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*  The American Journal of Tropical Medicine and Hygiene | Localization of eosinophil granule major basic protein in...
These observations support the hypothesis that the eosinophil, through toxic granule proteins such as major basic protein, ... The eosinophil granule major basic protein is toxic to helminths and mammalian cells in vitro, and its release has been used as ... all tissues were stained with polyclonal antibody to major basic protein; subsequently, colocalization of major basic protein ... using the polyclonal anti-major basic protein antibody, nine of nine tissues showed extracellular major basic protein ...
  http://www.ajtmh.org/content/journals/10.4269/ajtmh.1998.59.66
*  KAKEN - Research Projects | Cloning and functional analysis of molecules for eosinophil differentiation (KAKENHI-PROJECT...
... transactivates the promoter of the eosinophil granule major basic protein gene' BLOOD. 91. 3447-3458 (1998). *. Related Report ... We have been characterizing the regulatory regions of genes encoding eosinophil-specific proteins, including eosinophil ... peroxidase (EPO) Charcot-Leyden crystal (CLC) protein, and eosinophil major basic protein (MBP), to identify transcription ... GATA-1but not GATA-2 transactivates the promoter of granule major basic protein gene'Blood. 91. 3447-3458 (1998). *. ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10670959/
*  WikiGenes - Database [Publication Type]
A novel and highly divergent homolog of human eosinophil granule major basic protein. Plager, D.A., Loegering, D.A., Weiler, D. ... An ATPase domain common to prokaryotic cell cycle proteins, sugar kinases, actin, and hsp70 heat shock proteins. Bork, P., ... hMBPH was isolated from human eosinophil granule lysates, and its identity was verified by amino acid sequencing and by mass ... The 220-kDa rim protein of retinal rod outer segments is a member of the ABC transporter superfamily. Illing, M., Molday, L.L ...
  http://www.wikigenes.org/e/mesh/e/22496.html
*  Mouse Eosinophils: Identification, Isolation, and Functional Analysis - Current Protocols
Eosinophils are bone marrow-derived cells that differentiate in the bone marrow and migrate into the peripheral blood primarily ... Deposition of eosinophil granule major basic protein in eosinophil gastroenteritis and celiac disease. Gastroenterology, 102, ... Tajima, K., & Katagiri, T. (1996). Deposits of eosinophil granule proteins in eosinophilic cholecystitis and eosinophilic ... Activation of basophil and mast cell histamine release by eosinophil granule major basic protein. Journal of Experimental ...
  http://www.currentprotocols.com/WileyCDA/CPUnit/refId-im1443.html?quicktabs_cp=cited
*  Major basic protein - Wikipedia
"Eosinophil granule cationic proteins: major basic protein is distinct from the smaller subunit of eosinophil peroxidase". J. ... eosinophil granule major basic protein), also known as PRG2, is a protein which in humans is encoded by the PRG2 gene. The ... 1990). "Evidence of eosinophil granule major basic protein in human placenta". J. Exp. Med. 170 (6): 2051-2063. doi:10.1084/jem ... Barker RL, Gleich GJ, Pease LR (1988). "Acidic precursor revealed in human eosinophil granule major basic protein cDNA". J. Exp ...
  https://en.wikipedia.org/wiki/Major_basic_protein
*  Method for treating a metastatic carcinoma using a conditionally lethal gene - Patent # 5997859 - PatentGenius
Wasmoen et al., "Biochemical and Amino Acid Sequence Analysis of Human Eosinophil Granule Major Basic Protein," J. Biol. Chem ... and/or CD26 protein in their cell membrane, or from any cell type "engineered" to express such proteins. The resultant virions ... Ohlsson et al., "A beta-cell-specific protein binds to the two major regulatory sequences of the insulin gene enhancer," Proc. ... The E1a region contains the major transcriptional activators, such as the major late promoter (MLP). Id. at 616. The E1a region ...
  http://www.patentgenius.com/patent/5997859.html
*  Clinical and Laboratory Profile of Zika and Dengue Infected Patients: Lessons Learned From the Co-circulation of Dengue, Zika...
Activation of basophil and mast cell histamine release by eosinophil granule major basic protein. J Exp Med. 1983 Jun 1;157(6): ... MMastocytes and basophils are activated and release histamine upon stimulation by eosinophil-derived cationic granule proteins ... Total proteins (g/dL). 7.3 (7.1-7.4)(n=40). 7.0 (6.4-7.7)(n=6). 7.3 (7.1-7.4)(n=14). 7.0 (6.4-7.7)(n=3). 7.0 (6.4-7.7)(n=15). ... Total proteins (g/dL). 7.2 (6.9-7.4)(n=18 ). 7.3 (7.1-7.4)£ (n=46 ). 7.7 (7.3-7.9)+ (n=13 ). 7.4 (7.1-7.6) (n=15 ). ...
  http://currents.plos.org/outbreaks/article/clinical-and-laboratory-profile-of-zika-and-dengue-infected-patients-lessons-learned-from-the-co-circulation-of-dengue-zika-and-chikungunya-in-brazil/
*  anti-PRG2 antibody [1.B.787] | GeneTex
... eosinophil granule major basic protein)) for ELISA, IHC-Fr, IHC-P, WB. Anti-PRG2 mAb (GTX14462) is tested in Human samples. 100 ... proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein). ... Primary Antibodies Secondary Antibodies Proteins & Peptides Lysates & Slides Serum & Reagents Research Kits Isotype Controls ... Specific for eosinophil major basic protein (14kD) irrespective of the stages of eosinophil activation and can be regarded as a ...
  http://www.genetex.com/PRG2-antibody-1B787-GTX14462.html
*  Non-pregnancy related thyroiditis
Histologically, there is marked tissue eosinophilia and extracellular deposition of eosinophil granule major basic proteins. ... Elevation of serum C-reactive protein or ESR levels can occur in both conditions, although an elevated leucocytosis with left ...
  https://www.neurologyadvisor.com/endocrinology-metabolism/non-pregnancy-related-thyroiditis/article/595508/
*  Cellular and immunological markers of allergic and intrinsic bronchial asthma | SpringerLink
Dor PJ, Ackerman SJ, Gleich GJ (1984) Charcot-Leyden crystal protein and eosinophil granule major basic protein in sputum of ... Eosinophil-derived products, particularly eosinophil granule proteins, have been investigated as markers of eosinophil ... Frigas E, Loegering DA, Solley GO, Farrow GM, Gleich GJ (1981) Elevated levels of the eosinophil granule major basic protein in ... Ackerman SJ, Kephart GM, Habermann TM, Greipp PR, Gleich GJ (1983) Localisation of eosinophil granule major basic protein in ...
  https://link.springer.com/article/10.1007%2FBF00172846
*  Chlamydia pneumoniae immunoglobulin A reactivation and airway inflammation in acute asthma | European Respiratory Society
Noncytotoxic activation of neutrophils by eosinophil granule major basic protein: synergistic influence on superoxide anion ... Tomassini M, Tsicopoulis A, Tai PC, et al. Release of granule proteins by eosinophils from allergic and nonallergic patients ... Sputum eosinophil cationic protein (ECP) concentration at Visits 1 and 2 in subjects with (♦) and without (▪) an acute rise in ... Sputum supernatant eosinophil cationic protein (ECP) levels were determined by radioimmunoassay (ECP RIA; Kabi Pharmacia ...
  http://erj.ersjournals.com/content/20/4/834.long
*  Method for eliciting an immune response to human telomerase reverse transcriptase - Patent # 8709995 - PatentGenius
... the catalytic protein subunit of human telomerase. The polynucleotides and polypeptides of the invention are useful for ... "Elevated serum levels in human pregnancy of a molecule immunochemically similar to eosinophil granule major basic protein," J. ... Creighton, T. Proteins, Structures and Moleular Principles, 1983, WH Freeman and Co, New York, NY. cited by applicant.. Dagarag ... "A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye ...
  http://www.patentgenius.com/patent/8709995.html
*  MBP (mbp): Topics by WorldWideScience.org
Cytotoxic Properties of Eosinophil Granule Major Basic Protein for Tumor Cells Adolphson, Cheryl R.; Gleich, Gerald J.; ... Expression and purification of recombinant proteins by fusion to maltose-binding protein ... Identification of cDNA for Rat Homologues of Human Major Basic Protein and Eosinophil Cationic Protein ... Expression of myelin basic protein and glial fibrillary acidic protein genes in human glial tumors ...
  https://worldwidescience.org/topicpages/multi/DE/m/mbp.html
*  PRG2 Antibody 10766-1-AP | Proteintech
This protein can be cleaved into eosinophil granule major basic protein (MBP), which is the major constituent of the ... where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), ... proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) ... crystalline core of the eosinophil granule. MBP is highly basic and toxic to both mammalian cells and parasites, and it ...
  https://www.ptglab.com/Products/PRG2-Antibody-10766-1-AP.htm
*  US Patent # 9,593,320. Proteases with modified pro regions - Patents.com
"Elevated Serum Levels in Human Pregnancy of a Molecule Immunochemically Similar to Eosinophil Granule Major Basic Protein", J. ... Variant proteins encompass naturally-occurring variants and genetically engineered variant proteins. A variant protein in the ... The basic mechanism by which proteins are transported across membranes appears to be universal, with important features ... As used herein, "corresponding region," generally refers to an analogous position along related proteins or a reference protein ...
  http://patents.com/us-9593320.html
*  Nonoxidative Antimicrobial Reactions of Leukocytes | SpringerLink
Identification of a major basic protein in guinea pig eosinophil granules, J. Exp. Med. 137:1459.PubMedCrossRefGoogle Scholar ... I. Isolation of the cationic proteins from the granules of leukaemic myeloid cells, Scand. J. Haematol. 9:204.PubMedCrossRef ... Destruction of bloodstream forms of Trypanosoma cruzi by eosinophil granule major basic protein, Am. J. Trop. Med. Hyg. 30:775. ... Physicochemical and biological properties of the major basic protein from guinea pig eosinophil granules, J. Exp. Med. 140:313. ...
  https://link.springer.com/chapter/10.1007/978-1-4757-4862-8_10
*  EP0107498A2 - Synergistic human interferon activity - Google Patents
Distinctive cationic proteins of the human eosinophil granule: major basic protein, eosinophil cationic protein, and eosinophil ... Release of granule proteins from eosinophils cultured with IL-5.. Holtmann et al. 1987. Down regulation of the receptors for ... Antiproliferative activity of a pregnancy recognition hormone, ovine trophoblast protein-1. Vadhan-Raj et al. 1986. Phase I ... The proteins in the alpha series have been shown to possess both antiviral and cell growth inhibitory effects (1-10). Similarly ...
  https://patents.google.com/patent/EP0107498A2/en
*  E2F4 Modulates Differentiation and Gene Expression in Hematopoietic Progenitor Cells during Commitment to the Lymphoid Lineage ...
... and c/EBPε isoforms regulate transcription of the gene encoding eosinophil granule major basic protein. J. Biol. Chem. 277: ... binding to E2F-responsive promoter sequences in association with the pocket proteins p130 and p107. These pocket proteins are ... The E2F4 protein could then act as a repressor of a repressor, rendering accessible such genes as ikaros, il7ra, and pax5. ... The E2F4 protein is involved in gene repression and cell cycle exit, and also has poorly understood effects in differentiation ...
  http://www.jimmunol.org/content/180/6/3699.long
*  WikiGenes - GATA1 - GATA binding protein 1 (globin...
... and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein. Du, J., ... Expression of mRNA for the GATA-binding proteins in human eosinophils and basophils: potential role in gene transcription. Zon ... Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1. ... A T-cell specific TCR delta DNA binding protein is a member of the human GATA family. Joulin, V., Bories, D., Eléouet, J.F., ...
  https://www.wikigenes.org/e/gene/e/2623.html
*  Atopic Dermatitis - The Skin Manifestation of Atopy | Springer for Research & Development
Dermal deposition of eosinophil-granule major basic protein in atopic dermatitis. Comparison with onchocerciasis. N Engl J Med ... Kapp A (1993) The role of eosinophils in the pathogenesis of atopic dermatitis - eosinophil granule proteins as markers of ... Kaegi MK, Joller-Jemelka H, Wüthrich B (1992) Correlation of eosinophils, eosinophil cationic protein and soluble interleukin-2 ... Eosinophil cationic proteins (ECP and EPX) in health and disease. In: Yoshida T, Torisu M (eds) Immunobiology of the eosinophil ...
  https://rd.springer.com/chapter/10.1007/978-3-642-79446-9_8
*  Olivia Martinez | Stanford Medicine Profiles
We observed the deposition of the primary cytotoxic granule protein of eosinophils, major basic protein (MBP), within the ... Forkhead box (FOX) proteins are a family of important transcription factors and FOXO1 is a target of miR-182. As miR-182 ... that contain IL-5 mRNA and eosinophils also contain infiltrating cells that produce the cytotoxic mediator major basic protein ... Latent membrane protein 1 (LMP1), the major oncogenic protein of EBV, promotes tumorigenesis through activation of NF-kappaB, ...
  https://med.stanford.edu/profiles/olivia-martinez
*  CEBPE - Wikipedia
... and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein". The Journal of ... Williams SC, Cantwell CA, Johnson PF (Sep 1991). "A family of C/EBP-related proteins capable of forming covalently linked ... CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. ... It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal ...
  https://en.wikipedia.org/wiki/CEBPE
*  Eosinophils in glioblastoma biology | Journal of Neuroinflammation | Full Text
In response to various stimuli, the eosinophil is able to produce cytotoxic granules, neuromediators, and pro-inflammatory ... Although eosinophils have been identified in various central nervous system pathologies, and are known to operate in wound/ ... Of central importance to this report is the observation that eosinophil migration to the brain occurs in response to traumatic ... One cell type that is an established effector cell in the pathobiology of atopic disease is the eosinophil. ...
  https://jneuroinflammation.biomedcentral.com/articles/10.1186/1742-2094-9-11
*  Eosinophil Isolation Kit, human - Granulocytes and myeloid cells - MicroBeads and Isolation Kits - Cell separation reagents -...
The Eosinophil Isolation Kit is an indirect magnetic labeling system for the isolation of untouched eosinophils from lysed ... Eosinophils are characterized by granules that contain cytotoxic proteins (e.g. major basic protein, MBP) and ribonucleases. ... Isolation of untouched eosinophils from human peripheral blood using the Eosinophil Isolation Kit, an LS Column, and a MidiMACS ... The Eosinophil Isolation Kit is an indirect magnetic labeling system for the isolation of untouched eosinophils from lysed ...
  https://www.miltenyibiotec.com/BE-en/products/macs-cell-separation/cell-separation-reagents/microbeads-and-isolation-kits/granulocytes-and-myeloid-cells/eosinophil-isolation-kit-human.html
*  Major basic protein | definition of major basic protein by Medical dictionary
... major basic protein explanation free. What is major basic protein? Meaning of major basic protein medical term. What does major ... Looking for online definition of major basic protein in the Medical Dictionary? ... Acidic precursor revealed in human eosinophil granule major basic protein cDNA.. Expression of eosinophil-granule major basic ... Identification of angiotensinogen and complement C3dg as novel proteins binding the proform of eosinophil major basic protein ...
  http://medical-dictionary.thefreedictionary.com/major+basic+protein