Intracellular- and extracellular-derived Ca2+ influence phospholipase A2-mediated fatty acid release from brain phospholipids
Eicosanoids and the hypothalamo-pituitary axis. Prostaglandins Leukot Essent Fatty Acids. 1989;36:235-250. Scopus. [PubMed] ... cytosolic phospholipase A2. iPLA2. Ca2+-independent phospholipase A2. sPLA2. secretory phospholipase A2. PUFA. polyunsaturated ... Brain phospholipases A2: a perspective on the history. Prostaglandins Leukot Essent Fatty Acids. 2004;71:161-169. [PubMed] ... 1. Kudo I, Murakami M. Phospholipase A2 enzymes. Prostaglandins Other Lipid Mediat. 2002;68-69:3-58. [PubMed] ...http://pubmedcentralcanada.ca/pmcc/articles/PMC2735787/
Publications 2014 - Institut de pharmacologie de Sherbrooke - Université de Sherbrooke
Cytosolic phospholipase A2 and eicosanoids modulate life, death and function of human osteoclasts in vitro. Prostaglandins ... Prostaglandins Leukot. Essent. Fatty Acids 90, 39-45 (2014). Jones, J. D. et al. Serum C-X-C motif chemokine 13 is elevated in ... Allard-Chamard, H., Haroun, S. & de Brum-Fernandes, A. J. Secreted phospholipase A2 type II is present in Paget's disease of ... Yue, L., Haroun, S., Parent, J.-L. & de Brum-Fernandes, A. J. Prostaglandin D(2) induces apoptosis of human osteoclasts through ...https://www.usherbrooke.ca/ips/fr/publications/publications-2014/
Modulation of Membrane Lipid Composition and Homeostasis in Salmon Hepatocytes Exposed to Hypoxia and Perfluorooctane...
... phospholipase activity and eicosanoid production in Atlantic salmon (Salmo salar). Prostaglandins Leukot Essent Fatty Acids 49 ... For example, eicosanoids, including prostaglandins, thromboxanes and leukotrienes, belong to an extensive family of oxygenated ... Over-production of ARA-derived eicosanoids may be responsible for a number of pathophysical conditions in humans, such as ... Forman BM, Chen J, Evans RM (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome ...https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0102485
The Step Further to Understand the Role of Cytosolic Phospholipase A2 Alpha and Group X Secretory Phospholipase A2 in Allergic...
A. Saiga, N. Uozumi, T. Ono et al., "Group X secretory phospholipase A2 can induce arachidonic acid release and eicosanoid ... production without activation of cytosolic phospholipase A2 alpha," Prostaglandins and Other Lipid Mediators, vol. 75, no. 1-4 ... The Step Further to Understand the Role of Cytosolic Phospholipase A2 Alpha and Group X Secretory Phospholipase A2 in Allergic ... "Secretory phospholipase A2 receptor-mediated activation of cytosolic phospholipase A2 in murine bone marrow-derived mast cells ...https://www.hindawi.com/journals/bmri/2014/670814/ref/
Induction of Cytosolic Phospholipase A2α Is Required for Adipose Neutrophil Infiltration and Hepatic Insulin Resistance Early...
It plays a major role in the stimulus-initiated production of eicosanoids (prostaglandins and the chemoattractant leukotrienes ... Group IVA phospholipase A2 is associated with the storage of lipids in adipose tissue and liver. Prostaglandins Other Lipid ... Cytosolic phospholipase A2 is responsible for prostaglandin E2 and leukotriene B4 formation in phagocyte-like PLB-985 cells: ... Essential requirement of cytosolic phospholipase A2 for activation of the phagocyte NADPH oxidase. J Biol Chem 1998;273:441-445 ...http://diabetes.diabetesjournals.org/content/62/9/3053?with-ds=yes
Phospholipids are hydrolyzed by phospholipase A2 libera | Open-i
Phospholipids are hydrolyzed by phospholipase A2 liberating arachidonic acid and Lyso-PAF, regulators of insect's immune system ... Arachidonic acid is the substrate for eicosanoid production, prostaglandins via cyclooxygenase and leukotrienes via ... Arachidonic acid is the substrate for eicosanoid production, prostaglandins via cyclooxygenase and leukotrienes via ... 25] showed that eicosanoid biosynthesis inhibitors attenuated the PO activity in Galleria mellonella challenged with bacteria, ...https://openi.nlm.nih.gov/detailedresult.php?img=PMC2719633_1756-3305-2-33-3&req=4
Cerebrospinal fluid secretory [Ca.sup.2+]-dependent phospholipase [A.sub.2] activity is increased in alzheimer disease. - Free...
... dependent phospholipase [A.sub.2] activity is increased in alzheimer disease.(Proteomics and Protein Markers) by 'Clinical ... in proinflammatory eicosanoids (i.e., prostaglandins, leukotrienes, and thromboxanes) and isoprostanes, respectively (36, 37). ... Phospholipase A(2) Biochemistry. Cardiovasc Drugs Ther 2009;23:49-59. (2.) Farooqui AA, Horrocks LA. Phospholipase A2generated ... and serve as precursors for the synthesis of proinflammatory mediators such as eicosanoids (prostaglandins and leukotrienes) ...https://www.thefreelibrary.com/Cerebrospinal+fluid+secretory+%5BCa.sup.2%2B%5D-dependent+phospholipase+...-a0324398243
The role of specific eicosanoids in mediating the acute narcotic effects of ethanol. | Journal of Pharmacology and Experimental...
Pretreatment with prostaglandin agonists and antagonists suggest a significant role for prostaglandin E (PGE) and a minor role ... The pharmacological effects of ethanol may be in part due to increased membrane fluidity, resulting in increased phospholipase ... prostaglandins/leukotrienes). A significant correlation between the in vivo and in vitro potency of prostaglandin synthetase ( ... The role of specific eicosanoids in mediating the acute narcotic effects of ethanol.. G I Elmer and F R George ...http://jpet.aspetjournals.org/content/277/1/308
Fatty acid metabolism - Wikipedia
Every prostaglandin therefore contains 20 carbon atoms, including a 5-carbon ring. They are a subclass of eicosanoids and form ... This is catalyzed either by phospholipase A2 acting directly on a membrane phospholipid, or by a lipase acting on DAG (diacyl- ... A given prostaglandin may have different and even opposite effects in different tissues. The ability of the same prostaglandin ... The discovery of the prostaglandin transporter (PGT, SLCO2A1), which mediates the cellular uptake of prostaglandin, ...https://en.wikipedia.org/wiki/Fatty_acid_metabolism
PLA2G5 Human | ProSpec
sPLA2-VHis-Tagged Fusion protein is 15.5 kDa containing 118 amino acid residues of the human secreted phospholipase A2-V and 16 ... Secreted Phospholipase A2-V Human Recombinant was produced with N-terminal His-Tag. ... a precursor of eicosanoids including prostaglandins and leukotrienes. The same reaction also produces lysophosholipids, which ... Calcium-dependent phospholipase A2, EC 184.108.40.206, Phosphatidylcholine 2-acylhydrolase, PLA2-10, Group V phospholipase A2, GV-PLA2 ...https://www.prospecbio.com/PLA2G5_Human
... the membrane by the action of phospholipases. These compounds serve as the precursor for prostaglandins, leukotrienes, ... as well as aspects of channeling of intermediates in eicosanoid biosynthetic pathways and protein-protein recognition. ... thromboxanes, and other biologically active eicosanoids, and the enzymes involved in their biosynthesis represent drug targets ...https://www.lsu.edu/science/biosci/faculty_and_staff/newcomer.php
The low molecular weight fraction of human serum albumin upregulates COX2, prostaglandin E2, and prostaglandin D2 under...
COX enzymes catalyze the conversion of arachidonic acid, which is liberated from cell membranes by phospholipase A2, into ... PGH2 then acts as a substrate for a number of synthases and isomerases to produce a panel of eicosanoids, including ... Levels of prostaglandin E2 (PGE2) and prostaglandin D2 (PGD2) in the media were quantified by competitive ELISA. ... Prostaglandin enzyme-linked immunosorbent assays (ELISAs). Conditioned media for the two prostaglandin assays used in this ...http://pubmedcentralcanada.ca/pmcc/articles/PMC5613771/
Science - Biomol-Med - Antioxidative barrier
Eicosanoids synthesis - A2 phospholipase releases arachidonic acid from phospholipoids, which is transformed into ... prostaglandins, leukotriens, tromboxanes, and prostacyclins by cyclo- and lipoxygenases. ROS are generated in all these ... ROS activate A2 phospholipase.. Although it is not a free radical, hydrogen peroxide plays an important role in processes of ...http://biomol.pl/biomol/en_GB/articles/science/antioxidative-barrier.html
Small peptides and methods for blocking IGE mediated activation of an immune cell - Mowycal Lending, LLC
4. The prostaglandins, thromboxanes, and leukotrienes are known collectively as eicosanoids.. Anti-leukotrienes are members of ... and basophils is formed from membrane phospholipids by the activation of phospholipase A2. After its formation, arachidonic ... Like related prostaglandin compounds, leukotrienes are synthesized from arachidonic acid in the cell membrane. Arachidonic acid ... Leukotrienes are inflammatory substances related to prostaglandins; both are generated from arachidonic acid in cell membranes ...http://www.freepatentsonline.com/8809281.html
Membrane lipid - Wikipedia
The resulting substances, called eicosanoids: prostaglandins (PG), leukotrienes (LT), lipoxins and thromboxane (TX); and ... provides them with the possibility of changing their molecular structure through enzymes such as phospholipases, ...https://en.wikipedia.org/wiki/Membrane_lipid
Gene Ontology Classifications
Arachidonic acid is further metabolized into eicosanoids such as leukotrienes, thromboxanes and prostaglandins, that play ... phospholipase A2, group IVA (cytosolic, calcium-dependent). MGI:1195256 Go Annotations as Summary Text (Tabular View) (GO Graph ... The protein encoded by this gene is a member of the phospholipase A2 group IV family. This enzyme hydrolyzes membrane ...http://www.informatics.jax.org/go/marker/MGI:1195256
Biosynthesis and Metabolism of Inositol and Inositol Phosphates
... including prostaglandins via the action of the enzyme phospholipase A2, as well as the main source of diacylglycerols that ... Phosphatidylinositol is the primary source of the arachidonic acid required for biosynthesis of eicosanoids, ...https://ebooks.benthamscience.com/book/9781681080079/chapter/129093/
Alclometasone - Wikipedia
Without the oxidation of arachidonic acid, eicosanoids, such as prostaglandins, thromboxanes, and leukotrienes, can't be ... Alclometasone induces the production of lipocortins, formally known as annexins, which inhibit phospholipase A2 - the enzyme ...https://en.wikipedia.org/wiki/Alclometasone
Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s | JEM
Eicosanoids are a family of arachidonic acid metabolites that includes the prostaglandins and leukotrienes (LTs). Eicosanoids ... Eicosanoid biosynthesis is initiated by phospholipase A2, which releases arachidonic acid from membrane phospholipids (Fig. S1 ... Prostaglandin I2 signaling and inhibition of group 2 innate lymphoid cell responses. Am. J. Respir. Crit. Care Med. 193:31-42. ... Prostaglandin D2 regulates human type 2 innate lymphoid cell chemotaxis. J. Allergy Clin. Immunol. 133:899-901.e3. doi:10.1016/ ...http://jem.rupress.org/content/214/1/27.full
Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury ...
The eicosanoids produced in the brain postinjury depend upon the enzymes present locally at any given time. Eicosanoids are ... The dynamic metabolism of ArA to eicosanoids, and how they affect the injured brain, is poorly understood due to their diverse ... ArA metabolites form a class of over 50 bioactive eicosanoids that can induce both adaptive and/or maladaptive brain responses ... Kunz T, Marklund N, Hillered L, Oliw EH: Cyclooxygenase-2, prostaglandin synthases, and prostaglandin H2 metabolism in ...https://bmcgenomics.biomedcentral.com/articles/10.1186/1471-2164-14-303
Method of Treating Airway Diseases With Beta-Adrenergic Inverse Agonists - Patent application
... including eicosanoids such as prostaglandins. Thus, any treatment that can inhibit phospholipase C activity is relevant for the ... Effect of Treatment with Salbutamol or Nadolol on the Ratio of Phospholipase C to Actin in Cultured Tracheal Smooth Muscle ... Phospholipase C(PLC-β1) was determined by immunoblotting with an antibody specific for the enzyme. Actin was used as a loading ... The enzyme phospholipase C plays a key role in the pathway leading to asthmatic symptoms, as it cleaves a phosphodiester bond ...http://www.patentsencyclopedia.com/app/20080254022
VM139/VM104: Interrelationship of Nutrition and Immunity
These prostaglandins are produced in the cells following the oxidation of cellular membranes and are responsible for inhibiting ... Various stimuli, including stress hormones, activate phospholipase A2 which frees the 20-carbon fatty acid, arachidonic acid, ... reduce the detrimental effects of certain eicosanoids, and enhance humoral and cellular immune responses in disease stress, ... Vitamin E prevents oxidation and thus, the production of prostaglandins. It is well known that deficiencies of vitamin E and ...http://edis.ifas.ufl.edu/vm104
Glycerophospholipid - Wikipedia
... such as prostaglandins, eicosanoids, platelet activating factor and diacylglycerol. Thus, neural membrane phospholipids are a ... Receptor-mediated degradation of glycerophospholipids by phospholipases A(l), A(2), C, and D results in generation of second ...https://en.wikipedia.org/wiki/Glycerophospholipid
BPAI Board of Patent Appeals and Interferences Patent and Trademark Office (P.T.O.) EX PARTE JOHN L. KNOPE AND JAMES CLARK - IP...
These products are collectively referred to as ""eicosanoids." Overproduction of eicosanoids is responsible for certain systems ... and a phospholipase A2 enzyme and observing whether said phospholipase A2 enzyme cleaves said phospholipid and releases fatty ... The products of the arachidonic cascade are varied and include prostaglandins, thromboxanes, leukotrienes, and other ... said phospholipase A2 enzyme being characterized by an amino acid sequence selected from the group consisting of:. (a) an amino ...http://ipmall.info/content/bpai-board-patent-appeals-and-interferences-patent-and-trademark-office-pto-ex-parte-john-l
Phospholipase A2 Activity Test
... prostaglandins, leukotrienes, and thromboxanes, collectively called eicosanoids. Release of these mediators initiates the pain ... Phospholipase A2 is in fact a family of enzymes that are categorized by location and function. They have strong antibacterial ... is excited about our recently developed phospholipase A2 (PLA2) test that measures the activity of PLA2 in urine. We are the ... The enzyme in venom that triggers this immune response is phospholipase A2. This enzyme is also present in human tissue. During ...http://www.spiritofhealthkc.com/services/health-testing/urine-testing/phospholipase-a2-activity-test/