Loading...
*  Benefits of Vine Leaf on Different Biological Systems | IntechOpen
Flavonoids inhibit phospholipase A2 and cyclooxygenase enzymes, decreasing prostaglandins synthesis and, indirectly, all ... flavonoids increase the expression of enzyme γ‐glutamylcysteine synthetase, a rate‐limiting enzyme in the synthesis of ... Regarding the antioxidant enzymes, we found that only the dose of 50 mg/kg prevented the increasing on SOD activity in the ... Vine leaves extract (Vitis coignetiae Pulliat) decreases the leakage of biliary enzymes and attenuates liver fibrosis after 3 ...
  https://www.intechopen.com/books/grape-and-wine-biotechnology/benefits-of-vine-leaf-on-different-biological-systems
*  Brain Sciences | Free Full-Text | Ethanol Neurotoxicity in the Developing Cerebellum: Underlying Mechanisms and Implications |...
In prostaglandin synthesis, the enzyme phospholipase A2 (PLA2) catalyzes the formation of arachidonic acid from membrane-bound ... 9. Ethanol Increases Prostaglandin Production. Prostaglandins (PGs), especially prostaglandin E2 (PGE2), regulate CNS ... which is subsequently converted into prostaglandin by enzyme cyclooxygenase. In vitro and in vivo studies show that ethanol can ... Prostaglandins 1988, 36, 835-846. [Google Scholar]. *Luo, J.; Lindstrom, C.L.; Donahue, A.; Miller, M.W. Differential effects ...
  http://mdpi.com/2076-3425/3/2/941/htm
*  Intracellular- and extracellular-derived Ca2+ influence phospholipase A2-mediated fatty acid release from brain phospholipids
1. Kudo I, Murakami M. Phospholipase A2 enzymes. Prostaglandins Other Lipid Mediat. 2002;68-69:3-58. [PubMed] ... cytosolic phospholipase A2. iPLA2. Ca2+-independent phospholipase A2. sPLA2. secretory phospholipase A2. PUFA. polyunsaturated ... Brain phospholipases A2: a perspective on the history. Prostaglandins Leukot Essent Fatty Acids. 2004;71:161-169. [PubMed] ... 1. Overview of the phospholipase A2 families. Although PLA2 enzymes have been known for over 100 years, only within the last 15 ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC2735787/
*  Secretory phospholipase A2: A multifaceted family of proatherogenic enzymes | SpringerLink
... represents a class of enzymes that hydrolyze phospholipids from cellular membranes and lipoproteins, resulting in multifarious ... Prostaglandins Other Lipid Mediat 2005, 75:79-89.CrossRefPubMedGoogle Scholar ... Secretory phospholipase A2 (sPLA2) represents a class of enzymes that hydrolyze phospholipids from cellular membranes and ... A major physiological role for the group IIA enzyme that depends on the very high pi of the enzyme to allow penetration of the ...
  https://link.springer.com/article/10.1007/s11886-009-0064-2
*  An Essential Role of Cytosolic Phospholipase A2α in Prostaglandin E2-mediated Bone Resorption Associated with Inflammation | JEM
... cytosolic phospholipase A2α; EIA, enzyme immunoassay; mPGES, membrane-bound prostaglandin E synthase; PG, prostaglandin; PGE, ... Identification of human prostaglandin E synthase: A microsomal, glutathione-dependent, inducible enzyme, constituting a ... An Essential Role of Cytosolic Phospholipase A2α in Prostaglandin E2-mediated Bone Resorption Associated with Inflammation. ... Prostaglandin synthesis by fetal rat bone in vitro: evidence for a role of prostacyclin. Prostaglandins. 17:905-914. ...
  http://jem.rupress.org/content/197/10/1303
*  Prostaglandin | chemical compound | Britannica.com
Prostaglandins were discovered in human semen in 1935 by the Swedish physiologist Ulf von Euler, who named them, thinking that ... Prostaglandin, any of a group of physiologically active substances having diverse hormonelike effects in animals. ... These stimuli, either directly or indirectly, result in the activation of an enzyme called phospholipase A2. This enzyme ... More About Prostaglandin. 19 references found in Britannica articles. Assorted References. *major reference* In prostaglandin: ...
  https://www.britannica.com/science/prostaglandin
*  Cyclooxygenase-1 and -2 enzymes differentially regulate the brain upstream NF-κB pathway and downstream enzymes involved in...
2 enzymes differentially regulate the brain upstream NF-κB pathway and downstream enzymes involved in prostaglandin ... we examined the expression and activity of COX-2 and phospholipase A2 enzymes (cPLA2 and sPLA2), as well as the expression of ... M. Kerry O'Banion, Prostaglandin E2 synthases in neurologic homeostasis and disease, Prostaglandins & Other Lipid Mediators, ... metabolic pathway to prostaglandin E2 (PGE2), as well as enzyme activity, protein and mRNA levels of the reciprocal isozyme, ...
  http://onlinelibrary.wiley.com/doi/10.1111/j.1471-4159.2006.03926.x/abstract
*  Fluticasone (Topical) (Professional Patient Advice) - Drugs.com
... liposomal enzymes, prostaglandins) through the induction of phospholipase A2 inhibitory proteins (lipocortins) and sequential ...
  https://www.drugs.com/ppa/fluticasone-topical.html
*  Incepta Pharmaceuticals | Product details
Intasone (Hydrocortisone) inhibits prostaglandin synthesis by inhibiting the enzyme phospholipase A2. Hydrocortisone reduces ... Drugs that induce hepatic enzymes such as Phenobarbital, Phenytoin and Rifampin may increase the clearance of corticosteroids ...
  http://inceptapharma.com/view-product.php?pid=331
*  KAKEN - Research Projects | Isolation of Phospholipase A 2 Activating Peptide From Inflamed Gingival Tissues. (KAKENHI-PROJECT...
Prostaglandins are synthesized by phospholipase A_2 (PLase A_2), a rate-limiting enzyme for their synthesis. Thus, group of ... Phospholipase A_2 / Peptide / Gingival tissues / Carrageenin induced granuloma / ホスホリパ-ゼA_2 / 実験的炎症 / 起炎 / 血管透過性. ... Isolation of Phospholipase A_2 Activating Peptide From Inflamed Gingival Tissues.. Research Project ... Publications] Kudo T.: 'Involvement of lysosomal enzymes in enkephalin production in dental pulp of the rat' Dentistry in Japan ...
  https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01571014/
*  News Release | Scripps Research
... with phospholipase A2 enzymes making a more limited contribution. MAGL also regulated arachidonic acid and prostaglandins in ... Phospholipase A2 enzymes have long been considered the dominant producers of arachidonic acid, and thus a major element in ... They work by inhibiting the cyclo-oxygenase enzymes that convert arachidonic acid into prostaglandins. But NSAIDs also inhibit ... Nomura, Cravatt, and their colleagues confirmed in their experiments that phospholipase A2 enzymes play a major role in ...
  https://www.scripps.edu/news-and-events/press-room/2011/20111020cravatt.html
*  Innate Immunity | Boundless Anatomy and Physiology
This pathway is mediated by the enzymes phospholipase A2 (PLA2), cyclooxygenase-2 (COX-2), and prostaglandin E2 synthase. These ... A trigger of the fever, called a pyrogen, causes a release of prostaglandin E2 (PGE2). PGE2 then acts on the hypothalamus, ... The primary fever mediator in the human body is prostaglandin E2 (PGE2), which acts on the hypothalamus to raise the ... Fever is an elevation of body temperature above the regulatory set point, mediated through the release of prostaglandin E2. ...
  https://courses.lumenlearning.com/boundless-ap/chapter/innate-immunity/
*  1 - Today Binary Options Education Spreads
Eunuch, one of the precursors of prostaglandins, is made available for prostaglandin synthesis by the enzyme phospholipase A2. ...
  http://forexturboprofits.com/today-binary-options-education-spreads.html
*  Prostaglandins e | Article about Prostaglandins e by The Free Dictionary
Prostaglandins are highly potent substances... Explanation of Prostaglandins e ... Find out information about Prostaglandins e. any of a group of about a dozen compounds synthesized from fatty acids in mammals ... polyunsaturated fatty acids with a linear chain of 20 carbon atoms are released from phospholipids by the enzyme phospholipase ... prostaglandin. (redirected from Prostaglandins e). Also found in: Dictionary, Thesaurus, Medical. prostaglandin. (prŏs'təglăn` ...
  https://encyclopedia2.thefreedictionary.com/Prostaglandins+e
*  Non-steroidal anti-inflammatory drugs: list and prices - Treat simply
... which in turn is obtained from the phospholipids of the cell membrane by the enzyme phospholipase A2.Prostaglandins among other ... an inflammation enzyme) and do not affect the work of COX-1( protection enzyme). ... Most of the drugs in this group are nonselective inhibitors of the cyclooxygenase enzyme, suppressing the effect of both of its ... The mechanism of their action is based on the blocking of certain enzymes( COX, cyclooxygenase), they are responsible for the ...
  http://treat-simply.com/en/records/1678
*  April 2015 - Mast Attack
To make prostaglandins, an enzyme called phospholipase A2 turns diacylglycerol into arachidonic acid (AA). All prostaglandins ... To make prostaglandins from AA, cells use the enzymes COX-1 and COX-2. COX-1 produces regular low levels of prostaglandins, ... asthma, flushing, prostaglandin D2, prostaglandins, respiratory symptoms Prostaglandins and leukotrienes. Lisa Klimas. April 25 ... Other enzymes called prostaglandin synthases finish off making the prostaglandins into the right shapes. To make leukotrienes ...
  http://www.mastattack.org/2015/04/
*  Nutritional supplement to improve supplementary target protein fraction (TPF) delivery, intracellular absorption and...
... prostaglandin (PG) E2, and the inflammatory enzyme phospholipase A2. Embodiments of the present invention rely on benefits of ... and various enzymes including the digestive enzyme pepsin. Common chlorella without specialtreatment is hard to digest as the ... The proton pump consists of an enzyme reaction in the parietal cell membrane that uses ATP to transport H+ across the cell ... The primary role of chondroitin sulfate A-4 in promoting joint health lies in the ability to reduce the degenerative enzymes ...
  http://www.patentgenius.com/patent/8404246.html
*  Scripps Research Scientists Discover Inflammation Is Controlled Differently in Brain and Other Tissues - Healthcanal.com :...
... with phospholipase A2 enzymes making a more limited contribution. MAGL also regulated arachidonic acid and prostaglandins in ... Phospholipase A2 enzymes have long been considered the dominant producers of arachidonic acid, and thus a major element in ... They work by inhibiting the cyclo-oxygenase enzymes that convert arachidonic acid into prostaglandins. But NSAIDs also inhibit ... Nomura, Cravatt, and their colleagues confirmed in their experiments that phospholipase A2 enzymes play a major role in ...
  https://www.healthcanal.com/brain-nerves/22208-scripps-research-scientists-discover-inflammation-is-controlled-differently-in-brain-and-other-tissues.html
*  Lipoprotein-Associated Phospholipase A2 and Risk Stratification for Cardiovascular Disease: Not Ready for "Prime Time"
It states the role of prostaglandins in inflammation and mentions the two classes of the enzyme phospholipase A2 (PLA2) ... Characterization of Group X Phospholipase A2 as the Major Enzyme Secreted by Human Keratinocytes and its Regulation by the ... Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a calcium-independent phospholipase A2 that circulates in plasma in ... Lipoprotein-associated phospholipase A2 (Lp-PLA2) is an emerging risk factor and therapeutic target for cardiovascular disease ...
  http://connection.ebscohost.com/c/articles/24013409/lipoprotein-associated-phospholipase-a2-risk-stratification-cardiovascular-disease-not-ready-for-prime-time
*  Diverse Functions of Secretory Phospholipases A2
I. Kudo and M. Murakami, "Phospholipase A2 enzymes," Prostaglandins and Other Lipid Mediators, vol. 68-69, pp. 3-58, 2002. View ... "Expression of secretory phospholipase A2 enzymes in lungs of humans with pneumonia and their potential prostaglandin-synthetic ... M. Murakami, Y. Taketomi, C. Girard, K. Yamamoto, and G. Lambeau, "Emerging roles of secreted phospholipase A2 enzymes: lessons ... N. M. Muñoz, Y. J. Kim, A. Y. Meliton et al., "Human group V phospholipase A2 induces group IVA phospholipase A2-independent ...
  https://www.hindawi.com/journals/avm/2014/689815/ref/
*  Three Candidate Genes and Angiotensin-Converting Enzyme Inhibitor-Related Cough | Hypertension
... phospholipase C and/or A2, prostaglandins, neuropeptide Y) and to local release of histamine in the airways.2 3 Because cough ... An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme ... Three Candidate Genes and Angiotensin-Converting Enzyme Inhibitor-Related Cough. A Pharmacogenetic Analysis. Robert Y. L. Zee, ... Three Candidate Genes and Angiotensin-Converting Enzyme Inhibitor-Related Cough. Robert Y. L. Zee, Valluri S. Rao, Robert Z. ...
  http://hyper.ahajournals.org/content/31/4/925
*  Fever - Wikipedia
... is mediated by the enzymes phospholipase A2 (PLA2), cyclooxygenase-2 (COX-2), and prostaglandin E2 synthase. These enzymes ... A trigger of the fever, called a pyrogen, causes a release of prostaglandin E2 (PGE2). PGE2 then in turn acts on the ... PGE2 acts on neurons in the preoptic area (POA) through the prostaglandin E receptor 3 (EP3). EP3-expressing neurons in the POA ...
  https://en.wikipedia.org/wiki/Fever
*  Palmitoylethanolamide: a lipid transmitter | palmitoylethanolamide4pain
... growth factors and nutrients control the activity of a key set of lipid-modifying enzymes: phospholipases, prostaglandin ... Phospholipases. Ceramides for instance are lipids composed of sphingosine and a fatty acid and derive from the hydrolisis of ... These enzymes and their downstream targets constitute a complex lipid signalling network with multiple nodes of interaction and ... NAPE and is synthesized by NAPE hydrolyzing enzymes, the released PEA shuttles into the cytosol via protein carriers and ...
  https://palmitoylethanolamide4pain.com/about-2__trashed/scientific-sources/palmitoylethanolamide-a-lipid-transmitter/
*  Functional Characterization of Cyclooxygenase-2 Polymorphisms | Journal of Pharmacology and Experimental Therapeutics
... like phospholipases, specific prostaglandin synthases/isomerases, or possibly drug-metabolizing enzymes may be responsible for ... Cyclooxygenases (COX)-1 and -2 are the key enzymes in the conversion of arachidonic acid to prostaglandin (PG) H2, the ... Cyclooxygenases (COX)-1 and -2 are the key enzymes in the conversion of arachidonic acid to prostaglandins. COX-2 appears to ... 1989) Cloning of human gene encoding prostaglandin endoperoxide synthase and primary structure of the enzyme. Biochem Biophys ...
  http://jpet.aspetjournals.org/content/299/2/468.long
*  The role of the EP receptors for prostaglandin E2 in skin and skin cancer
Fukami K, Inanobe S, Kanemaru K, Nakamura Y. Phospholipase C is a key enzyme regulating intracellular calcium and modulating ... Prostaglandin E2 stimulates fibronectin expression through EP1 receptor, phospholipase C, protein kinase Calpha, and c-Src ... Prostaglandin receptor EP2 is responsible for cyclooxygenase-2 induction by prostaglandin E2 in mouse skin. Carcinogenesis. ... UVB light upregulates prostaglandin synthases and prostaglandin receptors in mouse keratinocytes. Toxicology and Applied ...
  http://pubmedcentralcanada.ca/pmcc/articles/PMC3236828/?lang=en-ca