicated). The uracil may be excised by uracil-DNA glycosylase (UNG), ... It creates mutations in DNA by deamination of cytosine base, which turns it into uracil (which is recognized as a thymine). In ... uracil) mismatch is then subject to one of a number of fates. The U:G mismatch is replicated across creating two daughter ...
  https://en.wikipedia.org/wiki/Activation-induced_cytidine_deaminase
*  Patent US6682889 - Amplification and detection of organisms of the Chlamydiaceae family - Google Patents
dU (uridine) is incorporated into amplification products and can be excised by treatment with uracil DNA glycosylase (UDG). ... The uracil-modified nucleic acids may then be specifically recognized and inactivated by treatment with uracil DNA glycosylase ... UDG may be inactivated by uracil DNA glycosylase inhibitor (UGI) prior to performing the subsequent amplification to prevent ...
  http://www.google.com/patents/US6682889?dq=6101531
*  PBAL39 18294 protein (Pedobacter sp. BAL39) - STRING interaction network
Uracil-DNA glycosylase ; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues ... Uracil-DNA glycosylase ; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues ... Uracil-DNA glycosylase ; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues ...
  https://string-db.org/network/391596.PBAL39_18294
*  Selection of soluble protein expression constructs: the experimental determination of protein domain boundaries | Biochemical...
... the standard dNTP mixture was doped with dUTP and then the product was treated with uracil-DNA glycosylase to excise the uracil ...
  http://www.biochemsoctrans.org/content/38/4/908
*  Maintaining genome integrity | EMBO Reports
P. Schär gave an intriguing view of thymine DNA N‐glycosylase (TDG), which excises uracil and thymine from G:U and G:T mispairs ... A main cytotoxic lesion is 3‐methyladenine (3‐meA), which is excised from DNA by 3‐meA‐DNA glycosylase (AAG). Derivatives of ...
  http://embor.embopress.org/content/7/4/377
*  Hypergammaglobulinemia - Wikipedia
This codes for Uracil DNA Glycosylase, which is responsible for excising previous uracil bases that are due to cytosine ... Immunodeficiency with hyper IgM type 5 is caused by a mutation in the Uracil-DNA glycosylase (UNG) gene, which, like AICDA, is ... deamination, or previous uracil misincorporation from double-stranded previous DNA substrates. This enzyme is also responsible ...
  https://en.wikipedia.org/wiki/Hypergammaglobulinemia
*  The cell cycle restricts activation-induced cytidine deaminase activity to early G1 | JEM
AID-induced uracil is excised by UNG, producing an abasic site that is further processed by a variety of different mechanisms, ... Uracil-qPCR detects uracil accumulation at the antibody 5′-Sμ region. (A) Diagram of how Pfu polymerase and its mutant Pfu-Cx ... Uracil-free DNA can be amplified by both Pfu and Pfu-Cx polymerases (left). The lack of uracil recognition by Pfu-Cx polymerase ... Uracil-qPCR. Uracil-qPCR was performed as previously described (Horváth and Vértessy, 2010), with minor modifications. The ...
  http://jem.rupress.org/content/early/2016/12/19/jem.20161649
*  DNAtraffic - a database for systems biology of DNA metabolism and repair
Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the ... Mismatch uracil glycosylase from Escherichia coli: a general mismatch or a specific DNA glycosylase? O'Neill RJ., Vorob'eva OV ... A new class of uracil-DNA glycosylases related to human thymine-DNA glycosylase. Gallinari P., Jiricny J. Nature, 1996 Oct, 383 ... Specifically hydrolyzes mismatched double-stranded DNA and polynucleotides, releasing free uracil.. ENZYME REGULATION:. Subject ...
  https://dnatraffic.ibb.waw.pl/protein/protein_detail/249/