*  Genome sequence of multidrug-resistant Escherichia coli EC302/04, isolated from a human tracheal aspirate.
Escherichia coli is an important etiologic agent of lower respiratory tract infections (LRTI). Multidrug-resistant E. coli ... DNA, Bacterial / chemistry*, genetics*. Drug Resistance, Multiple, Bacterial. Escherichia coli / drug effects, genetics*, ... Escherichia coli Infections / microbiology. Genome, Bacterial*. Humans. Molecular Sequence Data. Sequence Analysis, DNA*. ... Escherichia coli is an important etiologic agent of lower respiratory tract infections (LRTI). Multidrug-resistant E. coli ...
  http://www.biomedsearch.com/nih/Genome-Sequence-Multidrug-Resistant-Escherichia/23144425.html
*  Selection coefficients as function of antibiotic concen | Open-i
... function of antibiotic concentrations during competition experiments between strains carrying chromosomally carried resistance ... Anti-Bacterial Agents/metabolism*. *Drug Resistance, Multiple, Bacterial*. *Escherichia coli/drug effects*/genetics/isolation ... Escherichia coli/drug effects*/genetics/isolation & purification. *Klebsiella pneumoniae/drug effects*/genetics/isolation & ... three of the resistance cassettes, tetRA (tetracycline resistance), dhfr (trimethoprim resistance), and the mph operon ( ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4196238_mbo0051420220003&req=4
*  Frontiers | A TolC-Like Protein of Actinobacillus pleuropneumoniae Is Involved in Antibiotic Resistance and Biofilm Formation |...
Persistent infections caused by bacterial biofilms are recalcitrant to treat because of the particular drug resistance of ... The genetic-complementation of the tolC1 mutation restored the competent biofilm and drug resistance. Besides, biofilm ... The genetic-complementation of the tolC1 mutation restored the competent biofilm and drug resistance. Besides, biofilm ... Taken together, TolC1 is required for biofilm formation and is a part of the multidrug resistance machinery of both planktonic ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2016.01618/full
*  Patent US4403036 - Genetic reagents for generating plasmids containing multiple copies of DNA ... - Google Patents
The plasmid rings with modified restriction sites are also used in linear form to obtain head-to-tail joining of multiple DNA ... The reagents have utility in preparing multiples of protein-forming genes, and in preparing large amounts of homogeneous DNAs ... Genetic reagents for generating plasmids containing multiples of a DNA segment are prepared by modification of the restriction ... Examples are the Escherichia coli plasmids which provide resistance to antibiotics such as penicillin, tetracycline, ...
  http://www.google.com/patents/US4403036?dq=7,172,682
*  Vended foods in Lagos, Nigeria: A potential reservoir for the spread of emerging strains of drug resistant bacteria
Seventy-six bacterial isolates made up of six genera; Escherichia coli, Salmonella Typhimurium, Alcaligenes spp., Klebsiella ... It also indicated that vended foods are potential reservoir for the spread of emerging multiple drug resistant bacteria strains ... with a view to determining bacterial agents associated with the vended foods and to investigating antibacterial resistance of ... Most of the bacterial isolates were moderately sensitive to cotrimoxazole, nalidixic acid, amoxicillin and nitrofurantion ...
  http://www.scirp.org/journal/PaperInformation.aspx?paperID=29763
*  UPGMA dendrogram showing banding patterns of XbaI-diges | Open-i
DNA, Bacterial/chemistry/genetics. *Drug Resistance, Multiple, Bacterial/genetics. *Electrophoresis, Gel, Pulsed-Field/ ... Molecular characterization of enterohemorrhagic Escherichia coli isolates from cattle. Bakhshi B, Najibi S, Sepehri-Seresht S ... The isolates are presented incomparison with their phenotypic resistance profiles and integron resistance genecontents. ... The isolates are presented incomparison with their phenotypic resistance profiles and integron resistance genecontents. ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4197144_jvms-76-1195-g002&req=4
*  Development of Microarray for the Rapid and Simultaneous Detection and Tracking of Bacterial and Viral Foodborne Pathogens |...
... of antimicrobial resistance genes in bacterial pathogens that will be used as a marker to subtype and track distinct multi-drug ... Development of field-deployable oligonucleotide microarray system for identification of multiple bacterial and viral distinct ... Shigella spp and Escherichia coli. ... Developing A Real-Time PCR assay for detection of multi-drug ... Molecular mechanisms of resistance in Acinetobacter baumannii. *Phenotypic and genotypic characterization of multi-drug ...
  https://vet.osu.edu/idmel/development-microarray-rapid-and-simultaneous-detection-and-tracking-bacterial-and-viral-foodb
*  Doribax (Doripenem for Injection): Side Effects, Interactions, Warning, Dosage & Uses
... drug interactions, warnings, patient labeling, reviews, and related medications. ... Mechanism(s) of Resistance. Bacterial resistance mechanisms that affect doripenem include drug inactivation by carbapenem- ... Doripenem exerts its bactericidal activity by inhibiting bacterial cell wall biosynthesis. Doripenem inactivates multiple ... Escherichia coli. Klebsiella pneumoniae. Proteus mirabilis. Pseudomonas aeruginosa. Facultative Gram-positive Microorganisms. ...
  https://www.rxlist.com/doribax-drug.htm
*  La Jolla institute identifies critical cell in fighting E. coli... ( SAN DIEGO (July 15 2012) Despite ...)
"In the present era of ever increasing antibiotic resistance, innovative approaches to treatment of bacterial infections are ... by the La Jolla Institute scientists reveals HVEM as a candidate drug target with relevance to multiple pathogens and multiple ... Escherichia coli (abbreviated as E. coli) are a large and diverse family of bacteria. Although most strains of E. coli are ... La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions. 2. La Jolla Institute scientist ...
  http://www.bio-medicine.org/biology-news-1/La-Jolla-institute-identifies-critical-cell-in-fighting-E--coli-infection-25834-1/
*  Frontiers | E. coli Group 1 Capsular Polysaccharide Exportation Nanomachinary as a Plausible Antivirulence Target in the...
Evolution of such multidrug resistance is due to the fact that, most of the antibiotics target bacterial survival mechanisms ... Gram-negative Escherichia coli uses Wzy-polymerase dependent (Group 1 and 4) and ATP dependent (Group 1 and 3) pathways for CPS ... Thus, unencapsulating bacteria would be a good strategy for drug design, besides CPS itself being a good vaccine target, by ... Evolution of such multidrug resistance is due to the fact that, most of the antibiotics target bacterial survival mechanisms ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2017.00070/full
*  Untitled
Kruse H, Sørum H (1994) Transfer of multiple drug resistance plasmids between bacteria of diverse origins in natural ... The influence of the growth environment on the stability of a drug resistance plasmid in Escherichia coli K12. Journal of ... resistance genes in genetic engineering contribute to the increase in frequency of antibiotic resistance in bacterial pathogens ... Gadkari D (1991) Conjugation between two Escherichia coli strains and between Escherichia coli (donor) and Azospirillum ...
  http://online.sfsu.edu/repstein/GEessays/Survival%20PersistenceTransfer.htm
*  Structural Biochemistry/Enzyme/Reversible Inhibitors/Competitive Inhibitor/Penicillin - Wikibooks, open books for an open world
If further symptoms occur, however, the drug should not be taken anymore. Physicians say that any drug that interferes with ... Penicillin Resistance[edit]. Penicillin has been a widely used antibiotic for years. Although there has been evidence of new ... Penicillin irreversibly blocks bacterial cell wall synthesis by inhibiting the formation of peptidoglycan cross-links. ... Gram negative bacteria are usually more resistant to penicillin because they have multiple membrane layers, which allows them ...
  https://en.wikibooks.org/wiki/Structural_Biochemistry/Enzyme/Reversible_Inhibitors/Competitive_Inhibitor/Penicillin
*  Efflux (microbiology) - Wikipedia
Some efflux systems are drug-specific, whereas others may accommodate multiple drugs with small multidrug resistance (SMR) ... "AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance ... a given bacterial species may lead to a broad spectrum of resistance when considering the shared substrates of some multi-drug ... multiple drug resistance proteins (MDRs)- also referred as P-glycoprotein, multidrug resistance-associated proteins (MRPs), ...
  https://en.wikipedia.org/wiki/Efflux_%28microbiology%29
*  Bacterial morphological plasticity - Wikipedia
The ability of bacteria to decrease their susceptibility to antimicrobial drugs importantly affects both bacterial ecology and ... The filamentation contributes to a pathogen's resistance to this antimicrobial agent. The induction of bacterial filamentation ... The exposure to β-lactam antibiotics induced the SOS response in Escherichia coli. During repair of DNA damage, the SOS ... Chloramphenicol antibiotic can induce the formation of filamentous cells, which contain multiple copies of unsegregated ...
  https://en.wikipedia.org/wiki/Bacterial_morphological_plasticity
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
An open access genotypic drug resistance monitoring method to manage individuals and assess transmitted drug resistance is ... Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays ... The current challenge for many cancer researchers is to dissect these changes in each cell type during the multiple-step ... Although a number of anti HIV drugs have been approved, there are still problems with toxicity and drug resistance. This ...
  https://www.jove.com/visualize/abstract/24376513/drug-resistance-missense-mutations-cancer-are-subject-to-evolutionary
*  User Meeting 2016 (24-25 November 2016) · (Indico)
Multiple drug resistance (MDR) in Gram-negative bacteria represents one of the most intractable problems facing modern medicine ... moieties resulting in a reduced negative charge of the bacterial surface and exclusion of the drug. This modification is ... encoding an LptA homologue was identified in MDR Escherichia coli. We have determined the crystal structure of a full-length ... This study showed a 7:1 tumor-to-skin ratio and the possibility of realizing dose-painting by multiple rotations. SR-EBRT with ...
  https://events.synchrotron.org.au/event/39/timetable/?view=standard
*  CIPROFLOXACIN* EXTENDED-RELEASE TABLETS
Resistance to ciprofloxacin in vitro develops slowly (multiple-step mutation). Resistance to ciprofloxacin due to spontaneous ... that antibacterial drugs including Ciprofloxacin extended-release tablets should only be used to treat bacterial infections. ... Escherichia coli Klebsiella pneumoniae Proteus mirabilis Pseudomonas aeruginosa The following in vitro data are available, but ... DO NOT SPLIT, CRUSH, OR CHEW THE TABLET. (See CLINICAL PHARMACOLOGY, Drug-drug Interactions, PRECAUTIONS, Drug Interactions and ...
  https://dailymed.nlm.nih.gov/dailymed/archives/fdaDrugInfo.cfm?archiveid=3286
*  Colistin - Wikipedia
The first colistin-resistance gene in a plasmid which can be transferred between bacterial strains was found in 2011 in China ... It concluded that pan-drug resistant infections, particularly those in the blood stream, have a higher mortality. Multiple ... The following represents MIC susceptibility data for a few medically significant microorganisms: Escherichia coli: 0.12-128 μg/ ... The first colistin-resistance gene in a plasmid which can be transferred between bacterial strains was found in 2011 and became ...
  https://en.wikipedia.org/wiki/Colistin
*  Melinta Therapeutics Updates Pyrrolocytosine and Enhanced Macrolide Programs at ECCMID Showcasing Company's Structure-Based...
Results from in vitro studies of these four compounds against several multi-drug resistant (MDR) bacterial isolates will be ... Atomic eyesight is key to design of enhanced macrolides with true robustness to target-based resistance. Session: New drugs ... where multiple efflux pumps conspire to make them resistant to many, if not all, antibiotics. The isolates featured many ... including Escherichia coli, Klebsiella pneumoniae, Enterobacter sp., Acinetobacter baumannii and Pseudomonas aeruginosa. The ...
  https://stockguru.com/2017/04/21/melinta-therapeutics-updates-pyrrolocytosine-and-enhanced-macrolide-programs-at-eccmid-showcasing-companys-structure-based-drug-design/
*  JoVE | Peer Reviewed Scientific Video Journal - Methods and Protocols
An open access genotypic drug resistance monitoring method to manage individuals and assess transmitted drug resistance is ... Mapping Bacterial Functional Networks and Pathways in Escherichia Coli using Synthetic Genetic Arrays ... Despite offering considerable advantages, multiple cantilever sensor arrays have never been applied in quantifying drug-target ... This multidrug resistance is largely due to energy-dependent drug efflux pumps. The pumps expel anti-cancer drugs or ...
  https://www.jove.com/visualize/abstract/22284896/antibiotic-resistance-is-ancient-implications-for-drug-discovery
*  Mutation Rate and Evolution of Fluoroquinolone Resistance in Escherichia coli Isolates from Patients with Urinary tract...
Based on limited data it had been thought that MPC might be a simple multiple of MIC, which can easily be determined. However, ... The emergence of multidrug resistant bacteria world wide is a serious problem, and very few new drugs are under development. ... Mutant prevention concentration (MPC) dosing has been proposed as a strategy to reduce the selection of resistant bacterial ... Mutation Rate and Evolution of Fluoroquinolone Resistance in Escherichia coli Isolates from Patients with Urinary tract ...
  http://uu.diva-portal.org/smash/record.jsf?pid=diva2:170869
*  What Is Triclosan - Truth In Aging
The mar regulon: multiple resistance to antibiotics and other toxic insults. Trends Microbiol 1999;7:410-3. ,br /,. 15.*Barbosa ... Possible link between bacterial resistance and use of antibiotics and biocides. Antimicrob Agents Chemother 1998;42:2151. ,br ... The crisis in antibiotic resistance. Science 1992;257:1064-73. ,br /,. 2.*Levy SB. The antibiotic paradox. How miracle drugs ... Overexpression of marA, soxS or acrAB produces resistance to triclosan in Escherichia coli. FEMS Microbiol Lett 1998;166:305-9 ...
  https://www.truthinaging.com/review/what-is-it-triclosan
*  Fosfomycin - Wikipedia
The drug is well tolerated and has a low incidence of harmful side effects. However, development of bacterial resistance under ... Fosfomycin is a PEP analog that inhibits MurA by alkylating an active site cysteine residue (Cys 115 in the Escherichia coli ... As a single dose, fosfomycin is more convenient than a multiple-dose therapy norfloxacin, for the same antibacterial efficacy. ... because the drug is not affected by cross-resistance issues. Existing clinical data support use in uncomplicated UTIs, caused ...
  https://en.wikipedia.org/wiki/Fosfomycin
*  Evidence of common descent - Wikipedia
"Drug-resistance and its transferability of Shigella strains isolated in 1986 in Japan". Kansenshogaku Zasshi. 63 (1): 15-26. ... CS1 maint: Multiple names: authors list (link) Simpson, G. G. (1951), Horses: The story of the horse family in the modern world ... That's just what creationists say can't happen." In addition to the metabolic changes, the different bacterial populations were ... A large-scale example of experimental evolution is Richard Lenski's multi-generation experiment with Escherichia coli. Lenski ...
  https://en.wikipedia.org/wiki/Evidence_of_common_descent
*  Dr John Merlino - The University of Sydney
Dissemination of multiple drug resistance genes by Class 1 integrons in Klebsiella pneumoniae isolates from four countries: A ... Betteridge, T., Merlino, J., Natoli, J., Cheong, E., Gottlieb, T., Stokes, H. (2013). Plasmids and Bacterial Strains Mediating ... diversity in the gene pool allows prediction of third-generation cephalosporin and aminoglycoside resistance in Escherichia ... Dissemination of multiple drug resistance genes by Class 1 integrons in Klebsiella pneumoniae isolates from four countries: A ...
  http://sydney.edu.au/medicine/people/academics/profiles/john.merlino.php