*  The assessment of renal function in relation to the use of drugs in elderly in nursing homes; a cohort study
Background. Renal function decreases with age. Dosage adjustment according to renal function is indicated for many drugs, in order to avoid adverse reactions of medications and/or aggravation of renal impairment. There are several ways to assess renal function in the elderly, but no way is ideal. The aim of the study was to explore renal function in elderly subjects in nursing homes and the use of pharmaceuticals that may be harmful to patients with renal impairment.. Methods. 243 elderly subjects living in nursing homes were included. S-creatinine and s-cystatin c were analysed. Renal function was estimated using Cockcroft-Gault formula, Modification of Diet in Renal Disease (MDRD) and cystatin C-estimated glomerular filtration rate (GFR). Concomitant medication was registered and four groups of renal risk drugs were identified: metformin, nonsteroidal anti-inflammatory drugs (NSAID), angiotensin-converting enzyme -inhibitors/angiotensin receptor blockers and digoxin. ...
  http://liu.diva-portal.org/smash/record.jsf?pid=diva2:508144
*  Opposing Effects of β-Blockers and Angiotensin-Converting Enzyme Inhibitors on Development of New-Onset Diabetes Mellitus in...
YOU ARE HERE: Home , Latest in Cardiology , Opposing Effects of β-Blockers and Angiotensin-Converting Enzyme Inhibitors on Development of New-Onset Diabetes Mellitus in Patients With Stable Coronary Artery Disease ...
  http://www.acc.org/latest-in-cardiology/journal-scans/2011/05/04/18/34/opposing-effects-of-beta-blockers-and-ace-inhibitors
*  Purification and characterization of angiotensin I-converting enzyme inhibitory peptides of small red bean (<i>Phaseolus...
Angiotensin I-converting enzyme (ACE) inhibitory activity was investigated for small red bean (Phaseolus vulgaris) protein hydrolysate produced by sequential digestion of Alcalase, papain followed by in vitro gastrointestinal simulation. The hydrolysate had ACE inhibitory activity with IC50 of 67.2 ± 1.8 μg protein/mL. Peptides responsible for potent ACE inhibitory activity were isolated by a three-step purification process, including ultrafiltration, gel filtration and preparative reverse phase high performance chromatography (RP-HPLC). The fraction obtained after RP-HPLC fractionation with the highest activity yielded an IC50 of 19.3 ± 1.4 μg protein/mL. Enzymatic kinetic studies using this fraction demonstrated competitive inhibition with Ki of 11.6 ± 1.7 μg protein/mL. Mass spectrometric characterization identified for the first time the octapeptide PVNNPQIH which demonstrated an IC50 value of 206.7 ± 3.9 μM. The results expand the knowledge base of ACE inhibitory properties of small ...
  http://www.agr.gc.ca/eng/abstract/publication?id=28180000000080
*  Clinical effects of early angiotensin-converting enzyme inhibitor treatment for acute myocardial infarction are similar in the...
OBJECTIVES: We sought to determine whether the clinical effects of early angiotensin-converting enzyme (ACE) inhibitor (ACEi) treatment for acute myocardial infarction (MI) are influenced by the concomitant use of aspirin (ASA). BACKGROUND: Aspirin a
  http://www.biomedsearch.com/nih/Clinical-effects-early-angiotensin-converting/10841227.html
*  Bradykinin Mediates the Acute Effect of an Angiotensin-Converting Enzyme Inhibitor on Cerebral Autoregulation in Rats | Stroke
The major new finding of the present study is that Hoe140, a bradykinin BK2-receptor antagonist, inhibited the captopril-induced change in CBF autoregulation. The result suggests that the modulation of CBF autoregulation by captopril is mediated, at least in part, by bradykinin.. In a previous report, in which Hoe140 (0.75 nmol) was infused into the aorta in Sprague-Dawley rats, bradykinin-induced hypotension was still impaired by 71% 1 hour after infusion.13 In the present intravenous study, the dose of Hoe140 was similar to or even greater than that in the previous study, and it completely prevented the hypotensive effect of bradykinin. In a steady state, Hoe140 concentration in the circulating blood should be constant in the whole body, including cerebral vessels. This means that a sufficient concentration of Hoe140 to block BK2 receptors should have reached cerebral arteries during the experiment. Furthermore, there is no report that the distribution of BK2 receptor is different between ...
  http://stroke.ahajournals.org/content/32/5/1216
*  Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) | Lifescript.com
How does angiotensin-converting enzyme inhibitors ace inhibitors work with other drugs and supplements? Helpful and harmful angiotensin-converting enzyme...
  http://www.lifescript.com/health/centers/hypertension/drug_interactions/angiotensin-converting_enzyme_inhibitors_ace_inhibitors.aspx
*  A meta-analysis of the effect of angiotensin-converting enzyme inhibitors on functional capacity in patients with symptomatic...
The review addressed a clear question for which inclusion criteria were defined. However, decisions to exclude studies from the review might have been subject to bias, as the criteria for exclusion appear to have been defined after the retrieval of primary studies. Attempts were made to locate unpublished studies in the search for primary studies, though a number of unpublished studies were excluded as the data could not be obtained. Funnel plots suggested evidence of publication bias. It was unclear whether steps were taken to minimise bias and errors in the study selection and data extraction as these processes were not described. The authors stated that they did not assess study quality since the included studies were all double-blind RCTs of a similar design, but it would appear from comments in the discussion that the studies had several methodological limitations.. The statistical techniques used to combine the studies and to investigate heterogeneity were applied appropriately, and ...
  http://www.crd.york.ac.uk/crdweb/ShowRecord.asp?LinkFrom=OAI&ID=12004006880
*  ACE Inhibitor Use in Patients With Myocardial Infarction | Circulation
Is primary indication for ACE inhibitor the treatment of the patients with AMI syndrome or with LV dysfunction that at any time complicates AMI? In the first case, should all patients or only those at higher risk be treated (ie, anterior AMI, large AMI)?. When should ACE inhibitor treatment be started?. The two questions are presented together because the answer to question 1 is integrally related to question 2. The evidence available from the trials on ACE inhibitors is documented in detail in Tables 1⇑ and 2⇑ and may be summarized as follows. Treatment with ACE inhibitors has a beneficial effect in patients selected for the presence of LV dysfunction after AMI and in relatively unselected patients presenting with AMI. The benefit increases in patients with clinical or laboratory evidence of LV dysfunction. There is still uncertainty about treating all AMI patients without contraindications to ACE inhibitors or targeting a selected higher-risk group.. The ...
  http://circ.ahajournals.org/content/92/10/3132.full
*  CiNii 論文 - The Lipophilic Properties of Angiotensin I-Converting Enzyme Inhibitors Do Not...
The background for these investigations was the discovery that formation of angiotensin II by the renin angiotensin system can take place in extravascular tissues (e.g., cardiomyocytes and neurons) and within single cells. Consequently, the question arose about whether such tissue-based systems might be differentially influenced by angiotensin I-converting enzyme (ACE) inhibitors with distinct physicochemical properties. Therefore, the aim of this study was to investigate how the membrane penetration of various ACE inhibitors depends on their lipophilia. All diacid forms of ACE inhibitors are dissociated at a pH of 7.4 and scarcely extractable into octanol (extraction coefficient ,10%). In contrast, the extraction coefficients of the parent substances showed marked differences in the following order of increasing lipophilia: enalapril=perindopril,captopril=ceranapril,ramipril,quinapril,HOE288=zofenopril,fosinopril,HOE065. For selected ...
  http://ci.nii.ac.jp/naid/10008197565
*  Effects of long-term treatment with angiotensin-converting-enzyme inhibitors in the presence or absence of aspirin: a...
BACKGROUND: Results from a retrospective analysis of the Studies of Left Ventricular Dysfunction (SOLVD) study suggest that angiotensin-converting-enzyme (ACE) inhibitors may be less effective in patients receiving aspirin. We aimed to confirm or refute this theory. METHODS: We used the Peto-Yusuf method to undertake a systematic overview of data for 22060 patients from six long-term randomised trials of ACE inhibitors to assess whether aspirin altered the effects of ACE inhibitor therapy on major clinical outcomes (composite of death, myocardial infarction, stroke, hospital admission for congestive heart failure, or revascularisation). FINDINGS: Baseline characteristics, and prognosis in patients allocated placebo, differed strikingly between those who were and were not taking aspirin at baseline. Results from analyses of all trials, except SOLVD, did not suggest any significant differences between the proportional reductions in risk with ACE inhibitor ...
  https://www.ctsu.ox.ac.uk/publications/49313
*  Angiotensin-II Receptor Antagonists: Their Place in Therapy - American Family Physician
Angiotensin-II receptor antagonists (or blockers) are a newer class of antihypertensive agents. These drugs are selective for angiotensin II (type 1 receptor); unlike angiotensin-converting enzyme inhibitors, they do not inhibit bradykinin metabolism or enhance prostaglandin synthesis. Angiotensin-II receptor antagonists are well tolerated. Cough occurs much less often with these agents than with angiotensin-converting enzyme inhibitors, and they do not adversely affect lipid profiles or cause rebound hypertension after discontinuation. Clinical trials indicate that angiotensin-II receptor antagonists are effective and safe in the treatment of hypertension. Their use in congestive heart failure and renal disease is under investigation.
  http://www.aafp.org/afp/1999/0601/p3140.html
*  Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) | Aventura Hospital & Medical Center | Aventura, FL
Learn more about Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) at Aventura Hospital & Medical Center Arginine -Possible Harmful Interaction ...
  https://aventurahospital.com/hl/?/21382/Benazepril-Hydrochloride&com.dotmarketing.htmlpage.language=1
*  Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) | Doctors Hospital
Learn more about Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) at Doctors Hospital of Augusta Arginine -Possible Harmful Interaction ...
  https://doctors-hospital.net/hl/?/21382/ACE-Inhibitors--Angiotensin-Converting-Enzyme-Inhibitors&com.dotmarketing.htmlpage.language=1
*  Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) | Memorial Hospital
Learn more about Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) at Memorial Hospital Arginine -Possible Harmful Interaction ...
  https://memorialhospitaljax.com/hl/?/21382/Accupril&com.dotmarketing.htmlpage.language=1
*  Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) | Memorial Hospital
Learn more about Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) at Memorial Hospital Arginine -Possible Harmful Interaction ...
  http://memorialhospitaljax.com/hl/?/21382/Captopril&com.dotmarketing.htmlpage.language=1
*  Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) | Memorial Hospital
Learn more about Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) at Memorial Hospital Arginine -Possible Harmful Interaction ...
  http://memorialhospitaljax.com/hl/?/21382/Univasc&com.dotmarketing.htmlpage.language=1
*  Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) | Portsmouth Regional Hospital
Learn more about Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) at Portsmouth Regional Hospital Arginine -Possible Harmful Interaction ...
  http://portsmouthhospital.com/hl/?/21382/Altace&com.dotmarketing.htmlpage.language=1
*  Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) | LewisGale Regional Health System
Learn more about Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) at LewisGale Regional Health System Arginine -Possible Harmful Interaction ...
  https://lewisgale.com/hl/?/21382/lisinopril&com.dotmarketing.htmlpage.language=1
*  Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) | Grand Strand Health
Learn more about Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) at Grand Strand Medical Center Arginine -Possible Harmful Interaction ...
  http://grandstrandmed.com/hl/?/21382/Captopril&com.dotmarketing.htmlpage.language=1
*  Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) | Grand Strand Health
Learn more about Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) at Grand Strand Medical Center Arginine -Possible Harmful Interaction ...
  https://grandstrandmed.com/hl/?/21382/Lisinopril&com.dotmarketing.htmlpage.language=1
*  Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) | Blake Medical Center | Bradenton, FL
Learn more about Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) at Blake Medical Center Arginine -Possible Harmful Interaction ...
  https://blakemedicalcenter.com/hl/?/21382/Quinapril-Hydrochloride&com.dotmarketing.htmlpage.language=1
*  Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) | Orange Park Medical Center
Learn more about Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) at Orange Park Medical Center Arginine -Possible Harmful Interaction ...
  http://orangeparkmedical.com/hl/?/21382/enalapril&com.dotmarketing.htmlpage.language=1
*  Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) | Medical City Dallas
Learn more about Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors) at Medical City Dallas Arginine -Possible Harmful Interaction ...
  http://medicalcityhospital.com/hl/?/21382/Benazepril-Hydrochloride&com.dotmarketing.htmlpage.language=1