Secretory phospholipase A2: A multifaceted family of proatherogenic enzymes | SpringerLink
Secretory phospholipase A2 (sPLA2) represents a class of enzymes that hydrolyze phospholipids from cellular membranes and ... Saiga A, Uozumi N, Ono T, et al.: Group X secretory phospholipases A2 can induce arachidonic acid release and eicosanoid ... Prostaglandins Other Lipid Mediat 2005, 75:79-89.CrossRefPubMedGoogle Scholar ... Boyanovsky B, Webb N: Biology of secretory phospholipase A2. Cardiovasc Drugs Ther 2009, 23:61-72.CrossRefPubMedGoogle Scholar ...https://link.springer.com/article/10.1007/s11886-009-0064-2
Intracellular- and extracellular-derived Ca2+ influence phospholipase A2-mediated fatty acid release from brain phospholipids
Eicosanoids and the hypothalamo-pituitary axis. Prostaglandins Leukot Essent Fatty Acids. 1989;36:235-250. Scopus. [PubMed] ... cytosolic phospholipase A2. iPLA2. Ca2+-independent phospholipase A2. sPLA2. secretory phospholipase A2. PUFA. polyunsaturated ... Brain phospholipases A2: a perspective on the history. Prostaglandins Leukot Essent Fatty Acids. 2004;71:161-169. [PubMed] ... 1. Kudo I, Murakami M. Phospholipase A2 enzymes. Prostaglandins Other Lipid Mediat. 2002;68-69:3-58. [PubMed] ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2735787/
An Essential Role of Cytosolic Phospholipase A2α in Prostaglandin E2-mediated Bone Resorption Associated with Inflammation | JEM
Cytosolic phospholipase A2 is essential for both the immediate and the delayed phases of eicosanoid generation in mouse bone ... membrane-bound prostaglandin E synthase; PG, prostaglandin; PGE, prostaglandin E; PGES, PGE synthase; PLA2, phospholipase A2; ... Phospholipase A2 in eicosanoid generation. Am. J. Respir. Crit. Care Med. 161:S32-S35. ... An Essential Role of Cytosolic Phospholipase A2α in Prostaglandin E2-mediated Bone Resorption Associated with Inflammation. ...http://jem.rupress.org/content/197/10/1303
Publications 2014 - Institut de pharmacologie de Sherbrooke - Université de Sherbrooke
Cytosolic phospholipase A2 and eicosanoids modulate life, death and function of human osteoclasts in vitro. Prostaglandins ... Prostaglandins Leukot. Essent. Fatty Acids 90, 39-45 (2014). Jones, J. D. et al. Serum C-X-C motif chemokine 13 is elevated in ... Allard-Chamard, H., Haroun, S. & de Brum-Fernandes, A. J. Secreted phospholipase A2 type II is present in Paget's disease of ... Yue, L., Haroun, S., Parent, J.-L. & de Brum-Fernandes, A. J. Prostaglandin D(2) induces apoptosis of human osteoclasts through ...https://www.usherbrooke.ca/ips/fr/publications/publications-2014/
Modulation of Membrane Lipid Composition and Homeostasis in Salmon Hepatocytes Exposed to Hypoxia and Perfluorooctane...
... phospholipase activity and eicosanoid production in Atlantic salmon (Salmo salar). Prostaglandins Leukot Essent Fatty Acids 49 ... For example, eicosanoids, including prostaglandins, thromboxanes and leukotrienes, belong to an extensive family of oxygenated ... Over-production of ARA-derived eicosanoids may be responsible for a number of pathophysical conditions in humans, such as ... Forman BM, Chen J, Evans RM (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102485
The Step Further to Understand the Role of Cytosolic Phospholipase A2 Alpha and Group X Secretory Phospholipase A2 in Allergic...
A. Saiga, N. Uozumi, T. Ono et al., "Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid ... production without activation of cytosolic phospholipase A2 alpha," Prostaglandins and Other Lipid Mediators, vol. 75, no. 1-4 ... The Step Further to Understand the Role of Cytosolic Phospholipase A2 Alpha and Group X Secretory Phospholipase A2 in Allergic ... "Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells ...https://www.hindawi.com/journals/bmri/2014/670814/ref/
Induction of Cytosolic Phospholipase A2α Is Required for Adipose Neutrophil Infiltration and Hepatic Insulin Resistance Early...
It plays a major role in the stimulus-initiated production of eicosanoids (prostaglandins and the chemoattractant leukotrienes ... Group IVA phospholipase A2 is associated with the storage of lipids in adipose tissue and liver. Prostaglandins Other Lipid ... Cytosolic phospholipase A2 is responsible for prostaglandin E2 and leukotriene B4 formation in phagocyte-like PLB-985 cells: ... Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase. J Biol Chem 1998;273:441-445 ...http://diabetes.diabetesjournals.org/content/62/9/3053?with-ds=yes
Phospholipids are hydrolyzed by phospholipase A2 libera | Open-i
Phospholipids are hydrolyzed by phospholipase A2 liberating arachidonic acid and Lyso-PAF, regulators of insect's immune system ... Arachidonic acid is the substrate for eicosanoid production, prostaglandins via cyclooxygenase and leukotrienes via ... Arachidonic acid is the substrate for eicosanoid production, prostaglandins via cyclooxygenase and leukotrienes via ... 25] showed that eicosanoid biosynthesis inhibitors attenuated the PO activity in Galleria mellonella challenged with bacteria, ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2719633_1756-3305-2-33-3&req=4
Cerebrospinal fluid secretory [Ca.sup.2+]-dependent phospholipase [A.sub.2] activity is increased in alzheimer disease. - Free...
... dependent phospholipase [A.sub.2] activity is increased in alzheimer disease.(Proteomics and Protein Markers) by 'Clinical ... in proinflammatory eicosanoids (i.e., prostaglandins, leukotrienes, and thromboxanes) and isoprostanes, respectively (36, 37). ... Phospholipase A(2) Biochemistry. Cardiovasc Drugs Ther 2009;23:49-59. (2.) Farooqui AA, Horrocks LA. Phospholipase A2generated ... and serve as precursors for the synthesis of proinflammatory mediators such as eicosanoids (prostaglandins and leukotrienes) ...https://www.thefreelibrary.com/Cerebrospinal+fluid+secretory+%5BCa.sup.2%2B%5D-dependent+phospholipase+...-a0324398243
The role of specific eicosanoids in mediating the acute narcotic effects of ethanol. | Journal of Pharmacology and Experimental...
Pretreatment with prostaglandin agonists and antagonists suggest a significant role for prostaglandin E (PGE) and a minor role ... The pharmacological effects of ethanol may be in part due to increased membrane fluidity, resulting in increased phospholipase ... prostaglandins/leukotrienes). A significant correlation between the in vivo and in vitro potency of prostaglandin synthetase ( ... The role of specific eicosanoids in mediating the acute narcotic effects of ethanol.. G I Elmer and F R George ...http://jpet.aspetjournals.org/content/277/1/308
Recombinant Human phospholipase A2, group IID, His-tagged PLA2G2D-68H - Creative BioMart
sPLA2-IID His-Tagged Fusion protein is 16.4 kDa containing 125 amino acid residues of the human secreted phospholipase A2-IID ... Recombinant Human Secreted Phospholipase A2-IIDexpressed inE.Coliwas produced with N-terminal His-Tag. ... a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which ... SPLASH; sPLA2S; PLA2G2D;phospholipase A2, group IID; secretory phospholipase A2s; Group IID secretory phospholipase A2; GIID ...https://www.creativebiomart.net/description_4129_12.htm
Expression of PLA2G4A in cancer - Summary - The Human Protein Atlas
GO:0046456 [icosanoid biosynthetic process]. GO:0046872 [metal ion binding]. GO:0047498 [calcium-dependent phospholipase A2 ... Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, ... Phospholipase A2 group IVA (HGNC Symbol). Entrez gene summary. This gene encodes a member of the cytosolic phospholipase A2 ... GO:0004620 [phospholipase activity]. GO:0004622 [lysophospholipase activity]. GO:0004623 [phospholipase A2 activity]. GO: ...http://www.proteinatlas.org/ENSG00000116711-PLA2G4A/pathology
Fatty acid metabolism - Wikipedia
Every prostaglandin therefore contains 20 carbon atoms, including a 5-carbon ring. They are a subclass of eicosanoids and form ... This is catalyzed either by phospholipase A2 acting directly on a membrane phospholipid, or by a lipase acting on DAG (diacyl- ... A given prostaglandin may have different and even opposite effects in different tissues. The ability of the same prostaglandin ... The discovery of the prostaglandin transporter (PGT, SLCO2A1), which mediates the cellular uptake of prostaglandin, ...https://en.wikipedia.org/wiki/Fatty_acid_metabolism
PLA2G5 Human | ProSpec
sPLA2-VHis-Tagged Fusion protein is 15.5 kDa containing 118 amino acid residues of the human secreted phospholipase A2-V and 16 ... Secreted Phospholipase A2-V Human Recombinant was produced with N-terminal His-Tag. ... a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which ... Calcium-dependent phospholipase A2, EC 22.214.171.124, Phosphatidylcholine 2-acylhydrolase, PLA2-10, Group V phospholipase A2, GV-PLA2 ...https://www.prospecbio.com/PLA2G5_Human
Membrane lipid - Wikipedia
The resulting substances, called eicosanoids: prostaglandins (PG), leukotrienes (LT), lipoxins and thromboxane (TX); and ... provides them with the possibility of changing their molecular structure through enzymes such as phospholipases, ...https://en.wikipedia.org/wiki/Membrane_lipid
Best Weight Loss Programs That Work - Barnard Health Care
... cell membrane phospholipids via the action of phospholipase A2 results in the subsequent production of AA-derived eicosanoids, ... Regulation of Prostaglandin and Leukotriene Synthesis by Dietary Fatty Acids Last Updated on Wed, 24 Oct 2018 , Weight Loss ... The diverse physiologic and pathologic functions mediated by eicosanoids highlight the importance of their fatty acid ... and eicosanoids with different biological activity (PGE3 and LTB5) are produced through the cyclooxygenase and 5-lipoxy-genase ...https://www.barnardhealth.us/weight-loss-programs.html
Science - Biomol-Med - Antioxidative barrier
Eicosanoids synthesis - A2 phospholipase releases arachidonic acid from phospholipoids, which is transformed into ... prostaglandins, leukotriens, tromboxanes, and prostacyclins by cyclo- and lipoxygenases. ROS are generated in all these ... ROS activate A2 phospholipase.. Although it is not a free radical, hydrogen peroxide plays an important role in processes of ...http://biomol.pl/biomol/en_GB/articles/science/antioxidative-barrier.html
The low molecular weight fraction of human serum albumin upregulates COX2, prostaglandin E2, and prostaglandin D2 under...
COX enzymes catalyze the conversion of arachidonic acid, which is liberated from cell membranes by phospholipase A2, into ... PGH2 then acts as a substrate for a number of synthases and isomerases to produce a panel of eicosanoids, including ... Levels of prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) in the media were quantified by competitive ELISA. ... Prostaglandin enzyme-linked immunosorbent assays (ELISAs). Conditioned media for the two prostaglandin assays used in this ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5613771/
Recombinant Human PLA2G4A, His-tagged PLA2G4A-557H - Creative BioMart
sPLA2-X His-Tagged Fusion Protein, is 15.5 kDa containing 123 amino acid residues of the human secreted phospholipase A2. It is ... a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which ... PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) [ Homo sapiens ]. Synonyms:. PLA2G4A; phospholipase A2, ... calcium-dependent phospholipase A2 activity; hydrolase activity; lysophospholipase activity; phospholipase A2 activity. ...https://www.creativebiomart.net/description_6981_8.htm
JCI - The organization and consequences of eicosanoid signaling
Regulation of prostaglandin E2 biosynthesis by inducible membrane-associated prostaglandin E2 synthase that acts in concert ... Role of phosphorylation sites and the C2 domain in regulation of cytosolic phospholipase A2. J. Cell Biol. 1999. 145:1219-1232 ... 15-Deoxy-12,14-prostaglandin J2 inhibits multiple steps in the NF-κB signaling pathway. Proc. Natl. Acad. Sci. U. S. A. 2000. ... Inactivation of wild-type p53 tumor suppressor by electrophilic prostaglandins. Proc. Natl. Acad. Sci. U. S. A. 2000. 97:9215- ...https://www.jci.org/articles/view/18338
cPLA2α Inhibitor - Calbiochem | 525143
... cytosolic phospholipase A2α) (IC50 = 1.8 nM). - Find MSDS or SDS, a COA, data sheets and more information. ... cytosolic phospholipase A2α) (IC50 = 1.8 nM). Blocks the release of eicosanoids from A23187-stimulated THP-1 cells (IC50 = 22 ... 31 nM for prostaglandin E2; 13 nM for leukotriene C4). Exhibits ~230-fold greater potency in enzyme assays and ~3900-fold ... More,, cPLA2α Inhibitor is a cell-permeable, highly specific and potent inhibitor of cPLA2α (cytosolic phospholipase A2α) (IC50 ...http://www.merckmillipore.com/INTL/en/product/cPLA2-Inhibitor-Calbiochem,EMD_BIO-525143
Alclometasone - Wikipedia
Without the oxidation of arachidonic acid, eicosanoids, such as prostaglandins, thromboxanes, and leukotrienes, can't be ... Alclometasone induces the production of lipocortins, formally known as annexins, which inhibit phospholipase A2 - the enzyme ...https://en.wikipedia.org/wiki/Alclometasone
Small peptides and methods for blocking IGE mediated activation of an immune cell - Mowycal Lending, LLC
4. The prostaglandins, thromboxanes, and leukotrienes are known collectively as eicosanoids.. Anti-leukotrienes are members of ... and basophils is formed from membrane phospholipids by the activation of phospholipase A2. After its formation, arachidonic ... Like related prostaglandin compounds, leukotrienes are synthesized from arachidonic acid in the cell membrane. Arachidonic acid ... Leukotrienes are inflammatory substances related to prostaglandins; both are generated from arachidonic acid in cell membranes ...http://www.freepatentsonline.com/8809281.html
... the membrane by the action of phospholipases. These compounds serve as the precursor for prostaglandins, leukotrienes, ... as well as aspects of channeling of intermediates in eicosanoid biosynthetic pathways and protein-protein recognition. ... thromboxanes, and other biologically active eicosanoids, and the enzymes involved in their biosynthesis represent drug targets ...https://www.lsu.edu/science/biosci/faculty_and_staff/newcomer.php
Gene Ontology Classifications
Arachidonic acid is further metabolized into eicosanoids such as leukotrienes, thromboxanes and prostaglandins, that play ... phospholipase A2, group IVA (cytosolic, calcium-dependent). MGI:1195256 Go Annotations as Summary Text (Tabular View) (GO Graph ... The protein encoded by this gene is a member of the phospholipase A2 group IV family. This enzyme hydrolyzes membrane ...http://www.informatics.jax.org/go/marker/MGI:1195256