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*  Idiotype - Wikipedia
In immunology, an idiotype is a shared characteristic between a group of immunoglobulin or T cell receptor (TCR) molecules ... He defined idiotype as the set of epitopes on the V region of an antibody molecule, where epitope means an antigenic ... idiotype describes the distinctive sequence and region that makes any immunoglobulin/TCR unique from others of the same type ... Allotype (immunology) Isotype (immunology) Immune network theory Immunoglobulin idiotypes at the US National Library of ...
  https://en.wikipedia.org/wiki/Idiotype
*  Patent US20040009185 - Enhancing the immune response to an antigen by presensitzing with an ... - Google Patents
USA, 93:7252-7257 (1996)); idiotypic epitopes or antigens, for example, immunoglobulin idiotypes or T cell receptor idiotypes ... A tumor specific antigen is an antigen that is unique to tumor cells and is not expressed on normal cells. The term tumor ... a characteristic thought to improve its safety profile. ALVAC (1) is an attenuated canarypox virus-based vector that was a ... Composition containing a B epitope of the envelope glycoprotein of a retrovirus and a T epitope of another distinct protein of ...
  http://www.google.com/patents/US20040009185
*  Nelson Teng | Stanford Medicine Profiles
We report a unique case of a 27-year-old woman with stage I, high-grade primary leiomyosarcoma of the vagina treated with ... INITIAL EVALUATION OF A HUMAN IMMUNOGLOBULIN-M MONOCLONAL-ANTIBODY (HA-1A) IN HUMANS JOURNAL OF BIOLOGICAL RESPONSE MODIFIERS ... Specific recognition of lipid A and of a carbohydrate epitope on B lymphocytes by the two human mAb suggests a dual function ... and its characteristic repertoire, all suggest a role for this cell type in immunologically immature hosts. ...
  https://med.stanford.edu/profiles/nelson-teng
*  Plus it
... including the presentation of epitopes derived from their own unique immunoglobulin idiotype to CD4+ and CD8+ T cells ( 5- 7). ... 1B), whereas only few (6.4%) possessed a CD11blow/CD11chigh phenotype characteristic of myeloid DCs. As expected, few cells ... Recognition of immunoglobulin idiotypes by thymus-derived lymphocytes. Proc Natl Acad Sci U S A 1975; 72: 2357-60. ... The clonotypic idiotype of malignant B cells was the first tumor-specific antigen identified as capable of eliciting a T cell- ...
  http://cancerres.aacrjournals.org/content/68/13/5439
*  Antibody - Wikipedia
... involves the generation of a unique immunoglobulin variable region. The variable region of each immunoglobulin heavy or light ... Each Ig unit (labeled 1) has two epitope binding Fab regions, so IgM is capable of binding up to 10 epitopes. ... They have a characteristic immunoglobulin fold in which two beta sheets create a "sandwich" shape, held together by ... According to immune network theory, the adaptive immune system is regulated by interactions between idiotypes. ...
  https://en.wikipedia.org/wiki/Antibody
*  James Swartz | Stanford Medicine Profiles
The unique immunoglobulin idiotype expressed on the surface of B lymphoma cells can be used as an effective antigen in tumor- ... Peptide epitopes present in the diabody linker augmented the response by activating CD4(+) helper T cells. Consequently, the ... The biophysical affinity to ribosomes as well as the characteristic Hsp70 ATPase activity were both verified for the fusion ... The unique immunoglobulin (Ig) idiotype on the surface of each B-cell lymphoma represents an ideal tumor-specific antigen for ...
  https://med.stanford.edu/profiles/james-swartz
*  Frontiers | Antibody Engineering for Pursuing a Healthier Future | Microbiology
Phage libraries are useful for mapping antibody epitopes, and display millions of peptides/proteins with unique random ... Phage display and peptide mapping of an immunoglobulin light chain fibril-related conformational epitope. Biochem. Mol. Biol. ... This characteristic feature of the immunoglobins makes them an ideal tool for many applications including disease diagnosis and ... Peptide map, anti-idiotype immunoassay, potency, and other appropriate methods are used to determine its identity and ...
  https://www.frontiersin.org/articles/10.3389/fmicb.2017.00495/full
*  Patent US6815188 - Human kinases and polynucleotides encoding the same - Google Patentsuche
In addition, animals in which the unique NHP sequences described in SEQ ID NOS:1-5 are "knocked-out" provide a unique source in ... Antibodies that specifically recognize one or more epitopes of a NHP, or epitopes of conserved variants of a NHP, or peptide ... Antibodies to a NHP can, in turn, be utilized to generate anti-idiotype antibodies that "mimic" a given NHP, using techniques ... 77-96). Such antibodies may be of any immunoglobulin class, including IgG, IgM, IgE, IgA, and IgD, and any subclass thereof. ...
  http://www.google.de/patents/US6815188?hl=de&output=html_text
*  Through the barricades: overcoming the barriers to effective antibody-based cancer therapeutics, Glycobiology | 10.1093/glycob...
... a novel streptococcal cysteine proteinase with unique specificity for immunoglobulin G . EMBO J . 21 ( 7 ): 1607 - 1615 . ... 2011; Gorovits and Krinos-Fiorotti 2013). Perhaps the best-known example of an immunogenic glycan epitope is the Galα1,3Gal ... An anti-idiotype vaccine related to N-glycolyl-containing gangliosides - Preclinical and clinical data . Front Oncol . 2 : 150 ... biological or microbiological property or characteristic that must be within an appropriate limit, range or distribution to ...
  https://www.deepdyve.com/lp/ou_press/through-the-barricades-overcoming-the-barriers-to-effective-antibody-Ka8DgFUU88
*  Transgenic non-human animals capable of producing heterologous antibodies of various isotypes - GenPharm International Inc.
... capable of producing heterologous antibodies and transgenic non-human animals having inactivated endogenous immunoglobulin ... By screening a hybridoma population for antigen binding specificity (idiotype) and also screening for immunoglobulin class ( ... It also has a unique 5' XhoI site for cloning Vκ segments and a unique 3' SalI site for inserting additional cis-acting ... non-human animals of the invention with antibodies specific for immunoglobulin epitopes encoded by human immunoglobulin gene ...
  http://www.freepatentsonline.com/5877397.html
*  Compositions and methods relating to novel compounds and targets thereof - Glick, Gary D.
The term "epitope" as used herein refers to that portion of an antigen that makes contact with a particular immunoglobulin. ... The gene expression results for Bz-423 and Bz-OMe each provide a unique fingerprint of information. The structure of Bz-OMe is ... Antibody fragments that contain the idiotype (antigen binding region) of the antibody molecule can be generated by known ... Epidermal hyperplasia is a characteristic of numerous disorders, including but not limited to, psoriasis. ...
  http://www.freepatentsonline.com/y2006/0025388.html
*  METHODS FOR INCREASING DEFINITIVE ENDODERM PRODUCTION - Patent application
... particularly epitopes unique to an E-cadherin polypeptide or peptide (e.g., signature or unique sequences), are disclosed ... 0101]Anti-idiotype technology can be used to produce monoclonal antibodies that mimic an epitope. For example, an anti- ... In certain processes, the expression of marker genes characteristic of definitive endoderm as well as the lack of significant ... General techniques for cloning murine immunoglobulin variable domains are described, for example, by Orlandi et al., Proc. Natl ...
  http://www.patentsencyclopedia.com/app/20100197014
*  Compositions relating to novel compounds and targets thereof - The Regents of the University of Michigan
For example, if an antibody is specific for epitope "A," the presence of a protein containing epitope A (or free, unlabelled A ... As seen in Table 3, the effects on blocking proliferation were not unique to lymphoid cells which suggested a target, common to ... 0108] Antibody fragments that contain the idiotype (antigen binding region) of the antibody molecule can be generated by known ... 0110] As used herein, the term "immunoglobulin" or "antibody" refer to proteins that bind a specific antigen. Immunoglobulins ...
  http://www.freepatentsonline.com/y2004/0220180.html
*  Patent US5162504 - Monoclonal antibodies to a new antigenic marker in epithelial prostatic ... - Google Patents
The single type of immunoglobulin secreted by a hybridoma is specific to one and only one antigenic determinant, or epitope, on ... maintain a full set of characteristic biological or biochemical markers characteristic of prostatic epithelium and malignant ... This suggests that MoAb 9H10-A4 defined antigen could be unique for an individual prostatic tumor or perhaps even a single ... idiotype) of another antibody. In theory, based on Jerne's network model of idiotypic relationships (Jerne, Ann. Immunol. 125: ...
  http://www.google.com/patents/US5162504?dq=5,966,702
*  US20040204580A1 - Novel human mitochondrial proteins and polynucleotides encoding the same - Google Patents
Antibodies that specifically recognize one or more epitopes of a NHP, or epitopes of conserved variants of a NHP, or peptide ... When the unique NHP sequences described in SEQ ID NOS:1-12 are "knocked-out" they provide a method of identifying phenotypic ... 77-96). Such antibodies may be of any immunoglobulin class including IgG, IgM, IgE, IgA, IgD and any subclass thereof. The ... Antibodies to NHP can, in turn, be utilized to generate anti-idiotype antibodies that "mimic" a given NHP, using techniques ...
  https://patents.google.com/patent/US20040204580A1/en
*  Patent US7291477 - Method and device for trichomonas detection - Google Patents
The term "epitope" means an antigenic determinant capable of specific binding to an antibody. Epitopes usually consist of ... but is not limited to a polypeptide substantially encoded by an immunoglobulin gene or immunoglobulin genes, or fragments ... Unique double-stranded RNAS associated with the Trichomonas vaginalis virus. US5741662 *. 18 Dec 1995. 21 Apr 1998. Quidel ... The performance characteristic of the assay of the invention was determined from a composite reference standard sample set (CRS ...
  http://www.google.com.au/patents/US7291477
*  Viruses | Free Full-Text | Molecular Signatures of Hepatitis C Virus (HCV)-Induced Type II Mixed Cryoglobulinemia (MCII) | HTML
... such as the virus-induced expansion of selected subsets of B-cell clones expressing discrete immunoglobulin variable (IgV) gene ... Mapping b-cell epitopes of hepatitis c virus e2 glycoprotein using human monoclonal antibodies from phage display libraries. J ... Mackworth-Young, C.G.; Harmer, I.J.; Mageed, R.A. The role of antigen in the selection of the human v3-23 immunoglobulin heavy ... Anti-hiv-1 response elicited in rabbits by anti-idiotype monoclonal antibodies mimicking the cd4-binding site. PLoS One 2008, 3 ...
  http://www.mdpi.com/1999-4915/4/11/2924/htm
*  12:53 pm
For the immunoglobulin family, see Immunoglobulin superfamily. 'Antibodies' redirects here. For the film, see Antibodies (film ... An antibody (Ab), also known as an immunoglobulin (Ig), is a large Y-shaped protein produced by B-cells that is used by… ... involves the generation of a unique immunoglobulin variable region. The variable region of each immunoglobulin heavy or light ... Each Ig unit (labeled 1) has two epitope binding Fab regions, so IgM is capable of binding up to 10 epitopes. ...
  https://novoantibody.wordpress.com/2012/09/26/antibody/
*  Patent US5861164 - Vaccination against diseases resulting from pathogenic responses by specific ... - Google Patents
A peptide was synthesized based on a unique DNA sequence found in the V β 8 gene, and which is not found among other rat V β ... Yanagi et al., A human T cell specific cDNA clone encodes a protein having extenstive homology to immunoglobulin chains. Nature ... Alternatively, the vaccine can be a peptide corresponding to sequences of TCRs characteristic of the T cells mediating said ... but also usually for a single epitope on that antigen. These observations indicate that discrete populations of autoaggressive ...
  http://www.google.com/patents/US5861164?dq=6,232,546
*  Complement Receptors | Springer for Research & Development
Localization of the epitopes for several monoclonal antibodies, Biochem. J. 261: 551-560.PubMedGoogle Scholar ... Staunton, D. E., Dustin, M. L., Erickson, H. P., and Springer, T. A., 1990, The arrangement of the immunoglobulin-like domains ... Johnson, R. J., and Chenoweth, D. E., 1985, Labeling the granulocyte C5a receptor with a unique photoreactive probe, J. Biol. ... with an antibody to anti-factor H idiotype, J. Exp. Med. 155: 1400-1411.PubMedCrossRefGoogle Scholar ...
  https://rd.springer.com/chapter/10.1007/978-1-4757-9534-9_9
*  Geniron. Custom Antibody Services. Serum services Antibody Monoclonal. Purification Antibody Mono Y Genetic Immunization...
CHAPTER 6 ANTIBODY GENETICS: ISOTYPES, ALLOTYPES, IDIOTYPES CHAPTER 6 ANTIBODY GENETICS: ISOTYPES, ALLOTYPES, IDIOTYPES See ... Purification of Immunoglobulin G PURIFICATION AND FRAGMENTATION OF ANTIBODIES For many applications, both monoclonal and ... Superior TrueMAB TM monoclonal antibodies for the recognition of proteins native epitopes Superior TrueMAB TM monoclonal ... Heddy Zola, Child Health Research Institute, Adelaide, Australia Monoclonal antibodies are antibodies with a unique specificity ...
  http://docplayer.net/6111038-Geniron-custom-antibody-services-serum-services-antibody-monoclonal-purification-antibody-mono-y-genetic-immunization-genbody-polyclonal-antibody.html
*  Connective tissue growth factor antibodies - FibroGen, Inc.
The epitope group defined by mAb1 binds to a linear epitope on the N-terminal fragment of CTGF encoded by exon 3. A series of ... an immunoglobulin heavy chain sequence comprising the variable domain of SEQ ID NO:14, an immunoglobulin light chain sequence ... WO 03/049773.) The antibodies of the present invention represent a unique, therapeutically efficacious class of anti-CTGF ... idiotype, or species-specific monoclonal antibodies. In one embodiment, the cell line is a hybridoma cell line that produces ...
  http://www.freepatentsonline.com/9034643.html
*  PRODUCTION OF ANTI-SELF ANTIBODIES FROM ANTIBODY SEGMENT REPERTOIRES AND DISPLAYED ON PHAGE - Patent application
Human Anti-Idiotypes [0098]Anti-idiotype antibodies (antibodies directed against the antigen combining sites formed by the ... 0129]Example antibodies are the immunoglobulin isotypes and the Fab, F(ab')2, scFv, Fv, dAb, Fd fragments. Immunoglobulin ... population with said epitope so that individual rgdps with the desired specificity may bind to said epitope. The method may ... Clones from the unselected library using the DP47 VH segment and lacking the characteristic pattern of CDR3 did not bind to ...
  http://www.patentsencyclopedia.com/app/20090325815
*  Patent US7981863 - Treatment of Parkinson's disease with PDGF - Google Patents
The term "epitope" includes any protein determinant capable of specific binding to an immunoglobulin or T-cell receptor. ... contain an antigen binding site capable of immunoreacting with a particular epitope of the antigen characterized by a unique ... Antibody fragments that contain the idiotypes to a protein antigen may be produced by techniques known in the art including, ... The growth factor domain is characterized by an arrangement of cysteine residues and beta strands that is characteristic of the ...
  http://www.google.com/patents/US7981863?dq=7,134,016