*  Switch recombination and somatic hypermutation are controlled by the heavy chain 3′ enhancer region | JEM
The 3′ enhancers are important for somatic hypermutation. Past work has shown that elements within the 3′ enhancer region ( ... Indeed, we noticed that, in a standard genetic cross, the 774 transgene cosegregated with the endogenous heavy chain locus in ... Both the intronic enhancer (between the VDJ and Cμ exons) and the 3′ enhancers are shown as black circles. "2X INS" indicates ... S1) is altered by deletion of the 3′ enhancers. Depending on the transgenic line, the deletion of the 3′ enhancers has a small ...
  http://jem.rupress.org/content/206/12/2613
*  Cell Signaling Pathway Profiling
These systems consist of sets of vectors that each contain a distinct cis-acting enhancer element upstream of a reporter gene. ... These systems consist of sets of vectors that each contain a distinct cis-acting enhancer element upstream of a reporter gene. ... 1.14 Genetic Disease * 1.15 Synthetic Biology * 1.16 Neural Tube Defects * 1.17 Bats ... Most of the cis-acting enhancer elements included in our transcription factor systems are regulated by more than one ...
  http://www.clontech.com/US/Products/Fluorescent_Proteins_and_Reporters/Signal_Transduction/Pathway_Profiles?sitex=10020:22372:US&PROD=oCHiP7YT3XWVTLUF8-dL1rut:S&PROD_pses=ZG906EF0847B0E42E4D343B951F682D8066776EBF075765B2D5511AE709FB62FE23AEB77F9176110792432C5004ED1F9C96519AC6F436D8241
*  Specificity of CNS and PNS regulatory subelements comprising pan-neural enhancers of the deadpan and scratch genes is achieved...
We have identified a cis-acting enhancer element driving full pan-neural expression of the dpn gene which is composed of ... Genetic dissection of nodal function in patterning the mouse embryo. *. The dermomyotome dorsomedial lip drives growth and ... We have also identified CNS- and PNS-specific subelements of the scrt enhancer. Deletion analysis of the dpn and scrt PNS- ... Specificity of CNS and PNS regulatory subelements comprising pan-neural enhancers of the deadpan and scratch genes is achieved ...
  http://dev.biologists.org/content/121/11/3549
*  Exons Encode Enhancers | Science
Transcription factor binding to enhancer elements is critical for proper gene regulation. Enhancers are often found in ... Moreover, phenotypes seen in genetic knockout animals may be the result of not only the lack of expression of the deleted gene ... Mutation of these elements in zebrafish and mouse enhancer assays showed that although exonic sequences are necessary, they are ... Birnbaum et al. analyzed 25 mouse and human enhancer-associated ChIP-seq data sets in order to identify enhancer peaks that ...
  http://science.sciencemag.org/content/336/6079/277.1
*  Short DNA sequence patterns accurately identify broadly active human enhancers | BMC Genomics | Full Text
EnhancerDinucleotide repeat motifMachine learningGene expression. Background. Enhancers are DNA regulatory elements distal to ... An erythroid enhancer of BCL11A subject to genetic variation determines fetal hemoglobin level. Sci. 2013;342(6155):253-7.View ... Enhancers are DNA regulatory elements that influence gene expression. There is substantial diversity in enhancers' activity ... For consistency with the enhancer prediction analyses, we analyzed 600 bp regions centered on each enhancer for all enhancer ...
  https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-3934-9
*  Modified binding of proteins from calcitonin-negative tumor cells to the neuroendocrine-specific CANNTG motif of the calcitonin...
... cell line TT is modulated by a neuroendocrine-specific enhancer fragment (nucleotides -965 to -905) containing two CANNTG ... Enhancer Elements, Genetic*. Gene Expression Regulation, Neoplastic*. Hela Cells. Humans. Molecular Sequence Data. ... In CT-negative MTC cells (RO-D81), the Ets response element was active but the two copies of E2 were not. Similar results were ... Previous Document: Identification of positive and negative regulatory elements involved in the retinoic acid/cAMP induc.... ...
  http://www.biomedsearch.com/nih/Modified-binding-proteins-from-calcitonin/8265349.html
*  Pluripotential reprogramming of the somatic genome in hybrid cells occurs with the first cell cycle.
Oct4-green fluorescent protein (GFP) transgenes that do not contain the proximal enhancer (PE) region are widely used to ... Enhancer Elements, Genetic. Female. Gene Expression Regulation. Genome. Green Fluorescent Proteins / genetics. Hybrid Cells / ... Oct4-green fluorescent protein (GFP) transgenes that do not contain the proximal enhancer (PE) region are widely used to ...
  http://www.biomedsearch.com/nih/Pluripotential-reprogramming-somatic-genome-in/18065396.html
*  Imaging of flexor and extensor motoneurons targeted wit | Open-i
Enhancer Elements, Genetic. *Genes, Reporter. *Integrases/genetics. *Motor Neurons/cytology. *Rhodopsin/metabolism ... Bottom Line: Here we present a circuit-deciphering 'tool box' for fast, reliable and cheap genetic targeting of neuronal ... Bottom Line: Here we present a circuit-deciphering 'tool box' for fast, reliable and cheap genetic targeting of neuronal ... chick neural tube along with ubiquitously-expressed PBase and Cre under the control of the chick motoneuron-specific enhancer ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4231727_gku750fig6&req=4
*  Recent Articles | Agarose And Developmental Biology | The Scientist Magazine®| Page 9
Researchers show that genetic enhancer elements likely contribute to face shape in mice. ... In mice and flies, the Arc protein forms capsids and carries genetic information. ...
  https://www.the-scientist.com/?articles.list/tagNo/2915,5/tags/agarose,developmental-biology/pageNo/9/
*  Recent Articles | Developmental Biology, Disease/Medicine And Culture | The Scientist Magazine®| Page 83
Researchers show that genetic enhancer elements likely contribute to face shape in mice. ... In mice and flies, the Arc protein forms capsids and carries genetic information. ...
  https://www.the-scientist.com/?articles.list/tagNo/5,6,3/tags/developmental-biology,disease-medicine,culture/pageNo/83/
*  Recent Articles | Developmental Biology And Culture | The Scientist Magazine®| Page 32
Researchers show that genetic enhancer elements likely contribute to face shape in mice. ... of the genetics of earlobe attachment is just the latest collaborative research project to come out of the personal genetic ...
  https://www.the-scientist.com/?articles.list/tagNo/5,3/tags/developmental-biology,culture/pageNo/32/
*  Mutation analysis of sorted GFP+ C-GFP clones. Sorted G | Open-i
Enhancer Elements, Genetic. *Enzyme Activation. *Mutation. *TCF Transcription Factors/metabolism. *Transcription Factor 7-Like ... Bottom Line: The CA versus AA effect requires AID.The other cis-elements of Ig enhancers alone cannot attract the SHM machinery ... Bottom Line: The CA versus AA effect requires AID.The other cis-elements of Ig enhancers alone cannot attract the SHM machinery ... The other cis-elements of Ig enhancers alone cannot attract the SHM machinery. Collectively with other recent findings, we ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2822603_JEM_20090821_RGB_Fig5&req=4
*  ZFIN Publication: Gehrke et al., 2015
Animals; Enhancer Elements, Genetic; Fishes/anatomy & histology*; Fishes/genetics; Gene Expression Regulation, Developmental ( ... Animals; Enhancer Elements, Genetic; Fishes/anatomy & histology*; Fishes/genetics; Gene Expression Regulation, Developmental; ... Moreover, gar enhancers drive reporter gene expression in both the wrist and digits of mouse embryos in patterns that are ... Deep conservation of wrist and digit enhancers in fish. Gehrke, A.R., Schneider, I., de la Calle-Mustienes, E., Tena, J.J., ...
  http://zfin.org/ZDB-PUB-141224-10
*  The diverse evolutionary pattern of ESEs and ESSs in as | Open-i
Enhancer Elements, Genetic. *Gene Silencing. *Genetic Variation. *Humans. *Mice. *Models, Genetic. *Models, Statistical ... For easy visualization, we plot the copy with lower element density (Low) on the abscissa axis and the other with higher ... For easy visualization, we plot the copy with lower element density (Low) on the abscissa axis and the other with higher ... When compared to pre-duplication ancestors, we found that there is a significant overall loss of exonic splicing enhancers and ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3091315_gb-2009-10-11-r120-3&req=4
*  ZFIN Publication: Lee et al., 2015
Enhancer Elements, Genetic*; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental*; Gene Library; Gene ... Lee, H.J., Lowdon, R.F., Maricque, B., Zhang, B., Stevens, M., Li, D., Johnson, S.L., Wang, T. (2015) Developmental enhancers ... When tested in vivo using a transgenic zebrafish assay, 20 out of 20 selected candidate dsDMRs exhibit functional enhancer ... Developmental enhancers revealed by extensive DNA methylome maps of zebrafish early embryos ...
  http://zfin.org/ZDB-PUB-150224-20
*  Patterns of conservation (A, C), expression (D), and cr | Open-i
Enhancer Elements, Genetic*. *RNA, Untranslated/genetics*. *Regulatory Elements, Transcriptional*. *Retroelements*. Minor. * ... Transposable Elements and DNA Methylation Create in Embryonic Stem Cells Human-Specific Regulatory Sequences Associated with ... Transposable Elements and DNA Methylation Create in Embryonic Stem Cells Human-Specific Regulatory Sequences Associated with ... and POU5F1 proteins immobilized on a DNA scaffold may play a functional role at distal regulatory elements. ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4494056_evv081f6ap&req=4
*  T cell development in mIκB-α transgenic mice. Single | Open-i
Enhancer Elements, Genetic/genetics. *Flow Cytometry. *Interleukins/metabolism. *Mice. *Mice, Transgenic. *Mitogens/ ... under the control of the T cell-specific CD2 promoter and enhancer (mutant [m]IkappaB-alpha mice). Thymocyte development ... under the control of the T cell-specific CD2 promoter and enhancer (mutant [m]IkappaB-alpha mice). Thymocyte development ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC1887697_JEM981160.f3b&req=4
*  Msi1 BAC deletion studies suggest that both the 55-65 k | Open-i
Enhancer Elements, Genetic/genetics*. *Gene Expression Regulation*. *Introns/genetics*. *Nerve Tissue Proteins/genetics*/ ... element for Msi1 transcription in NS/PCs is located in the sixth intron of the Msi1 gene.The 595-bp D5E2 intronic enhancer can ... element for Msi1 transcription in NS/PCs is located in the sixth intron of the Msi1 gene.The 595-bp D5E2 intronic enhancer can ... Conclusions: A regulatory element for Msi1 transcription in NS/PCs is located in the sixth intron of the Msi1 gene. The 595-bp ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3108301_1756-6606-4-14-3&req=4
*  Inversion alleles reallocate the target of the heart en | Open-i
Inversion alleles reallocate the target of the heart enhancer.(A) A schematic representation of the three different inversions ... Enhancer Elements, Genetic*. *Heart/embryology/growth & development*. *Transcription Factor AP-2/biosynthesis/genetics* ... the enhancers and the TZ region were unchanged (S7 Fig.). In INV-M, the heart enhancer was now equidistant from Bmp7 and Tfap2c ... the enhancers and the TZ region were unchanged (S7 Fig.). In INV-M, the heart enhancer was now equidistant from Bmp7 and Tfap2c ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC4288730_pgen.1004897.g004&req=4
*  Response Elements | Harvard Catalyst Profiles | Harvard Catalyst
Regulatory Elements, Transcriptional [G05.360.340.024.340.137.750]. *Enhancer Elements, Genetic [G05.360.340.024.340.137. ... Dual functionality of cis-regulatory elements as developmental enhancers and Polycomb response elements. Genes Dev. 2017 03 15 ... "Response Elements" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject ... Elements of Grant Writing Tips and work plans for the grant writing process. ...
  https://connects.catalyst.harvard.edu/Profiles/display/Concept/Response%20Elements
*  H3.3 nucleosome splitting events are better markers for | Open-i
Enhancer Elements, Genetic*. *Histones/chemistry/genetics*. *Nucleosomes/genetics*/ultrastructure. Minor. *Cell Cycle/genetics ... H3.3-H4 tetramer splitting events feature cell-type specific enhancers. Huang C, Zhang Z, Xu M, Li Y, Li Z, Ma Y, Cai T, Zhu B ... H3.3-H4 tetramer splitting events feature cell-type specific enhancers. Huang C, Zhang Z, Xu M, Li Y, Li Z, Ma Y, Cai T, Zhu B ... We propose that the H3.3 nucleosomes at enhancers may be split by an active mechanism to regulate cell-type specific ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC3675017_pgen.1003558.g005&req=4
*  Activation of antioxidant response and induction of HMO | Open-i
Response Elements*. *Transcriptional Activation*. Minor. *Binding Sites. *Cell Line. *Enhancer Elements, Genetic ... In contrast, the transcriptional repressor BACH1 binds ARE-like enhancers in cells naïve to oxidative stress and antagonizes ... In contrast, the transcriptional repressor BACH1 binds ARE-like enhancers in cells naïve to oxidative stress and antagonizes ... Oxidative stress activates the transcription factor NRF2, which in turn binds cis-acting antioxidant response element (ARE) ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2175339_gkm638f1&req=4
*  Expression of the ATF in the ECV304 cells. Immunofluore | Open-i
Enhancer Elements, Genetic*. *Heme Oxygenase-1/biosynthesis*/genetics/metabolism. *Nuclear Localization Signals/chemistry/ ... We next analyzed the affinity of the ATF to the HMOX1 enhancer and the effect of the ATF on endogenous HMOX1 expression. The ... We next analyzed the affinity of the ATF to the HMOX1 enhancer and the effect of the ATF on endogenous HMOX1 expression. The ... In the current study, an HMOX1 (HO-1 gene) enhancer-specific artificial zinc-finger protein (AZP) was designed using ...
  https://openi.nlm.nih.gov/detailedresult.php?img=PMC2913762_JBB2010-168689.004&req=4