Genome sequence of multidrug-resistant Escherichia coli EC302/04, isolated from a human tracheal aspirate.
Escherichia coli is an important etiologic agent of lower respiratory tract infections (LRTI). Multidrug-resistant E. coli ... DNA, Bacterial / chemistry*, genetics*. Drug Resistance, Multiple, Bacterial. Escherichia coli / drug effects, genetics*, ... Escherichia coli Infections / microbiology. Genome, Bacterial*. Humans. Molecular Sequence Data. Sequence Analysis, DNA*. ... Escherichia coli is an important etiologic agent of lower respiratory tract infections (LRTI). Multidrug-resistant E. coli ...http://www.biomedsearch.com/nih/Genome-Sequence-Multidrug-Resistant-Escherichia/23144425.html
Increasing incidence of Escherichia coli bacteraemia is driven by an increase in antibiotic-resistant isolates: electronic...
To investigate trends in Escherichia coli resistance, bacteraemia rates and post-bacteraemia outcomes over time. METHODS: ... Aged, Aged, 80 and over, Anti-Bacterial Agents, Bacteremia, Drug Resistance, Multiple, Bacterial, Escherichia coli, Escherichia ... OBJECTIVES: To investigate trends in Escherichia coli resistance, bacteraemia rates and post-bacteraemia outcomes over time. ... Increasing incidence of Escherichia coli bacteraemia is driven by an increase in antibiotic-resistant isolates: electronic ...https://www.ndph.ox.ac.uk/publications/320375
Microbiology Society Journals | Bacterial antimicrobial metal ion resistance
Bacterial metal ion resistances were first discovered in the second half of the twentieth century. The detailed mechanisms of ... examines the prevalence and linkage of antimicrobial metal resistance genes to other antimicrobial resistance genes; and ... As the use of antimicrobial metals is limited, it is legitimate to ask: are antimicrobial metal resistances in pathogenic and ... Finally, we discuss the possible implications of the widespread dissemination of these resistances on re-emergent uses of ...http://jmm.microbiologyresearch.org/content/journal/jmm/10.1099/jmm.0.023036-0
The average MIC of E. coli clones (n=10) from fecal sam | Open-i
Drug Resistance, Multiple, Bacterial/genetics*. *Escherichia coli/genetics/growth & development*. *Feces/microbiology* ... Escherichia coli resistance to quinolones has now become a serious issue in large-scale pig farms of China. It is necessary to ... Escherichia coli resistance to quinolones has now become a serious issue in large-scale pig farms of China. It is necessary to ... Here, we present the hypothesis that the emergence of resistance in pigs requires drug accumulation for 7 days or more. To test ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4197147_jvms-76-1213-g002&req=4
Selection coefficients as function of antibiotic concen | Open-i
... function of antibiotic concentrations during competition experiments between strains carrying chromosomally carried resistance ... Anti-Bacterial Agents/metabolism*. *Drug Resistance, Multiple, Bacterial*. *Escherichia coli/drug effects*/genetics/isolation ... Escherichia coli/drug effects*/genetics/isolation & purification. *Klebsiella pneumoniae/drug effects*/genetics/isolation & ... three of the resistance cassettes, tetRA (tetracycline resistance), dhfr (trimethoprim resistance), and the mph operon ( ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4196238_mbo0051420220003&req=4
Frontiers | A TolC-Like Protein of Actinobacillus pleuropneumoniae Is Involved in Antibiotic Resistance and Biofilm Formation |...
Persistent infections caused by bacterial biofilms are recalcitrant to treat because of the particular drug resistance of ... The genetic-complementation of the tolC1 mutation restored the competent biofilm and drug resistance. Besides, biofilm ... The genetic-complementation of the tolC1 mutation restored the competent biofilm and drug resistance. Besides, biofilm ... Taken together, TolC1 is required for biofilm formation and is a part of the multidrug resistance machinery of both planktonic ...https://www.frontiersin.org/articles/10.3389/fmicb.2016.01618/full
ASMscience | Plasmid Diversity and Ad
In summary, the dynamics of bacterial genomes can be interpreted as resulting from the microevolution of a core genome and the ... There are two types of evolutionary events that impinge on bacterial genomes: microevolution (mutations and homologous ... Inhibition of fertility by multiple drug-resistance in Escherichia coli K-12. Jpn J Genet 37 : 66-69.[CrossRef] ... Phylogenetic relationships of drug-resistance factors and other transmissible bacterial plasmids. Bacteriol Rev 32 : 55-83.[ ...http://www.asmscience.org/content/book/10.1128/9781555818982.chap13
Patent US4403036 - Genetic reagents for generating plasmids containing multiple copies of DNA ... - Google Patents
The plasmid rings with modified restriction sites are also used in linear form to obtain head-to-tail joining of multiple DNA ... The reagents have utility in preparing multiples of protein-forming genes, and in preparing large amounts of homogeneous DNAs ... Genetic reagents for generating plasmids containing multiples of a DNA segment are prepared by modification of the restriction ... Examples are the Escherichia coli plasmids which provide resistance to antibiotics such as penicillin, tetracycline, ...http://www.google.com/patents/US4403036?dq=7,172,682
Dead bugs don't mutate: susceptibility issues in the emergence of bacterial resistance. (Perspectives). - Free Online Library
Pathogenic Prevention Drug resistance in microorganisms Microbial drug resistance Pathogenic bacteria Respiratory tract ... susceptibility issues in the emergence of bacterial resistance. (Perspectives).(Editorial) by 'Emerging Infectious Diseases'; ... Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid killing by fluoroquinolones. Antimicrob Agents ... Drugs 1995;49(Suppl 2):S29-35. (55.) Hooper DC. Bacterial resistance to fluoroquinolones: mechanisms and patterns. Adv Exp Med ...https://www.thefreelibrary.com/Dead+bugs+don%27t+mutate%3A+susceptibility+issues+in+the+emergence+of+...-a097116553
Vended foods in Lagos, Nigeria: A potential reservoir for the spread of emerging strains of drug resistant bacteria
Seventy-six bacterial isolates made up of six genera; Escherichia coli, Salmonella Typhimurium, Alcaligenes spp., Klebsiella ... It also indicated that vended foods are potential reservoir for the spread of emerging multiple drug resistant bacteria strains ... with a view to determining bacterial agents associated with the vended foods and to investigating antibacterial resistance of ... Most of the bacterial isolates were moderately sensitive to cotrimoxazole, nalidixic acid, amoxicillin and nitrofurantion ...http://www.scirp.org/journal/PaperInformation.aspx?paperID=29763
MCR-1-carrying Shigella found in China | CIDRAP
The gene has heightened concerns about antibiotic resistance because it confers resistance to a drug that is considered a last ... Isolate contains multiple resistance genes. The scientists screened a total of 2,127 S flexneri isolates from samples collected ... which means that other multidrug-resistant pathogens can acquire resistance to colistin. This raises the specter of bacterial ... Since the existence of the MCR-1 gene was first reported in Escherichia coli samples from pigs, pork products, and humans in ...http://www.cidrap.umn.edu/news-perspective/2018/03/mcr-1-carrying-shigella-found-china
Scientists Model Outer Membrane of 12 Bacterial Species to Speed New Drugs for 'Bad Bugs' | Infection Control Today
In Escherichia coli (E. coli), for example, the OmpF channel (porin) provides a translocation pathway for small molecules, ... If we lose, a UK-funded analysis predicts a frightening future where drug resistant bacterial infections kill more people ... Translocation is the action an antibiotic must take to penetrate the outer membrane of a bacterial cell in order to reach--and ... The lack of progress in creating 'new drugs for bad bugs' (a term coined by the European Commission's Innovative Medicines ...https://www.infectioncontroltoday.com/bacterial/scientists-model-outer-membrane-12-bacterial-species-speed-new-drugs-bad-bugs
Contribution of different mechanisms to the resistance to fluoroquinolones in clinical isolates of Salmonella enterica. - Free...
... general Drug resistance Physiological aspects Research Fluoroquinolones Dosage and administration Health aspects Quinolone ... antibacterial agents Quinolones Salmonella enteritidis Drug therapy Patient outcomes ... Contribution of different mechanisms to the resistance to fluoroquinolones in clinical isolates of Salmonella enterica.(Report ... including antibiotics of multiple classes); such pumps can be associated with multiple drug resistance (MDR). In the ...https://www.thefreelibrary.com/Contribution+of+different+mechanisms+to+the+resistance+to+...-a0386434984
UPGMA dendrogram showing banding patterns of XbaI-diges | Open-i
DNA, Bacterial/chemistry/genetics. *Drug Resistance, Multiple, Bacterial/genetics. *Electrophoresis, Gel, Pulsed-Field/ ... Molecular characterization of enterohemorrhagic Escherichia coli isolates from cattle. Bakhshi B, Najibi S, Sepehri-Seresht S ... The isolates are presented incomparison with their phenotypic resistance profiles and integron resistance genecontents. ... The isolates are presented incomparison with their phenotypic resistance profiles and integron resistance genecontents. ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC4197144_jvms-76-1195-g002&req=4
Analyzing Persister Physiology with Fluorescence-Activated Cell Sorting. - PubMed - NCBI
Drug Resistance, Multiple, Bacterial/genetics. *Escherichia coli/drug effects*. *Escherichia coli/growth & development ... Bacterial persisters are phenotypic variants that exhibit an impressive ability to tolerate antibiotics. Persisters are ... RSG produces a stable green fluorescent signal when reduced by bacterial reductases. Staining was diminished when cells were ...https://www.ncbi.nlm.nih.gov/pubmed/26468102?dopt=Abstract
Development of Microarray for the Rapid and Simultaneous Detection and Tracking of Bacterial and Viral Foodborne Pathogens |...
... of antimicrobial resistance genes in bacterial pathogens that will be used as a marker to subtype and track distinct multi-drug ... Development of field-deployable oligonucleotide microarray system for identification of multiple bacterial and viral distinct ... Shigella spp and Escherichia coli. ... Developing A Real-Time PCR assay for detection of multi-drug ... Molecular mechanisms of resistance in Acinetobacter baumannii. *Phenotypic and genotypic characterization of multi-drug ...https://vet.osu.edu/idmel/development-microarray-rapid-and-simultaneous-detection-and-tracking-bacterial-and-viral-foodb
Doribax (Doripenem for Injection): Side Effects, Interactions, Warning, Dosage & Uses
... drug interactions, warnings, patient labeling, reviews, and related medications. ... Mechanism(s) of Resistance. Bacterial resistance mechanisms that affect doripenem include drug inactivation by carbapenem- ... Doripenem exerts its bactericidal activity by inhibiting bacterial cell wall biosynthesis. Doripenem inactivates multiple ... Escherichia coli. Klebsiella pneumoniae. Proteus mirabilis. Pseudomonas aeruginosa. Facultative Gram-positive Microorganisms. ...https://www.rxlist.com/doribax-drug.htm
La Jolla institute identifies critical cell in fighting E. coli... ( SAN DIEGO (July 15 2012) Despite ...)
"In the present era of ever increasing antibiotic resistance, innovative approaches to treatment of bacterial infections are ... by the La Jolla Institute scientists reveals HVEM as a candidate drug target with relevance to multiple pathogens and multiple ... Escherichia coli (abbreviated as E. coli) are a large and diverse family of bacteria. Although most strains of E. coli are ... La Jolla Institute discovery could lead to new way to screen drugs for adverse reactions. 2. La Jolla Institute scientist ...http://www.bio-medicine.org/biology-news-1/La-Jolla-institute-identifies-critical-cell-in-fighting-E--coli-infection-25834-1/
Frontiers | E. coli Group 1 Capsular Polysaccharide Exportation Nanomachinary as a Plausible Antivirulence Target in the...
Evolution of such multidrug resistance is due to the fact that, most of the antibiotics target bacterial survival mechanisms ... Gram-negative Escherichia coli uses Wzy-polymerase dependent (Group 1 and 4) and ATP dependent (Group 1 and 3) pathways for CPS ... Thus, unencapsulating bacteria would be a good strategy for drug design, besides CPS itself being a good vaccine target, by ... Evolution of such multidrug resistance is due to the fact that, most of the antibiotics target bacterial survival mechanisms ...https://www.frontiersin.org/articles/10.3389/fmicb.2017.00070/full
Expression of Novel Gene Content Drives Adaptation to Low Iron in the Cyanobacterium Acaryochloris, Genome Biology and...
Contribution of the pfmdr1 gene to antimalarial drug-resistance. Acta Trop. 94(3):181-190. (d /d 0.1) on retained duplicates in ... as multiple independent events. Mol Cell Biol. 11:5244. Qian W, Liao B-Y, Chang AY-F, Zhang J. 2010. Maintenance of duplicate ... the nature of bacterial innovation. Nature 405(6784):299-304. Swingley WD, et al. 2008. Niche adaptation and genome expansion ... Molecular archaeology of the Escherichia supported by award NNA15BB04A from the National coli genome. Proc Natl Acad Sci U S A ...https://www.deepdyve.com/lp/ou_press/expression-of-novel-gene-content-drives-adaptation-to-low-iron-in-the-KfEQ0w0ZEd
Welcome to CDC stacks | Risk Factors for Colonization with Extended-Spectrum β-Lactamase-producing Bacteria and Intensive Care...
Drug-resistance Microbial Drug Resistance, Multiple, Bacterial Escherichia Coli Escherichia Coli Infections Female Humans ... are emerging pathogens that confer resistance to antimicrobial drugs. We conducted a 10-year study in France (January 2001- ... Beta-Lactam Resistance Beta Lactamases Cohort Studies Cross-Sectional Studies ... Of these, 117 were colonized with ESBL-producing Escherichia coli and Klebsiella spp., and 29 (25%) had a subsequent ESBL- ...https://stacks.cdc.gov/view/cdc/16690
Kruse H, Sørum H (1994) Transfer of multiple drug resistance plasmids between bacteria of diverse origins in natural ... The influence of the growth environment on the stability of a drug resistance plasmid in Escherichia coli K12. Journal of ... resistance genes in genetic engineering contribute to the increase in frequency of antibiotic resistance in bacterial pathogens ... Gadkari D (1991) Conjugation between two Escherichia coli strains and between Escherichia coli (donor) and Azospirillum ...http://online.sfsu.edu/repstein/GEessays/Survival%20PersistenceTransfer.htm
Type I protein exporter (IPR039421) | InterPro | EMBL-EBI
... such as cytotoxic drugs, out of cells leading to tumour cell resistance to multiple drugs [PMID: 2876781]. The bacterial ... TolC, an Escherichia coli outer membrane protein required for hemolysin secretion.. Proc. Natl. Acad. Sci. U.S.A. 87 4776-80 ... Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced ... Function of Escherichia coli MsbA, an essential ABC family transporter, in lipid A and phospholipid biosynthesis.. J. Biol. ...https://www.ebi.ac.uk/interpro/entry/IPR039421
Structural Biochemistry/Enzyme/Reversible Inhibitors/Competitive Inhibitor/Penicillin - Wikibooks, open books for an open world
If further symptoms occur, however, the drug should not be taken anymore. Physicians say that any drug that interferes with ... Penicillin Resistance. Penicillin has been a widely used antibiotic for years. Although there has been evidence of new ... Penicillin irreversibly blocks bacterial cell wall synthesis by inhibiting the formation of peptidoglycan cross-links. ... Gram negative bacteria are usually more resistant to penicillin because they have multiple membrane layers, which allows them ...https://en.wikibooks.org/wiki/Structural_Biochemistry/Enzyme/Reversible_Inhibitors/Competitive_Inhibitor/Penicillin
Efflux (microbiology) - Wikipedia
Some efflux systems are drug-specific, whereas others may accommodate multiple drugs with small multidrug resistance (SMR) ... "AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance ... a given bacterial species may lead to a broad spectrum of resistance when considering the shared substrates of some multi-drug ... multiple drug resistance proteins (MDRs)- also referred as P-glycoprotein, multidrug resistance-associated proteins (MRPs), ...https://en.wikipedia.org/wiki/Efflux_%28microbiology%29